Clinical trials: Pediatrics Cancer
Cancer, HIV Infections
The Use of a Distress Thermometer in a Pediatric Research Setting: An Exploratory Pilot Study
Medical illnesses and treatments can cause distress in patients, and medical professionals are very interested in identifying distress quickly to ensure that a patient can receive appropriate support and treatment.
- Trial name
- NCT00824278
- Where
- United States
- Volunteers
- 289 people
- Sponsor
- National Institute of Mental Health (NIMH)
Acute Lymphoblastic Leukemia
ALL2008 Protocol for Childhood Acute Lymphoblastic Leukemia (ALL) - 6MP Consolidation Therapy
The purpose of this study is to increase the fraction of patients, who become MRD-negative during consolidation for the non-HR ALL group through individualized intensification of the 6MP-dosage days 30-85.
- Trial name
- ALL2008con (NCT00816049)
- Testing
- 6MPindividualized, 6MPfixed
- Where
- 6 sites in Denmark, Finland and 3 more
- Volunteers
- 775 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Acute Lymphoblastic Leukemia, Pediatric
Parental Perception of Their Child's Emotional Quality of Life in Paediatric Oncology Before and After "Magic Massages"
Rationale: In France, 1,850 cases of cancer are diagnosed in children every year (28% of leukaemia). Despite a cure rate of 83% (all cancers combined), treatment remains a major burden.
- Trial name
- MASSAYA (NCT06107478)
- Testing
- Self-report questionnaires (only for parents), Interview (only for parents), Clinical data collection (only concerning Children)
- Volunteers
- 181 people, healthy volunteers welcome
- Sponsor
- Centre Leon Berard
Disorders of Sexual Development
Disorders of Sexual Development and Gonadal Tumor Risk
Disorders of Sexual Development are rare and represent a spectrum of heterogeneous pathologies. The risk of developing a malignant gonadal germ cell tumor (MGCT) exists and varies according to the etiology.
- Trial name
- DEV-GEN-RiTuGo (NCT06682078)
- Testing
- Not applicable . Non-interventional retrospective study, only on datas.
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Hospices Civils de Lyon
B-cell Non Hodgkin Lymphoma
A Global Study of Novel Agents in Paediatric and Adolescent Relapsed and Refractory B-cell Non-Hodgkin Lymphoma
The Glo-BNHL trial is trying to find better medicines for children and young people with B-cell non-Hodgkin Lymphoma (B-NHL) that does not go away (refractory B-NHL) or does but comes back again (relapsed B-NHL).
- Trial name
- Glo-BNHL (NCT05991388)
- Testing
- Odronextamab, Loncastuximab tesirine, Rituximab
- Where
- 11 sites in Australia, Austria and 5 more
- Volunteers
- 210 people
- Sponsor
- University of Birmingham
Leukemia, Childhood, Solid Tumor, Childhood
Observational MyPal-Child Study on the ePRO-based Early Palliative Care Digital System in Paediatric Oncology Patients
The main aim of the study is the evaluation of the feasibility of comprehensive service which has been developed while considering patient-orientated needs.
- Trial name
- MyPal4Kids (NCT04381221)
- Where
- 3 sites in Czechia, Germany
- Volunteers
- 100 people
- Sponsor
- Centre for Research and Technology Hellas
Immune Deficiency
Immunodeficiency and Cancer: Identification of Congenital Immune System Defects Underlying Paediatric Lymphomas
Inborn Errors of Immunity (IEI) are a heterogeneous group of disorders characterised not only by an infectious diathesis, but by a wide variety of other clinical manifestations.
- Trial name
- NCT06332196
- Testing
- Analysis of biological sample and clinical data
- Where
- 4 sites in Italy
- Volunteers
- 50 people
- Sponsor
- Meyer Children's Hospital IRCCS
Head and Neck Neoplasms, Congenital Abnormalities
3D Modeling of the Cervico-facial Region and Cranial Nerve Tractography: IMAG 2 ORL Project
3D modeling associated with the tracking of nerve fibers meets the needs of preoperative planning for tumors and cervico-facial congenital malformations.
- Trial name
- IMAG 2 ORL (NCT05763615)
- Testing
- Tractography MRI
- Where
- France
- Volunteers
- 7 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Stress, Health Knowledge, Attitudes, Practice
The PIFBO-study: Person-centred Information to Parents in Paediatric Oncology
The aim of this project is to evaluate a person-centred informational intervention aimed at parents of children with cancer. The following hypotheses will be tested: an informational intervention emanating from the parents'…
- Trial name
- PIFBO (NCT02332226)
- Testing
- Representational approach
- Where
- 2 sites in Sweden
- Volunteers
- 32 people
- Sponsor
- Umeå University
Cancer in Children, Hearing Loss
Cancer and Hearing Loss Related in Children
A limited number of relatively contradictory studies have suggested that the development of serious ototoxicity in children treated with cisplatin or, more rarely, carboplatin could be partly related to genetic risk factors…
- Trial name
- OTOPLAT (NCT02425397)
- Testing
- Genetic study, Genetic study MT-RN1
- Where
- France
- Volunteers
- 119 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
B Acute Lymphoblastic Leukemia, Recurrent Childhood Acute Lymphoblastic Leukemia
CD19 /22 CAR T Cells (AUTO3) for the Treatment of B Cell Acute Lymphoblastic Leukemia (ALL)
The purpose of this study is to test the safety and efficacy of AUTO3, a CAR T cell treatment targeting CD19 and CD22 in paediatric or young adult patients with relapsed or refractory B cell acute lymphoblastic leukaemia.
- Conditions
- B Acute Lymphoblastic Leukemia, Recurrent Childhood Acute Lymphoblastic Leukemia, Refractory Childhood Acute Lymphoblastic Leukemia, B-cell Acute Lymphoblastic Leukemia
- Trial name
- AMELIA (NCT03289455)
- Testing
- AUTO3 (CD19/22 CAR T cells
- Where
- 3 sites in United Kingdom
- Volunteers
- 23 people
- Sponsor
- Autolus Limited
Pediatric ALL
Medication Errors and Adverse Drug Events (ADEs) in Ambulatory Pediatrics
The purpose of this study is to determine the rates of medication errors in pediatric outpatients in 6 office practices. Further, we wish to determine the effectiveness of a computerized physician order entry (CPOE) system in…
- Trial name
- NCT00229671
- Testing
- Survey 1, Survey 2
- Where
- United States
- Volunteers
- 6,341 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Leukemia, Solid Tumors
Haploidentical Transplant With NK Cell Infusion for Pediatric Acute Leukemia and Solid Tumors
This study will assess the feasibility of utilizing a reduced intensity conditioning regimen, in the setting of haploidentical transplantation, for patients with recurrent acute lymphoblastic leukemia (ALL), AML and high risk or…
- Trial name
- NCT00582816
- Testing
- Clinimacs Cell Separation System, conditioning chemotherapy, DLI
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Wisconsin, Madison
Recurrent Lymphoma, Refractory Lymphoma
Vinblastine and Temsirolimus in Pediatrics With Recurrent or Refractory Lymphoma or Solid Tumours Including CNS Tumours
The purpose of this study is to determine the best dose of vinblastine that can be given with a new drug, temsirolimus.
- Conditions
- Recurrent Lymphoma, Refractory Lymphoma, Solid Tumours, Central Nervous System
- Trial name
- NCT02343718
- Testing
- Vinblastine, Temsirolimus
- Where
- 6 sites in Canada
- Volunteers
- 7 people
- Sponsor
- Canadian Cancer Trials Group
Neuroblastoma, Brain Tumors
Studies of Temozolomide in Combination With Topotecan in Refractory and Relapsed Paediatric Solid Tumours
The purpose of the study is to determine whether the combination of Hycamtin (Topotecan) and Temozolomide is effective in the treatment of relapsed and refractory neuroblastoma and other paediatric solid tumors.
- Conditions
- Neuroblastoma, Brain Tumors, Solid Tumors
- Trial name
- TOTEM2 (NCT00918320)
- Testing
- Temozolomide/Hycamtin (Topotecan)
- Where
- France
- Volunteers
- 129 people
- Sponsor
- Gustave Roussy, Cancer Campus, Grand Paris
Solid Tumours
Pazopanib Paediatric Phase II Trial Children's Oncology Group (COG) in Solid Tumors
The study design was an open-label Phase II pediatric clinical study. The purpose of Study X2203 was to identify any efficacy signal in subjects with the disease subtypes under study, when treated with pazopanib monotherapy.
- Trial name
- NCT01956669
- Testing
- Pazopanib
- Where
- 31 sites in United States, Canada and 5 more
- Volunteers
- 57 people
- Sponsor
- Novartis Pharmaceuticals
Pediatrics Cancer
A Nurse-led Multicomponent Interventional Protocol to Improve Sleep Quality in Paediatric Oncology Patients
Sleep is essential for a child's development, influencing cognitive function, emotional stability, recovery, and overall well-being.
- Trial name
- NCT07323069
- Testing
- Sleep Hygiene Education, Progressive Muscle Relaxation, Breathing exercises
- Where
- Hong Kong
- Volunteers
- 68 people
- Sponsor
- Chinese University of Hong Kong
Solid Tumour, Haematological Malignancy
DETERMINE Trial Treatment Arm 06: Capmatinib in Adult Patients With Cancers Harbouring MET Dysregulations
This clinical trial is looking at a drug called capmatinib. Capmatinib is approved as standard of care treatment for adult patients with certain types of lung cancer.
- Conditions
- Solid Tumour, Haematological Malignancy, Malignant Neoplasm, Neoplasms by Histologic Type
- Trial name
- DETERMINE (NCT06988475)
- Testing
- Capmatinib
- Where
- 17 sites in United Kingdom
- Volunteers
- 30 people
- Sponsor
- Cancer Research UK
Chronic Venous Insufficiency, Pediatric ALL
Venous Disease in Pediatric Population
Chronic venous disease (CVD) is widespread in adult subjects of western countries and is responsible of important morbidity and healthcare costs.
- Trial name
- VEDIPEDI (NCT04424095)
- Testing
- In-office vascular visit, Echo Duplex of lower limbs
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- University of Catanzaro
Childhood Cancer, Cancer
CANnabinoids in Pediatric ONCology
CANnabinoids in Pediatric ONCology is a randomized, double blind, adaptive clinical trial looking at the tolerability of cannabinoids in children with cancer across 3 Canadian children's hospitals.
- Trial name
- CAN-PONC (NCT05754840)
- Testing
- MPL-001, MPL-005, MPL-009
- Where
- 3 sites in Canada
- Volunteers
- 60 people
- Sponsor
- University of Manitoba