Clinical trials: Pelvic Prolapse
Prolapse; Female, Prolapse, Vaginal
What Affects Willingness to Self-manage a Pessary?
Pessary self-management is defined as the patient's ability to remove and reinsert their pessary themselves at home. Previous research has suggested that some women may prefer being able to remove and reinsert their pessary as…
- Trial name
- NCT05750615
- Testing
- Uncertain what intervention will be co-created
- Where
- United Kingdom
- Volunteers
- 132 people
- Sponsor
- Manchester University NHS Foundation Trust
Pelvic Organ Prolapse, Uterine Prolapse
Efficacy Study of Vaginal Mesh for Prolapse
The primary aim of this double-blind, randomized clinical trial (RCT) is to test the hypothesis that the addition of a standardized technique of interpositional synthetic polypropylene mesh placement improves the one-year outcome…
- Conditions
- Pelvic Organ Prolapse, Uterine Prolapse, Vaginal Prolapse, Cystocele
- Trial name
- VAMP (NCT00475540)
- Testing
- synthetic monofilament polypropylene mesh
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Medstar Health Research Institute
Pelvic Organ Prolapse
Platelet Rich Plasma as an Adjunct Therapy at the Time of Transvaginal Native Tissue Prolapse Surgery
The purpose of the study is to evaluate the surgical outcomes of injecting platelet-rich plasma (PRP) into the vaginal tissue as an adjunct therapy at the time of prolapse surgery
- Trial name
- PRP (NCT05731284)
- Testing
- Platelet rich plasma (PRP) Injection
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Alabama at Birmingham
Pelvic Organ Prolapse
Comparison of Anatomic Results Between Bilateral and Conventional Abdominal Sacral Hysteropexy
Investigators separated 20 patients with uterovaginal prolapse into 2 groups according to random numbers table. In one group, conventional abdominal sacral hysteropexy will be perform and another group bilateral abdominal sacral…
- Trial name
- NCT02667002
- Testing
- Bilateral Abdominal Sacral Hysteropexy, Conventional abdominal Sacral Hysteropexy, Nulliparous women with no uterovaginal prolapsed
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Zeynep Kamil Maternity and Pediatric Research and Training Hospital
Cystocele, Cystitis
Postoperative Catheterization After Anterior Colporrhaphy
Randomised controled multicenter trial about the appropriate length of postoperative catheterization after anterior colporrhaphy.
- Trial name
- NCT00622076
- Testing
- postoperative catheterization
- Where
- 2 sites in Netherlands
- Volunteers
- 230 people
- Sponsor
- Atrium Medical Center
Colorectal Carcinoma, Rectal Prolapse
Prospective Evaluation of Cornerstone Robotics Sentire Surgical System in Major Gastrointestinal and Urologic Surgery
Robotic assisted surgery has been performed for more than two decades with good success and safety profile. However, there was only one dominating robotic surgical system available in the past which led to high cost for robotic…
- Conditions
- Colorectal Carcinoma, Rectal Prolapse, Prostate Cancer (Adenocarcinoma), Bladder Cancer
- Trial name
- NCT06926374
- Testing
- Robotic surgery using the Sentire Surgical System
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Chinese University of Hong Kong
Pelvic Organ Prolapse
Surgical Correction of Pelvic Organ Prolapse
Objective: This prospective randomized trial evaluated outcomes of colposacropexy performed either by open or by conventional laparoscopic approach as therapy for uterovaginal prolapse.
- Trial name
- NCT01182090
- Testing
- Colposacropexy
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University Of Perugia
Stress Urinary Incontinence, Urethral Hypermobility
Comparing Voiding Trials After Midurethral Sling for Stress Incontinence
Urinary incontinence is a prevalent health and quality of life concern affecting almost half of women over the age of 20. Urinary retention (abnormal holding of urine) is a concern of many surgeons who perform midurethral sling…
- Conditions
- Stress Urinary Incontinence, Urethral Hypermobility, Cystocele
- Trial name
- NCT02400034
- Testing
- Voiding trial
- Where
- United States
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Pelvic Organ Prolapse, Prolapse
Pre-operative Bowel Preparation Prior to Minimally Invasive Sacral Colpopexy
Prior to surgery, gynecologists and urogynecologists have routinely prescribed preoperative mechanical bowel preparations in attempts to decrease the risk of infection, while also providing easier bowel manipulation and better…
- Trial name
- NCT01805310
- Testing
- Bowel preparation, No bowel preparation
- Where
- United States
- Volunteers
- 95 people
- Sponsor
- Halina M Zyczynski, MD
Pelvic Organ Prolapse
Effects of the Addition of Uterosacral Ligament Plication to Pectopexy Operation on Anatomical and Subjective Symptoms
The investigators planned to measure the effectiveness of laparoscopic pectopexy in apical prolapse and whether the addition of sacrouterine ligaments plication to pectopexy increases the effectiveness of pectopexy operation.
- Trial name
- NCT04508062
- Testing
- pectopexy operation, uterosacral ligaments plication operation.
- Where
- Turkey (Türkiye)
- Volunteers
- 38 people
- Sponsor
- Ataturk University
Vaginal Prolapse
Pudendal Block Using Liposomal Bupivacaine vs. Standard Treatment During Sacrospinous Ligament Fixation
A pudendal nerve block is a procedure where a local anesthetic is injected where the pudendal nerve is located. This allows quick pain relief to the perineum, vulva, and vagina.
- Trial name
- NCT03664986
- Testing
- Liposomal Bupivacaine
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- Atlantic Health System
Pelvic Organ Prolapse
Comparison of 2 Lightweight Y-meshes After Laparoscopic Sacrocolpopexy
The purpose of the study is to determine the clinical cure rates of pelvic organ prolapse from subjects that had a robotic-assisted sacrocolpopexy using Alyte Y mesh and Restorelle Y smartmesh lightweight mesh.
- Trial name
- NCT02248935
- Where
- United States
- Volunteers
- 316 people
- Sponsor
- Atlantic Health System
Pelvic Organ Prolapse
Pelvic Floor Repair Systems for Prolapse Repair
1. This is a prospective, multi-center, post market study, which will be conducted under a common protocol. 2. The primary objective of the study is to evaluate long-term efficacy of the AMS Pelvic Floor Repair System devices for…
- Trial name
- PROPEL (NCT00638235)
- Testing
- AMS Apogee™ with IntePro, AMS Apogee™ with Intexen LP, AMS Perigee™ with IntePro
- Where
- 28 sites in United States, Belgium and 5 more
- Volunteers
- 725 people
- Sponsor
- ASTORA Women's Health
Pelvic Organ Prolapse
Vaginal Tactile Imaging for Pelvic Floor Prolapse
The investigators will analyze biomechanical transformation of pelvic floor tissues and support structures under affected pelvic floor conditions and repaired states after the surgery.
- Trial name
- NCT02925585
- Testing
- Pre/post imaging
- Where
- 5 sites in United States
- Volunteers
- 119 people
- Sponsor
- Artann Laboratories
Anterior Vaginal Wall Prolapse, Pelvic Organ Prolapse
Transobturator Lateral Suspension in Anterior Colporrhaphy
Anterior colporrhaphy (AC) is commonly used for anterior vaginal wall prolapse, but suffers high recurrence rates. This randomized trial assessed whether adding transobturator lateral suspension (TOLS) to AC decreases objective…
- Trial name
- TLSAC (NCT07144397)
- Testing
- TOLS
- Where
- Slovenia
- Volunteers
- 44 people
- Sponsor
- University Medical Centre Maribor
Pelvic Organ Prolapse, Urogenital Prolapse
Investigation to Minimize Prolapse Recurrence of the Vagina Using Estrogen
This study randomizes postmenopausal women with symptomatic pelvic organ prolapse planning native tissue transvaginal surgical repair to 6-8 weeks of preoperative and 1-year continued postoperative vaginal estrogen cream compared…
- Conditions
- Pelvic Organ Prolapse, Urogenital Prolapse, Vaginal Vault Prolapse, Cystocele
- Trial name
- IMPROVE (NCT02431897)
- Testing
- Conjugated Estrogens Cream
- Where
- 3 sites in United States
- Volunteers
- 206 people
- Sponsor
- University of Texas Southwestern Medical Center
Uterine Fibroid, Uterine Bleeding
4K Versus 3D Laparoscopic Colporraphy by Surgeons in Training: a Prospective Randomized Trial
This prospective randomized trial aims to assess if the operative time of vaginal cuff suture performed by trainees could be reduced using 3D laparoscopy instead of 4K laparoscopy.
- Conditions
- Uterine Fibroid, Uterine Bleeding, Uterine Prolapse
- Trial name
- NCT04637022
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Catholic University of the Sacred Heart
Pelvic Organ Prolapse, Symptoms
Evaluation of Functional Outcomes After Laparoscopic Promontofixation (PFL).
Prolapse of the pelvic organs is a common pathology in women with a strong impact on the quality of life. Its prevalence tends to increase due to increased life expectancy and obesity.
- Conditions
- Pelvic Organ Prolapse, Symptoms, Satisfaction, Quality of Life
- Trial name
- PeSuLife (NCT03919123)
- Testing
- Evaluation of laparoscopic promontofixation
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Caen
Thymoma, Mediastinal Tumor
Clinical Investigation of the da Vinci Surgical System
This prospective, multicenter, single-arm study is being conducted to confirm safety, effectiveness, and usability of da Vinci Surgical System in performing robotic-assisted surgical procedures.
- Conditions
- Thymoma, Mediastinal Tumor, Gynecologic Disease, Gynecologic Cancer
- Trial name
- NCT05682742
- Testing
- Robotic-assisted Surgery
- Where
- 4 sites in United States
- Volunteers
- 53 people
- Sponsor
- Intuitive Surgical
Vaginal Prolapse
Comparison Between Transvaginal Mesh and Traditional Surgery for Pelvic Organ Prolapse
Pelvic organ prolapse is characterized by a lack of pelvic floor support causing the pelvic organs and vaginal walls to protrude.
- Trial name
- NCT00566917
- Testing
- Anterior colporrhaphy, Anterior PROLIFT
- Where
- 53 sites in Denmark, Finland and 2 more
- Volunteers
- 400 people
- Sponsor
- Karolinska Institutet