Clinical trials: Percutaneous Coronary Intervention Patients
ST Elevation (STEMI) Myocardial Infarction
High-Dose Rosuvastatin Preloading for Enhanced Outcomes in STEMI Patients Undergoing Primary PCI
To compare the efficacy of high dose rosuvastatin preloading vs placebo before primary PCI in terms of MACE at 30 days
- Trial name
- HEROS-PCI (NCT06924684)
- Testing
- Statin monotherapy (rosuvastatin or atorvastatin)
- Where
- 2 sites in Pakistan
- Volunteers
- 66 people
- Sponsor
- Sheikh Zayed Federal Postgraduate Medical Institute
Reperfusion Injury, Myocardial, Myocardial Infarction
Effect of L-Carnitine on Biomarkers of Myocardial Reperfusion Injury in Patients With STEMI
The study aims is to evaluate the efficacy and tolerability of L-Carnitine on biomarkers of myocardial reperfusion injury in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary PCI by the…
- Trial name
- NCT06564909
- Testing
- L-Carnitine, The standard care for the management of myocardial infarction post PCI
- Where
- Egypt
- Volunteers
- 76 people
- Sponsor
- Ain Shams University
Coronary Artery Disease
Sirolimus-Eluting Stent Versus Standard Stent in Diabetic
The purpose of this study was to determine whether Sirolimus stent implantation is effective in reducing neointimal hyperplasia as compared to Bare metal stent in diabetic patients with de novo coronary artery stenosis.
- Trial name
- DIABETES (NCT00755443)
- Testing
- Drug eluting stent, Bare metal stent
- Where
- Spain
- Volunteers
- 160 people
- Sponsor
- Hospital San Carlos, Madrid
Acute Myocardial Infarction
Inspiratory Muscle Training in Patients With Acute Myocardial Infarction
Pneumonia is uncommon high among patients with acute myocardial infarction (AMI), which increases adverse clinical events and prolongs the hospital stay.
- Trial name
- NCT04491760
- Testing
- Inspiratory Muscle Training
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Guangdong Provincial People's Hospital
Bleeding Complications
Clopidogrel Monotherapy in Patients With High Bleeding Risk
The goal of this research is to show that a shorter duration of two antiplatelet medications (compared to the standard of care) is safe and effective while reducing the risk of bleeding complications.
- Trial name
- NCT05223335
- Testing
- Clopidogrel, Prasugrel, Tricagrelor
- Where
- United States
- Volunteers
- 98 people
- Sponsor
- Mayo Clinic
Coronary Disease
RIAPRE - Non-interventional Registry of Anticoagulation Treatment (BI-006-IT)
RIAPRE is a non-interventional registry to be settled in Italy with the purpose of collecting data on 600 cases of high risk elective percutaneous coronary intervention (PCI) patients treated with an anticoagulation regime…
- Trial name
- NCT00317343
- Testing
- Bivalirudin (thrombin specific anticoagulant)
- Sponsor
- Nycomed
Coronary Artery Disease Left Main, Coronary Artery Disease
Fractional Flow Reserve Versus Angiography for Treatment-Decision and Evaluation of Significant Left MAIN Coronary Artery Disease
The primary purpose of the study was to determine whether the 2-year probability of major adverse cardiac events (primary composite outcome) differed significantly between patients who underwent angiography-guided Percutaneous…
- Trial name
- FATE-MAIN (NCT05829889)
- Testing
- FFR-Guided PCI, Angiography-Guided PCI
- Where
- 49 sites in Hong Kong, India and 3 more
- Volunteers
- 960 people
- Sponsor
- Seung-Jung Park
ST-elevation Myocardial Infarction
Follow-up of Patients Bound for PCI After Implementation of a Helicopter Emergency Medical System
This study compares patients bound for Percutaneous Coronary Intervention (PCI) who were transported by either ground ambulance or emergency medical helicopter.
- Trial name
- NCT02512991
- Testing
- Helicopter Emergency Medical Service
- Volunteers
- 1,604 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Coronary Angiography, Glucagon-Like Peptide 1
Plasma GLP1 and Acute Myocardial Infarction Undergoing Percutaneous Coronary Intervention
The purpose of this study is to evaluate the predicting role of plasma GLP1 level on major adverse cardiovascular events (MACE) in patients with acute myocardial infarction who undergo percutaneous coronary intervention.
- Trial name
- NCT02846168
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Chinese PLA General Hospital
STEMI
CHA2DS2-VASc Score as a Predictor of Thrombus Burden and Clinical Outcomes in Patients Undergoing PPCI.
Aim of the work is to evaluate the use CHA2DS2-VASc score in predicting no-reflow phenomenon and its impact on short term primary percutaneous coronary intervention outcomes (in-hospital mortality) and long term (6 months)…
- Trial name
- NCT04565808
- Testing
- primary percutaneous coronary intervention
- Volunteers
- 184 people
- Sponsor
- Assiut University
STEMI - ST Elevation Myocardial Infarction, Thrombosis Cardiac
Efficacy of Using 50 ml Syringe Manual Thrombectomy Catheter in Primary PCI With Heavy Thrombus Burden
In high thrombus burden subgroup of Acute STEMI, manual aspiration thrombectomy was associated with reduced cardiovascular death but increased stroke or transient ischemic attack.
- Trial name
- NCT06327659
- Testing
- 30 mL syringe manual thrombectomy catheter, 50 mL syringe manual thrombectomy catheter
- Where
- Egypt
- Volunteers
- 88 people
- Sponsor
- Helwan University
Coronary Artery Disease, Acute Coronary Syndromes
CRAGS (Coronary aRtery diseAse in younG adultS)
Young patients requiring myocardial revascularization are generally considered at low operative risk, but data on their immediate and late outcome are scarce.
- Conditions
- Coronary Artery Disease, Acute Coronary Syndromes, Young Patient, Percutaneous Coronary Intervention
- Trial name
- CRAGS (NCT01838746)
- Where
- 9 sites in Finland, Iceland and 2 more
- Volunteers
- 2,000 people
- Sponsor
- University of Turku
Ischemic Heart Disease, Acute Myocardial Infarction
Coronary Thromboaspiration and Infarct Size
Distal embolization can occur during coronary angioplasty performed in the acute phase of myocardial infarction and is associated with poor long-term outcome.
- Trial name
- NCT00456066
- Testing
- Export Aspiration System
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Acute Coronary Syndromes, STEMI
Early Single Antiplatelet Therapy After IVUS-Guided PCI in Acute Coronary Syndrome
This is a prospective, open-label, multicenter, randomized, phase IV clinical trial designed to evaluate the safety and efficacy of early aspirin discontinuation followed by potent P2Y12 inhibitor monotherapy after intravascular…
- Conditions
- Acute Coronary Syndromes, STEMI, NSTEMI, Unstable Angina
- Trial name
- SAPT-ACS (NCT07684742)
- Testing
- Early P2Y12 Inhibitor Monotherapy, Standard Dual Antiplatelet Therapy
- Where
- South Korea
- Volunteers
- 1,900 people
- Sponsor
- Gyeongsang National University Hospital
Acute Coronary Syndrome, Percutaneous Coronary Intervention
Registry of Coronary Artery Ill Patients With Platelet Test Results
ONASSIST is a registry of coronary ill patients who have had a functional test measuring anti-platelet effect and/or a genetic profile of response to anti-platelet drugs.
- Conditions
- Acute Coronary Syndrome, Percutaneous Coronary Intervention, Myocardial Infarction
- Trial name
- ONASSIST (NCT02762162)
- Where
- France
- Volunteers
- 5,000 people
- Sponsor
- Action, France
Coronary Artery Disease
The Effectiveness of Early Mobilisation on Back Pain in Patients Following Percutaneous Coronary Intervention
Percutaneous Coronary Intervention (PCI) is a common revascularization procedure for patients with coronary artery disease. Patients undergoing PCI are often required to remain in a supine position for several hours after the…
- Trial name
- NCT07475273
- Testing
- Early Mobilisation, Standard Post-PCI Care
- Where
- Indonesia
- Volunteers
- 66 people
- Sponsor
- Universitas Sumatera Utara
Multi Vessel Coronary Artery Disease, Non-ST Elevation Myocardial Infarction
PRospective Evaluation of Complete Revascularization in Patients With multiveSsel Disease Excluding chroNic Total Occlusions
This prospective, multicenter, non-randomized, single arm, objective performance goal (OPG) study is designed to evaluate clinical outcomes after complete revascularization by PCI and imaging guidance (OCT) in patients with…
- Conditions
- Multi Vessel Coronary Artery Disease, Non-ST Elevation Myocardial Infarction, Unstable Angina, Stable Angina
- Trial name
- PRESENT (NCT05230446)
- Testing
- PCI with OCT guidance
- Where
- Netherlands
- Volunteers
- 609 people
- Sponsor
- Erasmus Medical Center
PCI Patients, Single Coronary Vessel Disease
Non-Invasive Coronary Functional Evaluation of Patients With Single-vessel Coronary Artery Disease
Persistent or recurrent angina after successful percutaneous coronary intervention (PCI) remains a common clinical problem, affecting approximately 20-30% of patients despite complete epicardial coronary revascularization.
- Trial name
- NICE-CAD-PCI (NCT07805187)
- Testing
- Coronary flow reserve assessed by Echocardiography
- Volunteers
- 32 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Coronary Artery Disease, Percutaneous Coronary Intervention
The Efficacy, Safety and Pharmacokinetic of Antiplatelet Therapy for Vicagrel
This is a multi-center, randomized, double-blind, triple-dummy, parallel-controled, dose-exploration phase II trial. Patients with coronary atherosclerotic heart disease and planned percutaneous coronary intervention （PCI） will…
- Conditions
- Coronary Artery Disease, Percutaneous Coronary Intervention, Platelet Aggregation Inhibitors
- Trial name
- NCT03599284
- Testing
- Vicagrel 5mg, Vicagrel 6mg, Vicagrel 7.5mg
- Where
- 27 sites in China
- Volunteers
- 279 people
- Sponsor
- Jiangsu vcare pharmaceutical technology co., LTD
Myocardial Infarction, Statin Adverse Reaction
Low Dose Rosuvastatin Plus Ezetimibe Versus High-dose Rosuvastatin in AMI
Combination therapy of rosuvastatin 5mg and ezetimibe 10 mg showed similar achievement rate in decreasing LDL cholesterol level by 50% as single use of rosuvastatin 20 mg.
- Conditions
- Myocardial Infarction, Statin Adverse Reaction, HMG-CoA Reductase Inhibitor Toxicity
- Trial name
- ROSUZET-AMI (NCT04499859)
- Testing
- Ezetimibe 10mg + Rosuvastatin 5mg, Rosuvastatin 20mg
- Where
- 7 sites in South Korea
- Volunteers
- 3,548 people
- Sponsor
- Kiyuk Chang, MD,PhD