Clinical trials: Pediatric Population
Dehydration
Efficacy and Time and Resources for Hylenex-facilitated SC Rehydration Versus ORT for Dehydrated Children in the Emergency Department (ED)
The purpose is to evaluate the safety and efficacy as well as the time and resources needed in the ED setting to achieve rehydration in young pediatric subjects with mild to moderate dehydration using hylenex-facilitated SC…
- Trial name
- INFUSE-TM (NCT01120431)
- Testing
- Oral rehydration fluid, Isotonic hydration fluid and recombinant human hyaluronidase
- Sponsor
- Baxter Healthcare Corporation
Ventricular Arrhythmia
Radiofrequency Ablation of Symptomatic Frequent Ventricular Premature Complexes in Pediatric Population
To evaluate the effectiveness and safety of catheter ablation of frequent symptomatic PVCs in the pediatric population as first-line therapy compared with antiarrhythmic drugs.
- Trial name
- RAS (NCT02772354)
- Testing
- Radiofrequency catheter ablation, Metoprolol, Verapamil
- Where
- 2 sites in Russia
- Volunteers
- 124 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Anesthesia, Local
A Study of Safety and the Local Anesthetic Effect of AG-920 Ophthalmic Solution in a Pediatric Population
A Phase 3, randomized, active-controlled, study in pediatric subjects. It is designed to evaluate the safety and anesthetic efficacy of one dose of AG-920 ophthalmic solution compared to Proparacaine Hydrochloride Ophthalmic…
- Trial name
- NCT05325853
- Testing
- AG-920, Proparacaine Ophthalmic
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- American Genomics, LLC
Childhood Obesity
Mountain West Prevention Research Center Core Research Project
This hybrid type 3 effectiveness-implementation sequential multiple assignment randomized trial will assess the impact of integrating population health management (PHM) strategies-text messaging and enrollment in Building Healthy…
- Trial name
- MW-PRCCRP (NCT07479498)
- Testing
- Text Message-based recruitment, Active outreach follow-up
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Paul Estabrooks
Childhood Obesity
Therapeutic Education Groups for Childhood Obesity
The goal of this clinical trial is to test the efficacy of an educational therapeutic intervention in treating obesity in a pediatric population.
- Trial name
- GET-Obesity (NCT06239662)
- Testing
- Therapeutic Group, Usual care
- Volunteers
- 318 people
- Sponsor
- Azienda USL Reggio Emilia - IRCCS
Helminth Infections
A Study to Assess the Efficacy and Safety of Mebendazole for the Treatment of Helminth Infections in Pediatric Participants
The purpose of this study is to evaluate the efficacy and safety of mebendazole compared with placebo in pediatric participants with Helminth infections.
- Trial name
- NCT02034162
- Testing
- Mebendazole
- Where
- 3 sites in Ethiopia, Rwanda
- Volunteers
- 295 people
- Sponsor
- Janssen Research & Development, LLC
Bipolar I Depression
Lurasidone Pediatric Bipolar Study
A study to evaluate efficacy and safety of flexibly dosed Lurasidone in children and adolescents with bipolar I depression
- Trial name
- Illuminate (NCT02046369)
- Testing
- Lurasidone
- Where
- 66 sites in United States, Bulgaria and 9 more
- Volunteers
- 350 people
- Sponsor
- Sumitomo Pharma America, Inc.
Pain, Procedural, Distress, Procedural
Distraction for Reduction of Pain Associated With Venipuncture in the Pediatric Post-Transplant Population
Children with chronic diseases, particularly those who have received transplantation (e.g. cardiac, renal, or liver) are a population who undergo frequent painful procedures, such as venipuncture multiple times per week.
- Conditions
- Pain, Procedural, Distress, Procedural, Venipuncture
- Trial name
- NCT03004456
- Testing
- Distraction
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Columbia University
Peripheral Venous Catheterization
A Randomized Controlled Trial to Demonstrate the Safety and Efficacy of the OptiVein IV Catheter In a Pediatric Population
A prospective, single-center, open-label, randomized controlled trial to demonstrate the safety and efficacy of the OptiVein IV Catheter in the pediatric population.
- Trial name
- NCT02265380
- Testing
- Placement of IV catheter
- Where
- Finland
- Volunteers
- 188 people
- Sponsor
- Optomeditech Oy
Hematologic Malignancies, Nonmalignant Diseases
Study of Melphalan Drug Exposure in Pediatric Hematopoietic Stem Cell Transplant Patients
Melphalan is a chemotherapy drug used extensively in bone marrow transplantation. The goal of this study is to determine what causes some children to have different drug concentrations of melphalan in their bodies and if drug…
- Conditions
- Hematologic Malignancies, Nonmalignant Diseases, Immunodeficiencies, Hemoglobinopathies
- Trial name
- NCT03609827
- Testing
- Melphalan
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of California, San Francisco
Syphilis Acquired
Oral Amoxicillin Compared to Penicillin G Benzathine for the Treatment of Acquired Syphilis.
The goal of this clinical trial is to learn if oral amoxicillin has comparable therapeutic response than penicillin G benzathine for the treatment of acquired pediatric syphilis.
- Trial name
- AMOXSYP (NCT06877351)
- Testing
- Amoxicillin, Penicillin G, Benzathine
- Where
- Argentina
- Volunteers
- 120 people
- Sponsor
- Hospital de Niños R. Gutierrez de Buenos Aires
HIV Infections
Evaluation of the Population-level Impact of PMTCT Option B+ in Zimbabwe
This study evaluates the impact of Zimbabwe's program for the prevention of mother-to-child HIV transmission (PMTCT) on vertical transmission of HIV infection and HIV-free survival among infants exposed to HIV.
- Trial name
- NCT03388398
- Volunteers
- 30,642 people
- Sponsor
- University of California, Berkeley
Cystic Fibrosis (CF)
Population Pharmacokinetics of Elexacaftor-tezacaftor-ivacaftor in a Paediatric Population
Cystic fibrosis is a rare, progressive genetic disease caused by a mutation in the CFTR (cystic fibrosis transmembrane conductance regulator) gene. Respiratory and nutritional effects are crucial to patients' prognosis.
- Trial name
- IMPROVED (NCT07303621)
- Testing
- There is no intervention as this is a prospective pharmacokinetics study.
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Hospices Civils de Lyon
H Pylori Gastritis
Comparison of Efficacy of Triple Regimen Based on Clarithromycin VS Metronidazole in Children
All children from 1day to 18years of age, diagnosed with peptic ulcer disease due to H pylori at Pakistan Institute of Medical Sciences, Islamabad, from July 2020 to December 2021 will be included in the study.
- Trial name
- CETR (NCT04721704)
- Testing
- Clarithromycin+ Amoxicillin + Omeprazole, Metronidazole +Amoxicillin + Omeprazole
- Where
- 2 sites in Pakistan
- Volunteers
- 36 people
- Sponsor
- Shaheed Zulfiqar Ali Bhutto Medical University
Appendicitis, Appendix Mass
Identification of the Optimal Treatment Strategy for Complex Appendicitis in the Pediatric Population
Aim of this study is to evaluate the effect of different treatment strategies on overall complications, health related-Quality of Life (hr-QOL) and costs among two subtypes of complex appendicitis in children (<18 years old).
- Conditions
- Appendicitis, Appendix Mass, Appendicitis Perforated
- Trial name
- CAPP (NCT04755179)
- Testing
- Laparoscopic appendectomy, Open appendectomy, Non-operative treatment
- Where
- 32 sites in Netherlands
- Volunteers
- 1,308 people
- Sponsor
- Ramon Gorter
Heart Failure
Bio-signal Telemonitoring Using Electronic Textiles in a Pediatric Population
There is a need for developing reliable and convenient technologies for telemonitoring of physiological signals such as respiration, cardiac function, and activity level in children and especially for those with heart disease.
- Trial name
- NCT04305340
- Testing
- Myant SKIIN Device
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Aamir Jeewa
Asthma
Montelukast in Pediatric Allergic Asthma (0476-336)(COMPLETED)
This is a 3-week study to evaluate FEV1 following treatment with drugs in persistent asthma which is also active during allergy seasons in pediatric patients with seasonal aeroallergen sensitivity.
- Trial name
- NCT00289874
- Testing
- montelukast sodium
- Volunteers
- 421 people
- Sponsor
- Organon and Co
Pneumonia Childhood
Severe Pneumonia Diagnostic in Pediatric Population by Lung Ultrasonography and Procalcitonin
Lung ultrasound (LUS) in combination with a biomarker has not yet been studied. The investigators propose a clinical trial where the primary aims are: 1.
- Trial name
- PROLUSP (NCT04217980)
- Testing
- Lung ultrasonography (LUS) or Chest X ray (CXR)
- Where
- 2 sites in Spain
- Volunteers
- 202 people
- Sponsor
- Fundació Sant Joan de Déu
Helicobacter Pylori Infection
Urea Breath Test (UBT) With Breath Hp System /BreathID Hp Lab System Pediatrics
Clinical Study to Confirm Safety and Accuracy in Detection of H. pylori with 13C-Urea Breath Test using the BreathID® Hp and BreathID® Hp Lab Systems in the Pediatric Population
- Trial name
- NCT02905825
- Testing
- BreathID® Hp System, BreathID® Hp Lab System, Stool Test
- Where
- 6 sites in United States, Israel
- Volunteers
- 54 people
- Sponsor
- Meridian Bioscience, Inc.
Postoperative Pain
Rectal Dexmedetomidine Niosomes for Postoperative Analgesia in Pediatric Cancer Patients.
Applying nanotechnology in drug delivery systems improved the bioavailability and kinetic profile of drugs in biological systems
- Trial name
- DEX-NANO (NCT05340725)
- Testing
- DEX-IV, DEX-Rectal, DEX-Nano-Rectal
- Where
- Egypt
- Volunteers
- 45 people
- Sponsor
- Assiut University