Clinical trials: Pelvic Prolapse
Pelvic Organ Prolapse
Clinical Outcomes and Urodynamic Effects After Vaginal Tailored Mesh Surgery for Pelvic Organ Prolapse
To evaluate the clinical outcome and urodynamic effect of two novel vaginal tailored mesh surgeries.
- Trial name
- NCT02178735
- Testing
- Anterior vaginal tailored mesh surgery, Posterior vaginal tailored mesh surgery
- Where
- Taiwan
- Volunteers
- 104 people
- Sponsor
- National Taiwan University Hospital
Pelvic Organ Prolapse
Permanent Versus Absorbable Colpopexy Trial
Primary Aim: The primary aim of this randomized controlled trial (RCT) is to compare vaginal mesh and suture exposure rates in women undergoing robotic total hysterectomy and sacrocolpopexy with a light-weight polypropylene mesh…
- Trial name
- PACT (NCT02277925)
- Testing
- Polytetrafluoroethylene, Polydioxanone
- Where
- 5 sites in United States
- Volunteers
- 204 people
- Sponsor
- University of North Carolina, Chapel Hill
Diverticulum, Colon, Colorectal Neoplasms
Data Collection of Patients Treated With the ColonRing™ for the Creation of Circular Compression Anastomosis
The proposed study is a post marketing, observational, retrospective data collection intended to gather and record data on patients treated with the ColonRing™ device in routine clinical practice at a single center.
- Conditions
- Diverticulum, Colon, Colorectal Neoplasms, Crohn Disease, Colitis, Ulcerative
- Trial name
- RETROPRESS (NCT01301417)
- Testing
- ColonRing™
- Where
- United States
- Volunteers
- 171 people
- Sponsor
- novoGI
Pelvic Organ Prolapse
Axis(TM) Solvent-dehydrate Dermal Allograft in the Treatment of Pelvic Organ Prolapse.
The goal of this study is to assess improvement in subjects who have undergone Axis Dermis, biologic mesh for pelvic organ prolapse repair. [describe participant population/health conditions].
- Trial name
- NCT06263985
- Testing
- Axis Dermis biologic mesh repair for pelvic organ prolapse
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Michigan Institution of Women's Health PC
Rectal Prolapse
Safety and Performance Evaluation of a Biological Matrix Used for Rectal Prolapse Repair by Ventral Rectopexy
The general objective of the study is to confirm the medium/long-term safety and clinical performance of the CELLIS Rectopexy membrane used in rectal prolapse repair by ventral rectopexy and to identify emerging risks in…
- Trial name
- NCT04130555
- Testing
- CELLIS Rectopexy (Porcine Acellular Dermal Matrix, PADM)
- Where
- 3 sites in France
- Volunteers
- 55 people
- Sponsor
- Meccellis Biotech
Pelvic Organ Prolapse
Pelvic Floor Study: Biomechanical Properties of the Female Pelvic Floor
Pelvic floor dysfunction in the form of pelvic organ prolapse or urinary and fecal incontinence is a sequela for some women who experience injuries during birth. It affects adult women of all ages.
- Trial name
- NCT01042470
- Where
- Switzerland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- David Scheiner
Pelvic Organ Prolapse, Laparoscopy
Comparison of Laparoscopic Sacrohysteropexy, Modified Laparoscopic Lateral Suspension and Laparoscopic Pectopexy.
The aim of this study was to compare the results of laparoscopic sacrohysteropexy, laparoscopic modified lateral suspens9ion and laparoscopic pectopexy between January 2017 and December 2019 in our clinic.(Patients with at least…
- Trial name
- NCT04178083
- Testing
- medical examination
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Diyarbakir Women's and Children's Diseases Hospital
Pelvic Organ Prolapse
Vaginally Assisted Laparoscopic Hysteropexy Versus Vaginal Hysterectomy
Utero-vaginal prolapse is a common, often disabling, condition experienced by women of varying ages. The traditional surgical treatment for utero-vaginal prolapse often includes vaginal hysterectomy and anterior or posterior…
- Trial name
- NCT03436147
- Testing
- POP-Q
- Where
- Turkey (Türkiye)
- Volunteers
- 49 people
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Uterine Prolapse
Prospective Analysis of Restorelle in the Treatment of Uterine Prolapse
The purpose of this study is to determine the long term performance of Restorelle system for the treatment of uterine prolapse.
- Trial name
- NCT02921451
- Testing
- Restorelle Smartmesh
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Michigan Institution of Women's Health PC
Colorectal Disorders, Prolapse
Biological OviTex Versus Synthetic Graft in Robotic Prolapse Surgery
This prospective study aims to assess the efficacy of the OviTex 1S permanent mesh in pelvic floor surgery in comparison with the current standard polypropylene mesh.
- Conditions
- Colorectal Disorders, Prolapse, Prolapse Rectal, Prolapse Genital
- Trial name
- ProTex (NCT06430931)
- Testing
- Minimal invasive abdominal prolapse surgery using Polypropylene mesh, Minimal invasive abdominal prolapse surgery using OviTex 1S permanent mesh
- Where
- Netherlands
- Volunteers
- 184 people
- Sponsor
- Meander Medical Center
Pelvic Floor Dysfunction, Perineal Laceration
Perineal Protection Device for Reducing Perineal Trauma During Vaginal Delivery in First-time Mothers: a Multicenter Randomized Controlled Trial
The goal of this clinical trial is to determine whether using a soft perineal protection device (BabySlide®) in addition to standard manual perineal support during vaginal delivery can reduce the risk of perineal trauma in…
- Conditions
- Pelvic Floor Dysfunction, Perineal Laceration, Wound Dehiscence, Anal Incontinence
- Trial name
- PeriPROTECT (NCT07862660)
- Testing
- Perineal protection device, BabySlide, Standard manual perineal support
- Where
- Sweden
- Volunteers
- 4,226 people
- Sponsor
- Region Skane
Pelvic Organ Prolapse
Improvement of Pain Following Robotic Sacrocolpopexy and Rectocele Repair for Pelvic Organ Prolapse
To determine if the injection of liposomal bupivacaine to laparoscopic port sites and rectocele repair incisions at the completion of a robotic sacrocolpopexy with concomitant rectocele repair will result in decreased…
- Trial name
- NCT02449915
- Testing
- Bupivacaine
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- TriHealth Inc.
Urinary Incontinence,Stress, Stress Urinary Incontinence
Synchronized Core-Pelvic Floor Activation in Urinary Incontinence
This study aims to investigate whether co-activation of the pelvic floor and core muscles improves treatment outcomes in individuals with urinary incontinence.
- Conditions
- Urinary Incontinence,Stress, Stress Urinary Incontinence, Mixed Incontinence Due to Prolapse of Female Genital Organ, Urinary Incontinence
- Trial name
- NCT07387640
- Testing
- Conventional Pelvic Floor Muscle Training, Pelvic Floor and Core Muscle Co-activation Training
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Bezmialem Vakif University
Atrophy of Vagina, Vaginal Ulceration
Vaginal Creams to Reduce Vaginal Erosion in Pessary Users
To compare the use of Estrace ® vaginal cream against a placebo vaginal cream in reducing symptomatic vaginal discharge and vaginal erosion in patients who are using the Gellhorn or Ring with support pessaries.
- Conditions
- Atrophy of Vagina, Vaginal Ulceration, Vaginitis
- Trial name
- NCT02316249
- Testing
- Estradiol
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Northwell Health
Urinary Retention, Uterine Prolapse
Does Spinal Anesthesia for Prolapse Surgery With Lead to Urinary Retention?
The purpose of the study is to compare the risk of being unable to urinate shortly after surgery, also called acute post-operative urinary retention (POUR) between spinal and general anesthesia in women who undergo outpatient…
- Trial name
- NCT02547155
- Testing
- Spinal anesthesia, General anesthesia
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Pelvic Organ Prolapse, Cystocele
A Randomized Controlled Trial of Permanent vs Absorbable Suture for Uterosacral Ligament Suspension
Uterosacral ligament suspension (USLS) is a commonly performed, vaginal surgery for the correction of female pelvic organ prolapse. The original description of this procedure included the use of permanent sutures.
- Conditions
- Pelvic Organ Prolapse, Cystocele, Uterine Prolapse
- Trial name
- NCT02888093
- Testing
- Absorbent suture (polydioxanone) and Permanent suture (Gore-Tex CV2)
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Joseph Kowalski
Colon Cancer, Colon Polyp
Feasibility and Safety of Single Port Robot in Colorectal Procedures
The purpose of this study is to evaluate the safety and feasibility of using the Single Port (SP) robot (daVinci, Intuitive Surgical) to perform single port robotic colon surgery and transanal robotic surgery.
- Conditions
- Colon Cancer, Colon Polyp, Rectal Cancer, Diverticulitis
- Trial name
- NCT03700593
- Testing
- Single Port Robotic Colorectal Surgery
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Marks Colorectal Surgical Associates
Prolapse Genital
Comparison of Single Versus Multicenter Outcomes for Pelvic Organ Prolapse Repair Using a Mesh-capturing Device
Comparison of single versus multicenter outcomes for pelvic organ prolapse repair using a mesh-capturing device (The Uphold™ Vaginal Support System for apical and vaginal wall prolapse - Boston Scientific).
- Trial name
- KIDS (NCT03077490)
- Testing
- Transvaginal mesh Uphold TM Vaginal Support System, Transvaginal mesh Uphold TM Vaginal Support System.
- Volunteers
- 319 people
- Sponsor
- Karolinska Institutet
Pelvic Organ Prolapse
Modified Purandare's Cervicopexy Versus Abdominal Sacral Hysteropexy
This study aims to compare safety, efficacy and complications of modified Purandare's cervicopexy with abdominal sacral hysteropexy as conservative surgery in the treatment of genital prolapse in reproductive age group patients…
- Trial name
- NCT04852991
- Testing
- Modified Purandare cervicopexy, Abdominal sacral hysteropexy
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Ain Shams Maternity Hospital
Pelvic Organ Prolapse, Vaginal Atrophy
The Effects of Local Vaginal Estrogen in Postmenopausal Women With Pelvic Organ Prolapse
The purpose of this study is to find out how long it takes the vagina to respond to hormonal vaginal cream in women with pelvic organ prolapse (bulge in the vagina).
- Trial name
- NCT00803335
- Testing
- Vaginal conjugated estrogen cream 0.5gm, Vaginal conjugated estrogen cream 1.0gm
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- TriHealth Inc.