Clinical trials: Peptic Ulcer Hemorrhage
Bleeding Ulcer
Platelet Rich Plasma in Bleeding Peptic Ulcer
The most common cause of acute upper gastrointestinal bleeding (UGIB) is non-variceal, where peptic ulcer bleeding (PUB) remains the single most common cause, accounting for 25% to 67% of the causes of non-variceal upper…
- Trial name
- PRP (NCT03733171)
- Testing
- PLATELET RICH PLASMA, diluted epinephrine, hemoclips
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Zagazig University
Peptic Ulcer
PPI vs H2RA in Patients With Helicobacter Pylori-Negative Idiopathic Bleeding Ulcers
The aim of this study is to compare the efficacy of a proton pump inhibitor (lansoprazole) and a histamine-2 receptor antagonist (famotidine) in preventing recurrent ulcer bleeding in patients with a history of H.
- Trial name
- NCT01180179
- Testing
- Lansoprazole, Famotidine
- Where
- China
- Volunteers
- 228 people
- Sponsor
- Chinese University of Hong Kong
Peptic Ulcer Hemorrhage
Study Evaluating Pantoprazole in Peptic Ulcer Hemorrhage
The purpose of this study is to evaluate the efficacy and safety of intravenous pantoprazole in the prevention of rebleeding in patients with bleeding peptic ulcer disease after successful endoscopic hemostatic therapy.
- Trial name
- NCT00040495
- Testing
- Pantoprazole
- Volunteers
- 149 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Atherosclerotic Cardiovascular Disease, Coronary Artery Disease
Coated or Chewable Aspirin and a Hybrid Strategy to Mitigate Adverse Effects of Air Pollution in Stable Atherosclerotic Disease
Although both enteric-coated and plain formulations of aspirin are being used commonly, there are no high-quality comparisons between these formulations with respect to clinical efficacy outcomes in patients with atherosclerotic…
- Conditions
- Atherosclerotic Cardiovascular Disease, Coronary Artery Disease, Ischemic Heart Disease, Ischemic Stroke
- Trial name
- COATED-AIR (NCT06541691)
- Testing
- Enteric-coated aspirin, Plain aspirin, Hybrid strategy
- Where
- Iran
- Volunteers
- 3,000 people
- Sponsor
- Rajaie Cardiovascular Medical and Research Center
Peptic Ulcer Hemorrhage
Effect of High-dose Oral Rabeprazole on Recurrent Bleeding After the Endoscopic Treatment of Bleeding Peptic Ulcers
This study is conducted to compare and evaluate the effect of administering a high-dose intravenous proton pump inhibitors or high-dose oral Rabeprazole in preventing recurrent bleeding after the endoscopic treatment of bleeding…
- Trial name
- NCT00838682
- Testing
- omeprazole sodium IV, Rabeprazole
- Where
- 2 sites in South Korea
- Volunteers
- 106 people
- Sponsor
- The Catholic University of Korea
Gastrointestinal Hemorrhage, Stomach Ulcer
Pharmacogenetics of Gastrointestinal Bleeding
Gastrointestinal bleeding is a severe adverse effect occurring in subjects secondary to the use of nonsteroidal anti-inflammatory drugs (NSAIDs). The enzyme CYP2C9 is responsible for the elimination of several NSAIDs.
- Conditions
- Gastrointestinal Hemorrhage, Stomach Ulcer, Non-steroidal Anti-inflammatory Drug Sensitivity
- Trial name
- NCT00190255
- Testing
- CY2PC9 genotyping
- Where
- 4 sites in France
- Volunteers
- 200 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Peptic Ulcer, Bleeding
Effect of IV and Oral Esomeprazole in Prevention of Recurrent Bleeding From Peptic Ulcers After Endoscopic Therapy
The investigators previously showed that the use of a high-dose intravenous PPI regimen after endoscopic control of bleeding from peptic ulcers reduced rate of recurrent bleeding, decreased the need for endoscopic and surgical…
- Trial name
- IOE (NCT01142245)
- Testing
- Oral esomeprazole, Intravenous Esomeprazole
- Where
- 2 sites in China
- Volunteers
- 263 people
- Sponsor
- Chinese University of Hong Kong
Bleeding Peptic Ulcer
Argon Plasma Coagulation vs Hemoclipping for Bleeding Peptic Ulcers
Endoscopic treatment is recommended for initial hemostasis in nonvariceal upper gastrointestinal bleeding. However, the additional hemostatic efficacy of argon plasma coagulation (APC) has not been widely investigated.
- Trial name
- NCT04366583
- Testing
- argon plasma coagulation, hemoclipping
- Where
- Taiwan
- Volunteers
- 166 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Acute Upper Gastrointestinal Non Variceal Hemorrhage
Endoscopic Diagnosis and Treatment of Acute Nonvariceal Upper Gastrointestinal Bleeding
Acute nonvariceal upper gastrointestinal bleeding (ANVUGIB) is a common critical disease in gastroenterology. Due to the development of modern medical technology, the incidence rate of ANVUGIB has been decreasing in recent years…
- Trial name
- NCT04895904
- Testing
- No intervention
- Volunteers
- 3,200 people
- Sponsor
- The First Affiliated Hospital of Nanchang University
Upper Gastrointestinal Bleeding, Peptic Ulcer Hemorrhage
Anticoagulation With Enhanced Gastrointestinal Safety
This study is a pragmatic cluster randomized controlled trial to evaluate the effectiveness of a clinician-facing implementation strategy on the use of medication optimization (defined as either discontinuation of all…
- Conditions
- Upper Gastrointestinal Bleeding, Peptic Ulcer Hemorrhage, Anticoagulant-induced Bleeding
- Trial name
- AEGIS (NCT05563714)
- Testing
- Clinician Notification with Nurse Facilitation (CNNF), Wait list control
- Where
- United States
- Volunteers
- 341 people
- Sponsor
- University of Michigan
Upper Gastrointestinal Bleeding
UI-EWD for Endoscopic Hemostasis of Bleeding Peptic Ulcers and Bleeding After EMR/ESD
UI-EWD (NextBiomedical Co, Incheon, South Korea), a new hemostatic powder for endoscopic treatment of high-risk bleeding peptic ulcers and bleeding after ESD/EMR.
- Trial name
- NCT02978391
- Testing
- UI-EWD Hemostatic system, epinephrine endoscopic injection (conventional therapy)
- Where
- 2 sites in South Korea
- Volunteers
- 76 people
- Sponsor
- Next Biomedical Co., Ltd.
Peptic Ulcer
Natural History of Non-steroidal Anti-inflammatory Drug and Non-Helicobacter Pylori in Bleeding Peptic Ulcers
The aim of this study is to study the natural history of the ulcer healing while on proton pump inhibitors (PPI) and the ulcer recurrence without acid suppression therapy of Non-steroidal Anti-inflammatory Drugs (NSAID)…
- Trial name
- NCT00153712
- Where
- China
- Volunteers
- 391 people
- Sponsor
- Chinese University of Hong Kong
Peptic Ulcer Bleeding
Risk Factors of Rebleeding After Peptic Ulcer Bleeding: a Nationwide Cohort Study
The purpose of the investigators study is to investigate the factors associated with rebleeding in patients with peptic ulcer bleeding.
- Trial name
- KPUB (NCT02152904)
- Where
- South Korea
- Volunteers
- 892 people
- Sponsor
- Joon Sung Kim
Non-variceal Upper Gastrointestinal Bleeding, Gastrointestinal Ulcer
European Survey of Non-Variceal Upper Gastro Intestinal Bleeding (NVUGIB)
The aim of this study is to assess the current management strategies in a pan-European "real-life" setting to uncover the unmet need in this area: non-variceal gastrointestinal bleedings.
- Conditions
- Non-variceal Upper Gastrointestinal Bleeding, Gastrointestinal Ulcer, Gastrointestinal Hemorrhage
- Trial name
- ENERGIB (NCT00797641)
- Where
- 97 sites in Belgium, Greece and 5 more
- Volunteers
- 2,500 people
- Sponsor
- AstraZeneca
Peptic Ulcer
Efficacy of Proton Pump Inhibitor in Prevention of Clopidogrel-related Peptic Ulcer
Proton Pump Inhibitors (PPI) can prevent the recurrence of peptic ulcer in clopidogrel users.
- Trial name
- NCT01138969
- Testing
- esomeprazole
- Where
- Taiwan
- Volunteers
- 165 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Peptic Ulcer Bleeding
Phase II Clinical Study of Vonorasan Fumarate Injection in the Treatment of Peptic Ulcer Bleeding
A Multicenter, Randomized, Double-Blind, Parallel-Group Phase II Clinical Trial to Evaluate the Efficacy and Safety of Vonoprazan Fumarate Injection for the Treatment of Peptic Ulcer Bleeding
- Trial name
- NCT06783257
- Testing
- Vonorasan fumarate injection1, Vonorasan fumarate injection2, Esomeprazole sodium for injection
- Volunteers
- 150 people
- Sponsor
- Shandong New Time Pharmaceutical Co., LTD
Peptic Ulcer Bleeding
Comparing Two Doses of IV Esomeprazole After Successful Endoscopic Therapy
The investigators used two different doses of esomeprazole (40 mg IV q.d. and 40 mg IV q6h for three days followed by esomeprazole 40 mg q.d.
- Trial name
- lowdosePPI (NCT04407832)
- Testing
- heat probe or hemoclip
- Where
- Taiwan
- Sponsor
- Changhua Christian Hospital
Bacterial Infection Due to Helicobacter Pylori (H. Pylori), Peptic Ulcer Bleeding
Helicobacter Pylori and the Long-term Risk of Peptic Ulcer Bleeding
Low-dose aspirin (ASA) has emerged as the most important cause of peptic ulcer bleeding worldwide. In western countries, ASA has overtaken non steroidal antiinflammatory drugs (NSAIDs) as a major cause of peptic ulcer bleeding in…
- Trial name
- 2NA3NANC (NCT01591486)
- Where
- China
- Volunteers
- 904 people
- Sponsor
- Chinese University of Hong Kong
Peptic Ulcer Hemorrhage, Peptic Ulcer, Acute With Hemorrhage
Efficacy of Low Dose Intravenous Proton Pump Inhibitor for Peptic Ulcer Bleeding
We prepare this study to compare the efficacy of intermittent intravenous PPI infusion (relatively low dose PPI therapy) than continous PPI infusion method.
- Conditions
- Peptic Ulcer Hemorrhage, Peptic Ulcer, Acute With Hemorrhage, Peptic Ulcer, Proton Pump Inhibitor Overdose
- Trial name
- NCT03814421
- Testing
- intermittent (40mg as a bolus injection daily for 72hours)
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Samsung Changwon Hospital
Ulcer Hemorrhage
New Technologies for Endoscopic Treatment of Bleeding Gastroduodenal Ulcers
The purpose of the study was to improve treatment results of patients with bleeding gastroduodenal ulcers by endoscopic applications of autoplasma, enriched with platelets and granular sorbent aseptisorb-A.
- Trial name
- NCT04239118
- Testing
- Complex endoscopic treatment with the use of granular sorbent aseptisorb-A and autoplasm enriched with platelets, Traditional methods of endoscopic hemostasis
- Where
- Russia
- Volunteers
- 112 people
- Sponsor
- Voronezh N.N. Burdenko State Medical Academy