Clinical trials: Performance Status
Pancreatic Cancer
Pancreatic Resection in Fit Octogenarians With Nonmetastatic Pancreatic Cancer
This study looks at how different treatment approaches affect survival in older people with pancreatic cancer that has not spread to other parts of the body.
- Trial name
- PRONPaC (NCT07542782)
- Testing
- All types of surgical tumor resection procedures with curative intent, No surgical resection
- Where
- Germany
- Volunteers
- 2,048 people
- Sponsor
- Medizinische Hochschule Brandenburg Theodor Fontane
Cerebral Palsy, Cognitive Orientation
The Effect of the CO-OP Approach for Children With Cerebral Palsy
In the literature, despite the reported positive findings of the Cognitive Orientation to daily Occupational Performance (CO-OP) approach, studies in this area have been limited and it is stated that studies involving more sample…
- Trial name
- NCT04308200
- Testing
- CO-OP approach, NDT
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- ZEYNEP KOLİT
Cancer, Geriatric Syndrome
Risk-Based Geriatric Assessment-Driven Management in Older Patients Starting Chemotherapy
Older patients with cancer are at increased risk of severe chemotherapy-related toxicities due to comorbidities, functional impairments, and geriatric syndromes.
- Conditions
- Cancer, Geriatric Syndrome, Frailty, Chemotherapy Toxicity
- Trial name
- NCT07485634
- Testing
- Geriatric Assessment-Driven Management Algorithm (GA-MA)
- Where
- Hong Kong
- Volunteers
- 70 people
- Sponsor
- The University of Hong Kong
Carcinoma, Non-Small-Cell Lung
Efficacy and Safety Study of Afatinib to Treat Lung Cancer Patients
The purpose of this study is to examine the efficacy and safety of using afatinib (BIBW 2992) to treat non-small cell lung cancer patients considered unfit for chemotherapy and have either suspected or confirmed Epidermal Growth…
- Trial name
- TIMELY (NCT01415011)
- Testing
- Afatinib (BIBW 2992)
- Where
- 15 sites in United Kingdom
- Volunteers
- 39 people
- Sponsor
- University College, London
Carcinoma, Non-Small-Cell Lung, ErbB Receptors
Afatinib in EGFR+NSCLC (Recurrent or Stage IV) - Patients With Poor Performance Status (ECOG 2 or 3)
There is a medical need for improving treatment of poor performance status patients with EGFR driver mutations and documenting safety and tolerability of existing agents.
- Trial name
- NCT02695290
- Testing
- Afatinib
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Boehringer Ingelheim
Poor Performance Status
Nighttime Feeding and Morning Endurance Performance
The purpose of this study is to investigate the influence of a nighttime feeding on next morning running performance, hydration status, and exercise metabolism in female endurance athletes.
- Trial name
- NCT02160873
- Testing
- chocolate milk
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Florida State University
Brain Metastases From Solid Tumors
Comparison of the Therapeutic Effects of Methylprednisolone and Dexamethasone on Peritumoral Edema During Radiotherapy for Brain Metastases:
This study is a multicenter, open label, randomized controlled, adaptive phase II/III seamless design clinical trial aimed at comparing the efficacy and safety of methylprednisolone (MP) and dexamethasone (DEX) in the treatment…
- Trial name
- NCT07542288
- Testing
- Methylprednisolone (Corticosteroid), Dexamethasone
- Where
- China
- Volunteers
- 400 people
- Sponsor
- The Second Affiliated Hospital of Hainan Medical University
Cancer
E-MOSAIC Electronic Tool to Monitor Symptoms
RATIONALE: A hand held electronic tool used to monitor symptoms and assess quality of life may improve communication between patients and their doctors and improve the ability to plan treatment for patients with advanced cancer…
- Trial name
- NCT00477919
- Where
- 7 sites in Switzerland
- Volunteers
- 264 people
- Sponsor
- Swiss Cancer Institute
Malignant Neoplasm
Movement and Fitness Trackers in Determining Performance Status
This trial studies the use of movement and fitness trackers in determining performance status of patients with cancer who are taking part in early phase clinical.
- Trial name
- NCT03971266
- Testing
- Activity Monitor, Media Intervention
- Where
- 2 sites in United States
- Volunteers
- 31 people
- Sponsor
- University of Southern California
Gastrointestinal Cancer
Beyond Performance Status: Electronic Activity Monitoring to Assess Functional Activity of Patients With Gastrointestinal Malignancy During Chemotherapy.
Electronic activity monitoring (EAM) devices are wearable electronic devices that monitor functional activity and provide personal feedback on activity progression.
- Trial name
- NCT02909062
- Testing
- Electronic Activity Monitoring (EAM), Daily Questionnaire
- Where
- 6 sites in United States
- Volunteers
- 54 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Cancer
Do Self-Rated Performance Status Scores Correlate With Health-Care-Provider-Scores?
The purpose of this study is to determine if patients are able to self-rate their physical abilities and how these ratings compare to the ratings of their health-care provider.
- Trial name
- NCT00735111
- Testing
- Karnofsky Performance Status Score
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Florida
NSCLC
Iressa v BSC (Best Supportive Care) in First Line NSCLC
The purpose of the study is to determine if the addition of Iressa to Best Supportive Care treatment will increase the progression free survival of chemo-naïve, poor performance status patients, with stage IIIB or IV NSCLC.
- Trial name
- INSTEP (NCT00259064)
- Testing
- Gefitinib
- Where
- 36 sites in Australia, Canada and 3 more
- Volunteers
- 216 people
- Sponsor
- AstraZeneca
Adenocarcinoma of the Lung, Adenosquamous Cell Lung Cancer
Docetaxel With Either Cetuximab or Bortezomib as First-Line Therapy in Treating Patients With Stage III or Stage IV Non-Small Cell Lung Cancer
This randomized phase II trial is studying how well giving docetaxel together with either cetuximab or bortezomib works as first-line therapy in treating patients with stage III or stage IV non-small cell lung cancer.
- Conditions
- Adenocarcinoma of the Lung, Adenosquamous Cell Lung Cancer, Large Cell Lung Cancer, Malignant Pleural Effusion
- Trial name
- NCT00118183
- Testing
- docetaxel, cetuximab, bortezomib
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- National Cancer Institute (NCI)
Healthy
Hormonal Status, Performance and Health in Elite Female Athlete
The repercussions of the hormonal status of high-level sportswomen on their performance and health as well as on the Athlete's Biological Passport (ABP) have been little studied and remain poorly known.
- Trial name
- FEMMES (NCT05028959)
- Testing
- Multidisciplinary monitoring of healthy women
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Université Paris-Saclay-Assistance publique des hôpitaux de Paris
Lung Cancer
Erlotinib + Bevacizumab for PS 2 Chemotherapy Naïve Non-Small Cell Lung Cancer
The strategy for combining therapeutic agents in cancer treatments has been successful in multiple tumor types, including NSCLC. Erlotinib and bevacizumab target different pathways involved in tumor growth.
- Trial name
- NCT00367601
- Testing
- Erlotinib, Bevacizumab
- Where
- 13 sites in United States
- Volunteers
- 25 people
- Sponsor
- Nasser Hanna, M.D.
Acute Respiratory Failure
Effect Of Acute Inflammatory Mediators On Functional Limitations In Patients With Acute Respiratory Failure
This is a randomized, controlled, pilot study of two separate Cohorts of patients from the intensive care unit. Cohort I will enroll 50 patients and randomize to receive one physical therapy session per day or receive usual ICU…
- Trial name
- NCT01707303
- Testing
- Early ICU rehabilitation strategies, Usual Care
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Wake Forest University
NSCLC
A Survival Study for Women With Advanced Lung Cancer Who Have Not Previously Received Chemotherapy.
This is a randomized, open-label, multinational, phase III study in women with histologically- or cytologically-confirmed advanced NSCLC who are chemotherapy naïve and have PS 2.
- Trial name
- PIONEER (NCT00269828)
- Testing
- paclitaxel, paclitaxel poliglumex
- Where
- 143 sites in United States, Argentina and 9 more
- Volunteers
- 600 people
- Sponsor
- CTI BioPharma
Non Small Cell Lung Cancer
Performance Status During Treatment With Pemetrexed in Patients With NSCLC
The primary research objective of this observational study in pretreated patients with NSCLC of Stage IIIa/b or Stage IV is to evaluate patients' Karnofsky Index (KI) after the second cycle of second-line treatment with single…
- Trial name
- PERFORMANCE (NCT00540241)
- Testing
- Pemetrexed
- Where
- Germany
- Volunteers
- 542 people
- Sponsor
- Eli Lilly and Company
Primary Brain Tumor, Glioblastoma
Temozolomide in Elderly Patients With KPS < 70
The management of glioblastoma in elderly patients with poor performance status (KPS<70) is unsettled. This single arm phase 2 trial trial was designed to evaluate the efficacy and safety of temozolomide alone in this population
- Trial name
- TAG (NCT01242566)
- Testing
- Temozolomide
- Where
- France
- Volunteers
- 70 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Unsatisfactory or Defective Restoration of Tooth
Clinical Evaluation of Posterior Indirect Resin Composite Restorations With PBE
Evaluation of posterior indirect resin composite restorations with proximal box elevation technique. Restoration of large posterior defects extending below the cemento-enamel junction (CEJ) with coverage of one or more cusps…
- Trial name
- NCT03832829
- Testing
- Indirect composite restoration
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital