Clinical trials: Perforated Appendicitis
Appendiceal Abscess
Early Versus Delayed Operation for Perforated Appendicitis
The objective of this study is to scientifically evaluate two different operative strategies for perforated appendicitis with abscess.
- Trial name
- NCT00414375
- Testing
- Operation on Admission, Drainage and Interval Appendectomy
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Children's Mercy Hospital Kansas City
Appendicitis
Once Daily Metronidazole for Perforated Appendicitis
The objective of this study is to determine whether administering once-daily doses of metronidazole, an intravenous (IV) antibiotic used to prevent infection in perforated appendicitis, is as effective in children as delivering…
- Trial name
- METRO (NCT02561117)
- Testing
- Metronidazole
- Sponsor
- Ahmed Nasr
Appendicitis, Appendix Mass
Identification of the Optimal Treatment Strategy for Complex Appendicitis in the Pediatric Population
Aim of this study is to evaluate the effect of different treatment strategies on overall complications, health related-Quality of Life (hr-QOL) and costs among two subtypes of complex appendicitis in children (<18 years old).
- Conditions
- Appendicitis, Appendix Mass, Appendicitis Perforated
- Trial name
- CAPP (NCT04755179)
- Testing
- Laparoscopic appendectomy, Open appendectomy, Non-operative treatment
- Where
- 32 sites in Netherlands
- Volunteers
- 1,308 people
- Sponsor
- Ramon Gorter
Acute Appendicitis, Appendicitis Perforated
Clinical Trial for a Outpatient Clinical Management for Complicated Acute Appendicitis
The aim of this study is to evaluate the safety and efficacy of outpatient management of complicated acute appendicitis. For this purpose, a randomized clinical trial was designed.
- Conditions
- Acute Appendicitis, Appendicitis Perforated, Appendicitis Suppurative
- Trial name
- ASI2 (NCT06059365)
- Testing
- Hospitalization, Outpatient
- Volunteers
- 92 people
- Sponsor
- HJ23
Appendicitis, Perforated Appendicitis
Optimal Care of Complicated Appendicitis
When the appendix becomes infected and inflamed, it is called appendicitis. Sometimes, if the infection and inflammation get worse, the appendix can die or burst, leading to a larger infection or even pus pockets around the…
- Conditions
- Appendicitis, Perforated Appendicitis, Ruptured Appendicitis, Complicated Appendicitis
- Trial name
- NCT03159754
- Testing
- Early Appendectomy, Interval Appendectomy, Antibiotics
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Michigan
Appendicitis
Role of Delay and Antibiotics on Perforation Rate While Waiting Appendectomy
This study evaluates the effects of preoperative delay and antibiotics on perforation rate of appendix while waiting surgery for acute appendicitis.
- Trial name
- PERFECT (NCT04378868)
- Testing
- Antibiotics, cefuroxime and metronidazole, No antibiotics, urgent schedule
- Where
- 2 sites in Finland
- Volunteers
- 1,800 people
- Sponsor
- Helsinki University Central Hospital
Perforated Appendicitis
The Impact of IV Acetaminophen on Pain After Appendectomy for Perforated Appendicitis
The objective of this study is to evaluate two standard post-operative pain regimens routinely used after laparoscopic appendectomy for perforated appendicitis.
- Trial name
- NCT02881996
- Testing
- IV tylenol, No IV tylenol, Ketorolac
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Children's Mercy Hospital Kansas City
Perforated Appendicitis
Effect of Intraperitoneal Drain Placement on Postoperative Outcomes Following Laparoscopic Appendectomy in Adult Patients With Perforated Appendicitis
Acute appendicitis is the most common acute abdomen, and a small number of patients can progress to perforated appendicitis, which has significantly higher complications than non-perforated appendicitis.
- Trial name
- LADPA (NCT06927765)
- Testing
- No abdominal drain is placed
- Where
- China
- Volunteers
- 500 people
- Sponsor
- The Affiliated Hospital of Qingdao University
Gastric Ulcer With Perforation But Without Obstruction, Colon Cancer
Domestic Surgical Robot Clinical Study
Central South University in collaboration with Tianjin University developed the first domestically produced Chinese minimally invasive surgical (MIS) robot system which named "Micro Hand S" in 2013.
- Conditions
- Gastric Ulcer With Perforation But Without Obstruction, Colon Cancer, Cholecystolithiasis, Appendicitis
- Trial name
- NCT02752698
- Testing
- Micro Hand S robotic surgery, laparoscopic surgery, da Vinci robotic surgery
- Where
- China
- Volunteers
- 200 people
- Sponsor
- The Third Xiangya Hospital of Central South University
Acute Appendicitis, Acute Appendicitis With Rupture
Prostaglandin-E Urinary Metabolite (PGE-M) as a Predictor of Acute Appendicitis in Children
Diagnosing acute appendicitis in children remains a clinical challenge, with delayed or incorrect diagnosis potentially leading to serious complications or unnecessary surgery.
- Conditions
- Acute Appendicitis, Acute Appendicitis With Rupture, Abdominal Pain (AP)
- Trial name
- NCT07008092
- Testing
- Blood specimen collection, Urine collection
- Where
- Croatia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- KBC Split
Appendicitis Perforated
Intraperitoneal Administration of Fosfomycin, Metronidazole and Molgramostim Versus Intravenous Antibiotics for Perforated Appendicitis
The objective of this trial is to evaluate if intraoperative intraperitoneal administration of fosfomycin, metronidazole and recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) followed by oral…
- Trial name
- NCT03435900
- Testing
- Combination of fosfomycin, metronidazole and rhGM-CSF (administered together intraperitoneally) and three days of antibiotics p.o., Standard antibiotics intravenously
- Where
- 2 sites in Denmark
- Volunteers
- 13 people
- Sponsor
- Herlev Hospital
Acute Appendicitis, Acute Cholecystitis
Web-based International Register of Emergency Surgery and Trauma
The WIRES-T project (Web-based International Registry of Emergency General Surgery and Trauma) has been set up to allow to all the EGS (Emergency General Surgery) and Trauma surgeons to register their activity and to obtain a…
- Conditions
- Acute Appendicitis, Acute Cholecystitis, Acute Diverticulitis, Post-operative Complications
- Trial name
- WIRES-T (NCT03643718)
- Testing
- Emergency General Surgery
- Where
- Italy
- Volunteers
- 10,000 people
- Sponsor
- A.O. Ospedale Papa Giovanni XXIII
Acute, Perforated Appendicitis
Povidone-iodine Irrigation for Prevention of Intra-abdominal Abscess in Pediatric Perforated Appendicitis: a Multi-center Stepped Wedge Cluster Randomized Study
The purpose of this study is to determine the effect of intra-abdominal irrigation with povidone-iodine (PVI) versus usual care on the rate of 30-day postoperative intra-abdominal abscesses (IAA) and to determine the effect of…
- Trial name
- PAPPA (NCT04200729)
- Testing
- Irrigation with PVI, Usual care
- Where
- United States
- Volunteers
- 1,750 people
- Sponsor
- The University of Texas Health Science Center, Houston
Perforated Appendicitis
Role of Intravenous Versus Home Oral Antibiotics in Perforated Appendicitis
To compare the effect of a single-agent home intravenous (IV) versus oral antibiotic therapy on complication rates and resource utilization following appendectomy for perforated appendicitis
- Trial name
- NCT02724410
- Testing
- home intravenous ertapenem, home oral amoxicillin-clavulanate, peripheral inserted central Catheter
- Volunteers
- 82 people
- Sponsor
- Wake Forest University Health Sciences
Perforated Appendicitis
APPI-Cost Trial for Perforated Appendicitis
The purpose of this study to assess the clinical effectiveness and cost-effectiveness of povidone-iodine (PVI) irrigation in perforated appendicitis, to investigate barriers and facilitators to future implementation of PVI…
- Trial name
- NCT06705842
- Testing
- PVI, Usual Care
- Where
- United States
- Volunteers
- 346 people
- Sponsor
- The University of Texas Health Science Center, Houston
Perforated Appendicitis
Perforated Appendicitis and Postoperative Antibiotics Pilot Trial
The goal of this clinical trial is to learn if not giving antibiotics is as effective as giving antibiotics after surgery for patients who have surgery for a perforated (burst) appendix.
- Trial name
- PAPA Pilot (NCT07656636)
- Testing
- Postoperative antibiotico-prophylaxis, No postoperative antibiotics
- Volunteers
- 100 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Ruptured Appendicitis
Early Versus Interval Appendectomy for Ruptured Appendicitis in Children
The purpose of this randomized trial is to compare two commonly utilized surgical treatments for children with ruptured appendicitis: early appendectomy, versus interval appendectomy.
- Trial name
- RAPTOR (NCT00435032)
- Testing
- early appendectomy, interval appendectomy
- Where
- United States
- Volunteers
- 128 people
- Sponsor
- University of Tennessee
Appendicitis
Diagnostic Accuracy of Serum Bilirubin in the Prediction of Perforated Appendicitis
Hyperbilirubinemia is reported to be a positive predictor in diagnosing perforated appendicitis. Therefore we analysed the diagnostic accuracy of serum bilirubin in discriminating between perforated and simple/no appendicitis.
- Trial name
- NCT01698099
- Where
- Germany
- Volunteers
- 500 people
- Sponsor
- University Hospital Tuebingen
Appendicitis
Importance of Peritoneal Free Fluid Cultures in Acute Appendicitis
The purpose of this study is to evaluate the frequency of positive free fluid cultures in both perforated and non-perforated appendicitis. In addition predictors of positive free fluid cultures will be analyzed.
- Trial name
- IFFSA (NCT01953289)
- Where
- Belgium
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Acute Appendicitis, Acute Appendicitis With Rupture
Validation and Comparison of the Appendicitis Inflammatory Response Score and Adult Appendicitis Score
Acute appendicitis is one of the most frequent reasons of emergency laparotomy in adults. Symptoms of acute appendicitis overlap with other clinical conditions and might present as a challenge, especially in the early phases.
- Trial name
- NCT04730752
- Testing
- Appendicitis Inflammatory Response, Adult Appendicitis Score
- Where
- Turkey (Türkiye)
- Volunteers
- 174 people
- Sponsor
- Nigde Omer Halisdemir University