Clinical trials: Pediatric Pain
Sleep, Pediatrics
Postoperative Pain After Pediatric Adenotonsillectomy With Ketorolac or Ibuprofen
This prospective observational study will evaluate postoperative pain after outpatient pediatric adenotonsillectomy in adolescents prescribed either acetaminophen with ibuprofen or acetaminophen with oral ketorolac after…
- Conditions
- Sleep, Pediatrics, Adenotonsillectomy
- Trial name
- NCT07672418
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Baylor College of Medicine
Procedural Pain
Comparison of Virtual Reality, EMLA Cream, and Standard Care for Pain During Blood Draws in Children
This randomized controlled trial evaluates methods to reduce pain during venipuncture in children aged 3 to 15 years. The study compares three approaches: virtual reality distraction using a VR headset, topical anesthesia with…
- Trial name
- NCT07763132
- Testing
- Virtual Reality Distraction, Lidocaine-Prilocaine Cream
- Where
- Czechia
- Volunteers
- 450 people
- Sponsor
- Marie Lulková
Laparoscopic Appendectomy
Comparing Pain Relief Between Two Methods of Freezing Injections in Children Having Their Appendix Removed
Laparoscopic appendectomies are the most common emergency surgeries performed in children. Despite being considered minimally invasive surgeries, they can result in substantial postoperative pain and 2 of 3 patients require…
- Trial name
- NCT06945263
- Testing
- Rectus Sheath Block, Local Anesthetic at the Umbilical Port Site, Intravenous Dexamethasone
- Where
- Canada
- Volunteers
- 32 people
- Sponsor
- University of British Columbia
Post-operative Pain
Dexmedetomidine Added to Bupivacaine for ESP Block in Children Undergoing Lower Abdominal Surgeries
This study aims to evaluate the effect of adding dexmedetomidine to bupivacaine in erector spinae plane (ESP) blocks on the duration of postoperative analgesia in pediatric patients undergoing lower abdominal surgery.
- Trial name
- NCT07023991
- Testing
- Bupivacaine, Dexmedetomidine
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Pain Management
Pain Reduction Using Vibration and Topical Anesthesia
The goal of this clinical trial is to study if a powered toothbrush providing vibrations compared with 20% benzocaine topical gel is more effective in reducing pain before local anesthetic injections in children aged 6-12 years…
- Trial name
- TG-EB-Eff (NCT06804616)
- Testing
- 20% benzocaine Gel, Powered Toothbrush
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- University of Lahore
Chronic Pain
SPACE for Youth With Chronic Pain
The primary objective is to assess the feasibility and acceptability of a group-based parent training intervention for parents of youth with chronic pain.
- Trial name
- NCT07425691
- Testing
- Supportive Parenting for Anxious Childhood Emotions - Pain
- Where
- 2 sites in United States
- Volunteers
- 39 people
- Sponsor
- Children's Hospital of Philadelphia
Molar-Incisor Hypomineralization
Evaluation of Different Anesthesias in Children With Molar Incisor Hypomineralization
In children with molar-incisor hypomineralization (MIH), insufficient depth of anesthesia can lead to increased anxiety and behavior management problems, which may negatively affect the quality of restorations.
- Trial name
- NCT07268157
- Testing
- Computer-controlled anesthesia device (SleeperOne), Conventional injection technique
- Where
- Turkey (Türkiye)
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Canan Bayraktar Nahir
Regional Anesthesia, Hypospadias
Ultrasound-guided PNB and DPNB for Pediatric Distal Hypospadias Surgery
Hypospadias repair is a urological surgical operation that is very painful in the postoperative period and requires long-term analgesia.
- Trial name
- NCT04668183
- Testing
- Pudendal nerve block group, Dorsal penile nerve block group
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization
Anxiety
The Effects of Vibration and Pressure Interventions
This study aimed to evaluate two methods (pressure and vibration intervention) used to reduce pain during IM injections in children.
- Trial name
- NCT05656066
- Testing
- The Vibration Intervention, The Pressure Intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Pediatric, Headache
A Study of Family-based Cognitive-behavioral Therapy for Chronic Pediatric Headache and Anxiety
The primary aim of this proposal is to refine the intervention under investigation (i.e., family-based CBT) and evaluate the feasibility and acceptability of the intervention and methods (e.g., recruitment, assessments).
- Conditions
- Pediatric, Headache, Anxiety
- Trial name
- NCT01182051
- Testing
- CBT or relaxation training
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Johns Hopkins University
Chronic Pain
A Study to Assess the Safety, Dose Conversion, and Dose Individualization of Duragesic® (Fentanyl Transdermal Patch) in the Treatment of Children With Chronic Pain Requiring Narcotic Pain Relief Therapy
The objective of this study is to assess the safety of treatment with Duragesic® (a transdermal patch delivering the narcotic pain-reliever fentanyl) in doses of 12.5, 25, 50, 75 and 100 micrograms/hour in pediatric subjects…
- Trial name
- NCT00271466
- Testing
- Duragesic® (fentanyl) Therapeutic Transdermal System (TTS)
- Volunteers
- 199 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Juvenile; Scoliosis, Scoliosis Idiopathic
Studying Melatonin and Recovery in Teens
The goal of this feasibility clinical trial is to learn if melatonin can help teens having major musculoskeletal surgery by promoting healthy sleep.
- Conditions
- Juvenile; Scoliosis, Scoliosis Idiopathic, Scoliosis; Adolescence, Scoliosis;Congenital
- Trial name
- SurgerySMART (NCT06093477)
- Testing
- Fast-Dissolve Melatonin Pill
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Stanford University
Pain
J-Tip® Jet Injection of 1% Buffered Lidocaine or Saline Versus 4% Lidocaine Cream Before Venipuncture or IV Insertion
To measure and compare pain associated with venipuncture and peripheral intravenous catheter insertion among pediatric emergency department patients randomized to treatment with one of three different pain-reduction strategies…
- Trial name
- NCT00924963
- Testing
- J-Tip jet injector, Jet injection saline, lidocaine cream
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Anesthesia, Dental, Pain, Postoperative
Articaine vs Lidocaine for Pediatric Dental Procedures
The purpose of this study is to compare the efficacy of two types of local anesthesia (articaine and lidocaine) for infiltration anesthesia during restorative dental procedures on lower teeth in pediatric patients.
- Trial name
- NCT03318952
- Testing
- lidocaine, articaine
- Where
- United States
- Sponsor
- Boston University
Analgesia, Pain, Acute
Assessment of Efficacy of Sacral Erector Spinae Plane Block for Postoperative Analgesia in Pediatric Rectal Biopsies
The purpose of this study is to evaluate how sacral erector spinae block changed the postoperative analgesia requirements in pediatric patients undergoing rectal biopsies under general anesthesia.
- Trial name
- NCT06362811
- Testing
- Sacral Erector Spinae Plane Block
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people
- Sponsor
- Istanbul University
Pain, Acute, Congenital Heart Disease
Transverse Thoracic Plane Block in the Pediatric Cardiac Patient
Postoperative pain after cardiothoracic surgery can be a significant problem interfering with recovery, yet difficult to manage due to the sedating effects of opiates.
- Trial name
- TTPPCT (NCT04138745)
- Testing
- Transverse Thoracic Plane Block
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Ochsner Health System
Pain
The Effect of Acupressure on Pain in Children With Thalassemia
This randomized controlled trial evaluates the effect of acupressure on reducing the pain of blood collection in children with Thalassemia. The hypothesis of this study is that acupressure application reduces acute pain.
- Trial name
- acupressure (NCT06163196)
- Testing
- acupressure
- Where
- Turkey (Türkiye)
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Mersin University
Pain
Randomized, Double-blind, Placebo, Controlled Cross Over Design Topical Morphine for Analgesia in Pediatric Procedures
Introduction: Opioids, such as morphine, act at receptors in the central nervous system, but many studies have suggested direct action peripherally on opioid receptors in sensory neurons terminals, melanocytes, keratinocytes and…
- Trial name
- NCT02300194
- Testing
- Topic Morphine
- Where
- Argentina
- Sponsor
- Hospital General de Niños Pedro de Elizalde
Pain, Needle Phobia
The Efficacy of EMLA Cream vs. Synera Patch for Pain Reduction During Venipuncture in Children
This study compares the efficacy of the Synera patch with Eutectic Mixture of Local Anesthetics (EMLA) as a topical anesthetic for venipuncture in pediatric patients.
- Trial name
- NCT00530803
- Testing
- EMLA Cream, Synera Patch
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Montefiore Medical Center
Tonsillitis, Post-operative Nausea and Vomiting (PONV)
Opioid Sparing Anesthesia Care for Pediatric Patients Having Tonsil Surgery
This is a prospective, randomized, controlled, non-inferiority study of patients undergoing tonsil surgeries at Boston Children's Hospital Waltham.
- Conditions
- Tonsillitis, Post-operative Nausea and Vomiting (PONV), Emergence Delirium, Opioid Analgesic Adverse Reaction
- Trial name
- NCT06326983
- Testing
- Dexmedetomidine, Acetaminophen, Ketorolac
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Boston Children's Hospital