Clinical trials: Peptic Ulcers
Refractory Reflux Esophagitis
Compare D961H 20 mg Bid and 20 mg qd in Patients With Refractory Reflux Esophagitis (Inflammation of Lower Esophagus)
This is a phase 3 multicentre, randomised, double-blind, parallel-group, comparative study to evaluate the efficacy of esomeprazole (D961H) 20 mg twice daily and esomeprazole (D961H) 20 mg once daily in patients (in the form of…
- Trial name
- NCT01669811
- Testing
- Esomeprazole (D961H) twice daily, Esomeprazole (D961H) once daily
- Where
- 63 sites in Japan
- Volunteers
- 1,398 people
- Sponsor
- AstraZeneca
Helicobacter Infected Patients
Comparison of Conventional Triple Therapy Versus Sequential Therapy for H. Pylori in Peptic Ulcer Disease: Prospective Randomized Trial
The purpose of this study is to improve first line Helicobacter pylori eradication rate and to compare the sequential versus conventional triple therapy.
- Trial name
- NCT01418300
- Testing
- sequential versus triple
- Where
- South Korea
- Volunteers
- 159 people
- Sponsor
- Jun-Won Chung
Patients Need Upper Gastrointestinal Endoscopy, Peptic Ulcer
Adverse Events During Upper Gastrointestinal Endoscopy
The primary objective is to investigate the adverse events during upper gastrointestinal endoscopy with and without sedation in Chinese population
- Conditions
- Patients Need Upper Gastrointestinal Endoscopy, Peptic Ulcer, Gastric Cancer, Esophagus Cancer
- Trial name
- AEDUGESSH (NCT01979549)
- Where
- 3 sites in China
- Volunteers
- 6,000 people
- Sponsor
- RenJi Hospital
GERD, Reflux Esophagitis
A Novel Endoloop Pre-test to Treat Gastroesophageal Reflux
The purpose of this study was to evaluate the safety and efficacy of endoscopic endoloop pre-test for gastroesophageal reflux before anti-reflux surgery or endoscopic treatment.
- Trial name
- NCT05192538
- Testing
- Endoscopic endoloop pre-test treatment
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Affiliated Hospital to Academy of Military Medical Sciences
Reflux Esophagitis
Study to Investigate the Safety, Tolerability and Efficacy of YH4808 in Patients With Reflux Esophagitis
This study is to investigate the optimal clinical dose and administration methods of YH4808 in patients with reflux esophagitis by evaluating the safety and efficacy after YH4808 oral administration.
- Trial name
- NCT01538849
- Testing
- Esomeprazole 40mg, YH4808 A mg, YH4808 B mg
- Where
- South Korea
- Volunteers
- 154 people
- Sponsor
- Yuhan Corporation
Peptic Ulcers, Upper Gastrointestinal Bleeding
High Versus Standard Dose of Proton Pump Inhibitors (PPIs) in Peptic Ulcer Bleeding
High intravenous dosage of Proton Pump Inhibitors is not better than standard dosage in bleeding peptic ulcers successfully treated by endoscopic therapy
- Trial name
- NCT00374101
- Testing
- omeprazole, pantoprazole
- Where
- 10 sites in Italy
- Volunteers
- 450 people
- Sponsor
- Casa Sollievo della Sofferenza IRCCS
Gastric Ulcer, Gastric Cancer
Hypoxia During Gastroenterological Endoscope Procedures Sedated With Ciprofol In Overweight Or Obesity Patients
Ciprofol is a new general anesthetic, which combine with γ- Aminobutyric acid-a (GABAA) receptor. Ciprofol has shown equivalent anesthetic efficacy of propofol at 1/4 to 1/5 of the dosage.
- Conditions
- Gastric Ulcer, Gastric Cancer, Gastrointestinal Polyp
- Trial name
- SpO2 (NCT05518929)
- Testing
- Ciprofol, Propofol
- Where
- 5 sites in China
- Volunteers
- 1,090 people
- Sponsor
- RenJi Hospital
Bleeding Peptic Ulcer
Oral Omeprazole in Bleeding Peptic Ulcer
Find out if there is a significant difference between clinical outcome among the patients with bleeding peptic ulcer treated with oral omeprazole compared to those treated with intravenous omeprazole.
- Trial name
- NCT04170270
- Testing
- Omeprazole
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assiut University
Liver Cirrhosis, Peptic Ulcer
Proton Pump Inhibitor Plus Propranolol Versus Proton Pump Inhibitor Alone on Peptic Ulcer Healing in Patients With Liver Cirrhosis
Proton pump inhibitor plus propranolol versus proton pump inhibitor alone on peptic ulcer healing in patients with liver cirrhosis: a randomized trail
- Trial name
- PU (NCT04140591)
- Testing
- Proton-pump inhibitor, Propranolol+Proton-pump inhibitor
- Where
- Taiwan
- Volunteers
- 10 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Cardio-cerebrovascular Disease
Cardio-cerebrovascular Disease and Aspirin Ulcer Relapse Evaluation
The aim of this study is to evaluate the efficacy of proton pump inhibitor (PPI), comparing to the mucosal defensive drug, in the prevention of the recurrence of gastric and/or duodenal ulcers during 12 weeks observation in…
- Trial name
- CARE (NCT01051388)
- Testing
- Low-dose PPI (Rabeprazole sodium), High-dose PPI (Rabeprazole sodium), Non-PPI (Gefarnate)
- Where
- Japan
- Volunteers
- 280 people
- Sponsor
- Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan
Bleeding Peptic Ulcer
Over-the-scope Clip Versus Through-the-scope Clip for Endoscopic Hemostasis of High Risk Bleeding Peptic Ulcers
To compare in a multicenter, prospective, randomized, controlled trial the efficacy and safety of OTSC versus TTS clip for first-line hemostasis of high risk bleeding peptic ulcers
- Trial name
- OTSCvsTTS (NCT03551262)
- Testing
- OTSC, TTS clip
- Where
- Italy
- Volunteers
- 88 people
- Sponsor
- Azienda USL Modena
Gastric Cancer, Colon Cancer
Postoperative Oral Nutritional Supplementation After Major Gastrointestinal Surgery
Patients who underwent major gastrointestinal surgery is potentially at risk of malnutrition due to reduced oral intake, increased nutritional need, reduced gastrointestinal absorption function, and/or metabolic changes after…
- Conditions
- Gastric Cancer, Colon Cancer, Pancreatic Cancer, Duodenal Cancer
- Trial name
- NCT01838109
- Testing
- oral nutritional supplement
- Where
- South Korea
- Volunteers
- 174 people
- Sponsor
- Seoul National University Hospital
Stomach Ulcer, Duodenal Ulcer
A Safety and Efficacy Study of Lansoprazole in Preventing Aspirin-Induced Gastric and Duodenal Ulcers
The purpose of this study is to determine whether lansoprazole, once daily (QD), compared to gefarnate, twice daily (BID), is effective in preventing the recurrence of gastric and duodenal ulcers in patients receiving long term…
- Trial name
- NCT00762359
- Testing
- Lansoprazole, Gefarnate
- Where
- 65 sites in Japan
- Volunteers
- 461 people
- Sponsor
- Takeda
Achlorhydria, Gastrinoma
Evaluating Patients With Abnormal Levels of Gastric Acid
This study is used by the Digestive Diseases Branch to evaluate patients with suspected abnormalities in the secretion of gastric acid.
- Conditions
- Achlorhydria, Gastrinoma, Zollinger Ellison Syndrome
- Trial name
- NCT00001240
- Where
- United States
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Peptic Ulcer, Gastroesophageal Reflux
S-CEI of Nexium in Paediatric Patients
To capture safety and efficacy when Nexium are administered to pediatric patients in clinical practice after launch
- Trial name
- NCT03562026
- Where
- 31 sites in Japan
- Volunteers
- 240 people
- Sponsor
- AstraZeneca
Reflux Esophagitis
The Phase III Clinical Trial of X842 Capsules for Reflux Esophagitis
To evaluate the efficacy and safety of X842 Capsules 50 mg compared to Lansoprazole Enteric Capsules for the treatment of reflux esophagitis, and to characterize the population pharmacokinetics of X842 capsules in this patient…
- Trial name
- X842 (NCT07079540)
- Testing
- X842, Lansoprazole
- Where
- 53 sites in China
- Volunteers
- 380 people
- Sponsor
- Jiangsu Sinorda Biomedicine Co., Ltd
Duodenal Ulcer Bleeding
Prophylactic Injection Therapy Reduces Recurrent Bleeding In Forrest Type IIb Duodenal Ulcers
The purpose of this study is to determine whether prophylactic injection therapy reduces recurrent bleeding rate for duodenal ulcers which has the endoscopic stigmata of recent bleeding.
- Trial name
- NCT01471496
- Testing
- prophylactic injection therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Gastrointestinal Hemorrhage
A Comparison of Gastric pH Control With High Dose Intravenous or Oral Esomeprazole
The investigators hypothesize that high dose esomeprazole 80mg given as a bolus, followed by 8mg/h would render gastric pH near neutral and that pH control with esomeprazole given in such a high dose either intravenous or orally…
- Trial name
- NCT00164788
- Testing
- Intravenous bolus injection of esomeprazole, Oral esomeprazole
- Where
- China
- Volunteers
- 7 people
- Sponsor
- Chinese University of Hong Kong
Bleeding Ulcers
Argon Plasma Coagulation for Bleeding Peptic Ulcers
Background: A second endoscopic method added to injection therapy is recommended for high-risk bleeding peptic ulcers. Many endoscopic devices have been proved as useful hemostatic instruments, whereas the hemostatic efficacy of…
- Trial name
- NCT02241044
- Testing
- Argon plasma coagulation, Distilled water
- Where
- Taiwan
- Volunteers
- 116 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Peptic Ulcer
A Comparison of Two Therapeutic Strategies for the Treatment of Aspirin-associated Peptic Ulcers
Esomeprazole plus aspirin compared with esomeprazole alone for the treatment of aspirin-related peptic ulcers.
- Trial name
- NCT01353144
- Testing
- aspirin
- Where
- 3 sites in Taiwan
- Volunteers
- 178 people
- Sponsor
- Kaohsiung Veterans General Hospital.