Clinical trials: Pediatric Disorder, active
Acute Leukemia, Acute Lymphoblastic Leukemia, Pediatric
Brain MRF in Children, Adolescents and Young Adults With Acute Leukemia
The survival of children, adolescents and young adults (AYA) with acute leukemia has improved dramatically over the last two decades.
- Conditions
- Acute Leukemia, Acute Lymphoblastic Leukemia, Pediatric, Acute Myeloid Leukemia in Children, Myeloproliferative Neoplasm
- Trial name
- NCT06421155
- Testing
- MRF with neurocognative studies
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Case Comprehensive Cancer Center
Abdominal Pain, Isolated Extremity Fracture
Morphine or Ketamine for Analgesia
Pain is common in children presenting to the emergency department but is frequently undertreated, leading to both short- and long-term consequences.
- Conditions
- Abdominal Pain, Isolated Extremity Fracture, Pain, Pediatrics
- Trial name
- MoKA (NCT06835504)
- Testing
- Ketamine hydrochloride, Morphine sulphate
- Where
- 8 sites in United States
- Volunteers
- 1,010 people
- Sponsor
- Columbia University
Neurology, Aromatic Amino Acid Decarboxylase Deficiency
Newborn Screening and Early Diagnosis of AADC Deficiency in the Ligurian Population
Aromatic L-amino acid decarboxylase deficiency (AADC-D) is a rare genetic disorder that affects the production of neurotransmitters in the brain and can cause severe neurological and developmental problems.
- Conditions
- Neurology, Aromatic Amino Acid Decarboxylase Deficiency, Pediatric Neurological Disorder
- Trial name
- NBS3OMD22 (NCT07877714)
- Where
- 10 sites in Italy
- Volunteers
- 16,000 people
- Sponsor
- Istituto Giannina Gaslini
Pediatric Pain, Anxiety
PURSUIT: A Technologically Augmented School-based Program to Improve Child Coping and Prevent Substance Use.
The study investigators aim to test an online support platform for Michigan youth aged 8-18 years enrolled in elementary, middle, or high school and their parent/caregiver.
- Conditions
- Pediatric Pain, Anxiety, Mood, Stress
- Trial name
- NCT07266740
- Testing
- PURSUIT
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Michigan State University
Urology, Pediatric Disorder
Pelvic Floor Muscle Training and Dynamic Neuromuscular Stabilization Exercises in Pediatric Patients
Dysfunctional voiding (DY) is one of the most common conditions in children. Various treatments are available. Participants will be randomly assigned to either PFMT (Group I) or PFMT+DNS (Group II).
- Trial name
- NCT07267364
- Testing
- PFMT
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Necmettin Erbakan University
Disorders of Sex Development (DSD), Pediatric and Adolescent Cancers of the Genital Tract
Data Collection Study of Pediatric and Adolescent Gynecology Conditions
Background: Gynecologic conditions are those that are related to the reproductive system. They can be reproductive gland disorders or reproductive system tumors. They can also be inborn anomalies of the reproductive tract.
- Conditions
- Disorders of Sex Development (DSD), Pediatric and Adolescent Cancers of the Genital Tract, Reproductive Endocrine Conditions in Puberty, Structural Gynecologic Conditions Including Vulvar and Vaginal Conditions
- Trial name
- NCT04717349
- Where
- United States
- Volunteers
- 11,000 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Obesity, Adolescent, Healthy Nutrition
Wakaya: Rising Up for Choctaw Youth Health
Investigators will conduct a two-group randomized waitlist-control trial to assess the efficacy of the Wakaya: Rising Up for Choctaw Youth Health program on improving physical activity, reducing sedentary behaviors and improving…
- Conditions
- Obesity, Adolescent, Healthy Nutrition, Sedentary Behavior, Drug Abuse
- Trial name
- Wakaya (NCT05818384)
- Testing
- Wakaya: Rising Up for Choctaw Youth Curriculum
- Where
- 2 sites in United States
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- University of Washington
Preoperative Anxiety, Fear
Virtual Reality for Pediatric Perioperative Preparation
This pilot randomized controlled trial will evaluate whether a virtual reality (VR) preparation program can improve the perioperative experience of children aged 3 to 12 years undergoing elective surgery.
- Conditions
- Preoperative Anxiety, Fear, Pediatric Surgery, Preoperative Care
- Trial name
- NCT07650695
- Testing
- NixiKit Virtual Reality Preparation, Standard Nursing Preoperative Preparation
- Where
- Spain
- Volunteers
- 56 people
- Sponsor
- Fundación de investigación HM
Pediatric Migraine
Randomized Study in Children and Adolescents With Migraine: Acute Treatment
The purpose of this study is to test the safety and efficacy of BHV-3000 versus placebo in the acute treatment of moderate or severe migraine in children and adolescents.
- Trial name
- NCT04649242
- Testing
- Rimegepant/BHV3000
- Where
- 246 sites in United States, Canada and 7 more
- Volunteers
- 2,100 people
- Sponsor
- Pfizer
Host and Microbiome, Pregnancy Outcomes
Human Genes and Microbiota in Early Life
The long-term goal of the Human Genes and Microbiota in Early Life (HuGME) is to explore the short- and long-term effects of maternal microbiota during pregnancy and the microbiota colonization of their offspring early in life…
- Conditions
- Host and Microbiome, Pregnancy Outcomes, Pregnancy Complications, Neurodevelopmental Disorders
- Trial name
- HuGME (NCT06926166)
- Testing
- No intervention
- Where
- China
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Guangzhou Women and Children's Medical Center
Adolescent, Pediatric Obesity
Controlled Evaluation of an Exercise Program for Overweight Adolescents
Physical activity decreases as young people get older, especially during the shift from early to late adolescence. Unfortunately, around 81% of school-aged children worldwide between the ages of 11 and 17 do not meet the…
- Conditions
- Adolescent, Pediatric Obesity, Exercise Therapy, Health Promotion
- Trial name
- Now! (NCT06923865)
- Testing
- training group
- Where
- Switzerland
- Volunteers
- 150 people
- Sponsor
- University Hospital, Basel, Switzerland
Pediatric Disorder, Adult Disease
New Ways of Doing Magnetic Resonance Imaging in Children and Adults
This study is being done to see how we can prevent problems caused by movement during the MRI scan. Different ways of doing the scan (techniques) will be tested to see if they are practical and can prevent problems related to…
- Trial name
- NCT04643015
- Testing
- MRI
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Major Depressive Disorder (MDD), Thiamine
Oral Thiamine (Vitamin B1) for Depression in Children and Adolescents
The goal of this study is to examine the effectiveness of thiamine in reducing depressive symptoms in children and adolescents. The investigators hypothesize that thiamine administration will alleviate depressive symptoms in…
- Conditions
- Major Depressive Disorder (MDD), Thiamine, Vitamin B1, Thiamine Diphosphate (TDP)
- Trial name
- B1Ped (NCT07793071)
- Testing
- thiamine hydrochloride 100 mg
- Volunteers
- 40 people
- Sponsor
- Massachusetts General Hospital
Coronavirus Infection (COVID-19), Pulmonary Arterial Hypertension
Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)
The study investigators are interested in learning more about how drugs, that are given to children by their health care provider, act in the bodies of children and young adults in hopes to find the most safe and effective dose…
- Conditions
- Coronavirus Infection (COVID-19), Pulmonary Arterial Hypertension, Urinary Tract Infections in Children, Hypertension
- Trial name
- POPS or POP02 (NCT04278404)
- Testing
- The POP02 study is collecting bodily fluid samples (i.e., whole blood, effluent samples) of children prescribed the following drugs of interest per standard of care:
- Where
- 52 sites in United States, Canada
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Duke University
Respiratory Tract Diseases, Pediatric Disorders
The Effect of Using Virtual Reality Glasses and Gaming Cards on Fear, Anxiety, and Physiological Parameters in Children Administered Inhaler Medication
This study aims to evaluate the effects of using virtual reality headsets and play cards during the administration of inhaler medication in pediatric patients.
- Conditions
- Respiratory Tract Diseases, Pediatric Disorders, Anxiety, Fear
- Trial name
- NCT07780331
- Testing
- Virtual Reality Goggles (VR BOX), Interactive Distraction Cards (DistrACTION® Cards), Standard Clinical Care
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Bandırma Onyedi Eylül University
Rheumatic Diseases, Arthritis
Pain-Sleep in Rheumatic Disease
Overall, our understanding of how pain and sleep are experienced and how they can be treated in teenagers with rheumatic diseases is limited.
- Conditions
- Rheumatic Diseases, Arthritis, Lupus, Lupus Arthritis, Systemic Lupus Erythematosus
- Trial name
- NCT07775612
- Testing
- Better Nights, Better Days for Youth
- Volunteers
- 43 people
- Sponsor
- The Hospital for Sick Children
Anxiety, Fear
The Effect of Multisensory Stimulation Administered Before Clinical Encounters at the Pediatric Surgery Outpatient Clinic on Children's Anxiety and Fear Levels and Parental Anxiety
Encounters with healthcare services during childhood, particularly surgical evaluation processes, are a significant source of stress for both children and their parents.
- Conditions
- Anxiety, Fear, Multisensory Stimulation, Pediatric Surgery
- Trial name
- NCT07769788
- Testing
- Multisensory Stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Bilecik Seyh Edebali Universitesi
Pediatric Anxiety
Non-Wearable Audiovisual Distraction for Children's Medical Anxiety in the ED
Pediatric emergency department (ED) visits often cause significant anxiety and stress for young patients due to unfamiliar environments and invasive medical procedures.
- Trial name
- NCT07761637
- Testing
- Non-Wearable Audiovisual Distraction, Routine ED Care
- Where
- Taiwan
- Volunteers
- 90 people
- Sponsor
- National Taiwan University Hospital
Acute Pain, Procedural Anxiety
Little NIRVANA for Pediatric Pain and Anxiety
The aim of this study is to test the feasibility of using Little NIRVANA (augmented reality (AR)) for managing anxiety and pain for children 2-8 years old during hospital emergency peripheral intravenous (PIV) insertions.
- Conditions
- Acute Pain, Procedural Anxiety, Pediatric ALL, Emergency Medicine
- Trial name
- NCT06795126
- Testing
- Little NIRVANA
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Nationwide Children's Hospital
Perioperative Care, Pediatric Anesthesia
Giving Children a Voice in Paediatric Anaesthesia
This project will identify the research priorities for paediatric anaesthesia and perioperative medicine in participating countries and highlight areas where further research and information can be provided to optimise the…
- Conditions
- Perioperative Care, Pediatric Anesthesia, Pain Management, Anxiety
- Trial name
- TR-VP26 (NCT07524049)
- Where
- 7 sites in Switzerland
- Volunteers
- 1,040 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern