Clinical trials: Peptic Ulcer Hemorrhage
Bleeding Peptic Ulcers Disease
Optimal Dose of Omeprazole After Endoscopic Treatment of Bleeding Peptic Ulcers
Bleeding peptic ulcers are one of the major causes of morbidity and mortality for hospital emergency admissions.The initial treatment is endoscopic therapy followed by intravenous omeprazole.
- Trial name
- NCT00519519
- Testing
- Omeprazole
- Where
- 4 sites in Singapore
- Volunteers
- 126 people
- Sponsor
- Singapore General Hospital
Congenital Heart Disease, Upper Gastrointestinal Bleeding
Stress Ulcer Prophylaxis Versus Placebo in Critically Ill Infants With Congenital Heart Disease
Infants with congenital heart disease often require an intervention during their first year of life. Infants are generally admitted to a cardiac intensive care unit and are routinely prescribed stress ulcer prophylaxis to…
- Conditions
- Congenital Heart Disease, Upper Gastrointestinal Bleeding, Stress Ulcer, Infection
- Trial name
- SUPPRESS-CHD (NCT03667703)
- Testing
- Famotidine
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Boston Children's Hospital
Non-bleeding Peptic Ulcer
Diosmin as Adjuvant Therapy in Treatment of Non-bleeding Peptic Ulcer
The aim of the study is to evaluate the safety and efficacy of diosmin as adjuvant therapy in treatment of non-bleeding peptic ulcer patients.
- Trial name
- NCT05670457
- Testing
- Diosmin
- Where
- Egypt
- Volunteers
- 44 people
- Sponsor
- Tanta University
Peptic Ulcer Hemorrhage
Resolution Endoclips Vs Epinephrine Injection and Heater Probe
To compare the efficacy of a novel endoscopic clipping device(Resolution Clip™) and conventional epinephrine injection and heater probe thermocoagulation in control of peptic ulcer bleeding and prevention of recurrent bleeding
- Trial name
- NCT00165009
- Testing
- Resolution clip (endo-clipping device)
- Where
- China
- Volunteers
- 103 people
- Sponsor
- Chinese University of Hong Kong
Peptic Ulcer, Bleeding
TAE and Surgery in Patients With Peptic Ulcer Bleeding Uncontrolled by Endoscopic Therapy
The aim of the study is to compare the outcomes of trans-catheter arterial embolization (TAE) and surgery as salvage therapy of peptic ulcer bleeding after failed endoscopic therapy.
- Trial name
- NCT00766961
- Testing
- Trans-catheter arterial embolization, Surgery
- Where
- China
- Volunteers
- 34 people
- Sponsor
- Chinese University of Hong Kong
Gastroduodenal Ulcer, Marginal Ulcer
Efficacy of Low Dose of Proton Pump Inhibitor in Treatment Bleeding Ulcers
Determining the efficacy of low dose of PPI in management acute peptic ulcer bleeding
- Conditions
- Gastroduodenal Ulcer, Marginal Ulcer, Peptic Ulcer Hemorrhage
- Trial name
- NCT03163680
- Testing
- Omeprazole 40 MG
- Where
- Syria
- Volunteers
- 295 people
- Sponsor
- Damascus Hospital
Early Gastric Cancer, Gastric Dysplasia
Esomeprazole Plus Sucralfate for Post-ESD Ulcer Healing
Endoscopic submucosal dissection (ESD) is an established treatment for early gastric cancer and precancerous lesions. Post-ESD artificial ulcers may lead to complications including delayed bleeding (3-15%) and prolonged healing.
- Conditions
- Early Gastric Cancer, Gastric Dysplasia, Gastric Neoplasms, Peptic Ulcer With Haemorrhage
- Trial name
- NCT07312370
- Testing
- Esomeprazole (Intravenous), Esomeprazole (Oral), Sucralfate Suspension
- Where
- China
- Volunteers
- 120 people
- Sponsor
- LanZhou University
Peptic Ulcer Hemorrhage
Study Evaluating Pantoprazole in Peptic Ulcer Hemorrhage
This is a multicenter, randomized, double-blind, parallel-group, dose-ranging, comparator-controlled study of the effect of pantoprazole on intragastric pH after successful endoscopic hemostasis in hospitalized patients.
- Trial name
- NCT00037570
- Testing
- Pantoprazole
- Where
- 6 sites in United States
- Volunteers
- 12 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Stress Ulcers, Stress-related Mucosal Disease (SRMD)
China Survey of Stress Ulcer Bleeding in Critically Ill Neurosurgical Patients
Stress ulcers or stress-related mucosal disease (SRMD) is defined as "acute superficial inflammation lesions of the gastric mucosa induced when an individual is subject to abnormally elevated physiologic demands."[1] Studies have…
- Trial name
- SUP (NCT02316990)
- Where
- 11 sites in China
- Volunteers
- 1,416 people
- Sponsor
- AstraZeneca
Peptic Ulcer Hemorrhage
Ilaprazole for the Treatment and Prevention of Peptic Ulcer Bleeding in Chinese Patients
The purpose of this phase study is to confirm the efficacy and safety by compare ilaprazole and omeprazole in the treatment and prevention of peptic ulcer bleeding.
- Trial name
- NCT03362281
- Testing
- Ilaprazole, Omeprazole, Ilaprazole tablet
- Volunteers
- 540 people
- Sponsor
- Livzon Pharmaceutical Group Inc.
Peptic Ulcer Bleeding
Tegoprazan And Lansoprazole Effectiveness in Bleeding Peptic Ulcer Treatment
The goal of this clinical trial is to compare the effects of tegoprazan vs lansoprazole in healing bleeding peptic ulcers. It will also teach about the safety of both modalities.
- Trial name
- TALENT (NCT06894992)
- Testing
- Tegoprazan, Lansoprazole
- Where
- 2 sites in Indonesia
- Volunteers
- 162 people
- Sponsor
- Mario Steffanus
Ulcer Bleeding, Upper Gastrointestinal Tract Bleeding
The Use of Over-the-scope-clip for Prevention of Rebleeding in High Risk Peptic Ulcers
Non-variceal acute gastrointestinal bleeding is a common and potentially life-threatening problem. The conventional treatment of this condition is for esophagogastroduodenoscopy (OGD) for haemostasis.
- Trial name
- NCT03160911
- Testing
- Over-the-scope clip (OTSC), Conventional Endoscopic Haemostasis
- Where
- Hong Kong
- Volunteers
- 100 people
- Sponsor
- Chinese University of Hong Kong
Peptic Ulcers
Comparison of Intravenous Omeprazole to Ranitidine on Recurrent Bleeding After Endoscopic Treatment of Bleeding Ulcer
The present study will compare the hemostasis-maintaining effects of intravenous omeprazole and ranitidine in patients with upper gastrointestinal hemorrhage that have undergone endoscopic hemostasis, to establish which…
- Trial name
- NCT00247130
- Testing
- Omeprazole, Ranitidine
- Where
- Japan
- Sponsor
- Keio University
Acute Upper Gastrointestinal Hemorrhage
Endoscopic Treatment of Recurrent Upper GI Bleeding: OTSC [Over the Scope Clip] Versus Standard Therapy
Prospective-randomized trial. Patients with recurrent bleeding from gastroduodenal ulcers are randomized into either endoscopic treatment with the OTSC [Over The Scope Clip] or endoscopic standard therapy.
- Trial name
- STING (NCT01836900)
- Testing
- Endoscopic hemostasis
- Where
- Germany
- Volunteers
- 64 people
- Sponsor
- Kliniken Ludwigsburg-Bietigheim gGmbH
Peptic Ulcer With Haemorrhage
Efficacy of Vonoprazan Versus Intravenous Proton Pump Inhibitors for Prevention of Rebleeding in High Risk Peptic Ulcers Bleeding After Successful Endoscopic Hemostasis
Upper gastrointestinal hemorrhage (UGIH) is common urgency condition.The estimate mortality rate about 7 percent from peptic ulcers disease(PUD).
- Trial name
- NCT05005910
- Testing
- Vonoprazan, PPIs IV infusion
- Where
- Thailand
- Volunteers
- 194 people, healthy volunteers welcome
- Sponsor
- Uayporn Kaosombatwattana
Peptic Ulcers
Oral Versus IV Proton Pump Inhibitor in High-risk Bleeding Peptic Ulcers After Endoscopic Hemostasis
Endoscopic hemostasis has been documented by a number of clinical studies to be effective in decreasing rebleeding, need for emergency surgery, and hospitalization days.
- Trial name
- NCT01182597
- Testing
- Pantoprazole (Pantoloc), Lansoprazole (Takepron OD)
- Where
- 2 sites in Taiwan
- Volunteers
- 190 people
- Sponsor
- National Taiwan University Hospital
Peptic Ulcer Bleeding, Hypoalbuminemia
The Therapeutic Role of Intravenous Albumin Administration for Peptic Ulcer Bleeding Patients With Hypoalbuminemia
To test whether intravenous albumin can decrease the rebleeding rate or shorten the duration of hospitalization in patients with peptic ulcer bleeding and hypoalbuminemia.
- Trial name
- NCT01822600
- Testing
- Human albumin, Omeprazole
- Where
- Taiwan
- Volunteers
- 91 people
- Sponsor
- National Cheng-Kung University Hospital
Peptic Ulcer Bleeding
Tegoprazan Versus Lansoprazole for Endoscopic Ulcer Healing in Bleeding Peptic Ulcers
This clinical trial compares two medicines used to treat bleeding stomach ulcers in people in Indonesia. The researchers want to find out whether tegoprazan or lansoprazole is better at healing these ulcers after 2 weeks of…
- Trial name
- NCT07708545
- Testing
- Tegoprazan tablet, Lansoprazole capsules
- Where
- 3 sites in Indonesia
- Volunteers
- 162 people
- Sponsor
- Universitas Indonesia
Acute Gastrointestinal Bleeding
Randomized Trial of UI-EWD vs. Conventional Endoscopic Therapy for Nonvariceal Upper Gastrointestinal Bleeding
A prospective, multi-center, noninferiority randomized controlled trial designed to compare the efficacy of UI-EWD (Nexpowder™) hemostatic powder versus conventional endoscopic hemostatic therapy in patients presenting with acute…
- Trial name
- TREET (NCT06188585)
- Testing
- UI-EWD, Conventional therapy
- Where
- 14 sites in United States, Canada and 4 more
- Volunteers
- 278 people
- Sponsor
- Medtronic - MITG
Bleeding Peptic Ulcer
Oral Omeprazole in Bleeding Peptic Ulcer
Find out if there is a significant difference between clinical outcome among the patients with bleeding peptic ulcer treated with oral omeprazole compared to those treated with intravenous omeprazole.
- Trial name
- NCT04170270
- Testing
- Omeprazole
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assiut University