Clinical trials: Penile Hypospadias
Hypospadias
Prophylactic Antibiotics or Placebo After Hypospadias Repair
The primary purpose of this study is to determine if routine use of prophylactic (preventive) antibiotics after repair of mid-to-distal hypospadias is beneficial.
- Trial name
- PROPHY (NCT02096159)
- Testing
- trimethoprim-sulfamethoxazole
- Where
- 2 sites in United States, Canada
- Volunteers
- 93 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Ureteropelvic Junction Obstruction, Hypospadias
Effect of Oxybutynin on Opioid Use After Urologic Surgery in Children
The goal of this clinical trial is to determine whether giving oxybutynin before urologic reconstruction surgery reduces the amount of opioid pain medication needed in children.
- Trial name
- NCT07911137
- Testing
- Oxybutynin
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- University of Calgary
Postoperative Pain, Hypospadias
Comparison of Sacral ESP Block and Dorsal Penile Nerve Block in Pediatric Hypospadias Surgery
This randomized controlled trial aims to compare the postoperative analgesic efficacy of ultrasound-guided Sacral Erector Spinae Plane (ESP) block versus Dorsal Penile Nerve Block (DPNB) in pediatric patients aged 1-7 years…
- Trial name
- NCT07426731
- Testing
- Sacral ESP Block Group, Dorsal Penile Nerve Block Group
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Medipol University
Hypospadias
Antibiotic Use in Distal Hypospadias Repair
Hypospadias is a common condition where the opening of the penis is not located at the tip, but along the underside of the penis. It is estimated to occur in 1/300 live male births, making it one of the most common birth defects.
- Trial name
- NCT03275519
- Testing
- Randomization to not receive prophylactic antibiotics after surgery., Randomization to receive prophylactic antibiotics after surgery
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Arkansas Children's Hospital Research Institute
Hypospadias
Assessment of Postop Hypospadias Pain
One of the most common pediatric urology procedures is hypospadias repair, a surgery to correct curvature of the penis and move the urethral meatus into the glans.
- Trial name
- NCT04423107
- Testing
- Acetaminophen, Ibuprofen, Acetaminophen, Ibuprofen, Oxycodone
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Oklahoma
Caudal Block
Caudal Combination of Dexamethasone and/or Dexmedetomidine to Bupivacaine in Pediatric Hypospadias Surgery
One of the most commonly used regional anesthetic techniques in pediatric surgeries is the caudal epidural block. Its main disadvantage remains the short duration of action. Hence, different additives have been used.
- Trial name
- NCT03261921
- Testing
- Dexamethasone, Dexmedetomidine, Bupivacaine
- Volunteers
- 63 people
- Sponsor
- Cairo University
Anesthesia, General
The Effect of Anesthetics on Oxidative Stress and Apoptosis Status in Children
The purpose of this study is to determine whether Propofol and Sevoflurane affect the oxidative stress and apoptosis status in children undergoing hypospadias repair surgery.
- Trial name
- NCT02711280
- Testing
- Sevoflurane, Propofol
- Where
- China
- Volunteers
- 47 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Hypospadias Repair
TIP Repair of Distal Penile Hypospadias Using Rapidly Absorbable Braided Vs Slowly Absorbable Monofilament Sutures
Objective: To study the effect of tubularizing the urethral plate in DPH in children using 2 different absorbable suture materials, rapidly absorbable, braided 6/0 Vicryl and slowly absorbable monofilament 6/0 Polydioxanone, on…
- Trial name
- NCT06413901
- Testing
- TIP
- Where
- Egypt
- Volunteers
- 69 people
- Sponsor
- Cairo University
Postoperative Pain
Intravenous Dexmedetomidin on Postoperative Pain After Hypospadias Repair in Children
This study aimed to evaluate the efficacy of intravenous ketorolac versus dexmedetomidine as analgesia after Hypospadias repair surgery to determine the optimal procedure for pain control and postoperative reduction of analgesic…
- Trial name
- NCT05194904
- Testing
- Dexmedetomidine
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Assiut University
Post-COVID-19 Condition, Ulcerative Colitis
Emerging Indications for Hyperbaric Oxygen Treatment
This study will evaluate the effectiveness of hyperbaric oxygen therapy (HBOT) on treating emerging indications (i.e., conditions that have shown to potentially benefit from HBOT) using the Multicenter Registry for Hyperbaric…
- Conditions
- Post-COVID-19 Condition, Ulcerative Colitis, Crohn Disease, Calciphylaxis
- Trial name
- NCT07240649
- Testing
- Hyperbaric oxygen treatment (HBOT), 100% Oxygen
- Volunteers
- 100 people
- Sponsor
- Jay C. Buckey Jr.
Hydrocele, Inguinal Hernia
The Caudal Space in Children: Ultrasound Evaluation
Caudal anesthesia is commonly employed in pediatrics to produce postoperative analgesia in low abdominal or urologic surgery. An exact understanding of the anatomy of the sacral area including sacral hiatus and surrounding…
- Conditions
- Hydrocele, Inguinal Hernia, Hypospadia, Cryptorchidism
- Trial name
- NCT01896076
- Testing
- ultrasound evaluation of caudal space
- Where
- South Korea
- Volunteers
- 300 people
- Sponsor
- Yonsei University
Hypospadias, Caudal Block
Multifidus Plane Block Versus Caudal Block for Hypospadias
This study aims to evaluate the safety and efficacy of ultrasound-guided sacral multifidus plane block and compare its analgesic effect to ultrasound-guided caudal block in pediatric patients undergoing hypospadias surgery under…
- Trial name
- NCT06561269
- Testing
- Multifidus plane block, caudal block
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Ain Shams University
Hypospadias, Complication,Postoperative
Evaluation of TIP Urethroplasty With Spongioplasty-Dartosoraphy Reinforcement in Pediatric Hypospadias
The study aimed to evaluation of Tubularized incised palate urethroplasty with spongioplasty-dartosoraphy reinforcement (group A) through comparing of functional and cosmetic results of this technique with the conventional TIP…
- Trial name
- NCT05960123
- Testing
- Tubularized Incised Plate (TIP) urethroplasty
- Where
- Egypt
- Volunteers
- 220 people
- Sponsor
- Al-Azhar University
Disorders of Sex Development, Hypospadias
Genetics of Differences of Sex Development and Hypospadias
This study seeks to identify genetic causes of conditions that affect the gonads and genitals, and to study the impact on families of receiving genetic results.
- Trial name
- NCT03102554
- Testing
- Return of Genetic Results
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Boston Children's Hospital
Postoperative Pain
Perfusion Index in Assessment of Postoperative Pain in Children.
The aim of this study will be to examine the validity of perfusion index in predicting pain and evaluation of its severity in the postoperative period.
- Trial name
- NCT06245239
- Testing
- perfusion index
- Where
- Egypt
- Volunteers
- 65 people
- Sponsor
- Assiut University
Tonsillar Hypertrophy, Adenoid Hypertrophy
Interactive Perioperative Teaching Platform (IPTP)
The proposed study will assess whether an interactive perioperative teaching platform (IPTP) provided to families of patients undergoing ambulatory pediatric surgery will reduce families' anxiety, and improve satisfaction and…
- Conditions
- Tonsillar Hypertrophy, Adenoid Hypertrophy, Cryptorchidism, Hypospadias
- Trial name
- NCT03677453
- Testing
- Interactive Perioperative Teaching Platform
- Where
- United States
- Volunteers
- 151 people
- Sponsor
- Vidya Raman
Endocrinology, Disorders of Sexual Development
Retrospective Analysis of the Neonatal Management of Patients with an Antenatal Diagnosis of Genital Development Variation At the Hospital of Lyon
Variations in genital development (VDG) account for 0.5% to 1% of births. Advances in ultrasound techniques, as well as in prenatal diagnosis techniques, particularly in genetics, have led to improvements in the prenatal…
- Conditions
- Endocrinology, Disorders of Sexual Development, Prenatal Diagnosis, Psychology
- Trial name
- PECAN-VDG (NCT06687252)
- Where
- France
- Volunteers
- 170 people
- Sponsor
- Hospices Civils de Lyon
Distal Hypospadias
Incidence of Urethrocutaneous Fistula With and Without Caudal Epidural Block
The study is designed to explore any association between the caudal epidural block(CEB) given for perioperative analgesia and the occurrence of urethrocutaneous fistula postoperatively in children undergoing distal hypospadias…
- Trial name
- NCT03812731
- Testing
- Ropivacaine, Fentanyl Citrate
- Where
- India
- Volunteers
- 30 people
- Sponsor
- Sir Ganga Ram Hospital
Hypospadias
Efficacy of Fibrin Sealant in Hypospadias Surgery
The aim of the study was to evaluate if application of a fibrin sealant over the urethroplasty suture line for waterproofing instead of a dartos vascularized pedicled flap to reduce complications and improve the outcome in…
- Trial name
- NCT05666206
- Testing
- fibrin sealant in hypospadias
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Al-Azhar University
Spina Bifida, Urothelial Neoplasm
Urothelium Tissue Engineering Using Biopsies From Transurethral Resection of Prostate
Different clinical conditions can require urinary bladder augmentation or replacement. Tissue engineered bladder has been clinically evaluated but is not recommended due to diverse side effects.
- Conditions
- Spina Bifida, Urothelial Neoplasm, Bladder, Neurogenic, Bladder Exstrophy
- Trial name
- IMOPU (NCT03698721)
- Testing
- Transurethral Resection of Prostate
- Volunteers
- 365 people
- Sponsor
- Central Hospital, Nancy, France