Clinical trials: Pemphigus Disease
Pemphigus
European Trial of Adjuvant Oral Glucocorticoid Pulse Therapy in Pemphigus
By this study, the investigators want to test if the value of adjuvant pulse glucocorticoid therapy for pemphigus can be determined by comparing an experimental arm (dexamethasone pulse therapy, prednisolone, and azathioprine)…
- Trial name
- NCT00127764
- Testing
- dexamethasone (50mg 1dd6, 3 consecutive days/month)
- Where
- Netherlands
- Volunteers
- 60 people
- Sponsor
- University Medical Center Groningen
Pemphigus, Dermatologic Disease
Comparison of a Personalized Maintenance Therapy With the Standard Treatment in Pemphigus
Pemphigus diseases are life-threatening chronic autoimmune blistering diseases characterized by split formation within the epidermis and surface-close epithelia accompanied by acantholysis.
- Trial name
- RITUX4 (NCT05898308)
- Testing
- RiTUXimab Injection
- Where
- 34 sites in France, Guadeloupe
- Volunteers
- 133 people
- Sponsor
- University Hospital, Rouen
Pemphigus Vulgaris
Randomized Trial of IVIg With or Without Cyclophosphamide in Pemphigus
The purpose of this study is to compare two standard treatments for pemphigus to determine which more effectively improves the clinical manifestations of the disease and decreases serum level of the autoantibodies which cause the…
- Trial name
- NCT00483119
- Testing
- intravenous immunoglobulin, cyclophosphamide
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Pemphigus Vulgaris
Serum IL-21 Levels in Patients With Pemphigus Vulgaris
Pemphigus is severe antigen derived autoimmune bullous skin disorder, the word pemphigus is derived from the Greek word" pemphix " which means blister .
- Trial name
- NCT03177213
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Assiut University
Asthma
Promoting Risk Reduction Among Young Adults With Asthma During Wildfire Smoke Events (TRAK)
This research will contribute to fundamental knowledge about how young adults with asthma perceive their personal health risks to wildfire smoke, minimize their risk, and improve their health.
- Trial name
- TRAK (NCT04724733)
- Testing
- Smoke Sense, Smoke Sense Plus
- Where
- United States
- Volunteers
- 67 people
- Sponsor
- Washington State University
Pemphigus Vulgaris, Bullous Dermatoses
Comparative Analysis of the Th17 Cellular Response in Active and Inactive Pemphigus Vulgaris Patients
This study will compare the pattern of Th17 immune response in active and inactive pemphigus subjects. Skin and serum samples will be taken at the moment of enrollment.
- Conditions
- Pemphigus Vulgaris, Bullous Dermatoses, Autoimmune Diseases
- Trial name
- NCT04096222
- Where
- 2 sites in Mexico
- Volunteers
- 42 people
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Pemphigus, Bullous Pemphigoid
Human Leukocyte Antigen Class II (DRB1 and DQB1) Alleles and Haplotypes Frequencies in Patients With Pemphigus Vulgaris Among the Russian Population
Pemphigus is a rare autoimmune life-threatening blistering condition affecting skin and mucous membranes. Pemphigus belongs to a family of polygenic disorders.
- Conditions
- Pemphigus, Bullous Pemphigoid, Stevens-Johnson Syndrome, Toxic Epidermal Necrolyses
- Trial name
- NCT05284929
- Testing
- A single blood sample for HLA typing
- Where
- Russia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Sechenov University
Pemphigus
Effect of Anti CD20 in Pemphigus Desease
to treat in an open non comparative clinical study patients presenting pemphigus with corticodependance, corticoresistance and contre-indication to systemic steroids.
- Trial name
- NCT00213512
- Testing
- Mabthera
- Where
- France
- Volunteers
- 22 people
- Sponsor
- University Hospital, Rouen
Bullous Pemphigoid
Comparison of Two Therapeutic Strategies of Dermoval in Treatment of Bullous Pemphigus
to compare efficacity and tolerance of two stratégies of dermoval application in treatment of bullous pemphigus.
- Trial name
- NCT00213421
- Testing
- Dermoval
- Where
- France
- Volunteers
- 330 people
- Sponsor
- University Hospital, Rouen
Pemphigus
Comparative Study of Rituximab Versus Combination of Rituximab and Intravenous Cyclophosphamide in Severe Pemphigus
The purpose of this study is to compare the effectiveness of rituximab alone vs combination of rituximab and cyclophosphamide in the treatment of pemphigus not responding adequately to routine medications.
- Trial name
- NCT01974518
- Testing
- Rituximab and Cyclophosphamide IV
- Where
- 2 sites in India
- Volunteers
- 20 people
- Sponsor
- Uprety Shraddha
Age-Related Macular Degeneration, Allergies
Tissue Repository Providing Annotated Biospecimens for Approved Investigator-directed Biomedical Research Initiatives
To collect, preserve, and/or distribute annotated biospecimens and associated medical data to institutionally approved, investigator-directed biomedical research to discover and develop new treatments, diagnostics, and…
- Conditions
- Age-Related Macular Degeneration, Allergies, Alpha-Gal Syndrome, Alzheimer Disease
- Trial name
- NCT05635266
- Testing
- Specimen sample
- Where
- United States
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Sanguine Biosciences
Pemphigus
A Clinical Study of B007 in the Treatment of Pemphigus.
The purpose of this study is to evaluate the efficacy and safety of B007 in subjects with pemphigus.
- Trial name
- NCT06454357
- Testing
- B007
- Where
- 12 sites in China
- Volunteers
- 132 people
- Sponsor
- Shanghai Jiaolian Drug Research and Development Co., Ltd
Pemphigus Disease, Pemphigus Vulgaris (PV)
A Randomized Study on Pemphigus Treatment With Humanized CD38 Antibody CM313.
Pemphigus is characterized by the presence of IgG antibodies that lead to the loss of keratinocyte adhesion, resulting in blister formation.
- Trial name
- NCT06663943
- Testing
- CM313 (SC), Glucocorticoids
- Volunteers
- 100 people
- Sponsor
- Chao Ji
Galectin-3 and Pemphigus
Evaluation of Galectin-3 in Serum and Saliva of Pemphigus Patients
Assessment of the expression of galectin-3 in serum and saliva of pemphigus patients and compare it with age and sex matched controls.
- Trial name
- NCT05992727
- Testing
- Galectin 3 measurement in serum and saliva by ELIZA
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Assiut University
Pemphigus Vulgaris
Identifying Factors Influencing In-Hospital Relapse in Pemphigus Patients
The objective of this retrospective study was to investigate the factors influencing in-hospital relapse during acute episodes of pemphigus, an autoimmune blistering disease characterized by self-antibodies targeting desmogleins.
- Trial name
- NCT06167408
- Where
- China
- Volunteers
- 96 people
- Sponsor
- First Affiliated Hospital of Chongqing Medical University
Rheumatoid Arthritis (RA), Systemic Lupus Erythematosus (SLE)
COVID-19 Booster Vaccine in Autoimmune Disease Non-Responders
This is a randomized, multi-site, adaptive, open-label clinical trial comparing the immune response to different additional doses of COVID-19 vaccine in participants with autoimmune disease requiring IS medications.
- Conditions
- Rheumatoid Arthritis (RA), Systemic Lupus Erythematosus (SLE), Pemphigus Vulgaris, Multiple Sclerosis (MS)
- Trial name
- NCT05000216
- Testing
- Moderna mRNA-1273, BNT162b2, Ad26.COV2.S
- Where
- 29 sites in United States
- Volunteers
- 258 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Pemphigus
Treatment of Pemphigus Patients With Rituximab 1000mgX2 and Assessment of Immune Status Via Cylex
The purpose of this study is to determine whether Rituximab, in the same doses as used in rheumatoid arthritis patients, will benefit pemphigus patients.
- Trial name
- NCT01338103
- Testing
- Rituximab
- Where
- Israel
- Volunteers
- 10 people
- Sponsor
- Rabin Medical Center
Pemphigus Vulgaris, Rituximab (RTx)
Rituximab With Corticosteroids Versus Corticosteroids Plus Azathioprine for Moderate-to-Severe Pemphigus Vulgaris
This quasi-experimental study aims to compare the effectiveness and safety of rituximab combined with corticosteroids versus the standard regimen of oral corticosteroids plus azathioprine in patients with moderate to severe…
- Trial name
- NCT07769333
- Testing
- Rituxan (rituximab), Azathioprine (AZA)' plus corticosteroids
- Volunteers
- 92 people
- Sponsor
- Khyber Teaching Hospital
Pemphigus
Immunoadsorption, Dexamethasone Pulse Therapy and Rituximab for Pemphigus
Pemphigus is a severe autoimmune blistering disease mediated by circulating antibodies against certain proteins important for maintaining skin integrity.
- Trial name
- NCT00656656
- Testing
- Combination of Protein A Immunoadsorption, Rituximab, Dexamethasone plus Azathioprine
- Where
- Germany
- Volunteers
- 23 people
- Sponsor
- University of Luebeck
Hailey Hailey Disease, Skin Diseases
A Study to Investigate Safety and Efficacy of KB111 for the Treatment of Hailey-Hailey Disease
An open-label study to evaluate the safety and efficacy of KB111 in pediatric and adult subjects with Hailey-Hailey Disease
- Conditions
- Hailey Hailey Disease, Skin Diseases, Lesion Skin
- Trial name
- HALITE-1 (NCT07717346)
- Testing
- KB111
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Krystal Biotech, Inc.