Clinical trials: Pediatric Infectious Disorder
Human Immunodeficiency Virus (HIV), Acquired Immune Deficiency Syndrome (AIDS)
Pediatric Enhanced Surveillance Study
The Pediatric Enhanced Surveillance Study is a three part study of HIV-infected infants and children in South Africa to examine, clinical, immunologic, virologic, metabolic, psychosocial and behavioral outcomes.
- Trial name
- PESS (NCT02043769)
- Where
- 5 sites in South Africa
- Volunteers
- 396 people
- Sponsor
- Columbia University
Tick-borne Encephalitis
Prevalence of Tick-borne Encephalitis in the Pediatric Population Treated at the HUS and Characterization of Confirmed Pediatric Cases
Tick-borne encephalitis (TBE) is a zoonosis mainly transmitted to humans by the bite of ticks of the genus Ixodes and, to a lesser extent, by the consumption of contaminated and unpasteurized dairy products.
- Trial name
- TBE-KID (NCT05607394)
- Where
- France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Strasbourg, France
Herpes Simplex
Pharmacokinetics, Acceptability and Safety of Famciclovir in Infants (1 Month to Less Than 12 Months) With Herpes Simplex Infection
This study will evaluate the acceptability and safety of famciclovir in infants with herpes simplex infection
- Trial name
- NCT00448227
- Testing
- famciclovir
- Where
- 6 sites in United States
- Volunteers
- 18 people
- Sponsor
- Novartis
Pediculosis
Efficacy, Safety and Tolerability of a Novel Malathion Formulation in Patients 2 Years and Older With Head Lice
In this study, Malathion Gel 0.5% will be compared to Nix (permethrin 1%) as a treatment for head lice in patients 2 years of age and older. Malathion Gel 0.5% is a new formulation of an established head lice treatment.
- Trial name
- NCT00963508
- Testing
- Malathion gel 0.5%, Permethrin 1% rinse (Nix Crème)
- Where
- 7 sites in United States
- Volunteers
- 403 people
- Sponsor
- Sun Pharmaceutical Industries, Inc.
HIV Infections
A Study of the Safety and Effectiveness of Treating Advanced AIDS Patients Between Ages 4 and 22 With 7 Drugs, Some at Higher Than Usual Doses
The purpose of this study is to see if 7 drugs, some of them given at higher doses than normal, are safe and tolerated by young patients with AIDS who have failed to respond to other treatments.
- Trial name
- NCT00001108
- Testing
- Ritonavir, Nelfinavir mesylate, Saquinavir
- Where
- 19 sites in United States
- Volunteers
- 6 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HBV, Chronic Hepatitis B Virus
Prospective Cohort Study on PEG-IFN-α-2b in Improving Clinical Cure Rate of Pediatric Patients With Chronic Hepatitis B
In this study, comparisons will be made between the treatment group (which will receive pegylated interferon alfa-2b treatment) and the observation group (which will receive no drug treatment or be treated with nucleos(t)ide…
- Trial name
- NCT07231276
- Testing
- Peginterferon alfa-2b Injection
- Where
- China
- Volunteers
- 113 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Congenital Disorders
Chlorhexidine Swabs Effectiveness in Reducing Blood Stream Infections
Children's Healthcare of Atlanta (Children's) is collaborating with Child Health Corporation of America (CHCA) in the nationwide effort to reduce catheter related blood stream infections (BSIs).
- Trial name
- NCT00485992
- Where
- United States
- Volunteers
- 352 people
- Sponsor
- Children's Healthcare of Atlanta
Tracheostomy, Endotracheal Tube
Airway Microbiome Changes After Artificial Airway Exchange in Critically-ill Pediatric Patients.
Artificial airways, such as endotracheal tubes and tracheostomies, in the pediatric and neonatal intensive care units (PICU, NICU respectively) are lifesaving for patients in respiratory failure, among other conditions.
- Conditions
- Tracheostomy, Endotracheal Tube, Ventilator Associated Pneumonia, Tracheitis
- Trial name
- NCT06201130
- Testing
- Suctioning of artificial airway
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Northwell Health
Infectious Diseases, Metabolic Diseases
Drug Utilization Prevalence in a Pediatric Care Medical Center
One year prospective analysis of drug utilization and prescription point prevalence of medications in a pediatric tertiary care university medical center.
- Conditions
- Infectious Diseases, Metabolic Diseases, Cancer
- Trial name
- NCT00550706
- Where
- Israel
- Volunteers
- 567 people
- Sponsor
- Rambam Health Care Campus
Invasive Pulmonary Aspergillosis, Lymphoblastic Leukaemia
Nebulized Amphotericin B Lipid Complex in Invasive Pulmonary Aspergillosis in Paediatric Patients With Acute Leukaemia
The trial evaluates the overall tolerability of the drug and the efficacy of aerosolised amphotericin B as a lipid complex (ABLC) for primary prophylaxis of invasive pulmonary aspergillosis (IPA) in pediatric patients with acute…
- Conditions
- Invasive Pulmonary Aspergillosis, Lymphoblastic Leukaemia, Myeloblastic Leukaemia, Lymphoblastic Leukemia
- Trial name
- NCT01615809
- Testing
- AMPHOTERICIN B
- Where
- Spain
- Volunteers
- 32 people
- Sponsor
- Fundació Sant Joan de Déu
Blood Donors, Blood Transfusion
Transfusion Infections Pediatric Prospective Study (TRIPPS)
To conduct a prospective study of pediatric transfusion recipients to determine the risk of transmitting various infectious agents by blood transfusion.
- Conditions
- Blood Donors, Blood Transfusion, Cytomegalovirus Infections, Hepatitis, Viral, Human
- Trial name
- TRIPPS (NCT00029406)
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Naomi Luban
Pediatric Obesity, COVID-19
Exercise and Diet for Pediatric Obesity
The coronavirus disease (COVID-19), is a communicable pandemic disease as stated by the world health organization (WHO), which has been affecting the world since December 2019.
- Trial name
- NCT05336006
- Testing
- High-intensity aerobic training with high protein diet, Control group
- Where
- Saudi Arabia
- Volunteers
- 76 people
- Sponsor
- Prince Sattam Bin Abdulaziz University
HIV, AIDS
Bioequivalence Study of Pediatric Formulations to Treat HIV Infection
The purpose of the study is to determine the bioavailability/bioequivalence of two pediatric formulations (tablet and reconstitutable suspension) of lamivudine/zidovudine/ nevirapine in comparison to an innovator product.
- Trial name
- NCT01469520
- Testing
- Epivir®, Retrovir® and Viramune®, Lamivudine, Zidovudine and nevirapine, Lamivudine, zidovudine, nevirapine
- Where
- Nigeria
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Elim Pediatric Pharmaceuticals Inc.
HIV Infections
A Food-effect Study of the Pediatric Dispersible Tablet Formulations of TRIUMEQ® and DOVATO® in Healthy Adult Participants
This study will assess the effect of food on the pharmacokinetics (PK) of pediatric formulations of TRIUMEQ (dolutegravir [DTG] 5 milligrams [mg]/abacavir [ABC] 60 mg/lamivudine [3TC] 30 mg) dispersible tablets and DOVATO (DTG 5…
- Trial name
- NCT04827134
- Testing
- TRIUMEQ, DOVATO
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- ViiV Healthcare
Respiratory Syncytial Virus Infections
Safety and Immunogenicity of CodaVax-RSV in Seropositive and Seronegative Children
This study is a Phase 1, randomized, double-blind, placebo-controlled, dose-escalation clinical trial to evaluate the safety of and immune response to CodaVax-RSV in healthy children.
- Trial name
- NCT04919109
- Testing
- CodaVax-RSV, Normal Saline
- Where
- 5 sites in United States, South Africa
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Codagenix, Inc
HIV/AIDS
REMUNE HIV/AIDS Vaccine Phase II Pediatric Safety & Efficacy Clinical Study
The primary objective is to compare \& evaluate between the treatment groups the changes in decline/reduction of HIV viral load \& increase changes in WBC white blood cell counts in the adult Remune dose vs the low dose Remune…
- Trial name
- NCT02291809
- Testing
- REMUNE
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Immune Response BioPharma, Inc.
HIV Infections
Safety and Pharmacokinetics (PK) of Raltegravir in HIV (Human Immunodeficiency Virus)-Infected Children and Adolescents
Integrase is 1 of 3 HIV (Human Immunodeficiency Virus)-1 enzymes required for viral replication. Raltegravir is a drug that prevents integrase from working properly.
- Trial name
- NCT00485264
- Testing
- Raltegravir poloxamer film coated tablet, Raltegravir chewable tablet, Raltegravir oral granules for suspension (20 mg/mL)
- Where
- 42 sites in United States, Argentina and 4 more
- Volunteers
- 153 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Ventilator Associated Pneumonia
Ventilator Associated Pneumonia Care Bundle Prevention on Internship Students' Knowledge and Clinical Performance
The goal of this clinical trial is to determine the effect of a self-instructional module regarding ventilator-associated pneumonia care bundle prevention on internship students' knowledge and clinical performance in pediatric…
- Trial name
- NCT06090019
- Testing
- Routine PICU nursing care for children on mechanical ventilator., Self-instructional module for VAP care bundle prevention
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Community-acquired Pneumonia, Skin Infection
Improving Short Course Treatment for Common Pediatric Infections
Randomized quality improvement trial to improve the proportion of cases of community-acquired pneumonia (CAP) treated with no more than 5 days of antibiotics the proportion of cases of skin and soft tissue infections (SSTI)…
- Trial name
- NCT06087809
- Testing
- Education and feedback, Clinical decision support
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Boston Children's Hospital
Renal Stone, Kidney; Complications
Evaluation of Renal Oxygenation by NIRS in Pediatric Endourologic Stone Surgery
The study aims to compare renal oxygenation levels in retrograde intrarenal surgery (RIRS) and ureteroscopy (URS) procedures with a control group.
- Conditions
- Renal Stone, Kidney; Complications, Ureter Stone, Renal Oxygenation
- Trial name
- NCT06110247
- Testing
- NIRS, Taking a blood sample
- Where
- Turkey (Türkiye)
- Volunteers
- 136 people
- Sponsor
- Ankara City Hospital Bilkent