Clinical trials: Pelvic Cancer, open to volunteers
Colorectal Carcinoma
Organ Preservation in Rectal AdenoCa Using Hypofractionated Pelvic RT(Hypo-OPRA)
The combination of preoperative pelvic RT - either long-course chemoradiotherapy (LCCRT) or short-course radiotherapy (SCRT)- followed by surgery has been the standard of care in the curative treatment of locally advanced…
- Trial name
- Hypo-OPRA (NCT06991465)
- Testing
- Radiation Therapy, FOLFOX regimen, Capecitabine
- Where
- Canada
- Volunteers
- 35 people
- Sponsor
- Neil Kopek
Gynaecologic Cancer, Cervical Cancer
GCCC 2578 Randomized Photon vs Proton RT for Newly Diagnosed Gynecologic Primaries
The purpose of study is to compare the side effects of two different forms of radiation for endometrial and cervical cancer. If you decide to enroll in this study, you will be randomized to one of two treatment groups.
- Conditions
- Gynaecologic Cancer, Cervical Cancer, Radiation Therapy
- Trial name
- NCT07415681
- Testing
- Volume Modulated Arc Therapy (VMAT), Intensity Modulated Proton Therapy (IMPT)
- Where
- 5 sites in United States
- Volunteers
- 116 people
- Sponsor
- University of Maryland, Baltimore
Muscle Invasive Bladder Urothelial Carcinoma, Muscle Invasive Renal Pelvis Urothelial Carcinoma
Testing the Role of DNA Released From Tumor Cells Into the Blood in Guiding the Use of Immunotherapy After Surgical Removal of the Bladder, Kidney, Ureter, and Urethra for Urothelial Cancer Treatment, MODERN Study
This phase II/III trial examines whether patients who have undergone surgical removal of bladder, kidney, ureter or urethra, but require an additional treatment called immunotherapy to help prevent their urinary tract…
- Conditions
- Muscle Invasive Bladder Urothelial Carcinoma, Muscle Invasive Renal Pelvis Urothelial Carcinoma, Muscle Invasive Ureter Urothelial Carcinoma, Muscle Invasive Urethral Urothelial Carcinoma
- Trial name
- NCT05987241
- Testing
- Biospecimen Collection, cfDNA or ctDNA Measurement, Computed Tomography
- Where
- 505 sites in United States, Canada
- Volunteers
- 992 people
- Sponsor
- National Cancer Institute (NCI)
Urogynaecological Problem, Pelvic Floor Dysfunction, Cancer
Treatments for Urogynaecological Problems and Patient Selfreports
The research aims to assess the relationship between treatments for a range of urogynaecological problems (pelvic floor dysfunction, cancers) and patient reported values, psychological states, and quality of life.
- Trial name
- NCT02549157
- Testing
- Pelvic Floor Muscle Training
- Where
- United Kingdom
- Volunteers
- 500 people
- Sponsor
- Swansea University
Bladder Carcinoma, Ureter Carcinoma
ORACLE: Observation of ResiduAl Cancer With Liquid Biopsy Evaluation
The purpose of ORACLE is to demonstrate the ability of a novel ctDNA assay developed by Guardant Health to detect recurrence in individuals treated for early-stage solid tumors.
- Conditions
- Bladder Carcinoma, Ureter Carcinoma, Renal Pelvis Carcinoma, Non-small Cell Lung Cancer
- Trial name
- ORACLE (NCT05059444)
- Testing
- Guardant Reveal
- Where
- 57 sites in United States, France and 3 more
- Volunteers
- 2,285 people
- Sponsor
- Guardant Health, Inc.
Prostate Cancer (Post Prostatectomy), Urinary Incontinence (UI)
The Effect of Mobile-Based Perioperative Education on Urinary Incontinence and Erectile Function After Radical Prostatectomy
This prospective randomized controlled study aims to evaluate the effect of mobile-based perioperative education on postoperative urinary incontinence and erectile function in patients undergoing radical prostatectomy.
- Conditions
- Prostate Cancer (Post Prostatectomy), Urinary Incontinence (UI), Erectile Dysfunction Following Radical Prostatectomy
- Trial name
- MPE-RP (NCT07520916)
- Testing
- Mobile-Based Perioperative Education Program, Standard Perioperative Care
- Where
- Turkey (Türkiye)
- Volunteers
- 78 people
- Sponsor
- Giresun University
Abdomen Cancer, Pancreas Adenocarcinoma (MSI-H)
Implementation of a Pain Management Plan in Major Open Abdominal Surgeries.
Introduction: Major abdominal surgery encompasses a broad range of surgical procedures in heterogeneous patient populations.Management of postoperative pain has received keen attention in recent years with considerable concurrent…
- Conditions
- Abdomen Cancer, Pancreas Adenocarcinoma (MSI-H), Colectomy Left/Right/Total Under Laparotomy, Hepatectomy
- Trial name
- NCT07901582
- Testing
- Epidural administered opioid
- Where
- Greece
- Volunteers
- 58 people
- Sponsor
- National and Kapodistrian University of Athens
Prostate Cancer
Phase III Clinical Trial to Evaluate INR101 Injection for PET/CT Imaging in Patients With Prostate Cancer.
A multicenter, open-label, prospective Phase III clinical trial to evaluate INR101 injection for PET/CT imaging in patients with Prostate Cancer
- Trial name
- NCT06922903
- Testing
- INR101
- Where
- 32 sites in China
- Volunteers
- 240 people
- Sponsor
- Yunhe Pharmaceutical (Tianjin) Co., Ltd
High-risk Prostate Cancer
Delayed Pelvic Imaging With [68]Ga-PSMA PET/CT in a Patient With High-risk Prostate Cancer.
Recent evidence suggests that both standard-time and delayed-time [⁶⁸Ga]Ga-PSMA PET acquisitions can reveal clinically relevant findings, and neither phase should be excluded a priori in routine practice.
- Trial name
- SPIR202302 (NCT07357259)
- Testing
- Intervention Group
- Where
- Italy
- Volunteers
- 244 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Surgical Neoplasms, Abdominal Surgical Diseases
Prospective Collection and Registry Study of Multicenter, Multidisciplinary Surgical Minimally Invasive Videos
This is a prospective multicenter patient registry study. We continuously collect full-length intraoperative surgical videos from thoracoscope, laparoscope, hysteroscope, transcervical resectoscope, cystoscope, prostate…
- Conditions
- Surgical Neoplasms, Abdominal Surgical Diseases, Pelvic Surgical Diseases, Urologic Surgical Diseases
- Trial name
- VISION (NCT07752862)
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Chinese Academy of Sciences
Bladder Urothelial Carcinoma, Muscle-invasive Bladder Cancer
Bladder-Sparing Treatment With Disitamab Vedotin and Toripalimab With or Without Pelvic Lymph Node Dissection in Bladder Cancer
This is a prospective, multicenter, randomized controlled superiority study designed to evaluate whether the addition of pelvic lymph node dissection improves bladder-intact event-free survival in patients with cT2-3N0M0 bladder…
- Conditions
- Bladder Urothelial Carcinoma, Muscle-invasive Bladder Cancer, Bladder Cancer
- Trial name
- NCT07756008
- Testing
- Disitamab Vedotin (RC48), Toripalimab, Transurethral Resection of Bladder Tumor
- Where
- China
- Volunteers
- 114 people
- Sponsor
- Tianjin Medical University Second Hospital
Metastatic Bladder Urothelial Carcinoma, Metastatic Renal Pelvis and Ureter Urothelial Carcinoma
Therapeutic Plasma Exchange With Enfortumab Vedotin and Pembrolizumab for Treatment of Bladder Cancers
This phase II trial compares therapeutic plasma exchange followed by enfortumab vedotin and pembrolizumab to standard of care next-line therapy for the treatment of patients with bladder or upper urinary tract cancers that have…
- Conditions
- Metastatic Bladder Urothelial Carcinoma, Metastatic Renal Pelvis and Ureter Urothelial Carcinoma, Refractory Bladder Urothelial Carcinoma, Refractory Renal Pelvis and Ureter Urothelial Carcinoma
- Trial name
- RECIPE-B1 (NCT07087860)
- Testing
- Best Practice, Biospecimen Collection, Central Venous Cannula Insertion
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Mayo Clinic
Prostate Cancer, Oligo-metastatic Prostate Carcinoma
MR-guided Single-fraction SBRT for Nodal Oligorecurrent Prostate Cancer (PINPOINT)
This single-arm phase 2 trial investigates whether a single high-dose radiotherapy treatment can safely treat men whose prostate cancer has come back in a small number of lymph nodes in the pelvis or abdomen after curative…
- Conditions
- Prostate Cancer, Oligo-metastatic Prostate Carcinoma, Oligometastatic Cancer, Nodal Oligorecurrent Prostate Cancer
- Trial name
- PINPOINT (NCT07635108)
- Testing
- Single-fraction SBRT
- Where
- Denmark
- Volunteers
- 48 people
- Sponsor
- Odense University Hospital
Urothelial Carcinoma of the Renal Pelvis and Ureter, Transitional Cell Cancer of the Renal Pelvis and Ureter
Multicenter Clinical Trial of ST-02 for Ablation of Upper Tract Urothelial Carcinoma
The goal of this prospective clinical trial is to investigate the safety and efficacy of ST-02 (mucoadhesive gemcitabine suspension for pyelocaliceal instillation) to treat Upper Tract Urothelial Carcinoma (UTUC) in participants…
- Trial name
- NCT06124976
- Testing
- ST-02
- Where
- 8 sites in Canada
- Volunteers
- 70 people
- Sponsor
- Peter Black
Cervical Cancer, Endometrial Cancer
Hypogastric Plexus Block and Ganglion Impar Block for Cervical and Endometrial Cancer Pain Management
This study compared the efficacy and safety of superior hypogastric plexus block and ganglion impar block procedures on the management of pelvic and perineal cancer pain in patients with cervical and endometrial cancer
- Trial name
- NCT05427058
- Testing
- Superior Hypogastric Plexus Block, Ganglion Impar Block
- Where
- Indonesia
- Volunteers
- 36 people
- Sponsor
- University of Brawijaya
Rectal Cancer, Fecal Incontinence and Constipation
Aerobic Exercise and Guided Imagery in Low Anterior Resection Syndrome
Low Anterior Resection Syndrome (LARS) is a common complication after sphincter-preserving rectal cancer surgery and may negatively affect bowel function and quality of life.
- Conditions
- Rectal Cancer, Fecal Incontinence and Constipation, Aerobic Exercise, Guided Imagery Exercise
- Trial name
- NCT07732894
- Testing
- Exercise, guided imagery
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Biruni University
Rectal Cancer, Advanced Cancer
Non Inferiority Study of Preoperative Chemotherapy Without Pelvic Irradiation for Rectal Cancer
This study is a non-inferiority phase III randomised trial comparing preoperative chemotherapy alone (modified FOLFIRINOX) to chemotherapy followed by chemoradiotherapy in patients with primary resectable locally advanced rectal…
- Trial name
- NORAD01 (NCT03875781)
- Testing
- Chemotherapy, Radiochemotherapy
- Where
- France
- Volunteers
- 540 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Prostate Cancer
A Trial of 5 Fraction Prostate SBRT Versus 5 Fraction Prostate and Pelvic Nodal SBRT
This study will compare the safety and efficacy of curative radiotherapy to the prostate and lymph glands given in 5 visits to that of prostate alone radiotherapy given in 5 visits, in men with high risk localised prostate cancer.
- Trial name
- PACE-NODES (NCT05613023)
- Testing
- SBRT
- Where
- 42 sites in Ireland, New Zealand and 1 more
- Volunteers
- 1,128 people
- Sponsor
- Institute of Cancer Research, United Kingdom
Rectal Neuroendocrine Neoplasm
Lateral Pelvic Lymph Node Dissection for Rectal Neuroendocrine Neoplasms Undergoing Laparoscopic Total Mesenteric Excision
The purpose of this study is to investigate the metastatic status of lateral pelvic lymph nodes in rectal neuroendocrine neoplasms (rNENs) undergoing laparoscopic total mesenteric excision (TME).
- Trial name
- NCT06279299
- Testing
- lateral pelvic lymph node dissection
- Where
- China
- Volunteers
- 30 people
- Sponsor
- National Cancer Center, China
Cervical Carcinoma
Systemic and Tumor Immune Response During Pelvic (Chemo)Radiation and/or Brachytherapy for Cervical Cancer
Radiotherapy result in tumor cell death by creating an immune potentiation effect, but can also lead to long lasting immune suppression.
- Trial name
- STIRR (NCT06804135)
- Where
- India
- Volunteers
- 110 people
- Sponsor
- Tata Memorial Hospital