Clinical trials: Pelvis Disease
Cervical Cancer
Hypofractionated Whole Pelvic Chemoradiotherapy With iRex Optimization in Cervical Cancer
This study is a randomized controlled trial designed to compare hypofractionated whole pelvic radiotherapy with conventional radiotherapy in patients with cervical cancer undergoing concurrent chemoradiotherapy.
- Trial name
- HYPOCx-iRex (NCT07605507)
- Testing
- Hypofractionated Radiotherapy, Conventional Radiotherapy, Concurrent chemotherapy once a week
- Where
- Thailand
- Volunteers
- 40 people
- Sponsor
- Siriraj Hospital
Endometriosis
Extension to Study on Efficacy and Safety of Linzagolix for the Treatment of Endometriosis-associated Pain
The primary objective of this extension study is to assess the maintenance of efficacy of linzagolix administered orally once daily for up to an additional 6 months (for up to 12 months of treatment in total) in women who have…
- Trial name
- EDELWEISS 5 (NCT04372121)
- Testing
- 75 mg linzagolix tablet, 200 mg linzagolix tablet, Add-back capsule (E2 1 mg / NETA 0.5 mg)
- Where
- 25 sites in United States, Canada and 1 more
- Volunteers
- 30 people
- Sponsor
- Kissei Pharmaceutical Co., Ltd.
Gynecological; Surgery (Previous), Causing Obstructed Labor
Impact of Early Physiotherapy on Pain, Quality of Life, Pelvic Floor Function, and Sexual Health Post-Episiotomy
Surgical incision of the perineum and the posterior vaginal wall during a vaginal delivery (episiotomy) is among the most common surgical procedures performed in obstetrics.
- Trial name
- NCT06568406
- Testing
- Physiotherapy, Urogynaecology
- Where
- Czechia
- Volunteers
- 250 people
- Sponsor
- Brno University Hospital
Obstructive Defecation Syndrome, Chronic Constipation
Laparoscopic Ventral Mesh Rectopexy Combined With or Without Stapled Trans-anal Rectal Resection for Obstructed Defecation Syndrome
Obstructed defecation syndrome (ODS) is a common problem in women. Rectal prolapse and rectocoele are frequently identified in patients with ODS.
- Conditions
- Obstructive Defecation Syndrome, Chronic Constipation, Rectal Prolapse
- Trial name
- NCT03060330
- Testing
- Modified Laparoscopic Ventral Mesh Rectopexy, Modified Laparoscopic Ventral Mesh Rectopexy Combined with Stapled Trans-anal Rectal Resection
- Where
- China
- Volunteers
- 126 people
- Sponsor
- Renmin Hospital of Wuhan University
Dysmenorrhea, Adenomyosis
Electroacupuncture for Dysmenorrhea Secondary to Adenomyosis
The aim of this study is to preliminarily evaluate the is to assess the effects and safety of electroacupuncture for moderate to severe dysmenorrhea secondary to adenomyosis.
- Conditions
- Dysmenorrhea, Adenomyosis, Electroacupuncture
- Trial name
- NCT06364592
- Testing
- Electroacupuncture
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Guang'anmen Hospital of China Academy of Chinese Medical Sciences
Cancer of the Cervix
Oral Ondansetron Versus Transdermal Granisetron (Sancuso) for Women With Cervical, Endometrial or Vaginal Cancer Receiving Pelvic Chemoradiation
The goal of this clinical research study is to compare granisetron (when given through a patch) to ondansetron (when taken by mouth) for reducing nausea and vomiting in women with cervical, endometrial, or vaginal cancer having…
- Trial name
- NCT01536392
- Testing
- Granisetron, Ondansetron, Questionnaires
- Where
- 2 sites in United States
- Volunteers
- 76 people
- Sponsor
- M.D. Anderson Cancer Center
SBRT, Radiation Therapy
Pelvic Ultra-Hypofractionated Adjuvant Radiotherapy for Endometrial Cancer (PURE-cohort)
The PURE trial is a prospective multicenter phase II study evaluating the safety and feasibility of ultra-hypofractionated adjuvant pelvic radiotherapy in patients with high-intermediate-risk and high-risk endometrial cancer…
- Conditions
- SBRT, Radiation Therapy, Endometrial Cancer, Endometrial Cancer Stage III
- Trial name
- PURE-cohort (NCT07779109)
- Testing
- Ultra-hypofractionation schedule of 27.5Gy in 5 fractions on image-guided adjuvant pelvic IMRT/VMAT radiotherapy
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Instituto de Investigación Sanitaria Aragón
Metrorrhagia, Menorrhagia
Surgical Success After Laparoscopic vs Abdominal Hysterectomy
The purpose of the proposed pilot study is to investigate the effectiveness, cost, safety, and long-term impact on quality of life of laparoscopic hysterectomy (LH) in relation to abdominal hysterectomy (AH) for the treatment of…
- Conditions
- Metrorrhagia, Menorrhagia, Leiomyoma, Adenomyosis
- Trial name
- NCT01793584
- Testing
- Laparoscopic hysterectomy, Abdominal hysterectomy
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Bladder Cancer, Transitional Cell Cancer of the Renal Pelvis and Ureter
Combination Chemotherapy in Treating Patients With Advanced Cancer of the Urothelium and Decreased Kidney Function
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more cancer cells.
- Conditions
- Bladder Cancer, Transitional Cell Cancer of the Renal Pelvis and Ureter, Urethral Cancer
- Trial name
- NCT00005644
- Testing
- gemcitabine hydrochloride, paclitaxel
- Where
- 16 sites in United States
- Sponsor
- Eastern Cooperative Oncology Group
Ureteral Neoplasms
Lymphadenectomy in Urothelial Carcinoma
Two out of three tumours in the upper urinary tract are located in the renal pelvis. Muscle-invasive urothelial carcinoma is probably more common among tumours in the upper urinary tract compared to tumours in the urinary…
- Trial name
- NCT02607709
- Testing
- Lymphadenectomy in conjugation with nephroureterectomy, Nephroureterectomy without lymphadenectomy
- Where
- Denmark
- Volunteers
- 366 people
- Sponsor
- Zealand University Hospital
Urodynamic Stress Incontinence, Detrusor Overactivity
USI and/or DO in Women With Cystocele Before and After Cystocele Repair
The changes of lower urinary tract function after cystocele repair are important for perioperative consultation and management. Thus, the aim of this retrospective study was to evaluate the prevalence of urodynamic stress…
- Trial name
- NCT04978714
- Testing
- Cystocele repair
- Where
- Taiwan
- Volunteers
- 483 people
- Sponsor
- National Taiwan University Hospital
Rectal Prolapse
Pexy Versus Non-pexy for Full Thickness Rectal Prolapse
No randomized controlled trial (RCT) has compared no rectopexy to rectopexy for external full-thickness rectal prolapse (FTRP). This study was performed to test the hypothesis that recurrence rates for FTRP following no rectopexy…
- Trial name
- Bergamaschi (NCT01022034)
- Testing
- sacral rectopexy with sutures or meshes, full rectal mobilization from the sacrum without sacral rectopexy
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- Societa Italiana di Chirurgia ColoRettale
Uterine Prolapse, Urinary Incontinence
Delivery Method and Risk for Urogenital Prolapse 15-20 Years Later
The lifetime risk for a woman to undergo surgery for either vaginal prolapse or urinary incontinence is high. Previous studies have shown that pregnancy and childbirth are risk factors for developing prolapse.
- Conditions
- Uterine Prolapse, Urinary Incontinence, Fecal Incontinence
- Trial name
- uropro (NCT01766193)
- Testing
- vaginal delivery, forceps extraction, vacuum extraction
- Where
- Norway
- Volunteers
- 1,641 people
- Sponsor
- Norwegian University of Science and Technology
Prostate Cancer, Bladder Cancer
A Study of Adaptive Radiation Therapy for Pelvic Genitourinary Cancer
Radical radiation therapy for prostate cancer is a common treatment that has shown to improve clinical outcomes in a post-operative setting.
- Trial name
- ARTGU (NCT03909893)
- Testing
- Adaptive Radiation Therapy
- Where
- Canada
- Sponsor
- University Health Network, Toronto
Pelvic Floor Dysfunction
A National Observation Study on Pelvic Floor Dysfunction Diseases in China
In this protocol, our team intend to conduct a nation-wide multicenter cohort research to screening for PFD symptoms in early postnatal women in China.
- Trial name
- NCT06037226
- Testing
- Postpartum pelvic floor rehabilitation
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Postmenopausal Period, Vaginal Atrophy
Treatment of Vaginal Atrophy With Low Intensity Nanosecond Neodymium Laser
The aim of study is characteristic of changes in the vaginal wall after treatment of neodymium laser radiation with a wavelength of 1064 nm.
- Conditions
- Postmenopausal Period, Vaginal Atrophy, Vaginal Prolapse
- Trial name
- NCT05335317
- Testing
- Laser Treatment, Topical hormone estriol, Сlinical blood analysis
- Where
- Russia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- MeLSyTech, Ltd
Metrorrhagia, Pelvic Pain
Surgical Myomectomy Followed by Oral Myfembree Versus Standard of Care Trial (SOUL)
In this project, the proposition is that the use of daily dosed Myfembree ( a combination of relugolix with estradiol and norethindrone acetate), FDA-approved medication to treat heavy menses fibroid-related symptoms, has the…
- Conditions
- Metrorrhagia, Pelvic Pain, Menorrhagia, Leiomyoma
- Trial name
- SOUL (NCT05538689)
- Testing
- Myfembree Oral Product
- Where
- 6 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Chicago
Solid Cancers, Solid Tumor Cancer
A Dose-escalation, Dose-finding, and Expansion Study of XL495 in Participants With Locally Advanced or Metastatic Solid Tumors
The goal of this study is to obtain safety, tolerability, PK, and preliminary clinical antitumor activity for XL495 as a single agent and in combination with select cytotoxic agents in participants with locally advanced or…
- Conditions
- Solid Cancers, Solid Tumor Cancer, Solid Tumor Malignancy, Urothelial Cancer (Urinary Bladder, Ureters, or Renal Pelvis Cancer)
- Trial name
- NCT06630247
- Testing
- XL495, ADC cytotoxic agents
- Where
- 10 sites in United States
- Volunteers
- 9 people
- Sponsor
- Exelixis
Pelvic Floor Disorders
Evaluation of Levator Ani Muscle Injury in Primiparous
pelvic floor muscles play an important role in supporting the pelvic organs. Vaginal birth leads to defects in pelvic muscles and hence subsequent pelvic organ prolapse and urinary and fecal incontinence can occur .
- Trial name
- ULTRASOUND (NCT04980235)
- Testing
- transperineal 3D ultrasound
- Where
- Egypt
- Volunteers
- 355 people
- Sponsor
- Alexandria University
Urinary Retention, Urinary Incontinence
Reducing Postoperative Catheterization
After reconstructive pelvic surgery urinary retention occurs in up to 60% of patients requiring an indwelling catheter or self-catheterization (1-5).
- Conditions
- Urinary Retention, Urinary Incontinence, Pelvic Organ Prolapse, Urinary Tract Infections
- Trial name
- NCT03009968
- Testing
- Post-void residual free voiding trial
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill