Clinical trials: Perforation
Perforated Appendicitis
The Impact of IV Acetaminophen on Pain After Appendectomy for Perforated Appendicitis
The objective of this study is to evaluate two standard post-operative pain regimens routinely used after laparoscopic appendectomy for perforated appendicitis.
- Trial name
- NCT02881996
- Testing
- IV tylenol, No IV tylenol, Ketorolac
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Children's Mercy Hospital Kansas City
Esophageal Fistula, Esophageal Perforation
Endoscopic Management of Esophageal Wall Defects
The study aim at comparing outcomes from the implementation of various endoscopic closure techniques including stenting and suturing on the healing and resolution of esophageal wall defects.
- Trial name
- NCT04571541
- Testing
- Stenting
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Indiana University
Macular Hole, Surgery
Internal Limiting Membrane Peeling-reposition to Treat Idiopathic Macular Holes
To compare the morphologic and functional outcomes of internal limiting membrane peeling-reposition versus peeling in idiopathic macular holes
- Trial name
- NCT03020459
- Testing
- peeling-reposition, peeling, Brilliant Blue G
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Corneal Ulcer, Corneal Perforation
Topical Insulin - Utility and Results in Neurotrophic Keratopathy in Stages 2 and 3
Purpose: To evaluate the clinical outcome of patients with refractory Neurotrophic Keratopathy (NK) in stages 2 and 3 treated with topical insulin.
- Conditions
- Corneal Ulcer, Corneal Perforation, Corneal Epithelium Defect, Neurotrophic Keratitis
- Trial name
- NCT04820010
- Testing
- Topical Insulin
- Where
- Portugal
- Volunteers
- 20 people
- Sponsor
- Centro Hospitalar de Vila Nova de Gaia/Espinho, E.P.E.
Surgery, Emergencies
Laparoscopic Versus Open Repair of Peptic Ulcer Perforation
Although laparoscopic repair (LR) of perforated peptic ulcers (PPUs) has long been accepted, clinical evidence comparing LR versus open repair (OR) remains lacking.
- Conditions
- Surgery, Emergencies, Peptic Ulcer Perforation
- Trial name
- LOREPUP (NCT04447170)
- Testing
- Simple repair or Graham technique
- Where
- 13 sites in Italy
- Volunteers
- 200 people
- Sponsor
- Gianluca Costa
Sinus Perforation
Computer Guided Low Window Sinus Lift Technique
The study group included 12 patients that were treated using the low window lateral sinus lift technique with simultaneous implant placement. This was facilitated using a CAD-CAM generated surgical guide.
- Trial name
- NCT04618588
- Testing
- Low Window Sinus Lift technique
- Where
- Egypt
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Hams Hamed Abdelrahman
Periodontal Pocket
Gingival Crevicular Fluid Bone Morphogenetic Protein - 2 Release Profile Following the Use of Perforated Membrane
One of the most important elements suggested to be provided through membrane perforations to augment regeneration are cell released growth factors from the overlying periosteal and gingival cells.
- Trial name
- MPM (NCT01860495)
- Testing
- perforated membrane, G2
- Where
- Egypt
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Varicose Ulcer, Varicose Veins of Lower Limb
Venous Ulcer: Endovenous Radiofrequency Treatment Trial
The aim of this study is to analyze the effect of intravenous therapy with radiofrequency for superficial and perforating venous insufficiency versus compression therapy with multilayer banding in patients with active venous…
- Conditions
- Varicose Ulcer, Varicose Veins of Lower Limb, Saphenous Vein Injury
- Trial name
- VUERT (NCT03293836)
- Testing
- Radiofrequency ablation, Multilayer Compressive Bandage
- Where
- Brazil
- Volunteers
- 84 people
- Sponsor
- Juliana Puggina
Duodenal Perforation, Bowel Perforated
COMPARISON OF CONTINUOUS VERSUS INTERRUPTED-X SUTURING TECHNIQUE FOR CLOSURE OF RECTUS SHEATH IN PATIENTS UNDERGOING EMERGENCY LAPAROTOMY FOR HOLLOW VISCUS PERFORATION
THIS STUDY IS GOING TO COMPARE THE INCIDENCE OF BURST ABDOMEN IN PATIENTS UNDERGOING LAPAROTOMY WOUND CLOSURE IN CONTINUOUS VERSUS INTERRRUPTED-X MANNER
- Trial name
- NCT05632146
- Testing
- Continuous suturing, Interrupted X suturing
- Where
- Pakistan
- Volunteers
- 86 people
- Sponsor
- King Edward Medical University
Harm Reduction, Perforation During Colonoscopy
Fast Track Module Based Colonoscopy Training Programme for Surgical Trainees at North Jutland Surgical Departments
Specially educated trainers will be responsible for colonoscopy training of junior doctors. The educated trainers will have attended seminars held by Valori et al.
- Conditions
- Harm Reduction, Perforation During Colonoscopy, Colorectal Cancer
- Trial name
- NCT02425657
- Testing
- Training of junior doctors
- Where
- 3 sites in Denmark
- Volunteers
- 15 people
- Sponsor
- Aalborg University Hospital
Macular Holes
Small Macular Holes Treated With Air
Non-inferiority trial comparing intraocular air and gas tamponade for closure of macular holes.
- Trial name
- NCT06211907
- Testing
- Postoperative intraocular tamponade
- Where
- 7 sites in Greece, Norway and 1 more
- Volunteers
- 132 people
- Sponsor
- Helse Stavanger HF
Tympanic Membrane Perforation, Eardrum Perforation
Biodesign® Otologic Repair Graft
The post-market follow-up clinical trial of the Cook® Biodesign® Otologic Repair Graft will follow patients up to 3 months post-implantation to determine the percent of patients with complete closure of the tympanic membrane.
- Trial name
- NCT04635228
- Testing
- Biodesign Otologic Repair Graft
- Where
- 5 sites in United States, United Kingdom
- Volunteers
- 87 people
- Sponsor
- Cook Research Incorporated
Tympanic Membrane Perforation
Cartilage Versus Temporalis Fascia Graft in Tympanoplasty for Recurrent Tympanic Membrane Perforation '' Comparative Study ''
Use of Cartilage Versus Temporalis Fascia as a Graft in Tympanoplasty for Recurrent Tympanic Membrane Perforation
- Trial name
- NCT05282810
- Testing
- tympanoplasty
- Volunteers
- 26 people
- Sponsor
- Assiut University
Intrabony Periodontal Defect
Perforated Collagen Membrane With Nanohydroxyapatite for Intrabony Defects
The ultimate goal of periodontal therapy is the regeneration of periodontal tissues which have been destroyed due to periodontal disease.
- Trial name
- NCT03399279
- Testing
- Open flap debridment, Perforated collagen membrane, Occlusive membrane
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Peptic Ulcer Perforation
Peptic Ulcer Perforation Study
The objective of this study is to implement an optimized perioperative course for patients surgically treated for peptic ulcer perforation in order to improve the outcome for these patients.
- Trial name
- PULP (NCT00624169)
- Testing
- An optimized perioperative course
- Where
- 7 sites in Denmark
- Volunteers
- 200 people
- Sponsor
- Copenhagen University Hospital at Herlev
Gastrointestinal Fistula, Gastrointestinal Perforation
Endoscopic Treatment of Intestinal Fistulas and Perforations
Gastrointestinal leaks or perforations are currently treated through either open or laparoscopic surgical procedures. The purpose of this research is to determine whether new endoscopic tools are safe and effective in the…
- Trial name
- NCT01303653
- Testing
- endoscopic closure of gastrointestinal fistulas and perforations
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- The Oregon Clinic
Tympanic Membrane Perforation
Hearing Results and Post Surgical Outcomes Using Amniotic Membrane Allograft vs. Fascia for Tympanoplasty
The trial seeks to provide evidence that the Skye ActiveBarrier provides similar surgical and functional outcomes as fascia when used for tympanoplasties while offering benefits including reduced operative time, better patient…
- Trial name
- NCT03028272
- Testing
- Skye Barrier, Fascia
- Sponsor
- University of Missouri-Columbia
Atrial Septal Aneurysm
Transcatheter Exclusion of Atrial-septal-aneurysm (TEA)
This study aims to investigate the safety and efficacy of transcatheter exclusion of atrial septal aneurysm (ASA) via transseptal perforation in patients with ASA.
- Trial name
- TEA (NCT04561882)
- Testing
- Transcatheter exclusion of atrial septal aneurysm
- Where
- 2 sites in China
- Volunteers
- 70 people
- Sponsor
- China National Center for Cardiovascular Diseases
Peritonitis
Primary vs. Secondary Anastomosis for Hinchey Stage III-IV Diverticulitis a Prospective Randomized Trial
This study compares primary resection with anastomosis and Hartmann's procedure in an adult population with acute perforated colonic diverticulitis (Hinchey Stage III and IV) METHODS: The primary end point was postoperative…
- Trial name
- DIVERTI (NCT00692393)
- Testing
- Hartmann intervention, Protected anastomosis resection
- Where
- France
- Volunteers
- 102 people
- Sponsor
- University Hospital, Rouen
Acute Coronary Syndrome, Myocardial Infarction
Clopidogrel and the Optimization of Gastrointestinal Events (COGENT-1)
The purpose of the COGENT-1 clinical trial is to determine whether CGT-2168 (clopidogrel and omeprazole) compared to clopidogrel is safe and effective in reducing the incidence of gastrointestinal bleeding and symptomatic ulcer…
- Conditions
- Acute Coronary Syndrome, Myocardial Infarction, Coronary Artery Disease, Percutaneous Coronary Intervention
- Trial name
- COGENT-1 (NCT00557921)
- Testing
- CGT-2168 (clopidogrel 75 mg/omeprazole 20 mg) and aspirin, Plavix (clopidogrel 75 mg) and aspirin
- Where
- 491 sites in United States, Australia and 14 more
- Volunteers
- 5,000 people
- Sponsor
- Cogentus Pharmaceuticals