Clinical trials: Pediatric Population
Adolescent Obesity, Life Style, Healthy
CArdioMetabolic Prevention in Adolescents
The aim of the CArdioMetabolic Prevention (CAMP) pilot study is to investigate the effect of a group intervention on lifestyle in adolescents and on at least one adult family member.
- Conditions
- Adolescent Obesity, Life Style, Healthy, Body Weight Changes, Cardiometabolic Syndrome
- Trial name
- CAMP (NCT05350111)
- Testing
- lifestyle education
- Where
- Czechia
- Volunteers
- 40 people
- Sponsor
- Faculty Hospital Kralovske Vinohrady
Bladder Dysfunction
The Utility of Shanfield Implantation Technique During Creation of Mitrofanoff Procedure in Pediatric Age Group
Management of bladder dysfunction was revolutionized by the introduction of intermittent catheterization by Lapides. Later, Mitrofanoff described a trans-appendicular continent cystostomy, launching a new concept whereby the…
- Trial name
- NCT06472193
- Testing
- Shanfield implantation technique in Mitroffanof procedure
- Where
- Egypt
- Volunteers
- 10 people
- Sponsor
- Sohag University
Mental Health Disorder
CoCo-20: a Longitudinal Follow-up Study of the French Paediatric Population During and After the Coronavirus Pandemic COVID-19
In the context of a viral outbreak and of widespread quarantine measures, a significant increase in psychological disorders, such as stress or fear behaviours, had previously been observed.
- Trial name
- CoCo-20 (NCT04498416)
- Testing
- Quantitative and qualitative assessments of mental health
- Where
- France
- Volunteers
- 70 people
- Sponsor
- Fondation Lenval
Ocular Redness, Eye Irritation
An Investigation of FID 123320 for the Reduction of Ocular Redness in Pediatric and Adult Populations
The purpose of this study is to assess the safety and efficacy of FID 123320 Ophthalmic Solution compared to Vehicle for relieving redness of the eye due to minor eye irritations in pediatric and adult populations.
- Trial name
- NCT06538662
- Testing
- FID 123320 Ophthalmic Solution, Vehicle
- Where
- 10 sites in United States
- Volunteers
- 283 people
- Sponsor
- Alcon Research
Dissociative Disorders, Schizophrenia
Assessment of Adverse Events in a Naive Pediatric Population Treated With an Antipsychotic
We propose a prospective multicenter study, whose originality lies in the inclusion of the naive child and adolescent population.
- Trial name
- NCT02007928
- Testing
- Rispéridone, aripiprazole, olanzapine
- Where
- 14 sites in France
- Volunteers
- 200 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Pediatric, Symptomatic Obstructive Hypertrophic Cardiomyopathy
A Study to Evaluate the Effect of Aficamten in Pediatric Patients With Symptomatic Obstructive Hypertrophic Cardiomyopathy (oHCM).
The purpose of this study is to evaluate the efficacy, safety and pharmacokinetics of aficamten in a pediatric population with symptomatic obstructive hypertrophic cardiomyopathy (oHCM).
- Trial name
- CEDAR-HCM (NCT06412666)
- Testing
- Aficamten
- Where
- 36 sites in United States, Canada and 4 more
- Volunteers
- 65 people
- Sponsor
- Cytokinetics
Pediatric Leukemia, Pediatric Brain Neoplasms
Feasibility of Identifying a Chinese Study Population and Eligible Pediatric Cancer Cases, and Linking the Two Groups to Assess the Role of Periconceptional Folic Acid Supplements in Risk of Pediatric Cancer.
Background: Pregnant women are encouraged to take the vitamin folate. It helps prevent some birth defects. Children of mothers who take it also have less risk of some cancers.
- Conditions
- Pediatric Leukemia, Pediatric Brain Neoplasms, Other Pediatric Cancers
- Trial name
- NCT02160795
- Sponsor
- National Cancer Institute (NCI)
Functional Constipation (FC), Chronic Idiopathic Constipation (CIC)
A Study to Assess Adverse Events and Change in Symptoms With Linaclotide Versus Placebo in Pediatric Subjects, Ages 2 to 5 Years, With Functional Constipation
Functional constipation (FC) is a common healthcare problem in children of all ages, potentially due to genetic predisposition, inadequate fiber and fluid intake, and immobility.
- Trial name
- NCT05652205
- Testing
- Linaclotide
- Where
- 48 sites in United States, Bulgaria and 2 more
- Volunteers
- 123 people
- Sponsor
- AbbVie
Acute Lymphoblastic Leukemia, Nephrotic Syndrome
Steroid-Induced Osteoporosis in the Pediatric Population - Canadian Incidence Study
To determine the magnitude and rate of bone mass deficits following initiation of glucocorticoid therapy for the treatment of pediatric leukemia, rheumatic conditions and nephrotic syndrome, we propose a 6 year, prospective study…
- Conditions
- Acute Lymphoblastic Leukemia, Nephrotic Syndrome, Rheumatism
- Trial name
- STOPP-CIS (NCT01663129)
- Where
- 12 sites in Canada
- Volunteers
- 406 people
- Sponsor
- Children's Hospital of Eastern Ontario
Cardiac Toxicity, Unspecified Childhood Solid Tumor, Protocol Specific
Enalapril in Treating Heart Damage Patients Who Received Anthracycline Chemotherapy for Childhood Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Chemoprotective drugs, such as enalapril, may protect normal cells from the toxic effects of chemotherapy.
- Trial name
- NCT00003070
- Testing
- enalapril maleate, quality-of-life assessment
- Where
- 61 sites in United States, Canada and 1 more
- Volunteers
- 13 people
- Sponsor
- Children's Oncology Group
Monosymptomatic Nocturnal Enuresis
Pharmacokinetics and Pharmacodynamics of Desmopressin Oral Lyophilisate Formulation in the Paediatric Population
Patients suffering from nocturnal enuresis (starting from the age of 5 till adulthood) are all treated with the same dose of desmopressin, i.e. 120mcg once daily.
- Trial name
- NCT02584231
- Testing
- desmopressin
- Where
- Belgium
- Volunteers
- 25 people
- Sponsor
- University Ghent
Desmoid Tumor
Vinblastine and Methotrexate in Treating Children With Desmoid Tumors
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
- Trial name
- NCT00003019
- Testing
- methotrexate, vinblastine sulfate
- Where
- 39 sites in United States, Australia and 1 more
- Volunteers
- 28 people
- Sponsor
- Children's Oncology Group
Acne
Musculoskeletal Effects of Isotretinoin During Acne Treatment in Pediatric Population
This is a prospective study, that will follow participants over their course of treatment on Isotretinoin. All patients who are prescribed Isotretinoin for their acne treatment are registered in iPLEDGE.
- Trial name
- NCT00964119
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Wisconsin, Madison
Healthy Volunteers
Study To Evaluate Safety, Tolerability, and Pharmacokinetics of MAM01 in African Population
This study will test a new drug (MAM01) to find which doses are safe and could help prevent people from getting malaria for at least 4 months. The study will take place in parts of Africa where malaria is common.
- Trial name
- NCT06408857
- Testing
- MAM01 300 mg SC, MAM01 300 mg IM, MAM01 2000 mg IV
- Where
- 2 sites in Uganda
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Gates Medical Research Institute
Hypertension
Dose Ranging, Safety and Tolerability of TOPROL-XL® Extended-Release Tablets in Hypertensive Pediatric Subjects
This was a 4-week, multicenter, double-blind, placebo-controlled, randomized, parallel-group study to determine the antihypertensive dose range, efficacy, safety and tolerability of TOPROL-XL ® (metoprolol succinate)…
- Trial name
- 307A (NCT00255528)
- Testing
- metoprolol succinate
- Where
- 31 sites in United States, Dominican Republic
- Volunteers
- 144 people
- Sponsor
- AstraZeneca
Suicidal Ideation
Validation of the French Version of Ask Suicide-Screening Questions (ASQ) in Adolescents Managed in Pediatric Emergency Unit
The ASQ-Fr study aims at validating the French version of Ask Suicide-Screening Questions composed of 5 items in adolescents managed in pediatric emergency department.
- Trial name
- ASQ-Fr (NCT02900989)
- Testing
- Suicide screening
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Centre Hospitalier Universitaire de la Réunion
Anesthesia, Supraglottic Airway Efficiency
Clinical Efficacy Evaluation of Supraglottic Airway Device SafeLM™ in Paediatric Population
The goal of this interventional study is to evaluate the clinical efficacy of SafeLM™, a video laryngeal mask airway device in paediatric population. The main questions it aims to answer are: 1.
- Conditions
- Anesthesia, Supraglottic Airway Efficiency, Paediatric Airway Management
- Trial name
- NCT07266389
- Testing
- SafeLM™ as the airway management device during general anaesthesia
- Where
- 2 sites in Malaysia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National University of Malaysia
Procedural Pain, Venipuncture
Leap Motion Controller for Pain During Venipuncture in Pediatrics
Venipuncture is the most frequent invasive procedure in hospitals and clinics. In the pediatric population this is very often associated with fear, anxiety, distress and enhanced perception of pain.
- Trial name
- LeapRCT (NCT05441241)
- Testing
- Leap Motion Controller, Traditional distraction techniques
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- IRCCS Burlo Garofolo
Glaucoma, Ocular Hypertension
Long-Term Non-Interventional Latanoprost Study
This is a non-interventional, prospective, longitudinal cohort study. A total of 150 pediatric subjects with glaucoma or elevated intraocular pressure, including 75 latanoprost-treated subjects and 75 non-topical prostaglandin…
- Trial name
- LYNX (NCT01265719)
- Testing
- No intervention other than routine medical care
- Where
- 29 sites in Belgium, Colombia and 12 more
- Volunteers
- 175 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Spasticity
Study of Intramuscular Injections of OnabotulinumtoxinA to Assess Change in Disease Activity in Pediatric Participants With Spasticity Associated With Cerebral Palsy
Spasticity is often observed as muscle tightness and stiffness in the upper and/or lower limbs. Upper limb spasticity can interfere with joint movement and its severity can range from mild to severe.
- Trial name
- NCT06150729
- Where
- 8 sites in Mexico
- Volunteers
- 107 people
- Sponsor
- AbbVie