Clinical trials: Perfusion
Infant, Premature, Diseases, Respiratory Insufficiency Syndrome of Newborn
Impact of CPAP Level on V/Q Mismatch in Premature Infants
Continuous positive airway pressure (CPAP) is used in premature infants to maintain lungs open and facilitate gas exchange. When ventilation/perfusion (V/Q) mismatch is present, areas of the lung that are open for gas exchange do…
- Trial name
- NCT02983825
- Testing
- Continuous positive airway pressure (CPAP); level changes
- Where
- 3 sites in United States
- Volunteers
- 21 people
- Sponsor
- Children's Hospital of Philadelphia
Coronary Artery Disease (CAD), Myocardial Ischemia
A Study of XTR004 Radiotracer in Healthy Volunteers
XTR004 is a 18F-labeled myocardial perfusion positron emission tomography tracer use to measure myocardial perfusion and myocardial blood flow.
- Trial name
- NCT05195879
- Testing
- XTR004
- Where
- China
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Sinotau Pharmaceutical Group
Coronary Artery Disease
Comparison of Cardiac Imaging Techniques for Diagnosing Coronary Artery Disease
A large number of cardiac catheterizations are performed each year, primarily to diagnose heart disease. However, a cardiac catheterization is an invasive procedure which is associated with serious complications such as heart…
- Trial name
- PACIFIC (NCT01521468)
- Where
- Netherlands
- Volunteers
- 210 people
- Sponsor
- Amsterdam UMC, location VUmc
Peripheral Arterial Disease, Diabetes Mellitus
SPECT/CT Imaging of Skeletal Muscle Perfusion
This study will use SPECT/CT imaging to assess the effect of percutaneous revascularization treatments in patients with Peripheral arterial disease and diabetes mellitus, in whom the disease can progress more quickly than in…
- Trial name
- NCT02791204
- Testing
- SPECT/CT imaging following revascularization procedures, SPECT/CT imaging
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Yale University
Transcutaneous Monitoring, Microcirculation
Transcutaneous Monitoring of Oxygen and Carbon Dioxide in Surgical Patients
The study will investigate if non-invasive continuous transcutaneous blood gas monitoring can detect tissue perfusion and hypoxemia and the relation to other circulatory parameters such as pulse, blood pressure, cardiac output…
- Conditions
- Transcutaneous Monitoring, Microcirculation, Peripheral Perfusion, Tissue Metabolism
- Trial name
- NCT04040478
- Testing
- Transcutaneous monitoring
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Pneumoperitoneum, Trendelenburg Position
End-expiratory Pressure During Laparoscopic Surgery in the Trendelenburg Position by Electrical Impedance Tomography
Pneumoperitoneum (PNP) and the position of the patient required for laparoscopic surgery lead to pathophysiological changes that complicate anesthesia.
- Conditions
- Pneumoperitoneum, Trendelenburg Position, Laparoscopic Surgery
- Trial name
- CP-EIT (NCT06481124)
- Testing
- electrical impedance tomography
- Where
- Russia
- Volunteers
- 50 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Diaphragm Injury
Comparison of Supraclavicular and Costoclavicular Brachial Plexus Blocks in Adult Patients
Hemidiaphragmatic paresis is a common side effect of brachial plexus blocks such as supraclavicular or infraclavicular block techniques.
- Trial name
- NCT06329440
- Testing
- Ultrasonographic measurement of diaphragm thickness
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Istanbul University
Coronary Heart Disease
Optimization of 99mTc-Sestamibi Activities in SPECT/CT Myocardial Perfusion Imaging
This work suggests a methodology to adapt the injected radionuclide activity to the level of attenuation of each patient. The investigators propose a dose reduction adapted to the patient's weight, with no significant degradation…
- Trial name
- OSPECT (NCT05146323)
- Where
- France
- Volunteers
- 294 people
- Sponsor
- Centre Hospitalier Régional Metz-Thionville
Type1diabetes, Insulitis
Pancreas Ultrasound Imaging in type1 Diabetes
The overall goal of this study is to develop and test a novel method involving ultrasound imaging, in order to detect the development of type 1 diabetes.
- Conditions
- Type1diabetes, Insulitis, Pancreas Inflamed
- Trial name
- NCT05482321
- Testing
- Definity Suspension for Injection
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Type2 Diabetes Mellitus, Stable Coronary Artery Disease
Effects of SGLT2 Inhibition on Myocardial Insulin Sensitivity
A Phase III, single-centre, randomized, 2-arm, parallel-group, double blind, placebo-controlled study, consisting of a screening phase (Days -14 to -1), a 4-week double-blind, placebo-controlled treatment phase and a 4-week…
- Trial name
- DapaHeart (NCT03313752)
- Testing
- Dapagliflozin 10Mg Tab
- Where
- Italy
- Volunteers
- 25 people
- Sponsor
- Giaccari Andrea
Undetermined Ovarian Mass
Characterization of Ovarian Masses Unable to Classify With Gynecological Ultrasonography: Value of Pelvic MRI With Perfusion- and Diffusion-weighted Imaging
The aim of the study is to prospectively evaluate the value of pelvic MRI including diffusion- and perfusion-weighted sequences in the selected group of patients that have an undetermined ovarian mass at ultrasound.
- Trial name
- IOTAMRI (NCT02425540)
- Testing
- Pelvic MRI
- Where
- Belgium
- Volunteers
- 74 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Myocardial Infarction (MI)
Contribution of Myocardial Perfusion Imaging in the Initial Assessment of Acute Coronary Syndromes Without ST Elevation for the Diagnosis of Myocardial Infarction or Differential Diagnoses
Patients with myocardial infarction require invasive treatment involving coronary angiography to confirm the diagnosis and, in most cases, treatment by angioplasty/stenting.
- Trial name
- APRICOT (NCT07112820)
- Testing
- perfusion ultrasound
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Adebrelimab, Hepatocellular Carcinoma
Evaluation of Effectiveness and Safety of HAIC in Combination With Adebrelimab and Bevacizumab for Potentially Resectable Hepatocellular Carcinoma
Primary liver cancer mainly consists of three different pathologic types: hepatocellular carcinoma, intrahepatic cholangiocarcinoma, and hybrid HCC-ICC, of which HCC accounts for 90%.
- Trial name
- NCT06405061
- Testing
- Adebrelimab
- Where
- 4 sites in China
- Volunteers
- 40 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Cardiac Perfusion
Del Nido Cardioplegia Randomized Trial
The use of a modified depolarizing cardioplegia solution in adult cardiac surgery would allow for prolonged re-dosing intervals while providing equivalent myocardial protection.
- Trial name
- NCT02442050
- Testing
- del Nido solution, Blood-based cardioplegia
- Where
- 2 sites in United States
- Volunteers
- 99 people
- Sponsor
- Inova Health Care Services
The Time for Determine CPPopt
NIRS Directed Optimal Cerebral Perfusion Pressure in Aneurysmal Subarachnoid Hemorrhage Patients: A Feasibility Study
Neurologic dysfunction is common in aneurysmal subarachnoid hemorrhage (aSAH) patients. As we know, after the initial injury, secondary insults including poor cerebral perfusion are main contributors to poor outcome and their…
- Trial name
- NCT03879330
- Testing
- NIRS monitoring
- Volunteers
- 30 people
- Sponsor
- Xiangya Hospital of Central South University
Chest Pain
Prognosis of Very Low Dose SPECT
Nuclear stress testing evaluates whether the heart receives enough blood, by injection of a nuclear isotope during a stress on the heart that permits taking pictures of the heart muscle.
- Trial name
- NCT01387152
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Columbia University
Hypertension
The Effect of Renal Denervation on Biological Variables
Hypertension is a major and growing public health concern. Chronic elevation of sympathetic nervous system (SNS) activity has been identified as a major contributor to the complex pathophysiology of (essential) hypertension.
- Trial name
- NCT01427049
- Testing
- renal denervation
- Where
- Netherlands
- Volunteers
- 54 people
- Sponsor
- UMC Utrecht
Traumatic Brain Injury With Loss of Consciousness, Brain Injury Traumatic Severe
Cerebral Autoregulation, Brain Perfusion, and Neurocognitive Outcomes After Traumatic Brain Injury
Cognitive impairment after moderate to severe traumatic brain injury (msTBI) not only significantly affects the quality of life in individuals with msTBI, but also increases the possibility of late-life dementia.
- Conditions
- Traumatic Brain Injury With Loss of Consciousness, Brain Injury Traumatic Severe, Brain Injury Traumatic Moderate, TBI (Traumatic Brain Injury)
- Trial name
- CAPCOG-TBI (NCT06480838)
- Where
- 3 sites in United States
- Volunteers
- 130 people
- Sponsor
- University of Texas Southwestern Medical Center
Perfusion Index, Upper Extremity Surgery
Comparison of 90° and 120° Arm Positions in Costoclavicular Block
The costoclavicular approach of the infraclavicular brachial plexus block is widely used for upper extremity surgeries due to its reliable anatomy and high success rates.
- Conditions
- Perfusion Index, Upper Extremity Surgery, Brachial Plexus Block, Regional Anaesthesia
- Trial name
- COSTO-RCT (NCT07586670)
- Testing
- Costoclavicular Brachial Plexus Block
- Volunteers
- 106 people
- Sponsor
- Ankara Etlik City Hospital
Lung Diseases
Evaluating the Addition of Hemodiafiltration to EVLP - Impact on the Regeneration of Marginal Donor Lungs
The primary objective of the study is the evaluation of the effect of hemodiafiltration during ex vivo lung perfusion in marginal donor lungs, and its feasibility.
- Trial name
- NCT06082401
- Testing
- hemodiafiltration (HDF), Ex vivo lung perfusion (EVLP)
- Where
- Austria
- Volunteers
- 30 people
- Sponsor
- Medical University of Vienna