Clinical trials: Pediatric Hypertension, active
Adolescent Obesity, Hypertension,Essential
Treatment and Handling Severe Obesity-Related Comorbidities in Adolescents Through Exercise
The main objective of this project is to analyze the effect of a tailor-made, one-to-one, exercise program (aiming to treat and handle obesity-related comorbidities in adolescents with severe obesity at high risk of…
- Conditions
- Adolescent Obesity, Hypertension,Essential, Non-Alcoholic Fatty Liver Disease, Dyslipidemias
- Trial name
- THOR-X (NCT06520800)
- Testing
- Treatment and handling obesity-related comorbidities in adolescents through exercise
- Volunteers
- 24 people
- Sponsor
- University of Lisbon
Esophageal Varices, Portal Hypertension
Non-invasive Predictors of Esophageal Varices and Their Correlation to Upper Endoscopic Findings
The goal of this observational study: To evaluate the diagnostic accuracy of non-invasive markers in predicting the presence and grading of esophageal varices in children with portal hypertension.
- Trial name
- NCT07464522
- Volunteers
- 51 people
- Sponsor
- Assiut University
Intracranial Hypertension
Non Invasive Measurement With Trans Cranial Doppler Versus Invasive Measurement in Pediatric Age
An increase of intracranial pressure (ICP) is an important cause of secondary brain damage. The gold standard for measuring ICP is represented by invasive positioning of intracranial ICP devices.
- Trial name
- nICPped (NCT05340062)
- Testing
- bedside sonography
- Where
- 6 sites in Italy
- Volunteers
- 46 people
- Sponsor
- Azienda Ospedaliera di Padova
Congenital Diaphragmatic Hernia
Preliminary Study of Pediatric Diaphragmatic Elastography
This diaphragmatic elastography study is a preliminary pilot study to have first values of diaphragmatic stiffness in patients with a history of diaphragmatic hernia and to estimate the difference in stiffness compared to a group…
- Trial name
- ECHODIA (NCT06666140)
- Testing
- Ultrasonic elastography
- Where
- France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Strasbourg, France
Hypertension, Retinal Artery Stenosis
Exercise, Arterial Modulation and Nutrition in Youth South Africa Study
The ExAMIN Youth SA study aims to generate new knowledge on the pathophysiology involved in early vascular aging among South African children and to identify early novel biological markers for predicting the subclinical…
- Conditions
- Hypertension, Retinal Artery Stenosis, Childhood Obesity
- Trial name
- ExAMIN-Youth (NCT04056377)
- Where
- South Africa
- Volunteers
- 1,065 people, healthy volunteers welcome
- Sponsor
- North-West University, South Africa
Pulmonary Artery Hypertension
Potts-shunt for the Treatment of Pediatric Patients With Severe Pulmonary Hypertension
This is a multi-center, perspective, and exploratory study aimed at evaluating the 3-years clinical outcome of Potts-shunt procedure for pediatric patients with severe pulmonary artery hypertension (PAH).
- Trial name
- NCT06429579
- Testing
- Comprehensive therapy combined Potts-shunt procedure and conventional drug therapy, Only conventional drug therapy
- Where
- China
- Volunteers
- 120 people
- Sponsor
- China National Center for Cardiovascular Diseases
Pulmonary Arterial Hypertension
A Clinical Study of to Confirm the Doses of Selexipag in Children With Pulmonary Arterial Hypertension
The purpose of this study to confirm the selexipag starting dose(s), selected based on pharmacokinetic (PK) extrapolation from adults, that leads to similar exposure as adults doses in children from greater than or equal to (>=)…
- Trial name
- NCT03492177
- Testing
- selexipag (Uptravi)
- Where
- 34 sites in United States, Belarus and 14 more
- Volunteers
- 63 people
- Sponsor
- Actelion
Retinal Disease, Glaucoma
Optimize Pediatric OCT Imaging
Handheld optical coherence tomography (OCT) has become an important imaging modality to evaluate the pediatric retina. The objective of this pilot study is to compare a new contact OCT system (Theia Imaging) with an…
- Conditions
- Retinal Disease, Glaucoma, Optic Nerve Diseases
- Trial name
- NCT06139523
- Testing
- Investigational contact OCT system, Investigational noncontact OCT system:
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Duke University
Hyperlipidemias, Diabetes
Social Needs Screening and Chronic Diseases Study (WE CARE)
The goal of this clinical trial is to learn if the implementation of the WE CARE social determinants of health (SDOH) screening and referral intervention with an antiracist lens in primary care settings can lead to a meaningful…
- Conditions
- Hyperlipidemias, Diabetes, Depression, Pediatric Asthma
- Trial name
- NCT06903897
- Testing
- WE CARE SDOH System, Standard Pediatric Care
- Where
- 3 sites in United States
- Volunteers
- 68,000 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Worcester
Hypertension, Left Ventricular Hypertrophy
Pediatric Hypertension and the Renin-Angiotensin SystEm (PHRASE)
Studying the causal roles of components of the renin-angiotensin-aldosterone system (including angiotensin-(1-7) (Ang-(1-7)), angiotensin-converting enzyme 2 (ACE2), Ang II, and ACE), uric acid, and klotho in pediatric…
- Conditions
- Hypertension, Left Ventricular Hypertrophy, Left Ventricular Dysfunction, Left Atrial Dilatation
- Trial name
- PHRASE (NCT04752293)
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Coronavirus Infection (COVID-19), Pulmonary Arterial Hypertension
Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)
The study investigators are interested in learning more about how drugs, that are given to children by their health care provider, act in the bodies of children and young adults in hopes to find the most safe and effective dose…
- Conditions
- Coronavirus Infection (COVID-19), Pulmonary Arterial Hypertension, Urinary Tract Infections in Children, Hypertension
- Trial name
- POPS or POP02 (NCT04278404)
- Testing
- The POP02 study is collecting bodily fluid samples (i.e., whole blood, effluent samples) of children prescribed the following drugs of interest per standard of care:
- Where
- 52 sites in United States, Canada
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Duke University
Pediatric Heart Failure, Congenital Heart Disease (CHD)
MedlyPeds Feasibility Study
SickKids and UHN have developed MedlyPeds which is a smart phone application designed to remotely monitor patients with heart disease.
- Conditions
- Pediatric Heart Failure, Congenital Heart Disease (CHD), Acquired Heart Disease, Pulmonary Hypertension
- Trial name
- NCT07556185
- Testing
- MedlyPeds App
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- The Hospital for Sick Children
Hypertension, Obesity, Adolescent
National Blood Pressure Screening in Children to Improve Paediatric Healthcare in South Africa
The Childhood Hypertension Consortium of South Africa (CHCSA) was established to foster relationships between the healthcare sector and schools through community engagement and outreach as well as contributing to the…
- Conditions
- Hypertension, Obesity, Adolescent, Obesity, Childhood
- Trial name
- NCT05982847
- Testing
- Blood pressure screening
- Where
- 11 sites in South Africa, Switzerland
- Volunteers
- 22,464 people, healthy volunteers welcome
- Sponsor
- North-West University, South Africa
Central Venous Pressure
Non-invasive Central Venous Pressure Estimation in Pediatric Patients
Central Venous Pressure (CVP) is a standard parameter for hemodynamic monitoring and is currently measured through the insertion of a catheter.
- Trial name
- CPMX-CVP-Ped (NCT06885073)
- Testing
- CPMX2
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Compremium AG
Eye Diseases, Retinal Disease
Advancing Pediatric Retinal Imaging With Auto-aligned OCT
The goal of the current study is to conduct a pilot study to test a new version of the handheld OCT device capable of auto-alignment to image the retina in adult volunteers, and adult and pediatric patients in clinic.
- Conditions
- Eye Diseases, Retinal Disease, Glaucoma, Optic Nerve Diseases
- Trial name
- NCT06841575
- Testing
- Auto-aligned OCT
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Duke University
Pediatric Hypertension, Primary Hypertension
Endothelial Extracellular Vesicles as Biomarkers of Endothelial Activation in Children With Newly Diagnosed Hypertension
Childhood hypertension is associated with early endothelial dysfunction and an increased risk of future cardiovascular disease. Endothelial extracellular vesicles (EEVs) have emerged as promising biomarkers of endothelial…
- Conditions
- Pediatric Hypertension, Primary Hypertension, Endothelial Dysfunction
- Trial name
- HYPER-endoEV-c (NCT07728643)
- Where
- Croatia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Josip Juraj Strossmayer University of Osijek
Elevated Blood Pressure
Office, Home, and Ambulatory Blood Pressure
This will be a prospective observational study. The population would be pediatric patients 6 years to <19 years of age who were referred for elevated blood pressure to investigate if home blood pressure (HBP) can determine blood…
- Trial name
- HBPA (NCT05297708)
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Pulmonary Hypertension
Insights Into Pediatric Pulmonary Hypertension: A Real-World Registry of Epidemiology and Outcomes
Pediatric pulmonary hypertension (PH) shares similarities with PH in adulthood, but specific differences still require unique approaches.
- Trial name
- INSPIRE-PPH (NCT07495774)
- Where
- China
- Volunteers
- 450 people
- Sponsor
- Guangdong Provincial People's Hospital
Pulmonary Vascular Disease, Pulmonary Arterial Hypertension
Pediatric Pulmonary Hypertension Network (PPHNet) Informatics Registry
Patients are being asked to be in this research study because medical researchers hope that by gathering information about a large number of children with pulmonary hypertension over time, their understanding of the disease…
- Trial name
- PPHNet (NCT02249923)
- Where
- 14 sites in United States, Canada
- Volunteers
- 2,500 people
- Sponsor
- New York Medical College
Preterm Birth, Preeclampsia
The ROOT Study: Scaling the 'Standard of Care Plus' Obstetric Nutrition Model to Optimize Maternal and Infant Health
The 'Standard of Care Plus' ('PLUS') model in the ROOT Study consists of analyzing select micronutrient and gene variants of pregnant females to construct trimester-specific and personalized nutrition and lifestyle…
- Conditions
- Preterm Birth, Preeclampsia, Gestational Diabetes Mellitus (GDM), Small for Gestational Age (SGA)
- Trial name
- ROOT (NCT07559773)
- Testing
- 'Standard of Care PLUS'
- Volunteers
- 500 people
- Sponsor
- GrowBaby Life Project