Clinical trials: Pediatric Infectious Disorder
HIV/AIDS Treatment, HIV Infections
Lopinavir/Ritonavir (Kaletra) PK in Children
The objective of this study is to compare the pharmacokinetics of lopinavir tablets administered to pediatric patients as either whole or crushed tablets.
- Trial name
- NCT00810108
- Testing
- lopinavir/ritonavir (Kaletra®) tablets
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Scabies
Evaluating Pediatric Ivermectin in Children Under 15 kg (EPIC-15)
The EPIC-15 trial will evaluate the safety, pharmacokinetics, acceptability, and efficacy of pediatric ivermectin (CHILD-IVITAB) in scabies infected children weighing 5 to less than 15 kg.
- Trial name
- EPIC-15 (NCT06404333)
- Testing
- CHILD-IVITAB
- Where
- Brazil
- Volunteers
- 13 people
- Sponsor
- University of Oxford
Tinea Corporis
Safety and Efficacy of Product 33525 (Luliconazole Cream 1%) in Pediatric Participants With Tinea Corporis
The objective of this study was to evaluate the safety, efficacy, and pharmacokinetics of luliconazole cream 1% when applied topically for 7 days in pediatric participants 2 years to 17 years of age (inclusive) with tinea…
- Trial name
- NCT02767947
- Testing
- Luliconazole Cream 1%, Vehicle Cream
- Where
- 3 sites in Dominican Republic, Honduras
- Volunteers
- 75 people
- Sponsor
- Bausch Health Americas, Inc.
Chronic Myeloid Leukemia (CML), Acute Myelogenous Leukemia (AML)
CD34+ (Malignant) Stem Cell Selection for Patients Receiving Allogenic Stem Cell Transplant
The purpose of this study is to learn more about the effects of (classification determinant) CD34+ stem cell selection on graft versus host disease (GVHD) in children, adolescents, and young adults.
- Conditions
- Chronic Myeloid Leukemia (CML), Acute Myelogenous Leukemia (AML), Myelodysplastic Syndrome (MDS), Juvenile Myelomonocytic Leukemia (JMML)
- Trial name
- NCT02061800
- Testing
- CliniMACS CD34+ Reagent System, Thiotepa, Cyclophosphamide
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Diane George
Pediatric HIV, HIV Infections
Equivalence of Boosted Atazanavir Based Regimens and Currently Effective HAART Regimens
The hypothesis for this study is whether a treatment regimen containing Atazanavir in combination with Ritonavir will work as well as other regimens containing a protease inhibitor and/or a Non-nucleoside Reverse Transcriptase…
- Trial name
- NCT00940771
- Testing
- Boosted Atazanavir
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Phoenix Children's Hospital
HIV Infections
Routine Use of Antiretroviral Therapy to Prevent Mother-to-Child HIV Transmission in the Kafue District of Zambia
The investigators will enroll a cohort of HIV-infected pregnant women accessing PMTCT services, to better understand the incremental benefits (e.g. reduction in HIV transmission, improvements in HIV-free survival) and risks (e.g.
- Trial name
- NCT00753324
- Testing
- Routine three-drug antiretroviral prophylaxis
- Where
- Zambia
- Volunteers
- 284 people
- Sponsor
- University of North Carolina, Chapel Hill
Ventriculitis, Infectious
Effect of Probiotic and Zinc Supplementations on the Clinical Outcome in Pediatric Patients With Ventriculitis
The aim of the study is to evaluate the effect of non-antibiotic-based supplemental interventions in the management of ventriculitis among pediatric patients.
- Trial name
- NCT06151392
- Testing
- Probiotic Formula, Zinc
- Where
- Egypt
- Volunteers
- 140 people
- Sponsor
- Ain Shams University
Hepatitis C Virus (HCV)
Efficacy Study Of Oral Glecaprevir/Pibrentasvir Tablet In Pediatric (12 Years and Older) And Adult Treatment-Naive Participants With Chronic Hepatitis C Genotypes 1 To 6 And Liver Cirrhosis
Hepatitis C Virus (HCV) infection is among the most common of all chronic liver diseases. HCV predominantly affects liver cells and causes the liver to become inflamed and damaged.
- Trial name
- EASY (NCT04352309)
- Where
- 6 sites in Russia
- Volunteers
- 99 people
- Sponsor
- AbbVie
COVID-19, SARS-CoV-2 Infection
Clinical Characteristics and Outcomes of Pediatric COVID-19
Rationale: The clinical manifestations of SARS-CoV-2 infection in children are poorly characterized. Preliminary findings indicate that they may be atypical.
- Conditions
- COVID-19, SARS-CoV-2 Infection, Pediatric ALL, Pneumonia, Viral
- Trial name
- PERN-COVID-19 (NCT04330261)
- Testing
- Exposure (not intervention) - SARS-CoV-2 infection
- Where
- Canada
- Volunteers
- 10,610 people
- Sponsor
- University of Calgary
HIV Infections
A Study of the Safety and Effectiveness of Treating Advanced AIDS Patients Between Ages 4 and 22 With 7 Drugs, Some at Higher Than Usual Doses
The purpose of this study is to see if 7 drugs, some of them given at higher doses than normal, are safe and tolerated by young patients with AIDS who have failed to respond to other treatments.
- Trial name
- NCT00001108
- Testing
- Ritonavir, Nelfinavir mesylate, Saquinavir
- Where
- 19 sites in United States
- Volunteers
- 6 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Meningitis, Pediatric Infectious Diseases
Paediatric Infections Point-Of-Care
This study aims to identify the aetiology of childhood meningitis in Southwestern Uganda and develop and evaluate new methods for point-of-care diagnosis of childhood meningitis in a low-income setting.
- Trial name
- PI-POC (NCT03900091)
- Testing
- Multiplex PCR assay for meningitis, Multiplex vertical flow microarrray assay for meningitis, Profiling of blood proteins by multi-analyte Profiling technology
- Where
- 2 sites in Uganda
- Volunteers
- 351 people
- Sponsor
- Karolinska Institutet
Covid19, Pediatric ALL
Pediatric Intensive Care and COVID-19
In this prospective longitudinal cohort the investigators reported the clinical, and biological characteristics of all critically ill patients admitted in the pediatric intensive care unit (PICU) of Bicêtre Hospital during the…
- Conditions
- Covid19, Pediatric ALL, Infection, Critical Illness
- Trial name
- CLOVIS (NCT04544878)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Bicetre Hospital
Covid19, Corona Virus Infection
A Study of Baricitinib (LY3009104) in Children With COVID-19
The purpose for this study is to determine if the study drug baricitinib is effective and safe in hospitalized pediatric participants with Coronavirus disease 2019 (COVID -19) and to confirm the dose.
- Trial name
- COV-BARRIER (NCT05074420)
- Testing
- Baricitinib
- Where
- 14 sites in United States, Brazil and 2 more
- Volunteers
- 6 people
- Sponsor
- Eli Lilly and Company
Febrile Neutropenia (FN), Pediatric Cancer
Early Discontinuation of Antibiotics in Paediatric High-risk Febrile Neutropenia
The goal of this clinical trial is to evaluate whether stopping antibiotic treatment early is safe in paediatric patients with cancer who develop high-risk febrile neutropenia but show good clinical evolution and low biomarker…
- Conditions
- Febrile Neutropenia (FN), Pediatric Cancer, Hematologic Malignancies, Solid Tumors
- Trial name
- E-STOP2 (NCT07590648)
- Testing
- Early Discontinuation of Antibiotics, Standard Antibiotic Continuation Strategy
- Where
- 4 sites in Spain
- Volunteers
- 136 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Osteomyelitis
Dalbavancin vs Comparator in Pediatric Subjects With Acute Hematogenous Osteomyelitis
Dalbavancin for Pediatric Osteomyelitis
- Trial name
- AHOM (NCT02344511)
- Testing
- Dalbavancin, cefazolin, nafcillin, oxacillin or vancomycin
- Sponsor
- Durata Therapeutics International BV (an Affiliate of Actavis, Inc.)
Rheumatoid Arthritis, Polyarticular Juvenile Idiopathic Arthritis
Comparison of PK and Tolerability of MSB11022 Administered by AI or PFS
The primary objective of this study is to demonstrate equivalence of the pharmacokinetic (PK) profile of MSB11022 administered by either an auto-injector (AI) or a pre-filled syringe (PFS) as single subcutaneous (s.c.) injection…
- Conditions
- Rheumatoid Arthritis, Polyarticular Juvenile Idiopathic Arthritis, Psoriatic Arthritis, Ankylosing Spondylitis
- Trial name
- NCT04018599
- Testing
- 40 mg MSB11022
- Where
- 2 sites in United States
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- Fresenius Kabi SwissBioSim GmbH
SARS-CoV Infection, Covid19
A Study to Evaluate the Efficacy, Immune Response, and Safety of a COVID-19 Vaccine in Adults ≥ 18 Years With a Pediatric Expansion in Adolescents (12 to<18 Years) at Risk for SARS-CoV-2
This is a phase 3, randomized, observer-blinded, placebo-controlled study to evaluate the efficacy, safety, and immunogenicity of SARS-CoV-2 rS with Matrix-M1 adjuvant in adult participants and adolescent participants.
- Trial name
- NCT04611802
- Testing
- SARS-CoV-2 rS/Matrix-M1 Adjuvant (Initial Vaccination Period), SARS-CoV-2 rS/Matrix-M1 Adjuvant (Crossover Vaccination period), SARS-CoV-2 rS/Matrix-M1 Adjuvant (Booster Vaccination)
- Where
- 154 sites in United States, Mexico and 1 more
- Volunteers
- 33,000 people, healthy volunteers welcome
- Sponsor
- Novavax
HIV Infections
Effect of Tenofovir DF on Bone Metabolism in Children
This study will examine the long-term effects, particularly on bone metabolism, of the drug tenofovir DF in children with HIV infection.
- Trial name
- NCT00088309
- Testing
- Eye exam, Oral exam, CT scan
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- National Cancer Institute (NCI)
Illness Absenteeism, Handwashing Behavior
Jerusalem Handwashing Study
The primary objective of this preschool intervention trial was to determine whether a hygiene program can promote handwashing and thereby reduce illness absenteeism.
- Trial name
- JHS (NCT00610376)
- Testing
- Preschool handwashing intervention program, Home component intervention
- Where
- Israel
- Volunteers
- 1,029 people, healthy volunteers welcome
- Sponsor
- Hebrew University of Jerusalem
HIV Infection
Correlation of HIV Levels With Clinical and Immunologic Outcome in Children Treated With Didanosine
Recent studies have shown that patients receiving state-of-the-art treatment for HIV infection (highly active antiretroviral therapy, or HAART) show discordant responses to therapy-that is, they improve both clinically and…
- Trial name
- NCT00026676
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- National Cancer Institute (NCI)