Clinical trials: Pelvic Neoplasms
Cognitive/Functional Effects, Constipation, Impaction, and Bowel Obstruction
Probiotic Therapy in Preventing Gastrointestinal Complications in Patients Undergoing Chemotherapy and Pelvic Radiation Therapy
RATIONALE: Probiotic therapy may reduce or prevent gastrointestinal complications in patients undergoing chemotherapy and pelvic radiation therapy.
- Conditions
- Cognitive/Functional Effects, Constipation, Impaction, and Bowel Obstruction, Diarrhea, Fatigue
- Trial name
- NCT01473290
- Testing
- live freeze-dried lactic acid bacteria probiotic
- Sponsor
- Alliance for Clinical Trials in Oncology
Abdominal Cancer, Pelvic Cancer
Radiotherapy Treatments for Neoplasms in the Abdominal-pelvic Region
Evaluation of clinical and dosimetric aspects, tolerance, and effectiveness of abdominal-pelvic region radiotherapy treatments in patients undergoing radiotherapy for primary or secondary neoplasms localized in the…
- Trial name
- NCT06335238
- Where
- Italy
- Volunteers
- 7,700 people
- Sponsor
- European Institute of Oncology
Nonmalignant Neoplasm, Prostate Cancer
Pelvic Floor Muscle Training and Biofeedback or Standard Therapy in Men Who Have Undergone Radical Prostatectomy or Transurethral Resection of the Prostate
RATIONALE: Personalized training by a health professional may improve urinary incontinence. It is not yet known whether pelvic floor muscle training and biofeedback are more effective than standard therapy in improving urinary…
- Conditions
- Nonmalignant Neoplasm, Prostate Cancer, Psychosocial Effects of Cancer and Its Treatment, Sexual Dysfunction
- Trial name
- NCT00632138
- Testing
- exercise intervention, questionnaire administration, biofeedback
- Where
- 37 sites in United Kingdom
- Volunteers
- 800 people
- Sponsor
- Aberdeen Royal Infirmary
Bladder Urothelial Carcinoma, Muscle-invasive Bladder Cancer
Bladder-Sparing Treatment With Disitamab Vedotin and Toripalimab With or Without Pelvic Lymph Node Dissection in Bladder Cancer
This is a prospective, multicenter, randomized controlled superiority study designed to evaluate whether the addition of pelvic lymph node dissection improves bladder-intact event-free survival in patients with cT2-3N0M0 bladder…
- Conditions
- Bladder Urothelial Carcinoma, Muscle-invasive Bladder Cancer, Bladder Cancer
- Trial name
- NCT07756008
- Testing
- Disitamab Vedotin (RC48), Toripalimab, Transurethral Resection of Bladder Tumor
- Where
- China
- Volunteers
- 114 people
- Sponsor
- Tianjin Medical University Second Hospital
Dysmenorrhea Primary, Dysmenorrhea
Effect of 'Cramp Bites' on Period Cramps in Women Aged 18-25
85 percent of women of reproductive age experience consistent period cramps/menstrual pain, and 60% indicate that they do not use painkillers to relieve menstrual symptoms; there is a need for natural and non-medicative…
- Conditions
- Dysmenorrhea Primary, Dysmenorrhea, Menstrual Discomfort, Menstrual Problem
- Trial name
- NUTRITION; GYN (NCT06227676)
- Testing
- Cramp Bites by Aunt Flo's Kitchen
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Cornell University
Patients With Prostate Cancer
Prostate Cancer Patients With Biochemical Recurrence
Evaluation of detection rate of 18F-Fluciclovine compared to current standard of care imaging techniques within 30 days of the standard of care imaging study and a 6 month phone follow-up
- Trial name
- NCT03527199
- Testing
- Pelvic CT or MRI + MDP bone scan + or - 18F-NaF PET/CT(SOC)
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Medhat Osman
Breast Cancer, Lung Cancer
Blood Sample Collection to Evaluate Biomarkers in Subjects With Untreated Solid Tumors
The primary objective of this study is to obtain de-identified, clinically characterized, whole blood specimens to evaluate biomarkers associated with cancer for diagnostic assay development.
- Conditions
- Breast Cancer, Lung Cancer, Colorectal Cancer, Prostate Cancer
- Trial name
- NCT03662204
- Testing
- Blood Sample Collection
- Where
- 119 sites in United States
- Volunteers
- 5,133 people
- Sponsor
- Exact Sciences Corporation
Rectal Adenocarcinoma
Pelvic Radiotherapy With Concurrent Neoadjuvant FOLFOX for Patients With Newly Diagnosed Rectal Adenocarcinoma
The purpose of this study is to assess the effects, both good and bad, of adding very low dose fractionated radiation therapy (LDFRT) to the pelvis, with FOLFOX chemotherapy prior to surgery.
- Trial name
- GCC 1314 (NCT02319304)
- Testing
- FOLFOX {5-fluorouracil (5-FU), leucovorin, and oxaliplatin}, Low dose fractionated radiation therapy (LDFRT)
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Maryland, Baltimore
Prostate Adenocarcinoma
Staging Prostate Cancer With Hybrid C11-Choline PET/MR and mpMRI
The purpose of this study is to find out if a PET/MR scan in combination with standard MRI and CT scans can improve the early detection and treatment of patients with prostate cancer.
- Trial name
- NCT03404648
- Testing
- C-11 choline PET tracer, Gadobutrol, PET/MR scanner
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Mayo Clinic
Cervical Cancer, Postoperative Bladder Dysfunction
Transcutaneous Electrical Nerve Stimulation in Nerve-Sparing Radical Hysterectomy: Effects on Bladder Management and Quality of Life in Cervical Cancer
To evaluate the effects of transcutaneous electrical nerve stimulation (TENS) on bladder management, pelvic floor muscle strength, and quality of life (QoL) in patients undergoing nerve-sparing radical hysterectomy (NSRH) for…
- Conditions
- Cervical Cancer, Postoperative Bladder Dysfunction, Urinary Retention, Pelvic Floor Muscle Weakness
- Trial name
- NCT07070687
- Testing
- Transcutaneous Electrical Nerve Stimulation (TENS)
- Where
- China
- Volunteers
- 78 people
- Sponsor
- Fudan University
Cervical Cancer
A Phase II Study of Extended Field IMRT External Beam Irradiation and Intracavitary Brachytherapy
Recent studies have shown that the chance of survival among women with advanced cervical cancer is increased when they receive concurrent chemotherapy and radiation to the pelvis.
- Trial name
- NCT00590967
- Testing
- IMRT extended field external beam radiation therapy, Brachytherapy, Cisplatin
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- Washington University School of Medicine
Cervical Adenocarcinoma, Cervical Adenosquamous Carcinoma
Testing the Addition of Paclitaxel and Carboplatin Given After Standard Chemotherapy and Radiation for Cervical Cancer in HIV-positive Women
This phase II trial studies how well standard chemotherapy and radiation therapy given with or without paclitaxel and carboplatin work in treating human immunodeficiency virus (HIV)-positive women with cervical cancer that has…
- Conditions
- Cervical Adenocarcinoma, Cervical Adenosquamous Carcinoma, Cervical Squamous Cell Carcinoma, Not Otherwise Specified, FIGO Stage IIB Cervix Carcinoma
- Trial name
- NCT03834571
- Testing
- Carboplatin, Cisplatin, Paclitaxel
- Where
- 3 sites in South Africa, Zimbabwe
- Sponsor
- AIDS Malignancy Consortium
Bladder Cancer, Prostate Cancer
Medtronic Hugo™ Robotic Assisted Surgery (RAS) System in Urologic Surgery (Expand URO)
This study will evaluate the safety and performance of the Medtronic Hugo™ RAS System when used for urologic RAS procedures.
- Conditions
- Bladder Cancer, Prostate Cancer, Kidney Cancer, Pelvic Tumor
- Trial name
- NCT05696444
- Testing
- RAS Prostatectomy, RAS Cystectomy, RAS Nephrectomy
- Where
- 6 sites in United States
- Volunteers
- 144 people
- Sponsor
- Medtronic - MITG
Renal Pelvic Carcinoma, Tislelizumab
Nephron-sparing Treatment of Tislelizumab + Nab-Paclitaxel for Renal Pelvic Cancer
This study is designed as an open-label, single-arm, single-center, phase II clinical trial, aiming to evaluate the efficacy of nephron-sparing treatment combining Tislelizumab and Nab-Paclitaxel for HER-2 expressing renal pelvic…
- Conditions
- Renal Pelvic Carcinoma, Tislelizumab, PD-1 Inhibitor, Kidney-sparing
- Trial name
- NCT07233252
- Testing
- Nab-paclitaxel, Tislelizumab, endoscopic intervention
- Where
- China
- Volunteers
- 35 people
- Sponsor
- Tianjin Medical University Second Hospital
Crohn Disease, Polyposis
Clinical Database of Colorectal Robotic Surgery
Evaluation of robot Da Vinci Xi by determining its learning curve.The operating time will be defined by patient then the operating average will be calculated.
- Conditions
- Crohn Disease, Polyposis, Ulcerative Colitis, Diverticulitis
- Trial name
- ROBOT CR (NCT04013152)
- Testing
- Clinical database
- Where
- 4 sites in France
- Volunteers
- 1,800 people
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
Rectal Cancer, Ileostomy; Functional Disturbance
Trial Evaluating the Tailored Versus the Systematic Use of Defunctioning Stoma After Total Mesorectal Excision for Rectal Cancer (GRECCAR17)
GRECCAR 17 will be the first prospective and randomized trial to assess a tailored policy in the use of defunctioning stoma after TME according to the personalized risk of anastomotic leakage.
- Trial name
- GRECCAR17 (NCT05233787)
- Testing
- Tailored use of defunctioning stoma after TME, Systematic use of defunctioning stoma
- Where
- 28 sites in France
- Volunteers
- 212 people
- Sponsor
- University Hospital, Bordeaux
Uterine Fibroids, Endometriosis
AMH Levels Change During Treatment With GnRh Agonist
To evaluate the variation of AMH levels in women undergoing treatment with GnRHa, and to assess whether this variation correlates with changes in the antral and pre-antral follicle ultrasonographic count (AFC).
- Conditions
- Uterine Fibroids, Endometriosis, Endometriosis of Uterus, Pelvic Pain
- Trial name
- NCT02086279
- Testing
- GnRH analogue
- Where
- Italy
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- University Magna Graecia
Cancer, Childhood Cancer
Bladder and Bone Effects of Pelvic Radiation Therapy in Childhood Cancer Survivors
The aim of this study is to measure and evaluate the effects of pelvic external beam radiation therapy (EBRT) on lower urinary tract (LUT) function and bone mineralization.
- Trial name
- NCT05818462
- Testing
- Uroflow testing, Bladder Scan, Dysfunctional Voiding Scoring System Survey
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of Colorado, Denver
Rectal Cancer, Treatment
Safety and Efficacy Study of Cylindrical Abdominoperineal Resection to Treat Rectal Cancer
The purpose of this study is to determine whether cylindrical abdominoperineal resection is effective in the treatment of advanced very low rectal cancer
- Conditions
- Rectal Cancer, Treatment, Postoperative Complications, Neoplasm Recurrence, Local
- Trial name
- NCT00949273
- Testing
- cylindrical abdominoperineal resection
- Where
- 7 sites in China
- Volunteers
- 300 people
- Sponsor
- Beijing Chao Yang Hospital
Locally Advanced Bladder Urothelial Carcinoma, Locally Advanced Renal Pelvis Urothelial Carcinoma
ARID1A and/or KDM6A Mutation and CXCL13 Expression
This phase II trial studies the effect of nivolumab in urothelial cancer that has spread to other places in the body (metastatic), specifically in patients with aberrations in ARID1A gene (ARID1A mutation) and correlate with…
- Conditions
- Locally Advanced Bladder Urothelial Carcinoma, Locally Advanced Renal Pelvis Urothelial Carcinoma, Locally Advanced Ureter Urothelial Carcinoma, Locally Advanced Urethral Urothelial Carcinoma
- Trial name
- NCT04953104
- Testing
- Diagnostic Laboratory Biomarker Analysis, Nivolumab, Relatlimab
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- M.D. Anderson Cancer Center