Clinical trials: Pelvic Prolapse
Pelvic Organ Prolapse
Long-term Success Rate of Transvaginal Mesh for the Treatment of Pelvic Organ Prolapse: The Extended RCT Study
The original RCT trial is designed to compare self-tailored titanium-coated polypropylene mesh procedure with mesh-kit in the treatment of POP stage III-IV in terms of efficacy, safety and cost-effective at 1-year follow-up.
- Trial name
- NCT05938881
- Testing
- self-cut mesh procedure, mesh-kit procedure
- Where
- 11 sites in China
- Volunteers
- 336 people
- Sponsor
- Peking Union Medical College Hospital
Pelvic Organ Prolapse
Ischia Spinous Fascia Fixation Surgery for Pelvic Organ Prolapse
Pelvic organ prolapse is a common problem. The primary treatment is surgery. Ischia spinous fascia fixation procedure is developed in China for vaginal apex fixation with native tissue.
- Trial name
- NCT01760603
- Testing
- ISFF
- Where
- 4 sites in China
- Volunteers
- 75 people
- Sponsor
- Peking Union Medical College Hospital
Urinary Retention, Lower Urinary Tract Symptoms
Tamsulosin vs Placebo to Prevent Postoperative Urinary Retention in Female Pelvic Reconstructive Surgery
This is a placebo controlled randomized controlled trial of perioperative use of tamsulosin to prevent postoperative urinary retention in female pelvic reconstructive surgery.
- Conditions
- Urinary Retention, Lower Urinary Tract Symptoms, Stress Urinary Incontinence, Pelvic Organ Prolapse
- Trial name
- NCT03524339
- Testing
- Tamsulosin
- Where
- 2 sites in United States
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Pelvic Organ Prolapse
Comparison of Post-operative Symptoms After Two Surgeries for Patients With Pelvic Organ Prolapse
Collect and review the patients who underwent surgical treatment due to pelvic floor organ prolapse from 2020 to 2021, make statistics on their postoperative questionnaire data, and evaluate the clinical effects of different…
- Trial name
- NCT05697796
- Testing
- Two different surgical methods
- Where
- China
- Volunteers
- 2 people
- Sponsor
- Peking University People's Hospital
Pelvic Organ Prolapse
A Randomized Controlled Trial of Modified Ischial Spinous Fascia Fixation and Sacrospinous Ligament Fixation in the Treatment of Pelvic Organ Prolapse
Background: Pelvic organ prolapse is one of the most common benign gynecological disorders in middle-aged and elderly women, and it has a significant negative impact on women's social, physical, and psychological health.
- Trial name
- NCT06418451
- Testing
- sacrospinous ligament fixation (SLFF), modified ischial spinous fascia fixation (modified ISFF)
- Volunteers
- 370 people
- Sponsor
- Lan Zhu
Pelvic Organ Prolapse
The Surgical Benefit and Pt.Tolerability Between Two Different Bowel Cleansing Regimens Performed Prior to Pelvic Reconstructive Surgery. Does One Bowel Cleansing Regimen Improve the Surgeons Visual Field Significantly Better Than the Other.
Does mechanical bowel preparation (complete bowel cleansing)help the Surgeon with visualization of the operative field during laparoscopic pelvic reconstructive surgery?
- Trial name
- MBP (NCT01522261)
- Testing
- Mechanical Bowel Prep, No Mechanical Bowel Prep
- Where
- United States
- Volunteers
- 176 people
- Sponsor
- Boston Urogynecology Associates
Leiomyoma, Uterine, Benign Gynecological Disease
Deep Neuromuscular Blockade and a Low-Residue Diet for the Surgical Field in vNOTES Hysterectomy
vNOTES (vaginal natural orifice transluminal endoscopic surgery) hysterectomy is performed entirely through the vagina, with no abdominal incision.
- Conditions
- Leiomyoma, Uterine, Benign Gynecological Disease, Abnormal Uterine Bleeding (AUB), Uterine Prolapse
- Trial name
- vNOTES_NMBDIET (NCT07730970)
- Testing
- Deep Neuromuscular Blockade (NMB), Standard (moderate) neuromuscular blockade, Preoperative low-residue diet
- Where
- 3 sites in Turkey (Türkiye)
- Volunteers
- 160 people
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Pelvic Organ Prolapse
Comparison of V-NOTES and Laparoscopic Mesh-Free Sacrocolpopexy Techniques
This study aims to compare the surgical outcomes, safety profiles, and patient satisfaction between two minimally invasive techniques for pelvic organ prolapse repair: Vaginal Natural Orifice Transluminal Endoscopic Surgery…
- Trial name
- vnotes (NCT07082023)
- Testing
- V-NOTES Mesh-Free Sacrocolpopexy, Laparoscopic Mesh-Free Sacrocolpopexy
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- Havva Betül Bacak
Uterine Prolapse, Urinary Stress Incontinence
A Study on the Anti-incontinent Effectiveness of the mTVM Method in POPQ Stage II-III Patients
An increasing number of specific procedures have been described for the surgical repair of pelvic organ prolapse (POP) and concomitant stress urinary incontinence (SUI).
- Conditions
- Uterine Prolapse, Urinary Stress Incontinence, Side Effects
- Trial name
- TVMvsmTVM (NCT02935803)
- Testing
- Trans-vaginal Mesh operation
- Where
- Hungary
- Volunteers
- 76 people
- Sponsor
- Szeged University
Rectal Prolapse
Laparoscopic Rectopexy for Rectal Prolapse
The aim of the present prospective, double-blind, randomized study is to study whether laparoscopic anterior mesh rectopexy is as good as laparoscopic posterior rectopexy with respect to obstructive defecation afterwards.
- Trial name
- NCT00946205
- Testing
- Laparoscopic posterior rectopexy, Laparoscopic anterior mesh rectopexy
- Where
- Denmark
- Volunteers
- 75 people
- Sponsor
- Aarhus University Hospital
Pelvic Organ Prolapse
Location and Anatomic Characterization of the Sacrospinous Ligaments in Women With Pelvic Organ Prolapse
Pelvic organ prolapse is a common disorder that results in significant patient morbidity. Approximately 1 in 9 women undergo surgery for the correction of pelvic organ prolapse (POP) and associated bladder and bowel dysfunction.
- Trial name
- NCT01852422
- Where
- Israel
- Sponsor
- Pop Medical Solutions
Use of Pessary Reduce the Number of Prolapse Recurrence, Uterine Prolapse
The Effect of Pessary Post Vaginal Prolapse Repair, for One Month, to Reduce the Recurrence Rate of Prolapse
Genital prolapse is a common complain. 30-40% of women will complain of uterine prolapse or cystocele or rectocele, or mixed. About half of them will require surgical repair for the prolapse, with or without hysterectomy.
- Conditions
- Use of Pessary Reduce the Number of Prolapse Recurrence, Uterine Prolapse, Cystocele, Rectocele
- Trial name
- pfgp (NCT03056586)
- Testing
- vaginal pessary
- Volunteers
- 100 people
- Sponsor
- Meir Medical Center
Pelvic Organ Prolapse
Intraoperative Costs and Patient Perceptions in Sacrocolpopexy for Prolapse
Robotic sacrocolpopexy (a procedure for female pelvic organ prolapse) has been demonstrated to have equivalent surgical outcomes to open abdominal sacrocolpopexy and has been previously deemed more cost effective due to the…
- Trial name
- NCT04179955
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Mayo Clinic
Prolapse, Sacrocolpopexy
Retrospective Data Analysis PelviGYNious/EndoGYNious
The retrospective patient chart review aims to generate additional data to substantiate the safety and performance of EndoGYNious and PelviGYNious.
- Conditions
- Prolapse, Sacrocolpopexy, Pelvic Organ Prolapse (POP)
- Trial name
- NCT06927752
- Testing
- PelviGYNious, EndoGYNious
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- A.M.I. Agency for Medical Innovations GmbH
Same Day Discharge, Pelvic Organ Prolapse
Same Day Discharge Following Pelvic Reconstructive Surgery
This is a prospective cross-sectional study in which patients undergoing major pelvic reconstructive surgery with total vaginal hysterectomy will be recruited and enrolled.
- Conditions
- Same Day Discharge, Pelvic Organ Prolapse, Total Vaginal Hysterectomy
- Trial name
- NCT04804826
- Testing
- Pelvic Reconstructive Surgery
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- TriHealth Inc.
Pelvic Organ Prolapse
Impact of Level III Support Procedure on Enlarged Genital Hiatus After Minimally Invasive Sacrocolpopexy
This is a randomized controlled surgical trial evaluating the use of a concomitant posterior colporrhaphy and/or perineorrhaphy at the conclusion of minimally invasive sacrocolpopexy to narrow enlarged genital hiatuses in a…
- Trial name
- MERIT (NCT04480671)
- Testing
- Level III support procedure, Minimally Invasive Sacrocolpopexy, Transperineal ultrasound of the Pelvic Floor
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- University of Pittsburgh
Behavior, Health, Behavior, Maternal
Women Lift Safely! An Intervention Study to Reduce the Risks of Heavy Lifting
The Women Lift Safely! Intervention study aims to increase safe carrying behavior to reduce health risks of heavy lifting in a rural area of Nepal (i.e. reducing weight and using safe lifting techniques).
- Conditions
- Behavior, Health, Behavior, Maternal, Work Related Stress
- Trial name
- NCT05154006
- Testing
- Information about benefits of the behavior, Instruction on how to perform a behavior, Self-efficacy
- Where
- 2 sites in Nepal
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of Bern
Sacrospinofixation, Apical Prolapse
Concordance of Pelvic Organ Mobility Measurements Between the Finite Element Model and the Dynamic Pelvic Floor MRI in Patients Undergoing a Sacrospinofixation Surgery
The primary objective of this study is to demonstrate the feasibility of using a Finite Element model of pelvic organs by evaluating the concordance of pelvic organ mobility measurements performed by this mechanical model…
- Trial name
- BiomécaRichter (NCT04551859)
- Testing
- Dynamic Pelvic Floor MRI
- Volunteers
- 41 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Urogenital Prolapse
Sacrospinous Ligament Fixation vs Ischial Spine Fascia Fixation
A Prospective, Randomized Comparison of Efficacy and Effect on Quality of Life Between Sacrospinous Ligament Fixation and Ischial Spine Fascia Fixation.
- Trial name
- NCT03005613
- Testing
- ischial spine fascia fixation, sacrospinous ligament fixation
- Where
- China
- Volunteers
- 76 people
- Sponsor
- Peking Union Medical College Hospital
Pelvic Organ Prolapse
Alterations in Connective Tissue in Patients With or Without Pelvic Organ Prolapse
The aim of our study is to investigate the alterations in connective tissue of vaginal wall in patients with and without pelvic organ prolapse (POP).
- Trial name
- NCT01749696
- Where
- Finland
- Volunteers
- 78 people
- Sponsor
- Turku University Hospital