Clinical trials: Pelvic Prolapse
Colonic Neoplasms, Rectal Neoplasms
NITI CAR27 (ColonRing) Compression Anastomosis in Colorectal Surgery
After resection of diseased segments of the large intestine, the continuity of the intestine has to be restored. This can be done by suturing or with so called stapling devices.
- Conditions
- Colonic Neoplasms, Rectal Neoplasms, Diverticulitis, Inflammatory Bowel Diseases
- Trial name
- NCT01056913
- Testing
- Compression Anastomosis Device, follow-up colonoscopy
- Volunteers
- 62 people
- Sponsor
- St John of God Hospital, Vienna
Obstetric; Injury Pelvic Floor
The Effect of Pregnancy and Labour on the Pelvic Floor Diagnosed With 3D and 4D Ultrasound
Injuries to the pelvic floor muscles and fascias during delivery and childbirth may lead to urinary incontinence (25-45 %), faecal incontinence (11-45%), pelvic organ prolapse (7-23%), sexual dysfunction (15-33 %) and chronic…
- Trial name
- NCT01045135
- Where
- Norway
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University Hospital, Akershus
Pelvic Organ Prolapse
The Extended Operations And Pelvic Muscle Training In The Management Of Apical Support Loss Study
Women will be invited to participate in E-OPTIMAL at their last clinical follow-up visit for OPTIMAL (at 24 months post surgery).
- Trial name
- E-OPTIMAL (NCT01166373)
- Testing
- Enrollment video, SSLF, ULS
- Where
- 7 sites in United States
- Volunteers
- 285 people
- Sponsor
- NICHD Pelvic Floor Disorders Network
Urinary Tract Infections
Nitrofurantoin and Urinary Tract Infections (UTIs)
Urinary tract infection (UTI) is the most common complication after surgery for prolapse or urinary incontinence. UTIs are painful and have the potential to turn into kidney infections.
- Trial name
- APPIC (NCT00678041)
- Testing
- Nitrofurantoin
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Quality of Recovery, Same Day Surgery
Dexamethasone Administration To Improve Patient Recovery In Ambulatory Vaginal Prolapse Surgery: Is There A Role?
To the investigators knowledge there are no studies in the literature evaluating the effect of Dexamethasone administration on patients undergoing outpatient vaginal prolapse surgeries.
- Conditions
- Quality of Recovery, Same Day Surgery, Nausea and Vomiting, Postoperative, Vaginal Prolapse
- Trial name
- NCT03338400
- Testing
- Dexamethasone, Normal saline
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- The Cleveland Clinic
Pelvic Organ Prolapse
Apical Support During Hysterectomy for Pelvic Organ Prolapse
This is a retrospective chart review using TriHealth Electronic Privacy Identification Center (EPIC) to determine whether gynecologic surgeons at a large community hospital are already meeting the recently recommended best…
- Trial name
- NCT03379246
- Where
- United States
- Volunteers
- 236 people
- Sponsor
- TriHealth Inc.
Pelvic Organ Prolapse (POP)
Operations and Pelvic Muscle Training in the Management of Apical Support Loss: The OPTIMAL Trial
Pelvic organ prolapse is common among women with a prevalence that has been estimated to be as high as 30%. Pelvic organ prolapse often involves a combination of support defects involving the anterior, posterior and/or apical…
- Trial name
- OPTIMAL (NCT00597935)
- Testing
- SSLF, ULS, PMT
- Where
- 9 sites in United States
- Volunteers
- 374 people
- Sponsor
- NICHD Pelvic Floor Disorders Network
Vaginal Prolapse
Observational Data Collection of Surgical Outcomes in the Treatment of Vaginal Prolapse With AMS Products
This registry was observational (only collected information typically noted by the surgeon when their patients were routinely seen); there was no change to the care the patient received as a result of being part of the registry).
- Trial name
- POWER1012 (NCT00388947)
- Testing
- AMS Prolapse Product
- Where
- United States
- Volunteers
- 1,543 people
- Sponsor
- ASTORA Women's Health
Pelvic Organ Prolapse, Abdominal Surgery
The Effect of Abdominal Binder Use on Postoperative Pain and Mobility in Patients Undergoing Pelvic Surgery
To determine the effect of post-operative abdominal binder usage on total narcotic usage after undergoing surgery. To determine if abdominal binder usage results in decreased visual analog scale (VAS) pain scores and shorter time…
- Conditions
- Pelvic Organ Prolapse, Abdominal Surgery, Laparoscopic Surgery, Post Operative Pain
- Trial name
- NCT03684304
- Testing
- Abdominal binder
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Anaemia Postoperative
Clinical Utility of Postoperative Hemoglobin Testing
The purpose of this study is to evaluate how many patients have hemoglobin less than 10 g/dL at post-operative day 1
- Trial name
- NCT04170764
- Where
- United States
- Volunteers
- 664 people
- Sponsor
- TriHealth Inc.
Pelvic Organ Prolapse (POP)
Restorelle Direct Fix Anterior and Posterior (A&P) for Female Pelvic Organ Prolapse: A Prospective Post Market Study
This is a prospective, multi-center study designed to assess the palpability of the Restorelle Direct Fix A\&P mesh after vaginal reconstruction surgery.
- Trial name
- (A&P) (NCT01378065)
- Testing
- Restorelle Direct Fix A&P
- Where
- 6 sites in United States
- Volunteers
- 31 people
- Sponsor
- Coloplast A/S
Pelvic Organ Prolapse
IV Acetaminophen for Postoperative Pain After Pelvic Organ Prolapse Repair
The purpose of this study is to determine whether preoperative IV Acetaminophen reduces postoperative pain and narcotic consumption in women undergoing surgical repair of pelvic organ prolapse.
- Trial name
- NCT02155738
- Testing
- IV Acetaminophen, IV normal saline
- Where
- United States
- Volunteers
- 204 people
- Sponsor
- Halina M Zyczynski, MD
Pelvic Organ Prolapse
Sacro-Spinous Ligaments Anterior Apical Anchoring
Anterior-apical compartment mesh implants for pelvic floor reconstruction are anchored here to the Sacro-Spinous ligaments and evaluated being a feasible and effective method.
- Trial name
- NCT01842464
- Testing
- Anterior Sacro-Spinous
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Western Galilee Hospital-Nahariya
Catheter-Associated Urinary Tract Infection
Nitrofurantoin Administration for the Prevention of Short-Term Catheter Associated Urinary Tract Infection After Pelvic Surgery
The specific aim of this randomized double-blind placebo-controlled trial is to evaluate the efficacy of administration of nitrofurantoin prophylaxis after catheter discontinuation for the prevention of catheter-associated…
- Trial name
- NAUTICA (NCT03287089)
- Testing
- Nitrofurantoin 100 MG
- Where
- United States
- Volunteers
- 164 people
- Sponsor
- Wake Forest University Health Sciences
Pelvic Organ Prolapse
Postoperative Virtual Clinical Encounters
Postoperative follow up is necessary following any surgical procedure and has been conducted in the same manner since the field of surgery began.
- Trial name
- NCT04138810
- Testing
- VCE, Survey
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- University of Pennsylvania
Postoperative Urinary Tract Infection, Pelvic Organ Prolapse
Gentamicin Intravesical Efficacy for Infection of Urinary Tract
Urinary tract infection (UTI) is a common problem after surgery for pelvic organ prolapse and stress urinary incontinence. This prospective, randomized, single-masked (subject), two-parallel armed study aims to determine the…
- Conditions
- Postoperative Urinary Tract Infection, Pelvic Organ Prolapse, Stress Urinary Incontinence
- Trial name
- GIVEIT (NCT04246996)
- Testing
- gentamicin sulfate, Catheter clamping only
- Where
- 2 sites in United States
- Volunteers
- 370 people
- Sponsor
- Kaiser Permanente
Prolapse
Surgical Study Comparing 2 Procedures for the Treatment of a Dropped Bladder
The purpose of this study is to determine whether vaginal repair or abdominal repair is the procedure of choice for the surgical management of a prolapsed bladder.
- Trial name
- NCT00271102
- Testing
- anterior vaginal repair (colporrhaphy), abdominal paravaginal defect repair
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Geisinger Clinic
Pelvic Organ Prolapse
Calistar A vs. Calistar S - Comparative Cohort Retrospective Analysis of Single Incision POP Systems
The main objective of this study is to compare the initial outcomes and complication of two meshes implanted through a single incision to treat anterior and apical prolapses, Calistar A and a second-generation low weight mesh…
- Trial name
- NCT03715803
- Testing
- Calistar A mesh to treat anterior and apical POP, Calistar S mesh to treat anterior and apical POP
- Where
- Argentina
- Volunteers
- 217 people
- Sponsor
- Agustin Sampietro
Pelvic Organ Prolapse, Menopause
Effect of Preoperative Estrogen Treatment on Connective Tissues of the Pelvic Floor
This is a study to determine how vaginal estrogen cream given for several weeks before pelvic reconstructive therapy will effect elastic fiber assembly in the muscularis layer of the vaginal wall.
- Trial name
- PET (NCT01778985)
- Testing
- Premarin
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Genital Diseases, Female, Pelvic Organ Prolapse
A Long Term Follow up of Anterior Meshes for Recurrent Prolapse
Prolapse of the vaginal wall and uterus are common conditions affecting up to 50% of parous women. The socioeconomic, psychological and physical impacts of prolapse are considerable.
- Trial name
- NCT02642835
- Testing
- vaginal wall mesh
- Where
- United Kingdom
- Volunteers
- 48 people
- Sponsor
- Medway NHS Foundation Trust