Clinical trials: Pelvic Prolapse
Pelvic Organ Prolapse
Effect of Local Anesthesia on Postoperative Pain Following Sacrospinous Ligament Fixation
During surgery for pelvic organ prolapse, it is common for the surgeon to inject fluid into the vaginal tissues to help with tissue dissection.
- Trial name
- NCT02890199
- Testing
- Bupivacaine liposomal, Lidocaine
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Hartford Hospital
Pelvic Organ Prolapse (POP), Synthetic Mesh
Safety and Performance of a Pelvic Floor Mesh Implant for Laparoscopic Sacrocolpopexy (ProGYNious)
The purpose of this clinical investigation is to collect clinical data about the ProGYNious Mesh based on a prospective clinical investigation.
- Conditions
- Pelvic Organ Prolapse (POP), Synthetic Mesh, Laparoscopic Surgery, Gynecologic Laparoscopic Surgery
- Trial name
- ProGYNious (NCT07497321)
- Testing
- Surgical mesh for pelvic organ prolapse repair (ProGYNious)
- Where
- 4 sites in Austria, Germany
- Volunteers
- 100 people
- Sponsor
- A.M.I. Agency for Medical Innovations GmbH
Pelvic Organ Prolapse, Gynecologic Disorders
Comparison of Learning Curves for Two Different Techniques in Vaginal Hysterectomy
Randomized prospective monocentric interventional study to compare learning curves for traditional vaginal hysterectomy and vaginal hysterectomy performed by bipolar coagulation comparing short-term outcomes for both procedures.
- Conditions
- Pelvic Organ Prolapse, Gynecologic Disorders, Surgery
- Trial name
- NCT06220253
- Testing
- vaginal hysterectomy by bipolar vessels sealing, vaginal hysterectomy by traditional technique
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Pelvic Organ Prolapse
Laparoscopic Sacropexy and Vaginal Natural Orifice Transluminal Endoscopic Surgery Shull Suspension Comparison Trial
This is a prospective, randomized multicenter study whose objective is to compare two surgical techniques routinely used at our center for the correction of pelvic organ prolapse (laparoscopic cervicosacropexis versus…
- Trial name
- V-PULSE (NCT05856201)
- Testing
- Laparoscopic cervicosacropexy, Shull technique via V-NOTES
- Volunteers
- 90 people
- Sponsor
- Azienda Ospedaliero, Universitaria Pisana
Pelvic Organ Prolapse
Radiofrequency and Pelvic Organ Prolapse
Aim To compare the effectiveness of the application of non-ablative radiofrequency (RF) applied in combination with the usual treatment for the treatment of pelvic organ prolapse (POP) versus the usual treatment in lowering its…
- Trial name
- NCT04855071
- Testing
- Non-ablative radiofrequency application, Usual intervention
- Volunteers
- 40 people
- Sponsor
- Fundació d'investigació Sanitària de les Illes Balears
Pelvic Organ Prolapse
Treatment of Urinary Stress Incontinence During or Following Correction of Pelvic Organ Prolapse
The incidence of pelvic organ prolapse (POP) in parous women is estimated over 50%. A variety of urinary, bowel and sexual symptoms may be associated with POP.
- Trial name
- NCT00697489
- Testing
- correction of POP plus preventive continence procedure, POP surgery followed by eventual incontinence procedure
- Where
- Italy
- Sponsor
- University Magna Graecia
Pelvic Organ Prolapse, Vaginal Prolapse
The Impact of Long-term Pessary Use on Pelvic Organ Prolapse oìduring Covid-19 Pandemic in Patients Attending Surgery
Patients aged 45 to 80 years with a clinical diagnosis of stage III and IV genital prolapse involving the anterior and/or middle compartments and candidates for surgery will be considered.
- Trial name
- NCT06234449
- Testing
- Vaginal pessary before surgery for pelvic organ prolapse
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- IRCCS San Raffaele
Pelvic Organ Prolapse
Uphold Versus Robotic Surgery for Pelvic Prolapse Repair: A Decision Analytic Approach
Within the general objective of investigating optimal medical techniques for pelvic prolapse repair, this study proposes to: (1) test the hypothesis that the UPHOLD procedure is more cost effective than robotic surgery for pelvic…
- Trial name
- NCT01611285
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Atlantic Health System
Pelvic Floor Disorders, Stress Urinary Incontinence
Educating Women About Pelvic Floor Disorders During Pregnancy
The purpose of this study is to assess the increase in knowledge of pregnant patients regarding pelvic floor disorders when comparing two educational interventions: written handouts vs interactive workshops.
- Conditions
- Pelvic Floor Disorders, Stress Urinary Incontinence, Pelvic Organ Prolapse
- Trial name
- NCT05440539
- Testing
- Written Handouts, Interactive Workshop
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- The Methodist Hospital Research Institute
Pelvic Organ Prolapse
A Study of the Effects of Physiotherapy to Prevent Pelvic Organ Prolapse
Pelvic organ prolapse is a problem experienced by women where a bulge comes down in the vagina, and may even drop down outside the vagina.
- Trial name
- PREVPROL (NCT01171846)
- Testing
- Pelvic Floor Muscle training
- Where
- 3 sites in New Zealand, United Kingdom
- Volunteers
- 337 people
- Sponsor
- Glasgow Caledonian University
Pelvic Organ Prolapse
ProViS (Prolift+M and Vita Sexualis) Study
Transvaginal meshes (TVM) are indicated for the treatment of pelvic organ prolapse (POP) where surgical intervention is necessary.
- Trial name
- ProViS (NCT01997996)
- Where
- 4 sites in Germany, Switzerland
- Volunteers
- 18 people
- Sponsor
- Dr. med. Tanja Hülder
Stress Urinary Incontinence, Pelvic Organ Prolapse
Evaluating the Necessity of TOT Implantation in Women With Pelvic Organ Prolapse and Occult Stress Urinary Incontinence
Nowadays the clinical significance of an occult stress urinary incontinence and its optimal treatment is not known.Regarding treatment, there are 2 main approaches : either the systematic preventive treatment of the occult stress…
- Trial name
- ATHENA (NCT01095692)
- Testing
- Pelvic Organ Prolapse and Suburethral TOT implantation, Pelvic Organ Prolapse intervention
- Where
- France
- Volunteers
- 21 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pelvic Organ Prolapse
Clinical Investigation to Evaluate Safety and Performance of the EndoFast Reliant™ System in Vaginal Wall Reinforcement
The purpose of this study is to clinically assess the safety and performance of the EndoFast Reliant™ system as a less invasive treatment for Pelvic Organ Prolapse.
- Trial name
- NCT00446693
- Testing
- EndoFast Reliant™ system for Pelvic Organ Prolapse repair
- Where
- 3 sites in France, Israel
- Volunteers
- 20 people
- Sponsor
- Endogun Medical Systems Ltd.
Uterine Prolapse, Stage III
GYNECARE PROSIMA* Procedure Versus Modified Total Pelvic Floor Reconstructive Surgery for Uterine Prolapse Stage III
Pelvic Organ prolapse (a feeling of bulge in the vagina) may cause some distressing symptoms such as loss of control of the bowel or bladder, and may also cause problems with patient's sex life.
- Trial name
- NCT01396109
- Testing
- Procedure: TVH and GYNECARE PROSIMA* Pelvic Floor Repair System, Procedure: TVH and Modified Pelvic Floor Reconstruction Surgery with mesh
- Where
- 10 sites in China
- Volunteers
- 200 people
- Sponsor
- Peking Union Medical College Hospital
Sigmoid Diverticulosis, Sigmoid Diverticulitis
Feasibility, Safety and Outcome of Transrectal Hybrid-NOTES Anterior Resection
Natural orifice transluminal endoscopic surgery has become an important topic. NOTES access routes give the opportunity to reduce surgical access trauma leading to a more painless surgery and enhancing a fast postoperative…
- Conditions
- Sigmoid Diverticulosis, Sigmoid Diverticulitis, Colon Adenoma, Rectal Prolapse
- Trial name
- NCT01992406
- Where
- Switzerland
- Volunteers
- 60 people
- Sponsor
- Cantonal Hospital, Baselland
Urinary Retention Postoperative, Pelvic Organ Prolapse
Catheter Management After Pelvic Reconstructive Surgery
This is a randomized controlled trial comparing plug-unplug catheter management, continuous drainage catheter systems and patients that do not get discharged with catheters after inpatient pelvic reconstructive surgery.
- Trial name
- NCT03071211
- Testing
- Plug-unplug catheter management, Continuous drainage catheter management
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Hartford Hospital
Pelvic Organ Prolapse
AMBULAPSE STUDY Feasibility Study on Laparoscopic Double-mesh Sacrocolpopexy With or Without Robotic Assistance, in Female Patients Presenting With Symptomatic Pelvic Organ Prolapse, Based on an Outpatient Treatment Model.
Pelvic organ prolapse is an increasingly common functional disorder which affects approximately 30 to 40% of the female population, 12% of whom have a symptomatic form, with a psychological, physical and social impact.
- Trial name
- AMBULAPSE (NCT03764852)
- Testing
- outpatient laparoscopic
- Where
- 5 sites in France
- Volunteers
- 55 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Urinary Bladder, Overactive, Pelvic Organ Prolapse
BOTOX® at the Time of Prolapse Surgery for OAB
The purpose of the study will be to assess the efficacy and safety of bladder BOTOX® for overactive bladder symptoms, such as urinary urgency and frequency, given at the time of prolapse surgery.
- Trial name
- NCT04807920
- Testing
- OnabotulinumtoxinA 100 UNT, Injectable saline
- Where
- United States
- Volunteers
- 138 people
- Sponsor
- Walter Reed National Military Medical Center
Pelvic Organ Prolapse
Uphold Mesh for the Surgical Treatment of Uterine-predominant Prolapse
The primary objective of this study is to evaluate the efficacy of the UpholdTM LITE mesh over a 12 month follow up period, using a composite outcome including a good anatomical correction for both anterior and apical…
- Trial name
- NCT01559168
- Testing
- UpholdTM LITE placement
- Where
- 13 sites in France
- Volunteers
- 121 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Decisional Conflict
Effect of a Decision Aid on Decision Making for the Treatment of Pelvic Organ Prolapse
Pelvic organ prolapse is a common condition that affects millions of women every year. There are many options for treatment and it can be difficult to make a decision as how best to proceed.
- Trial name
- NCT01798082
- Testing
- Pelvic organ prolapse decision aid
- Where
- United States
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Hartford Hospital