Clinical trials: Pediatric Disease
Pediatric Respiratory Diseases, Respiratory Failure
Use of Lung Ultrasound to Diagnose the Etiology of Respiratory Failure in a PICU.
The purpose of this study is to determine the utility of point-of-care lung ultrasound (POC-LUS) in identifying the etiology of acute respiratory failure in pediatric patients admitted to the pediatric intensive care unit.
- Trial name
- NCT03744169
- Testing
- Lung ultrasound, Clinical exam, Chest x-ray
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- University of Wisconsin, Madison
Pediatric Crohns Disease
Clinical Hypnosis in Pediatric Crohn's Disease
Inflammatory bowel disease (IBD), which includes Crohn's disease (CD) and ulcerative colitis (UC), is a chronic, immune-mediated disease increasingly prevalent in youth.
- Trial name
- HypnoCrohns (NCT03809195)
- Testing
- Clinical Hypnosis
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Vanderbilt University Medical Center
Effect of Drugs, Progression
Famitinib Plus Camrelizumab & Famitinib Alone & Famitinib Plus Ifosfamide in Advanced Osteosarcoma
Results of previous study showed high objective response but short-term activity of anti-angiogenesis tyrosine kinase inhibitors in advanced osteosarcoma.
- Conditions
- Effect of Drugs, Progression, Pediatric Cancer
- Trial name
- NCT04044378
- Testing
- Famitinib, Ifosfamide, Camrelizumab
- Where
- China
- Sponsor
- Peking University People's Hospital
Elastography, Fibrosis, Liver
The Use of the Transient Elastography Paediatric Probe, Compared to the M Probe, Indirect Biomarkers and Histology
The purpose of this study is to assess the reliability, reproducibility and accuracy of the paediatric probe of transient elastography in detecting liver fibrosis in children, besides its limitations and side effects.
- Conditions
- Elastography, Fibrosis, Liver, Pediatrics, Chronic Liver Disease
- Trial name
- NCT04380493
- Testing
- hepatic transient elastography using S probe and M probe
- Where
- Spain
- Volunteers
- 141 people
- Sponsor
- Hospital Vall d'Hebron
Pediatric Gastroesophageal Reflux Disease
Phase 1 Dexlansoprazole Delayed-Release Capsules for Acid-Related Disorders in Infants Aged 1 to 11 Months
The purpose of this study is to assess the pharmacokinetics (PK) and pharmacodynamics (PD) [after daily administration for 7 days] and safety [after daily administration for 8 weeks] of dexlansoprazole in pediatric participants…
- Trial name
- NCT02442752
- Testing
- Dexlansoprazole
- Where
- 22 sites in United States, Israel and 3 more
- Sponsor
- Takeda
Pediatric Respiratory Diseases
Diagnostic Role of Chest Ultrasound in Children Presenting With Respiratory Distress in Pediatric Intensive Care Unit (PICU) Compared to Chest X-ray
The use of POCUS in pediatrics is gaining momentum, and whilst pediatric specific data remains limited when compared to adult critical care, there is growing pediatric evidence demonstrating the high sensitivity and specificity…
- Trial name
- PICU (NCT04328220)
- Testing
- chest ultrasound
- Volunteers
- 100 people
- Sponsor
- Assiut University
Rheumatoid Arthritis, Polyarticular Juvenile Idiopathic Arthritis
Comparison of PK and Tolerability of MSB11022 Administered by AI or PFS
The primary objective of this study is to demonstrate equivalence of the pharmacokinetic (PK) profile of MSB11022 administered by either an auto-injector (AI) or a pre-filled syringe (PFS) as single subcutaneous (s.c.) injection…
- Conditions
- Rheumatoid Arthritis, Polyarticular Juvenile Idiopathic Arthritis, Psoriatic Arthritis, Ankylosing Spondylitis
- Trial name
- NCT04018599
- Testing
- 40 mg MSB11022
- Where
- 2 sites in United States
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- Fresenius Kabi SwissBioSim GmbH
Obsessive-Compulsive Disorder, Children
Intravenous Immunoglobulin for PANDAS
Background: Some children experience a sudden onset of symptoms similar to those found in obsessive-compulsive disorder that may be caused by the body s reaction to an infection with streptococcal bacteria, most commonly seen as…
- Conditions
- Obsessive-Compulsive Disorder, Children, Anxiety Disorder, Autoimmune Disease
- Trial name
- NCT01281969
- Testing
- Gamunex Intravenous Immunoglobulin
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- National Institute of Mental Health (NIMH)
Crohn Disease, Pediatric Crohns Disease
FMT in Pediatric Crohn's Disease
The goal of this study is to evaluate the safety of Fecal Microbiota Transplantation (FMT) in children with Crohn's disease who are in remission. Safety will be the primary endpoint and Pediatric Crohn's Disease.
- Trial name
- FMTPCD (NCT03194529)
- Testing
- FMT
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Children's Hospital Los Angeles
Pediatrics, Heart Failure
Platelet and Tissue cAMP: Novel Biomarkers of Milrinone Efficacy in Children
The purpose of this study is to identify if circulating platelet cyclic adenosine monophosphate (cAMP) levels can be used as a biomarker of milrinone efficacy in children following cardiac surgery or undergoing heart transplant.
- Conditions
- Pediatrics, Heart Failure, Congenital Heart Disease, Therapeutics
- Trial name
- NCT02728128
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- University of Colorado, Denver
Pediatric Respiratory Diseases
Structured Light Plethysmography in Obstructive Airways Disease
Obstructive airways disease is the most common group of acute illnesses leading to hospital treatment in children. This group consists of different age-related diagnoses, such as bronchiolitis in infants or wheezing and asthma in…
- Trial name
- NCT03499938
- Testing
- Structured Light Plethysmography
- Where
- United Kingdom
- Volunteers
- 57 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Cardiac Disease, Pediatric Disease
Parametric Mapping in Paediatric Magnetic Resonance Imaging
Magnetic resonance imaging (MRI) is increasingly an important tool for diagnosis and management of cardiac diseases in children.
- Conditions
- Cardiac Disease, Pediatric Disease, Cardiomyopathies, Congenital Disorders
- Trial name
- NCT04068987
- Testing
- MRI parametric mapping
- Where
- Hong Kong
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Hong Kong Children's Hospital
Pediatric Crohn's Disease
Trial of Enhanced Pre-Consent Discussion
Nested within the COMBINE pragmatic clinical trial, the investigators will conduct a cluster randomized controlled trial to determine whether, in parents (of children with Crohn's Disease) or patients > 18 years old being…
- Trial name
- NCT02869880
- Testing
- Enhanced Pre-Consent Discussion, Standard Pre-consent Discussion
- Where
- United States
- Volunteers
- 241 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Obesity, Childhood, Cardiac Disease
Chronotropic Incompetence During Exercise Testing in Obese Adolescents
In adolescents with obesity cardiopulmonary exercise testing (CPET) has become an important clinical examination providing valuable information with regard to the integrative exercise responses, including the pulmonary…
- Conditions
- Obesity, Childhood, Cardiac Disease, Cardiovascular Risk Factor
- Trial name
- NCT04185753
- Testing
- The prevalence of chronotropic incompetence during maximal cardiopulmonary exercise testing
- Where
- Belgium
- Volunteers
- 60 people
- Sponsor
- Hasselt University
Pediatric Respiratory Diseases
Asynchronies in Pediatric Noninvasive Ventilation
The term ''Non-invasive ventilation'' (NIV) refers to various methods of respiratory assistance, in the absence of an indwelling endotracheal tube.
- Trial name
- Asyn-Vent (NCT04017780)
- Testing
- Single-Limb Turbine-Driven Ventilator, Double-Limb Intensive Care Unit ventilator, Double-Limb Turbine-Driven Ventilator
- Where
- Italy
- Volunteers
- 12 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Failing Fontan Physiology, Pediatric Congenital Heart Disease
Noninvasive Negative Pressure Ventilation to Support Failing Fontan Physiology
The purpose of this study is to assess for acute hemodynamic changes after implementation of noninvasive negative pressure ventilation (as compared with spontaneous respiration) in pediatric patients with Fontan failure using…
- Trial name
- NCT03223168
- Testing
- Hayek RTX ventilator
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Michigan
Sickle Cell Disease, Pediatric
Impact on the Length of Stay in Incentive Spirometry and Pain in the Decompensation of Sickle Cell Disease: .
In this prospective observational study among sickle cell children aged 7 to 17 years, who face many experience of pain, pain will be assessed during incentive spirometry sessions.
- Trial name
- SPIDO (NCT04041180)
- Where
- France
- Volunteers
- 25 people
- Sponsor
- Centre Hospitalier Régional d'Orléans
Pneumonia, Pediatric Disorder
Standardization of Mid-Level Providers Using Point of Care Ultrasound to Diagnose Pediatric Pneumonia
The POCUS training program aims to bring sustainable, affordable access to POCUS to patients in need of diagnostic services in Uganda.
- Conditions
- Pneumonia, Pediatric Disorder, Diagnostic and Monitoring Radiological Devices Associated With Adverse Incidents
- Trial name
- POCUS (NCT03969342)
- Testing
- Point of care ultrasound training
- Where
- Uganda
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Bridge to Health Medical and Dental
Sleep Apnea, Obstructive, Otorhinolaryngologic Diseases
Randomized Control Trials of Surgery for Pediatric OSA
Randomized study on pediatric OSA with 2 groups: mild-moderate OSA and severe OSA. Mild-moderate are randomized to either expectancy or ATE. Severe are randomized to either ATE or APP. Pediatric age span of 2 until 4,9 years.
- Conditions
- Sleep Apnea, Obstructive, Otorhinolaryngologic Diseases, Pediatric Disorder
- Trial name
- NCT02315911
- Testing
- ATE, APP
- Where
- Sweden
- Volunteers
- 143 people
- Sponsor
- Karolinska University Hospital
Oral Disease, Graft-versus-host-disease
Prevalence of Chronic Oral Graft Versus Host Disease Risk Factors in Pediatric Patients
our aim is estimating the Prevalence and predicting risk factors for developing chronic oral graft versus host disease in pediatric patients subjected to hematopoietic stem cells transplantation
- Conditions
- Oral Disease, Graft-versus-host-disease, Stem Cell Transplant Complications, Pediatric Disorder
- Trial name
- NCT03880214
- Volunteers
- 250 people
- Sponsor
- yasmeen magdi sholkamy