Clinical trials: Percutaneous Coronary Intervention Patients
Atrial Fibrillation, Coronary Artery Disease
Optimizing Antithrombotic Care in Patients With AtriaL fibrillatiON and Coronary stEnt (OAC-ALONE) Study
The purpose of the study is to evaluate non-inferiority of oral anticoagulant (OAC) monotherapy to OAC plus single antiplatelet therapy (APT) in patients with atrial fibrillation (AF) and prior (>12 months) coronary stenting.
- Trial name
- OAC-ALONE (NCT01962545)
- Testing
- OAC alone
- Where
- Japan
- Volunteers
- 690 people
- Sponsor
- Satoshi Shizuta
Coronary Artery Disease
Patient-reported Outcomes After Percutaneous Coronary Intervention
The main objective is to investigate i) continuity of care, ii) health literacy and self-management, iii) adherence to treatment, and iv) patient preferences, healthcare utilization and costs, and to determine associations with…
- Trial name
- CONCARD (NCT03810612)
- Where
- 7 sites in Denmark, Norway
- Volunteers
- 3,417 people
- Sponsor
- Haukeland University Hospital
Acute Coronary Syndrome
Efficacy and Safety Study of Ticagrelor
The purpose of this study is to compare the efficacy and safety of ticagrelor with clopidogrel
- Trial name
- NCT01812330
- Testing
- Clopidogrel, Ticagrelor
- Where
- China
- Volunteers
- 180 people
- Sponsor
- General Hospital of Chinese Armed Police Forces
ST Elevation Myocardial Infarction
Early Initiation of Low Dose Tirofiban for PPCI in STEMI Patients.
Anti-platelet therapy is a key point of acute myocardial infarction (AMI) treatment. Nowadays, dual anti-platelet therapy based on aspirin and ADP-P2Y12 receptor inhibitor is the preferred treatment before primary percutaneous…
- Trial name
- NCT03797729
- Testing
- Tirofiban, Normal saline
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Shanghai Zhongshan Hospital
Platelet Reactivity
Ticagrelor Loading Dose Versus Clopidogrel Loading and Reloading With Ticagrelor.
In the PLATO substudy referring to patients presenting with an ST-elevation Myocardial Infarction(STEMI), out of the 4201 who received ticagrelor, 1326 had been pre-treated with a 600mg clopidogrel loading dose (LD) within 24…
- Trial name
- NCT01961856
- Testing
- Clopidogrel and Ticagrelor, Ticagrelor
- Where
- Greece
- Volunteers
- 74 people
- Sponsor
- University of Patras
Coronary Artery Disease
FAME II - Fractional Flow Reserve (FFR) Guided Percutaneous Coronary Intervention (PCI) Plus Optimal Medical Treatment (OMT) Verses OMT
The overall purpose of the FAME II trial is to compare the clinical outcomes, safety and cost-effectiveness of FFR-guided PCI plus optimal medical treatment (OMT) versus OMT alone in patients with stable coronary artery disease.
- Trial name
- NCT01132495
- Testing
- Stenting plus OMT, OMT, Standard of care
- Where
- 29 sites in United States, Belgium and 11 more
- Volunteers
- 1,170 people
- Sponsor
- Abbott Medical Devices
STEMI (ST Elevation MI), STEMI - ST Elevation Myocardial Infarction
Effect of Guanxinning Tablet on Coronary Microcirculation After Primary Percutaneous Coronary Intervention in Patients With Acute Myocardial Infarction
①Research objective: In a small sample population, through the pre - experimental method, explore and evaluate the effect of Guanxinning tablets on the coronary microcirculation after primary percutaneous coronary intervention…
- Conditions
- STEMI (ST Elevation MI), STEMI - ST Elevation Myocardial Infarction, STEMI, CMD
- Trial name
- NCT07621107
- Testing
- Guanxinning Tablet(GXNT)
- Volunteers
- 70 people
- Sponsor
- Beijing Anzhen Hospital
Contrast-Induced Nephropathy
Sodium Bicarbonate Versus Saline for the Prevention of Contrast-induced Nephropathy
Contrast-induced nephrophaty (CIN) accounts for more than 10% of hospital-acquired renal failure. Hydration with sodium bicarbonate is more protective than isotonic saline in animals. Limited data are available in humans.
- Trial name
- NCT00606827
- Testing
- Sodium Bicarbonate, Isotonic Saline
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- Ospedale Misericordia e Dolce
Myocardial Injury
Cardioprotective Effects of Electroacupuncture Pretreatment Against Coronary Stenting
Myocyte necrosis as a result of elective percutaneous coronary intervention (PCI) occurs in approximately one third of cases and is associated with subsequent cardiovascular events.
- Trial name
- NCT01020942
- Testing
- Electroacupuncture stimulation, No intervention
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Xijing Hospital
ST Elevation Myocardial Infarction
Minimal Invasive Procedure for Myocardial Infarction
In the setting of primary Percutaneous Coronary Intervention (PCI), the investigators hypothesize that a 24-48 hour delay strategy of stenting after successful thrombus aspiration and establishment of Thrombolysis In Myocardial…
- Trial name
- MIMI (NCT01360242)
- Testing
- MIMI procedure (two-step strategy), Immediate Stenting (one-step strategy)
- Where
- 24 sites in France
- Volunteers
- 160 people
- Sponsor
- Centre Hospitalier Annecy Genevois
Coronary Artery Disease
STEEL Percutaneous Coronary Intervention
The principal hypothesis of this study is that two different maintenance regimens of ticagrelor are safe, tolerable and associated with significant inhibition of erythrocyte adenosine reuptake compared to clopidogrel in patients…
- Trial name
- STEEL-PCI (NCT02327624)
- Testing
- Clopidogrel, Ticagrelor 60, Ticagrelor 90
- Where
- United Kingdom
- Volunteers
- 180 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Acute Coronary Syndrome, Percutaneous Coronary Intervention
Registry of Coronary Artery Ill Patients With Platelet Test Results
ONASSIST is a registry of coronary ill patients who have had a functional test measuring anti-platelet effect and/or a genetic profile of response to anti-platelet drugs.
- Conditions
- Acute Coronary Syndrome, Percutaneous Coronary Intervention, Myocardial Infarction
- Trial name
- ONASSIST (NCT02762162)
- Where
- France
- Volunteers
- 5,000 people
- Sponsor
- Action, France
Contrast Induced Nephropathy, Acute Myocardial Infarction
Comparison Between Iso-Osmolar and Ipo-Osmolar Contrast Agents in Patients With Acute Myocardial Infarction (AMI) Undergoing Primary Percutaneous Coronary Intervention (PCI)
The purpose of this study is to determine the incidence of contrast induced nephropathy and myocardial tissue reperfusion following iso-osmolar iodixanol or ipo-osmolar iopromide administration in patients with acute myocardial…
- Trial name
- CONTRAST-AMI (NCT00827788)
- Testing
- Iodixanol, Iopromide
- Where
- Italy
- Volunteers
- 432 people
- Sponsor
- Ospedale San Donato
Percutaneous Coronary Intervention, Virtual Reality
Pain During Femoral Sheath Removal in Patients Undergoing Percutaneous Coronary Intervenion
It is to examine the effect of virtual reality and ice application on the pain level due to femoral sheath extraction.
- Conditions
- Percutaneous Coronary Intervention, Virtual Reality, Nursing Caries, Cryotherapy
- Trial name
- NCT06445387
- Testing
- Virtual Reality Glasses, Ice Application Group, Control Group
- Where
- Turkey (Türkiye)
- Volunteers
- 108 people
- Sponsor
- Amasya University
Acute Myocardial Infarction
TicAgrelor Versus CLOpidogrel in Stabilized Patients With Acute Myocardial Infarction: TALOS-AMI
The purpose of this study is to evaluate the efficacy and safety of clopidogrel in stabilized patients with acute myocardial infarction (AMI) who performed percutaneous coronary intervention (PCI) with drug-eluting stents (DES)…
- Trial name
- NCT02018055
- Testing
- Aspirin+Ticagrelor, Aspirin+Clopidogrel
- Where
- South Korea
- Volunteers
- 2,590 people
- Sponsor
- The Catholic University of Korea
ST Elevation Myocardial Infarction (STEMI)
Effect of Very Early and Rapid Lowering Cholesterol With Evolocumab on Left Ventricular Remodeling in Patients With Anterior STEMI Undergoing Primary PCI
For patients with anterior ST elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI), whether early application of proprotein convertase subtilisin kexin type 9 (PCSK9) inhibitors to…
- Trial name
- EVALUATE-STEMI (NCT05613426)
- Testing
- Rosuvastatin 20 mg, Evolocumab 140 mg/1 ml Subcutaneous Solution [REPATHA]
- Where
- 6 sites in China
- Volunteers
- 119 people
- Sponsor
- Henan Institute of Cardiovascular Epidemiology
Coronary Artery Disease
Korean Multicenter Randomized Controlled Trial (RCT) of Pidogul for Patients With Coronary Stenting
The aim of the current study is to compare the antiplatelet efficacy and safety of clopidogrel napadisilate and clopidogrel bisulfate in Coronary Artery Disease (CAD) patients after coronary stent implantation.
- Trial name
- NCT01584791
- Testing
- clopidogrel napadisilate + aspirin, clopidogrel bisulfate + aspirin
- Where
- South Korea
- Volunteers
- 148 people
- Sponsor
- Seoul National University Hospital
Myocardial Ischemia, Coronary Artery Bypass Grafting
The Effects of Allicor on Patients After Coronary Arteria Revascularization Treatment
Coronary revascularization interventions such as coronary artery bypass graft (CABG) and percutaneous coronary intervention (PCI) are the standard of surgical treatment of patients with myocardial ischemia.
- Conditions
- Myocardial Ischemia, Coronary Artery Bypass Grafting, Coronary Arteriosclerosis, Percutaneous Coronary Revascularization
- Trial name
- TEA-CART (NCT05803759)
- Testing
- Allicor
- Where
- Russia
- Volunteers
- 200 people
- Sponsor
- Institute for Atherosclerosis Research, Russia
Coronary Arterial Disease (CAD), Percutaneous Coronary Intervention (PCI)
Prasugrel Monotherapy Reduced Dose in Acute and Chronic Coronary Syndrome Patients After Percutaneous Coronary Intervention (PROMOTE)
Rationale: Dual antiplatelet therapy, consisting of aspirin and a P2Y12-inhibitor, reduces the risk of stent-related and non-stent-related ischemic events after percutaneous coronary intervention (PCI).
- Trial name
- PROMOTE (NCT06916520)
- Testing
- Prasugrel 5 mg, Dual Antiplatelet (DAPT) Therapy
- Where
- Netherlands
- Volunteers
- 300 people
- Sponsor
- J.P.S Henriques
Myocardial Infarction
Percutaneous Coronary Intervention for Myocardial Infarction at Fujian Provincial Hospital
Research Objectives: This clinical trial aims to evaluate the efficacy and safety of percutaneous coronary intervention (PCI) in patients with myocardial infarction (MI).
- Trial name
- Fu-AMI (NCT07405788)
- Testing
- Percutaneous Coronary Intervention
- Volunteers
- 1,344 people, healthy volunteers welcome
- Sponsor
- Kaiyang Lin