Clinical trials: Perforation
Macular Holes
Compare the Healing Process of Idiopathic Macular Hole With Different Surgical Techniques
To compare anatomic and functional results, and to evaluate postoperatively the healing process in 2 different techniques for the closure of the macular holes (MH)
- Trial name
- NCT03888625
- Testing
- Conventional ILM Peeling, Inverted ILM Peeling
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Federal University of São Paulo
Bone Augmentation
Use of Perforated Barrier Membranes and IPRF Nano- Micro Sticky Bone
Comparing amount of horizontal bone gain 4 months after alveolar ridge augmentation using IPRF Nano- micro Sticky Bone with perforated collagen membrane versus occlusive barrier membrane by : 1.
- Trial name
- NCT04775940
- Testing
- Perforated collagen membrane, Occlusive collagen membrane
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Esophageal Strictures, Esophageal Leak
Esophageal Stent Migration With Endoscopic Suture Fixation Compared to Standard Deployment
Esophageal stents are commonly used for benign esophageal pathology, especially strictures or esophageal mucosal defects such as leaks, fistulae, or perforations.
- Conditions
- Esophageal Strictures, Esophageal Leak, Esophageal Perforation, Esophageal Fistula
- Trial name
- NCT02751333
- Testing
- FCSEMS with Endostitch (ES), FCSEMS with No Suturing (NS), Fully Covered Self-Expanding Metal Stents (FCSEMS)
- Where
- United States
- Sponsor
- Johns Hopkins University
Tympanic Membrane Perforation
Evaluation of Prognostic Factors in Tympanoplasty
Tympanoplasty is the surgical operation performed for the reconstruction of the eardrum and/or the ossicles. Tympanoplasty is classified into five different types, originally described by Horst Ludwig Wullstein.
- Trial name
- NCT03416725
- Testing
- Otoscope
- Volunteers
- 70 people
- Sponsor
- Assiut University
Perforated Appendicitis
Use of Antibiotic Irrigation to Decrease Wound Infections in Pediatric Perforated Appendicitis
The proposed study will investigate whether antibiotic irrigation using a gentamicin/clindamycin solution during laparoscopic appendectomy is superior in preventing postoperative wound infections and IAA in perforated…
- Trial name
- PA protocol (NCT04039750)
- Testing
- antibiotic rinse with suction, suction only
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Prisma Health-Upstate
Necrotizing Enterocolitis
Analysis of Integrated Clinical, Laboratory and Prognostic Data of Neonates With Necrotizing Enterocolitis
This is a retrospective study led by The Sixth Affiliated Hospital, Sun Yat-sen University, focusing on newborns diagnosed with necrotizing enterocolitis (NEC)-a serious gastrointestinal disease that threatens newborns'…
- Trial name
- ACLPNEC (NCT07207915)
- Testing
- Observational retrospective cohort study
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Acute Abdomen
Upper Gastrointestinal Perforations: a Nationwide Registry-based Study
The primary aim of this project is to increase the knowledge about how perforations in the esophagus, stomach and small intestine are treated on a national level.
- Trial name
- NCT06154603
- Testing
- Surgical treatment type
- Where
- Sweden
- Volunteers
- 2,000 people
- Sponsor
- Region Stockholm
Perforated Appendicitis
Evaluation the Role of Laparoscopic Management of Perforated Appendicitis
A laparoscopic appendectomy (LA) was first reported by Semm in 1983. Since then, its advantages, such as the aesthetic appearance of the wound, less postoperative pain, and faster recovery which facilitates early discharge, have…
- Trial name
- NCT03267082
- Testing
- Laparoscopic management of perforated appendicitis
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Assiut University
Emergent Surgery, Perforated Peptic Ulcer
Short Term Outcome Following Post Operative Enhanced Recovery Implementation in Patients With Perforated Peptic Ulcer
This study aimed to evaluate the effect of implementing post operative enhanced recovery on perforated peptic ulcer surgery outcome.
- Trial name
- NCT06570018
- Testing
- Post operative enhanced recovery elements
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Pectus Excavatum, Pain, Postoperative
Sub-Paraspinal Block in Nuss Patients. A Pilot Project
The purpose of this pilot study was to evaluate effectiveness of a novel regional anesthesia technique developed at the investigators institution, as part of a quality improvement initiative, to assist with multilevel thoracic…
- Trial name
- NCT02169297
- Testing
- Ultrasound-guided Sub-Paraspinal Block, PCA only
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Nemours Children's Clinic
Reconstructive Surgery Using Pedicled Perforating or Free Perforating Flaps, Pelvic Eschar
Study and Modeling of Perforator Flap Vascularization
The aim of reconstructive surgery is to restore physical integrity altered by trauma, congenital malformations or cancerous pathologies.
- Conditions
- Reconstructive Surgery Using Pedicled Perforating or Free Perforating Flaps, Pelvic Eschar, Traumatic Pathology of the Lower and/or Upper Limb
- Trial name
- EMoVaLP (NCT07084740)
- Testing
- PeriCam and PeriFlux measurements
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Montpellier
Macular Holes
Clinical Research on the Effect of Different Extents of Internal Limiting Membrane Peeling on Macular Hole Closure and Visual Acuity
Observing and describing the surgical effects of different extents of internal limiting membrane peeling combined with internal limiting membrane insertion for macular hole
- Trial name
- NCT03805763
- Testing
- Large extent of ILM Peeling, Small extent of ILM Peeling
- Volunteers
- 60 people
- Sponsor
- Wenzhou Medical University
Corneal Perforation, Corneal Stromal Lenticule,Sandwich Technique
A Novel Sandwich Technique of Minimally Invasive Keratoplasty for Corneal Perforation
The goal of this type of study to describe a new sandwich technique of minimally invasive keratoplasty (STMIK) by using SMILE-extracted lenticules for treatment corneal perforation and effectiveness.
- Trial name
- STMIK (NCT06233409)
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Tianjin Eye Hospital
Macular Holes, Epiretinal Membrane
Multimodal Imaging in Vitreo-retinal Surgery and Macular Dystrophies
The aim of the study is to identify morphological and functional biomarkers of post-operative recovery after vitreoretinal surgery, using decisional support systems (DSS), based on multimodal big-data analysis by means of machine…
- Conditions
- Macular Holes, Epiretinal Membrane, Retinal Detachment, Macular Dystrophies
- Trial name
- MICAI (NCT05747144)
- Testing
- Biometry, Retinography (Color) + Autofluorescence (AF), OCT B-scan and OCT angiography (OCTA)
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Bowel Perforation, Abscess
Clinical Significance of Intra-abdominal Hypertension in Surgical Patients With Severe Sepsis
Intra-abdominal pressure(IAP) is defined as a steady state pressure of the abdominal cavity many studies have proved IAP as a prognostic factor that elevated IAP influences hemodynamics and multiple organs dysfunction In previous…
- Conditions
- Bowel Perforation, Abscess, Leakage, Peritonitis
- Trial name
- NCT01784458
- Volunteers
- 46 people
- Sponsor
- University of Ulsan
Coronary Artery Perforation, Coronary Stent Occlusion
Glasgow Natural History Study Of Covered Coronary Interventions
Covered stents (CS) are a potentially lifesaving treatment for grade III coronary perforation but delivery can be challenging, and the long-term durability and safety including risk of acute stent thrombosis are unknown.
- Conditions
- Coronary Artery Perforation, Coronary Stent Occlusion, Stent Thrombosis
- Trial name
- GNOCCI (NCT03862352)
- Testing
- Covered coronary stent
- Where
- United Kingdom
- Volunteers
- 161 people
- Sponsor
- NHS National Waiting Times Centre Board
Orthodontics
Effect of Micro-osteo-perforations on the Rate of Alignment of Mandibular Anterior Teeth.
Micro osteoperforation is an easy, safe and effective method of accelerating orthodontic tooth movement by 2-3 times.it has been reported to increased the osteoblastic activity and some acceleration of the rate of canine…
- Trial name
- NCT05132764
- Testing
- Microosteoperforations
- Where
- Pakistan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Rehman Medical Institute - RMI
Intestinal Obstruction, Intestinal Perforation
Pathophysiology of Perioperative Fluid Management in Emergency Laparotomy
Pathophysiology of perioperative fluid management in patients undergoing emergency laparotomy.
- Conditions
- Intestinal Obstruction, Intestinal Perforation, Anastomotic Leak, Fluid Overload
- Trial name
- NCT03997721
- Where
- Denmark
- Volunteers
- 73 people
- Sponsor
- Copenhagen University Hospital, Hvidovre
Perforated Duodenal Ulcer
Scoring System in Predicting Perforated Duodenal Ulcer Morbidity and Mortality in Bpkihs
Different scoring systems were developed for risk prediction and adjustment of morbidity from perforated duodenal ulcer. However, these scoring systems are not routinely used in perforated duodenal ulcer patient in everyday…
- Trial name
- NCT04994184
- Where
- Nepal
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- B.P. Koirala Institute of Health Sciences
Tympanic Membrane Perforation
A Study on the Regenerative Treatment of Tympanic Membrane With NPC-18 and FBG-18
To assess the efficacy and safety of the regeneration treatment of tympanic membrane with NPC-18 and FBG-18.
- Trial name
- NCT02550314
- Testing
- fiblast,gelatin sponge,fibrin glue
- Volunteers
- 20 people
- Sponsor
- Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan