Clinical trials: Pelvic Prolapse
Pelvic Organ Prolapse
Comparison of Suturing Technique Types on Pubocervical Fascia at Colpographhy Anterior for Cystocele Repair
Anterior colporrhaphy is the commonly performed surgery for pelvic organ prolapse. However the success rates of native tissue repair techniques for anterior vaginal prolapse range from %30-%70.
- Trial name
- NCT05444023
- Testing
- Pubocervical fascia reconstruction
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Pelvic Organ Prolapse
Self-management Pessary Project
The goal of this multicenter observational study is to study self-management of pessary therapy in patients with pelvic organ prolapse.
- Trial name
- ZPP (NCT05885711)
- Testing
- self-management
- Where
- Netherlands
- Volunteers
- 288 people
- Sponsor
- Zuyderland Medisch Centrum
Uterine Fibroids, Adenomyosis
Ovarian Reserve Modification After Lps Hysterectomy With Bilateral Salpingectomy
The aim of this RCT of study is to compare the standard TLH with adnexal preservation with TLH plus prophylactic bilateral salpingectomy (PBS) in terms of ovarian reserve and surgical outcomes
- Conditions
- Uterine Fibroids, Adenomyosis, Pelvic Pain, Pelvic Prolapse
- Trial name
- NCT02086344
- Testing
- PBS, TLH _adnexal preservation
- Where
- Italy
- Volunteers
- 167 people, healthy volunteers welcome
- Sponsor
- University Magna Graecia
Postoperative Constipation, Pelvic Organ Prolapse Vaginal Surgery
Impact of Defecation Posture on Ease of First Bowel Movement Following Posterior Repair
This study will determine if defecation posture, when using a defecation posture modification device (DPMD), improves ease with first bowel movement following pelvic reconstructive surgery, specifically posterior repair.
- Conditions
- Postoperative Constipation, Pelvic Organ Prolapse Vaginal Surgery, Defecation Function
- Trial name
- NCT06253689
- Testing
- Defecation Posture Modification Device
- Where
- 3 sites in United States
- Volunteers
- 160 people
- Sponsor
- TriHealth Inc.
Uterine Prolapse, Pelvic Organ Prolapse Vaginal Surgery
The Finnish Uterine Prolapse Surgery Trial (The Fin-UP Trial)
The goal of this clinical trial is to compare the Manchester procedure and vaginal hysterectomy in treating patients with symptomatic uterine prolapse.
- Conditions
- Uterine Prolapse, Pelvic Organ Prolapse Vaginal Surgery, Pelvic Organ Prolapse (POP)
- Trial name
- Fin-UP (NCT07566949)
- Testing
- Manchester procedure, Vaginal hysterectomy
- Where
- 6 sites in Finland
- Volunteers
- 426 people
- Sponsor
- Tampere University Hospital
Pelvic Organ Prolapse
Sacrospinous Ligament Fixation With Conventional Surgical Instruments in Chinese Apical Prolapse Female Patients
SSLF is typically a suture-based attachment of the vaginal apex to the sacrospinous ligament, either unilaterally or bilaterally.
- Trial name
- SSLF-CSI (NCT03782285)
- Testing
- sacrospinous Ligament Fixation
- Where
- 9 sites in China
- Volunteers
- 100 people
- Sponsor
- Peking Union Medical College Hospital
Pelvic Organ Prolapse
Systemic Markers of Collagen Metabolism and Vitamin C in Smokers and Non-Smokers With Pelvic Organ Prolapse
Data on smoking and POP are conflicting. In a study done by Alnaif et al, smoking was found to be associated with severe POP. The authors' proposed explanation was that smoking impairs tissue and wound healing.
- Trial name
- NCT01548105
- Testing
- Blood draw for the study participants
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- TriHealth Inc.
Urinary Incontinence, Pelvic Organ Prolapse
Effect of Standardized Consent for Urogynecological Procedures on Patient Satisfaction
The investigators aim is to augment the current process for surgical consent for patients undergoing urogynecological procedures by incorporating visual media.
- Trial name
- NCT02313701
- Testing
- Standardized visual presentation
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Pelvic Organ Prolapse, Prolapse, Urogenital
Race, Ethnicity, Socioeconomic Status and Prolapse-rElated Decisional ConflicT
This study is trying to see if people from different backgrounds have different feelings when making treatment decisions about prolapse.
- Trial name
- RESPECT (NCT04977141)
- Testing
- Decisional Conflict Scale
- Where
- United States
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Women and Infants Hospital of Rhode Island
Rectal Prolapse
Swedish Rectal Prolapse Trial
Rectal prolapse is a medical condition where rectum is protruding through the anal opening. The treatment is by surgery that can be performed with an anterior approach through the abdomen or a posterior perineal approach.
- Trial name
- NCT04893642
- Testing
- Suture rectopexy, resection rectopexy, Delorme's operation
- Where
- 12 sites in Sweden
- Volunteers
- 134 people
- Sponsor
- Danderyd Hospital
Pelvic Organ Prolapse
The Efficacy of Transcutaneous Electrical Nerve Stimulation on LUTS: One Prospective Study.
The study is a prospective study at a single institution. Investigators create strict inclusion and exclusion criteria, selecting 126 patients who undergo the pelvic reconstructive surgery.
- Trial name
- NCT03634722
- Testing
- PHENIX4-8-8 PLUS
- Where
- China
- Volunteers
- 126 people
- Sponsor
- Peking University People's Hospital
Pelvic Organ Prolapse
ACell MatriStem Pelvic Floor Matrix Versus Native Tissue Repair, Comparative Study
The primary objective of this study is to assess the safety and effectiveness of MatriStem Pelvic Floor Matrix as compared to native tissue repair for the treatment of pelvic organ prolapse.
- Trial name
- NCT02021279
- Testing
- MatriStem Pelvic Floor Matrix, native tissue repair
- Where
- 13 sites in United States
- Volunteers
- 161 people
- Sponsor
- Integra LifeSciences Corporation
Pelvic Organ Prolapse
VESPER: Pelvic Organ Prolapse Study
Patients seen with Stage 1-2 pelvic organ prolapse (POP) who have failed conservative treatments will be offered to participate in a sham controlled RCT of outpatient therapy with the Fotona Smooth Erbium Yag Laser.
- Trial name
- VESPER:POP (NCT03995797)
- Testing
- Laser therapy
- Sponsor
- Hampshire Hospitals NHS Foundation Trust
Vaginal Prolapse
Comparison of Two Vaginal Mesh Kits in the Management of Vaginal Prolapse
Our study is a non-randomized prospective study compared two groups matched for anterior/apical POP-Q grade: 84 received Elevate Ant™ single-incision mesh (group A) and 42 Perigee™ transvaginal mesh (group B).
- Trial name
- ELEPE (NCT03187574)
- Testing
- Elevate Ant™, Perigee™
- Volunteers
- 126 people
- Sponsor
- Hospices Civils de Lyon
Pelvic Organ Prolapse
Safety and Efficacy of Different Procedures of Colpocleisis: a Randomized Controlled Trial
Background: Pelvic organ prolapse (POP) is one of the most common benign gynecological diseases among middle-aged and elderly women, which severely affects the quality of life of patients.
- Trial name
- NCT06482697
- Testing
- total colpocleisis, partial colpocleisis (LeFort)
- Volunteers
- 330 people
- Sponsor
- Lan Zhu
All Patients Who Have Undergone a Pessary Fitting
Characteristics Predictive of Pessary Success
Pessaries are mechanical support devices worn vaginally to treat the symptoms of pelvic organ prolapse, such as vaginal pressure or a vaginal bulge.
- Trial name
- NCT01123213
- Where
- United States
- Volunteers
- 158 people
- Sponsor
- University of California, Irvine
Pelvic Organ Prolapse, Patient Education
PREgnancy-associated Pelvic Floor Health Knowledge And REDuction of Symptoms: The PREPARED Trial
The pelvic floor is composed of muscles and connective tissue which acts to provide support for pelvic organs, and weakness or injury to the pelvic floor can result in pelvic floor dysfunction.
- Trial name
- PREPARED (NCT02947282)
- Testing
- Educational Workshop
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- University of British Columbia
Pelvic Organ Prolapse
A Feasibility Study on the Value of Pelvic Floor Training After Pelvic Organ Prolapse Surgery
The main objective is to assess the feasibility of a randomized controlled trial that investigates the effects of pelvic floor training on recurrence in pelvic organ prolapse surgeries.
- Trial name
- NCT04539782
- Testing
- Physiotherapy intervention
- Where
- Iceland
- Volunteers
- 50 people
- Sponsor
- Landspitali University Hospital
Cystocele, Uterine Prolapse
Anterior Pelvic Prolapse Reconstruction With TiLOOP® Total 6
The purpose of this study is to determine the influence of Anterior Pelvic Prolapse Reconstruction with a titanised polypropylene mesh on rate of erosion and patients quality of live.
- Trial name
- NCT01084889
- Testing
- surgical mesh implantation (TiLOOP® Total 6)
- Where
- 9 sites in Germany
- Volunteers
- 292 people
- Sponsor
- pfm medical gmbh
Pelvic Organ Prolapse
Single Versus Multi-port Robotic Assisted Sacrocolpopexy for Repair of Vaginal Apex Prolapse
A prospective randomized controlled study intended to compare the efficacy of 2 methods of robotic assisted sacrocolpopexy for the repair of vaginal apex prolapse: 1. Via single-port. 2. Via multi-port.
- Trial name
- NCT03034499
- Testing
- Single-port sacrocolpopexy, Multi-port sacrocolpopexy
- Where
- Israel
- Volunteers
- 80 people
- Sponsor
- Rambam Health Care Campus