Clinical trials: Pediatric Inflammatory Bowel Diseases
Fistula in Ano, Crohn Disease
Pediatric MSC-AFP Sub-study for Crohn's Fistula
The purpose of this study is to determine the safety of using an autologous mesenchymal stromal cell (MSC) coated fistula plug in people with fistulizing Crohn's disease.
- Trial name
- NCT03449069
- Testing
- MSC-AFP
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Mayo Clinic
Crohn's Disease
Efficacy and Safety of Adalimumab in Pediatric Subjects With Moderate to Severe Crohn's Disease
The purpose of this study is to determine Efficacy, Pharmacokinetics, and Safety of Adalimumab in Pediatric Subjects With Moderate to Severe Crohn's Disease
- Trial name
- NCT00409682
- Testing
- Adalimumab
- Where
- 45 sites in United States, Belgium and 6 more
- Volunteers
- 192 people
- Sponsor
- Abbott
Crohn's Enteritis, Crohn Disease
Impact of a Physical Activity Program on Bone Mineral Density in Children and Adolescents With Chronic Inflammatory Bowel Disease
Muscle and physical activity play an important role in in growth, development and bone health in healthy children, especially during puberty.
- Conditions
- Crohn's Enteritis, Crohn Disease, Ulcerative Colitis, Chronic; Colitis (Noninfective)
- Trial name
- PROPHYSICOS (NCT03774329)
- Testing
- Usual care, adapted physical activity
- Where
- 2 sites in France
- Volunteers
- 15 people
- Sponsor
- University Hospital, Lille
Exacerbation of Ulcerative Colitis, Ulcerative Colitis, Active Severe
Manipulating the Microbiome in IBD by Antibiotics and FMT
the etiology of Inflammatory Bowel Diseases (IBD) is closely associated with the gut microbiome. The results of previous studies on the effectiveness of antibiotics and fecal macrobiota transplantation (FMT) are contradicting.
- Conditions
- Exacerbation of Ulcerative Colitis, Ulcerative Colitis, Active Severe, Crohn's Colitis
- Trial name
- FMT (NCT02033408)
- Testing
- AB (antibiotics), CS (corticosteroids) Only
- Where
- 12 sites in Canada, Finland and 4 more
- Volunteers
- 28 people
- Sponsor
- Shaare Zedek Medical Center
Pediatric Inflammatory Bowel Disease
Impact of Therapeutic Strategies in the Pediatric Inflammatory Bowel Disease: a Population Based Study (1988-2011).
Crohn's disease (CD) and ulcerative colitis (UC) are chronic Inflammatory Bowel Disease (IBD) and may affect all segments of the digestive tract.
- Trial name
- Inspired (NCT02392221)
- Where
- 2 sites in France
- Volunteers
- 966 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Crohn's Diseases, Crohn's Disease in Pediatric Patient
The Efficacy and Safety of Infliximab Combination With Azathioprine in Crohn's Disease in Children
The goal of this clinical trial is to investigate whether there are significant differences in the efficacy of infliximab monotherapy and combined azathioprine therapy in treating pediatric Crohn's disease, as well as whether…
- Trial name
- NCT07424040
- Testing
- Infliximab combined with azathioprine therapy, Infliximab monotherapy
- Where
- 4 sites in China
- Volunteers
- 154 people
- Sponsor
- The Children's Hospital of Zhejiang University School of Medicine
Malnutrition, Pneumonia
Childhood Acute Illness and Nutrition Network
The CHAIN Network aims to identify modifiable biomedical and social factors driving the greatly increased risk of mortality among young undernourished children admitted to hospital with acute illness, as inpatients and after…
- Conditions
- Malnutrition, Pneumonia, Diarrhea, Sepsis
- Trial name
- CHAIN (NCT03208725)
- Where
- 8 sites in Bangladesh, Kenya and 3 more
- Volunteers
- 4,335 people
- Sponsor
- University of Oxford
Ulcerative Colitis, Crohn's Disease
Development of 'Emma'--a Pediatric IBD Quiz
We would like to collaborate and further develop an ipad-based, interactive quiz game 'Emma'; to identify gaps in knowledge of inflammatory bowel disease in pediatric patients. These gaps can be used to improve patient education.
- Conditions
- Ulcerative Colitis, Crohn's Disease, Inflammatory Bowel Disease
- Trial name
- NCT02065089
- Testing
- playing the ipad quiz game
- Where
- 2 sites in United States
- Volunteers
- 116 people
- Sponsor
- Mayo Clinic
Ulcerative Colitis (UC), IBD-unclassified (IBD-U)
Therapeutic Drug Monitoring for Biological Therapy in Pediatric Inflammatory Bowel Disease
Inflammatory Bowel Diseases (IBD), which include Crohn's disease (CD), ulcerative colitis (UC), and the unclassified form referred to as indeterminate colitis, are most commonly diagnosed during adolescence and early adulthood.
- Trial name
- TDMpIBD (NCT06954311)
- Where
- 10 sites in Austria
- Volunteers
- 120 people
- Sponsor
- Medical University Innsbruck
Crohn Disease
Comparison of Bowel Ultrasound & MR Enterography in the Follow-up of Previously Diagnosed Pediatric Small Bowel Crohn Disease
To establish the accuracy of bowel ultrasound in the follow-up of known (previously diagnosed) pediatric small bowel Crohn disease, using MR Enterography (magnetic resonance imaging technology used to obtain detailed images of…
- Trial name
- NCT01671579
- Testing
- Bowel ultrasound, magnetic resonance enterography (MRE)
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Crohn Disease, Pediatric Crohns Disease
FMT in Pediatric Crohn's Disease
The goal of this study is to evaluate the safety of Fecal Microbiota Transplantation (FMT) in children with Crohn's disease who are in remission. Safety will be the primary endpoint and Pediatric Crohn's Disease.
- Trial name
- FMTPCD (NCT03194529)
- Testing
- FMT
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Children's Hospital Los Angeles
Crohn's Disease
Use of Crohn's Disease Exclusion Diet on Top of Standard Therapy Versus Standard Therapy Alone in Unstable Pediatric Crohn's Disease Patients.
This research is a multicenter French randomized and single blinded phase III clinical trial evaluating two treatment strategies among Crohn's disease (CD) patients.
- Trial name
- ASCENSION (NCT04777656)
- Testing
- Phase1 : CDED/Modulen™IBD® + Maintenance therapy, Phase2 and 3 :
- Where
- 4 sites in France
- Volunteers
- 120 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Crohn Disease, Ulcerative Colitis
Occupational Insertion and Educational Level of Adult Patients With Pediatric Early Inflammatory Bowel Disease (IBD)
The main objective of this project is to assess the occupational insertion of these adult patients with pediatric-onset IBD and to compare it with the general population. The secondary objectives are: 1.
- Trial name
- PROMICI (NCT04887428)
- Where
- France
- Volunteers
- 343 people
- Sponsor
- University Hospital, Lille
Crohn's Disease, Ulcerative Colitis
Quality of Life in Pediatric Inflammatory Bowel Disease
Measurement of the quality of life (QoL) of children and adolescents with inflammatory bowel diseases (IBD) has had little attention, despite the importance of understanding key factors affecting QoL, especially for measuring the…
- Trial name
- NCT00061737
- Where
- 6 sites in United States
- Volunteers
- 350 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Inflammatory Bowel Diseases, Colitis, Ulcerative
Initial Experience With a Novel Single-Balloon Enteroscopy System in Children With IBD
To evaluate the safety and efficacy of the NaviAid™ AB in children with known or suspected IBD.
- Conditions
- Inflammatory Bowel Diseases, Colitis, Ulcerative, Crohn Disease
- Trial name
- NCT02629211
- Testing
- NaviAid™ AB
- Where
- Israel
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Smart Medical Systems Ltd.
Colitis, Ulcerative
A Study of Vedolizumab in Children and Teenagers With Moderate to Severe Ulcerative Colitis (UC)
Vedolizumab is a medicine that helps to reduce inflammation and pain in the digestive system. In this study, children and teenagers with moderate to severe ulcerative colitis will be treated with vedolizumab.
- Trial name
- NCT04779307
- Testing
- Vedolizumab
- Where
- 65 sites in United States, Australia and 12 more
- Volunteers
- 121 people
- Sponsor
- Takeda
IBD
Capsule Endoscopy in Inflammatory Bowel Disease (IBD) in Children
Most of the studies evaluating the roles of MRE and WCE conducted in pediatric patients have been retrospective with the main goal of making a diagnosis in patients with suspected IBD.
- Trial name
- CE (NCT02182947)
- Testing
- Capsule endoscopy
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Children's Mercy Hospital Kansas City
Inflammatory Bowel Diseases
An Efficacy and Safety Study of Infliximab Dose Escalation in Pediatric Participants With Inflammatory Bowel Disease
The purpose of this study is to evaluate whether trough serum infliximab concentrations at the time of loss of clinical response will identify pediatric participants with inflammatory bowel disease (IBD) who would benefit (regain…
- Trial name
- ADAPT (NCT02566889)
- Testing
- Infliximab
- Where
- 36 sites in United States, Canada
- Volunteers
- 53 people
- Sponsor
- Janssen Scientific Affairs, LLC
Ulcerative Colitis, Protein Metabolism
Metabolic Response to Infliximab in Pediatric Ulcerative Colitis
The metabolic response to ulcerative colitis, including increased proteolysis and lipolysis and changes in energy expenditure, plays a significant role in the resulting malnutrition from which these patients suffer.
- Conditions
- Ulcerative Colitis, Protein Metabolism, Energy Expenditure
- Trial name
- NCT00586807
- Testing
- Stable amino acid isotopes
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Indiana University
Peripheral Vascular Access in Pediatric Patients, Peptic Ulcer
The Effect of Vascular Imaging Devices on Success Rates of Peripheral Vascular Access in Pediatric Patients
The study was designed as a prospective, observational study. Pediatric patients under 18 years of age scheduled for peripheral vascular access placement during day-case surgery or non-operating room anesthesia (NORA) will be…
- Conditions
- Peripheral Vascular Access in Pediatric Patients, Peptic Ulcer, Cataract, Crohn's Disease
- Trial name
- NCT07315711
- Where
- 6 sites in Turkey (Türkiye)
- Volunteers
- 500 people
- Sponsor
- Sibel Seçkin Pehlivan