Clinical trials: Percutaneous Closure
Ventricular Septal Defect, Closure; Interventricular Septum
The Effect of Transcatheter Ventricular Septal Defect Closure on Heart Rate Variability Parameters
In this study; we evaluated the heart rate variability parameters of pediatric patients whose VSDs were closed with the transcatheter method before and after, and compared with the control group.
- Conditions
- Ventricular Septal Defect, Closure; Interventricular Septum, Autonomic Nervous System Imbalance
- Trial name
- NCT04859036
- Testing
- 24 hours ambulatory Holter monitoring
- Where
- Turkey (Türkiye)
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Kayseri City Hospital
Surgical Wound
VASCADE ANTEGRADE-PVD Post-Market Registry
The objective of the registry is to collect procedural outcomes data when the Cardiva VASCADE Vascular Closure System (VCS) is used to seal femoral arterial access sites at the completion of ipsilateral peripheral interventional…
- Trial name
- NCT02948257
- Testing
- Cardiva Medical VASCADE VCS
- Where
- 5 sites in United States
- Volunteers
- 52 people
- Sponsor
- Cardiva Medical, Inc.
Atrial Fibrillation
Interventional Strategies in Treatment of Atrial Fibrillation: Percutaneous Closure of the Left Atrial Appendage Versus Catheter Ablation
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia, associated with an increased risk of morbidity and mortality1.
- Trial name
- ISAR-AF (NCT01363895)
- Testing
- Percutaneous closure of LAA, Catheter ablation of AF
- Where
- Germany
- Volunteers
- 120 people
- Sponsor
- Deutsches Herzzentrum Muenchen
ASD, Brady Arrythmia
Electrocardiographic and Electrophysiologic Changes After Percutaneous Closure of Atrial Septal Defect
Primary outcomes : Determining the incidence of SAN and AVN dysfunction before and after percutaneous ASD closure Comparing ECG and EP parameters of SAN and AVN before and after percutaneous ASD closure Secondary outcomes …
- Trial name
- NCT06761807
- Testing
- Electrophysiology study of heart
- Volunteers
- 65 people
- Sponsor
- Assiut University
VSD, Pediatric Cardiology
Follow-up After Percutaneous Device Closure of Ventricular Septal Defects
Ventricular septal defects (VSDs) are the most common congenital heart defects, accounting for 30-40% of congenital cardiac anomalies.
- Trial name
- NCT07715032
- Testing
- • Amplatzer™ Ductal Occluder (ADO) • Amplatzer™ Muscular VSD Occluder • Amplatzer™ Membranous VSD Occluder
- Volunteers
- 85 people
- Sponsor
- Assiut University
Foramen Ovale, Patent, Nickel Sensitivity
Investigation of Nickel Sensitization After Percutaneous Implantation of Patent Foramen Ovale Occluder
Percutaneous PFO closure has been established as a first-line therapy for preventing recurrent strokes in selected patients. The devices used for the specific purpose contain and release nickel, which is considered as the most…
- Conditions
- Foramen Ovale, Patent, Nickel Sensitivity, Dermatitis Contact Irritant, Metal Allergy
- Trial name
- INSPIRE (NCT04713683)
- Testing
- Percutaneous Patent Foramen Ovale Closure
- Where
- Greece
- Volunteers
- 96 people
- Sponsor
- National and Kapodistrian University of Athens
Cardiogenic Shock, Extracorporeal Membrane Oxygenation
Feasibility and Safety of Total Percutaneous Closure of Femoral Arterial Access Sites in the Veno-arterial ECMO Patients
The most frequent access site for veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is the common femoral artery (CFA), using either an open or percutaneous technique.
- Conditions
- Cardiogenic Shock, Extracorporeal Membrane Oxygenation, Myocarditis, Hypertension, Pulmonary
- Trial name
- NCT04689451
- Volunteers
- 40 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Anal Fistulas, Rectal Fistulas
A Prospective European Post-Market Clinical Evaluation of the CuraSeal Percutaneous Intraluminal Closure System for Anorectal Fistulas
The study is designed as a prospective, non-randomized clinical trial comparing safety and effectiveness of the CuraSeal PICS-AF device to historical data from commercially available devices for the treatment of anorectal…
- Trial name
- NCT02456324
- Testing
- PICS-AF Device, Historical Controls Treated with Commercially Available Fistula Plugs
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Curaseal Inc.
ASD - Atrial Septal Defect
A Multicenter Randomized Controlled Trial of Echocardiography-Guided Atrial Septal Defect Closure Performed in a Mobile Surgical Unit
Cardiovascular disease remains a major threat to global health, and structural heart disease which encompassing congenital heart defects, valvular disease, and cardiomyopathies constitutes a substantial proportion of its burden.
- Trial name
- NCT07273227
- Testing
- Mobile Surgical Vehicle Echocardiography-guided ASD closure Group, Conventional Operating Room Echocardiography-guided ASD closure Group
- Where
- China
- Volunteers
- 300 people
- Sponsor
- China National Center for Cardiovascular Diseases
Minimally Invasive Cardiac Surgery
Percutaneous Plug-based Arteriotomy Closure Device Use in Minimally Invasive Cardiac Surgery
A single-center prospective study. Patients undergoing minimally invasive cardiac surgery between 2017 and 2022 at the Karolinska University Hospital in Stockholm, Sweden are eligible.
- Trial name
- NCT05462769
- Testing
- Percutaneous vascular closure
- Where
- Sweden
- Volunteers
- 600 people
- Sponsor
- Karolinska University Hospital
Atrial Fibrillation, Atrial Appendage
AntiPlatelet theraPy stratEgy followiNg Left Atrial appenDAGe closurE
The APPENDAGE study is a phase 4 multicentre randomized opened clinical trial comparing 2 different antithrombotic strategies following left atrial appendage closure (LAAC) in patients with non valvular atrial fibrillation (AF).
- Conditions
- Atrial Fibrillation, Atrial Appendage, Anticoagulants, Stroke
- Trial name
- APPENDAGE (NCT04796714)
- Testing
- Double antiplatelet therapy, Aspirin, Brain MRI
- Where
- 2 sites in France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Bordeaux
Percutaneous Closure of Artery Access Sites
InSeal Vascular Closure Device Clinical Study Protocol
The InSeal vascular closure device (VCD)is assessed as percutaneous closure of artery access sites for quick hemostasis and ambulation in patients who have undergone large bore endovascular catheterization procedures.
- Trial name
- VCD (NCT01896401)
- Testing
- InSeal's Vascular Closure Device
- Where
- Germany
- Volunteers
- 33 people
- Sponsor
- InSeal Medical Ltd.
Angioplasty, Transluminal, Percutaneous Coronary, Coronary Arteriosclerosis
Safety and Effectiveness Study of the Ensure Medical Vascular Closure Device
The purpose of this study is to determine whether the Ensure Medical Vascular Closure Device is more effective than standard manual compression at sealing the puncture made in the femoral artery following a cardiac or peripheral…
- Conditions
- Angioplasty, Transluminal, Percutaneous Coronary, Coronary Arteriosclerosis, Peripheral Arteriosclerosis
- Trial name
- NCT00345631
- Testing
- Manual Compression, Vascular Closure Device
- Where
- 17 sites in United States
- Volunteers
- 488 people
- Sponsor
- Cordis US Corp.
Aortic Valve Stenosis
Comparison Between Manta and Prostar Closure Devices
Use of the closure device in patient with percutaneous transfemoral aortic valve replacement
- Trial name
- NCT05662748
- Testing
- Transfemoral aortic valve replacement
- Where
- Germany
- Volunteers
- 250 people
- Sponsor
- RWTH Aachen University
Embolism, Paradoxical, Heart Septal Defects, Atrial
PC-Trial: Patent Foramen Ovale and Cryptogenic Embolism
The purpose of this study is to compare two treatments strategies to prevent further attacks in patients who have suffered an stroke or occlusion of a major artery with no obvious reason other than a persistent small opening…
- Trial name
- NCT00166257
- Testing
- Percutaneous closure of patent foramen ovale, Medical antitrhombotic treatment
- Where
- 6 sites in Australia, Austria and 2 more
- Volunteers
- 414 people
- Sponsor
- Foundation for Cardiovascular Research, Zurich
Peripheral Vascular Diseases, Percutaneous Intervention Via Femoral Artery
Angio-seal VIP Versus Perclose ProGlide for Closure of the Femoral Artery in Peripheral Vascular Disease
This study is designed to evaluate the efficacy (device deployment characteristics and performance) and safety (adverse access site related events) of Perclose ProGlide (Abbott Vascular Devices) for femoral access site closure in…
- Trial name
- NCT05334095
- Testing
- Perclose ProGlide, Angio-seal VIP
- Where
- China
- Volunteers
- 1,062 people
- Sponsor
- Xiongjing Jiang
Surgical Wound
RESPECT Trial - (Rapid Extravascular Sealing Via PercutanEous Collagen ImplanT)
The objective of this trial is to demonstrate the safety and effectiveness of the Cardiva VASCADE™ Vascular Closure System (VCS) in sealing femoral arterial access sites.
- Trial name
- RESPECT (NCT01297322)
- Testing
- Manual compression, Cardiva VASCADE™ Vascular Closure System
- Where
- 21 sites in United States, Australia
- Volunteers
- 420 people
- Sponsor
- Cardiva Medical, Inc.
Percutaneous Closure of Artery Access Sites
InSeal VCD Large Bore Vascular Closure Device Safety and Effectiveness Clinical Study
The InSeal vascular closure device (VCD) is assessed as percutaneous closure of artery access sites for quick hemostasis and ambulation in patients who have undergone large bore endovascular catheterization procedures.
- Trial name
- InSealVCD (NCT02628782)
- Testing
- InSeal's Vascular Closure Device
- Where
- 2 sites in Israel
- Volunteers
- 16 people
- Sponsor
- InSeal Medical Ltd.
PFO, Cognitive
Multimodal Brain Function in Migraine Patients With Patent Foramen Ovale
This investigator-initiated, single-center prospective study is designed to clarify how patent foramen ovale (PFO) relates to brain function abnormalities in patients with drug-refractory migraine with aura (MA), and whether…
- Conditions
- PFO, Cognitive, Cognitive Functions, Migraine
- Trial name
- NEURO-PFO (NCT07343154)
- Volunteers
- 45 people
- Sponsor
- Second Xiangya Hospital of Central South University
Arterial Closure Device, Percutaneous Coronary Intervention (PCI)
Femoral Closure Versus Radial Compression Devices Related to Percutaneous Coronary Interventions Study
FERARI is a single centre observational study comparing patients undergoing PCI either using radial compression devices or femoral closure devices at the corresponding access site.
- Conditions
- Arterial Closure Device, Percutaneous Coronary Intervention (PCI), Access Site Bleeding, Adverse Cardiac Events
- Trial name
- FERARI (NCT02455661)
- Testing
- TR Band (TM), AngioSeal, StarClose
- Where
- Germany
- Volunteers
- 600 people
- Sponsor
- Universitätsmedizin Mannheim