Clinical trials: Pediatric Infectious Disorder
HIV Infections
Drug Levels of Tablet and Liquid Forms of Lamivudine, Nevirapine, and Stavudine in HIV Infected Thai Children
The purpose of this study is to compare the blood levels, absorption, and breakdown of lamivudine (3TC), nevirapine (NVP), and stavudine (d4T) in a fixed-dose tablet to that of the individual liquid formulations of the same…
- Trial name
- NCT00312091
- Testing
- Lamivudine, nevirapine, and stavudine fixed-dose tablet, Lamivudine, Nevirapine
- Where
- 4 sites in Thailand
- Volunteers
- 44 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Uveitis
Adalimumab Plus Methotrexate for the Treatment of Pediatric Uveitis
The aim of this study is to determine the efficacy and safety of ADA plus MTX for the treatment in non-infectious pediatric panuveitis.
- Trial name
- NCT04588818
- Testing
- Adalimumab plus Methotrexate
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Sun Yat-sen University
Pediculosis
Efficacy, Safety and Tolerability of a Novel Malathion Formulation in Patients 2 Years and Older With Head Lice
In this study, Malathion Gel 0.5% will be compared to Nix (permethrin 1%) as a treatment for head lice in patients 2 years of age and older. Malathion Gel 0.5% is a new formulation of an established head lice treatment.
- Trial name
- NCT00927472
- Testing
- Malathion gel 0.5%, Permethrin 1% rinse
- Where
- 2 sites in United States
- Volunteers
- 254 people
- Sponsor
- Sun Pharmaceutical Industries, Inc.
Newborn Sepsis, Fever
Interest of the Presepsin Assay as a Biomarker of Bacterial Infection, in the Management of Newborns and Infants Under 3 Months of Age Admitted for Fever in Pediatric Emergency Service (Presepsin)
The purpose of this study is to validate presepsin as a biological marker for identifying bacterial fever among febrile syndromes of infants under three months of age.
- Trial name
- presepsin (NCT04076345)
- Testing
- Prespesin assay on PATHFAST analyser
- Where
- France
- Volunteers
- 31 people
- Sponsor
- University Hospital, Clermont-Ferrand
Hip Effusion, Septic Arthritis
Accuracy of Pediatric Emergency Medicine Providers in Diagnosing Hip Effusions Using Point of Care Ultrasound
The purpose of this study is to determine if pediatric emergency medicine providers can accurately diagnose a hip effusion using point-of-care ultrasound (POCUS) compared to radiology ultrasound (RADUS).
- Conditions
- Hip Effusion, Septic Arthritis, Transient Synovitis, Hip
- Trial name
- NCT05971745
- Where
- 6 sites in United States, Australia
- Volunteers
- 161 people
- Sponsor
- Connecticut Children's Medical Center
HIV, HIV Infections
Measurement of Adherence to ART in HIV-Infected Children in Uganda (The CHARTA Study)
This study will compare methods of determining whether HIV-infected children take their medications.
- Trial name
- NCT00868257
- Where
- Uganda
- Volunteers
- 120 people
- Sponsor
- Massachusetts General Hospital
COVID-19, Post-Acute COVID-19
Genetic Risk Factors for Multi-system Inflammatory Syndrome in Children and Pediatric Post COVID Condition
We will perform Whole Exome Sequencing on DNA from saliva. We will include: Children with a history of MIS-C; children with post-COVID condition; and controls in order to identify rare, high impact genetic variants in…
- Conditions
- COVID-19, Post-Acute COVID-19, Post-Acute COVID19 Syndrome, Multi-System Inflammatory Syndrome in Children
- Trial name
- GRIP (NCT05722717)
- Testing
- Saliva collection at home
- Where
- Netherlands
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Pediatric Respiratory Diseases, Asthma
Analysis of Lung Sounds Collected by RESP Biosensor to Support Decision Making in Monitored Hospitalized Pediatric Patients
This observational clinical trial is designed to confirm whether RESP™ Biosensor could be deployed to support clinical decision making in challenging pediatric cases, minimize clinician-to-clinician variability in lung sound…
- Conditions
- Pediatric Respiratory Diseases, Asthma, RSV Infection, COVID-19
- Trial name
- NCT05661422
- Testing
- RESP™ Biosensor
- Where
- United States
- Sponsor
- Strados Labs, Inc.
HIV Infections
Assessment of Asymptomatic Heart Disease in Children With HIV
The purpose of this study is to perform cardiac evaluation in HIV-1 (predominantly clade C)infected children by history, physical examination, echocardiogram and plasma N-terminal pro-B-type natriuretic peptide (N-BNP)measurement…
- Trial name
- NCT00426374
- Testing
- echocardiography and blood test
- Where
- Israel
- Sponsor
- Hadassah Medical Organization
Infection, Coronavirus, Infections
Xofluza-Wearables Feasibility-Study
The goal of this prospective, interventional, single-center study is to assess whether the early detection of Influenza with smart wearable device algorithms and alerting, rapid testing, and subsequent Baloxavir treatment…
- Conditions
- Infection, Coronavirus, Infections, Influenza, Transplant
- Trial name
- NCT06161454
- Testing
- Baloxavir Marboxil
- Where
- United States
- Volunteers
- 498 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Japanese Encephalitis
Long Term Immunity and Safety Following Vaccination With the JEV IC51 (IXIARO®, JESPECT®) in Pediatric Population In Non Endemic Countries. Uncontrolled, Ph3 FU-Study
The study investigates long-term immunity and safety of IC51 (IXIARO®, JESPECT®) in a pediatric population vaccinated in the parent study IC51-322.
- Trial name
- NCT01246479
- Testing
- Blood draw, IC51 has given in the parent study IC51-322
- Where
- 5 sites in United States, Australia and 1 more
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Valneva Austria GmbH
Dental Caries, Pulp Necrosis
Moringa Oleifera vs Sodium Hypochlorite for Root Canal Irrigation in Nonvital Primary Molars
This randomized clinical trial aims to evaluate and compare the antimicrobial efficacy of Moringa Oleifera leaf extract versus sodium hypochlorite as root canal irrigants in pulpectomy of nonvital primary molars in pediatric…
- Conditions
- Dental Caries, Pulp Necrosis, Primary Tooth Pulpectomy, Pediatric Dentistry
- Trial name
- MORvNAOCL (NCT06971055)
- Testing
- Sodium hypochlorite, Moringa Oleifera Leaf Extract
- Where
- Egypt
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Cairo University
Hepatitis C, Chronic
Study of PEG-Intron Plus REBETOL in Pediatric Subjects With Chronic Hepatitis C (Study P02538 Part 1)
The primary objective is to assess the safety, efficacy and tolerability of the combination of PEG-Intron plus REBETOL in pediatric subjects with chronic hepatitis C.
- Trial name
- NCT00104052
- Testing
- peginterferon alfa-2b (PEG2b) (SCH 54031), ribavirin (SCH 18908)
- Volunteers
- 107 people
- Sponsor
- Merck Sharp & Dohme LLC
Cough, Upper Respiratory Tract Infection
Comparison of Efficacy and Tolerability of Two Cough Syrups in Cough Due to Cold in Children.
The purpose of this study is to determine if there is comparable efficacy between carbocisteine and a protective cough syrup from natural ingredients in children's cough due to upper respiratory tract infections (URTI) such as…
- Trial name
- URTI (NCT01968434)
- Testing
- protective cough syrup, carbocisteine cough syrup
- Where
- 4 sites in Israel
- Volunteers
- 150 people
- Sponsor
- Clalit Health Services
Pneumonia, Acute Respiratory Infection
Pediatric Pneumonia Lung Ultrasound
The purpose of this study is to evaluate the impact of LUS on the diagnosis and management of childhood pneumonia in developing countries
- Trial name
- PLUS (NCT03187067)
- Testing
- Lung ultrasound
- Where
- 2 sites in Mozambique, Pakistan
- Volunteers
- 270 people
- Sponsor
- Save the Children
Respiratory Syncytial Virus Infection, Acute Bronchiolitis Due to Respiratory Syncytial Virus
RSV-Positive Children <5 Years Presenting to Pediatric Emergency Departments in Türkiye: TRUST-RSV
Respiratory syncytial virus (RSV) is a leading cause of acute lower respiratory tract infection in infants and young children and contributes substantially to pediatric emergency department (ED) visits and hospitalizations.
- Conditions
- Respiratory Syncytial Virus Infection, Acute Bronchiolitis Due to Respiratory Syncytial Virus, Pneumonia, Upper Respiratory Tract Infection
- Trial name
- TRUST-RSV (NCT07346963)
- Volunteers
- 4,000 people
- Sponsor
- Eskisehir Osmangazi University
Infection, Human Immunodeficiency Virus
Bioavailability Study of a Dolutegravir Dispersible Tablet and Effect of Different Types of Water on the Dispersible Tablet in Healthy Volunteers
Dolutegravir (DTG) is an HIV-1 integrase inhibitor approved in the United States, Canada, Australia and EU. A dispersible tablet has been developed for pediatric use as an alternative to the granule formulation, already in…
- Trial name
- NCT02185300
- Testing
- Dolutegravir Pediatric Granules, Dolutegravir Dispersible Tablet
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- ViiV Healthcare
Otorrhea
Natural History Study of Incidence of Otorrhea Following Tympanostomy Tube Insertion in Children 6 Months to 12 Years
This study was conducted to describe the time to first incidence of otorrhea post tympanostomy tube insertion.
- Trial name
- NCT01111877
- Where
- United States
- Volunteers
- 1,389 people
- Sponsor
- Alcon Research
Tinea Corporis
Pediatric Subjects With Tinea Corporis
The study is being done to see how well the study cream works when applied once a day to affected area of child (where they have ringworm).
- Trial name
- NCT02227290
- Testing
- Naftin Cream
- Where
- 19 sites in United States, Dominican Republic and 3 more
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- Merz North America, Inc.
Upper Respiratory Infection
Improving Communication During Pediatric Visits for Acute Respiratory Illness
The excessive use of outpatient antibiotics in the pediatric population has contributed to the rapid development of resistance in many strains of Streptococcus pneumoniae.
- Trial name
- NCT01168778
- Testing
- Physician Workshop
- Volunteers
- 1,313 people
- Sponsor
- University of Washington