Clinical trials: Percutaneous Coronary Intervention (PCI)
Hypertension, Acute Coronary Syndrome (ACS) Undergoing Percutaneous Coronary Intervention (PCI)
Neck-to-Waist Ratio Identifies Chronic Hypertensive Phenotype and Occlusive Myocardial Infarction in Patients Presenting With Acute Coronary Syndrome
aim of this study was to evaluate the relationship between multiple conventional and novel anthropometric measurements and hypertension in patients presenting to the ED with ACS and whether anthropometric indices differ according…
- Conditions
- Hypertension, Acute Coronary Syndrome (ACS) Undergoing Percutaneous Coronary Intervention (PCI), Obesity (Disorder)
- Trial name
- NCT07676656
- Where
- Turkey (Türkiye)
- Volunteers
- 238 people
- Sponsor
- Ercis Sehit Rıdvan Cevik State Hospital
Coronary Angioplasty, Bifurcation Coronary Artery Disease
Initial Study of a MOTHER-DAUGHTER SIDE-BRANCH ACCESS™ DES System (FIH Feasibility Study)
This first in human feasibility study is designed to evaluate the feasibility MD-SBA DES in subjects undergoing percutaneous coronary intervention (PCI) to treat bifurcation lesions.
- Conditions
- Coronary Angioplasty, Bifurcation Coronary Artery Disease, Ischemic Heart Disease (IHD), Percutaneous Coronary Intervention (PCI)
- Trial name
- NCT07649798
- Testing
- MD-SBA DES System
- Where
- Paraguay
- Volunteers
- 13 people
- Sponsor
- Advanced Bifurcation Systems Inc.
Depressive Disorder (Per DSM-V Criteria, Mild-to-moderate), Acute Coronary Syndrome (ACS)
Efficacy of Transcutaneous Auricular Vagus Nerve Stimulation on Alleviating Major Depressive Disorder in Patients With Acute Coronary Syndrome After Percutaneous Coronary Intervention:A Prospective, Double-Blind,Randomized Controlled Study
This is a randomized, controlled study. ACS follow- up patients aged 18 to 80 years old with hemodynamic stability, who are 14 days to 1 year after PCI, are screened through the HAMD score and the HAMA score.
- Conditions
- Depressive Disorder (Per DSM-V Criteria, Mild-to-moderate), Acute Coronary Syndrome (ACS), Percutaneous Coronary Intervention (PCI), Depressive Disorder
- Trial name
- NCT07454070
- Testing
- Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) Intervention
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Jing Han
Acute Coronary Syndrome (ACS) Undergoing Percutaneous Coronary Intervention (PCI)
Livalozet Versus High-intensity Statin in Older Patients With Coronary Artery Disease Undergoing Percutaneous Coronary Intervention
Acute myocardial infarction is one of the leading causes of death in elderly patients, and the importance of lipid-lowering therapy as a secondary prevention strategy to reduce cardiovascular events is emphasized.
- Trial name
- SMARTDECISION2 (NCT07626840)
- Testing
- Pitavastatin/ezetimibe, Atorvastatin or Rosuvastatin
- Volunteers
- 5,000 people
- Sponsor
- Samsung Medical Center
Angina (Stable), Percutaneous Coronary Intervention (PCI)
Advanced Invasive Diagnosis Strategy for Post-PCI Patients With Stable Coronary Syndromes Undergoing Coronary Angiography
AID Post-PCI Angina is as an observational, prospective, single-cohort, multicenter study designed to investigate the causes and origins of post-PCI angina by using the advance invasive diagnosis (AID) strategy combining with…
- Conditions
- Angina (Stable), Percutaneous Coronary Intervention (PCI), INOCA (Ischemia With Non Obstructive Coronary Artery Disease), Chronic Coronary Syndrome
- Trial name
- NCT07638137
- Testing
- An advanced invasive diagnosis (AID) strategy combining with angiography derived physiology (ADP)
- Where
- 5 sites in Spain
- Volunteers
- 246 people
- Sponsor
- Fundacion Investigacion Interhospitalaria Cardiovascular
Coronary Arterial Disease (CAD), Acute Coronary Syndrome (ACS) Undergoing Percutaneous Coronary Intervention (PCI)
Artificial Intelligence Based Timing, Infarct Size and Outcomes in Acute Coronary Occlusion Myocardial Infarction
The present study is practice-driven and merely observational and prospective. In clinical routine, patients who suffer from suspected ACS and do not show ST elevation in the ECG, different timing proposals in the guidelines and…
- Trial name
- ANOMI (NCT06910436)
- Testing
- Coronary Angiogram
- Where
- Italy
- Volunteers
- 1,500 people
- Sponsor
- Azienda Ospedaliera di Bolzano
Coronary Arterial Disease (CAD), Percutaneous Coronary Intervention (PCI)
OPtimal stEnt Deployment stRategy oF Contemporary sTents - Registry to Evaluate Percutaneous Coronary Intervention Using Bioresorbable Scaffolds With Thinner-strut Construction and Guidance by intracOronary Imaging to REduce Scaffold Failure
Implantation of a metallic drug-eluting stent (DES) is currently the gold standard in percutaneous coronary intervention (PCI). However, a DES has several limitations on the long-term, such as chronic local inflammation which may…
- Trial name
- PERFECTRESTORE (NCT06919562)
- Testing
- Percutaneous coronary intervention with protocolized implantation of a second generation thin-strut bioresorbable scaffold guided by intracoronary imaging
- Where
- Netherlands
- Volunteers
- 117 people
- Sponsor
- Albert Schweitzer Ziekenhuis, Netherlands
Percutaneous Coronary Intervention (PCI), Radial Artery Occlusion
Use of Various Types of Introducers in Conventional Radial Access
The purpose of this intervention study is to compare different types of radial introducers used in traditional radial access in terms of the incidence of complications. The main questions it aims to answer are: 1.
- Conditions
- Percutaneous Coronary Intervention (PCI), Radial Artery Occlusion, Radial Artery Spasm
- Trial name
- TIRE (NCT07572422)
- Testing
- catheterization of the radial artery using an classic introducer, catheterization of the radial artery using an introducer with a standard outer diameter and an outer hydrophilic coating, catheterization of the radial artery using an introducer with a reduced outer diameter and an outer hydrophilic coating
- Where
- 2 sites in Russia
- Volunteers
- 3,307 people
- Sponsor
- Pirogov Russian National Research Medical University
Coronary Artery Disease, High Risk PCI
CHIP-CC Registry: A Prospective Multicenter Registry of Complex High-Risk PCI in China
This is a prospective, multicenter, observational registry designed to evaluate clinical outcomes in patients undergoing complex high-risk indicated percutaneous coronary intervention (CHIP-PCI) in China.
- Conditions
- Coronary Artery Disease, High Risk PCI, Percutaneous Coronary Intervention (PCI)
- Trial name
- CHIP-CC (NCT07557238)
- Testing
- Percutaneous Coronary Intervention, Mechanical Circulatory Support
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Guofeng Gao
Percutaneous Coronary Intervention (PCI), Atrial Fibrillation (AF)
Monotherapy With P2Y12 Inhibitors in Patients With Atrial fIbrillation Undergoing Supraflex Stent Implantation
Patients with atrial fibrillation undergoing percutaneous coronary intervention with stent implantation require treatment with different antithrombotic drugs.
- Conditions
- Percutaneous Coronary Intervention (PCI), Atrial Fibrillation (AF), Oral Anticoagulation, P2Y12 Inhibitor
- Trial name
- MATRIX-2 (NCT05955365)
- Testing
- P2Y12 inhibitor, Aspirin, DOAC
- Where
- 15 sites in Belgium, France and 7 more
- Volunteers
- 3,010 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Coronary Arterial Disease (CAD), Coronary Calcification
Orbital Atherectomy vs Intravascular Lithotripsy for the Treatment of Calcified Coronary Nodules (ORBIT-SHOCK).
The ORBIT-SHOCK pilot study is a multicenter, prospective, randomized clinical trial initiated by investigators. It will include patients diagnosed with atherosclerotic coronary artery disease presenting calcified nodules (CN)…
- Conditions
- Coronary Arterial Disease (CAD), Coronary Calcification, Coronary Calcified Nodules, Orbital Atherectomy
- Trial name
- ORBIT-SHOCK (NCT06736665)
- Testing
- Orbital atherectomy, Intravascular lithotripsy, Optical Coherence Tomography (OCT)
- Where
- 6 sites in Spain
- Volunteers
- 50 people
- Sponsor
- Spanish Society of Cardiology
Drug Coated Balloon, Bioresorbable Scaffold
Leave Nothing Behind Study Which Compares DCB With Bail Out BRS Versus BRS Strategy Alone
The goal of this study is to investigate the equivalence in early and long-term efficacy between the two "Leave nothing behind strategies" (Drug-Coated Baloon [DCB] strategy with bail-out BioResorbable Scaffold [BRS] versus BRS…
- Conditions
- Drug Coated Balloon, Bioresorbable Scaffold, Percutaneous Coronary Intervention (PCI), Acute Coronary Syndrome (ACS)
- Trial name
- LNB (NCT07038408)
- Testing
- Angioplasty with DCB (bail-out BRS), Angioplasty with BRS
- Where
- Estonia
- Volunteers
- 2,256 people
- Sponsor
- Ceric Sàrl
Coronary Arterial Disease (CAD), Percutaneous Coronary Intervention (PCI)
Prasugrel Monotherapy Reduced Dose in Acute and Chronic Coronary Syndrome Patients After Percutaneous Coronary Intervention (PROMOTE)
Rationale: Dual antiplatelet therapy, consisting of aspirin and a P2Y12-inhibitor, reduces the risk of stent-related and non-stent-related ischemic events after percutaneous coronary intervention (PCI).
- Trial name
- PROMOTE (NCT06916520)
- Testing
- Prasugrel 5 mg, Dual Antiplatelet (DAPT) Therapy
- Where
- Netherlands
- Volunteers
- 300 people
- Sponsor
- J.P.S Henriques
Coronary Artery Disease, Percutaneous Coronary Intervention (PCI)
Drug Coated Balloon vs. Drug-eluting Stent in Patients With Coronary Artery Disease
Studies exploring the feasibility of drug-eluting balloon (DCB) in de-novo coronary lesions are limited. There are scarce data comparing DCB with drug-eluting stent (DES) in patients with high bleeding risk (HBR), a situation in…
- Trial name
- DCB_DES (NCT07442500)
- Testing
- Drug coated balloon, Drug-eluting stent
- Where
- South Korea
- Volunteers
- 470,000 people
- Sponsor
- Samsung Medical Center
Coronary Artery Disease (CAD), Chronic Total Occlusion (CTO)
AGECTO Study: PCI vs. Optimal Medical Therapy for CTO in the Octogenarian Patients
The study compares an interventional strategy (PCI) with optimal medical therapy (OMT) in ultra-octogenarians with chronic total occlusions (CTO).
- Conditions
- Coronary Artery Disease (CAD), Chronic Total Occlusion (CTO), Percutaneous Coronary Intervention (PCI), Optimal Medical Therapy
- Trial name
- AGECTO (NCT07442526)
- Where
- Italy
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- San Luigi Gonzaga Hospital
Percutaneous Coronary Intervention (PCI), Acute Myocardial Infarction
Aerobic Exercise-induced Effect on Endothelial Function in Patients With Ischaemic Heart Disease
Endothelial dysfunction is one of the aetiological factors in ischaemic heart disease (IHD). Aerobic exercise is effective in improving endothelial function, as measured by flow-mediated dilation (FMD), in patients with IHD.
- Conditions
- Percutaneous Coronary Intervention (PCI), Acute Myocardial Infarction, Angina (Stable), Unstable Angina Pectoris
- Trial name
- ENDO-R (NCT06788275)
- Testing
- Aerobic exercise (MIT), Aerobic exercise (Short HIIT), Aerobic exercise (Long HIIT)
- Where
- 2 sites in Spain
- Volunteers
- 132 people
- Sponsor
- Instituto de Investigación Sanitaria y Biomédica de Alicante
Myocardial Infarction (MI), ST-Elevation Myocardial Infarction
Drug-Coated Balloon Primary PCI in ST-Segment Elevation Myocardial Infarction
Drug-eluting stent (DES)-based primary percutaneous intervention (pPCI) has been established as the standard of care for patients presenting with ST-segment elevation myocardial infarction (STEMI), having demonstrated superiority…
- Conditions
- Myocardial Infarction (MI), ST-Elevation Myocardial Infarction, STEMI, STEMI (STE-ACS)
- Trial name
- DCB-STEMI (NCT07436429)
- Testing
- Drug-Coated Balloon
- Where
- Austria
- Volunteers
- 300 people
- Sponsor
- Medical University of Vienna
Acute Coronary Syndrome (ACS) Undergoing Percutaneous Coronary Intervention (PCI), Anxiety
Educational Video to Improve Understanding and Reduce Anxiety in Heart Attack Patients
Patients who are diagnosed with a heart attack are often confronted with an unexpected hospital admission and an urgent heart catheterization.
- Conditions
- Acute Coronary Syndrome (ACS) Undergoing Percutaneous Coronary Intervention (PCI), Anxiety, Patient Education Materials
- Trial name
- VID-ACS (NCT07424482)
- Testing
- Educational Video
- Where
- Germany
- Volunteers
- 140 people
- Sponsor
- Tobias Schreiber
High-Risk Percutaneous Coronary Intervention (High-risk PCI), Left Ventricular Assist Devices
Interventional Ventricular Assist System for PCI in CHIP Patients
In patients with complex coronary artery disease (CAD), determining the optimal revascularization strategy (percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) remains a challenge.
- Trial name
- REC-CHIPMCS (NCT06373120)
- Testing
- Microaxial flow pump, VA-ECMO
- Where
- China
- Volunteers
- 262 people
- Sponsor
- Shenzhen Core Medical Technology CO.,LTD.
Coronary Artery Disease, Percutaneous Coronary Intervention (PCI)
The 3D Stent Study
The goal of this observational study is to assess the diagnostic performance of 3D Stent to detect stent under-expansion in patients undergoing percutaneous coronary intervention.
- Trial name
- NCT06898021
- Testing
- 3DStent
- Where
- 4 sites in Belgium, France and 2 more
- Volunteers
- 200 people
- Sponsor
- CoreAalst BV