Clinical trials: Perfusion Imaging, open to volunteers
Sickle Cell Disease
Relationship Between Abnormal Myocardial Perfusion and Diastolic Dysfunction in Sickle Cell Disease Using PET
There is limited information on what causes injury to the heart in individuals with Sickle Cell Disease (SCD). Researchers in this study want to see if decreased blood flow to the heart during stress could be causing the heart…
- Trial name
- NCT05583721
- Testing
- [13N]NH3, Lexiscan, Positron emission tomography
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- St. Jude Children's Research Hospital
Pulmonary Embolism, Venous Thromboembolism
Residual Pulmonary Vascular Obstruction Index Computed With Ventilation/Perfusion SPECT/CT Imaging to Predict the Risk of Venous Thromboembolism Recurrence in Patients With Pulmonary Embolism (PRONOSPECT)
Major risk after pulmonary embolism (PE) is recurrence, fatal in 10% of patients. Patients with PE can be stratified in 3 groups according to the risk of recurrence : very low risk, high risk or Intermediate risk.
- Trial name
- PRONOSPECT (NCT06372730)
- Testing
- Ventilation/Perfusion Single Photon Emission Computed Tomography (V/Q SPECT/CT)
- Where
- 13 sites in France
- Volunteers
- 665 people
- Sponsor
- University Hospital, Brest
Myofascial Pain Syndrome (MPS), Chronic Low-back Pain (cLBP)
Imaging Metabolic and Perfusion Changes in Acupuncture Therapy for Myofascial Pain Syndrome
This study will evaluate the clinical and biological effects of acupuncture for chronic low back pain associated with myofascial pain syndrome (MPS).
- Trial name
- IMPACT-MPS (NCT07494162)
- Testing
- Acupuncture, Total-Body PET/CT Imaging
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- University of California, Davis
Ventricular Tachycardia, Monomorphic, Ventricular Tachycardia (V-Tach)
Imaging and Treatment Planning for Cardiac Radioablation
Cardiac radioablation is a new treatment for ventricular tachycardia (VT), which uses beams of radiation to treat heart scar that causes VT.
- Conditions
- Ventricular Tachycardia, Monomorphic, Ventricular Tachycardia (V-Tach), Ischemia, Myocardial
- Trial name
- ITPCR (NCT06938074)
- Testing
- CT and MRI
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- Stewart Gaede
Lung Neoplasm
Ventilation Using Radiographic Examination: Functional Lung Imaging Techniques for the Reduction of Toxicity in Functional Avoidance Radiation Therapy
The goal of this observational validation study is to determine the best implementation of fluoroscopic and CT ventilation imaging in patients having non-stereotactic ablative body radiotherapy (non-SABR) radiotherapy for stages…
- Trial name
- VENTURE (NCT06159660)
- Where
- Australia
- Volunteers
- 15 people
- Sponsor
- University of Sydney
Gynecologic Cancers, Ovarian Cancer
Near-Infrared Fluorescence Imaging With Indocyanine Green to Evaluate Bowel Anastomoses in Gynecologic Oncology Surgery
The goal of this study is to evaluate if indocyanine green (ICG) fluorescence imaging helps reduce complications in bowel surgery performed during gynecologic cancer operations.
- Conditions
- Gynecologic Cancers, Ovarian Cancer, Endometrial Cancers, Cervical Cancers
- Trial name
- INOCA (NCT06871787)
- Testing
- Indocyanine Green, Near-Infrared Fluorescence Imaging System
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Istanbul University
Type1diabetes, Insulitis
Pancreas Ultrasound Imaging in type1 Diabetes
The overall goal of this study is to develop and test a novel method involving ultrasound imaging, in order to detect the development of type 1 diabetes.
- Conditions
- Type1diabetes, Insulitis, Pancreas Inflamed
- Trial name
- NCT05482321
- Testing
- Definity Suspension for Injection
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Heart Failure With Reduced Ejection Fraction (HFrEF), Chronic Heart Failure
Vericiguat and Reverse Remodeling Indices in Heart Failure
The goal of this clinical trial is to investigate how vericiguat benefits adults with stable heart failure with reduced ejection fraction (HFrEF) who are already receiving guideline-directed medical therapy.
- Trial name
- VERI-PATH (NCT07405944)
- Testing
- Vericiguat, Guideline Directed Medical Therapy for Heart Failure (GDMT)
- Where
- 4 sites in Slovenia
- Volunteers
- 70 people
- Sponsor
- University Medical Centre Ljubljana
Coronary Artery Disease
Chronic Coronary Syndrome in Swedish Primary Care
The goal of this clinical trial is to learn about a new procedure for investigation of possible coronary heart disease and to see if it is faster, cheaper or more expensive, promotes healthier behavior, mental well-being…
- Trial name
- COSPRI (NCT05782582)
- Testing
- Package investigation, Sound registration with Cadscore® and added risk calculation, Standard investigation
- Where
- 3 sites in Sweden
- Volunteers
- 500 people
- Sponsor
- Region Östergötland
Achilles Tendon Repairs/Reconstructions, Pilon Fracture of Tibia
Enhancing Wound Perfusion in High-Risk Lower Extremity Orthopaedic Surgery: A Study on Nitropaste Using Intraoperative SPY Imaging.
Enhancing Wound Perfusion in High-Risk Lower Extremity Orthopaedic Surgery: A Feasibility Study on Nitropaste Using Intraoperative SPY Imaging.
- Conditions
- Achilles Tendon Repairs/Reconstructions, Pilon Fracture of Tibia, Tibial Plateau Fracture, Ankle Fracture (Bimalleolar Equivalent, Bimalleolar, or Trimalleolar)
- Trial name
- SPY NITROPASTE (NCT07004764)
- Testing
- Nitroglycerin Ointment 2%
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- Johns Hopkins University
Neuro ICU, Sub Arachnoid Hemorrhage
Comparison of Ultrasound Cerebral Perfusion Imaging With Routine Perfusion CT
The primary goal of neurocritical care is to prevent secondary brain injury, which worsens neurological outcomes. Because clinical monitoring is often insufficient due to the patient's condition and medical treatments, multimodal…
- Conditions
- Neuro ICU, Sub Arachnoid Hemorrhage, Neurological Complication, Cerebral Ischemia
- Trial name
- SCULPT (NCT07324421)
- Testing
- Ultrasound contrast agent (Contrast-enhanced ultrasound)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Resolve Stroke
Coronary Artery Disease
A Head-to-Head Comparison of A New Perfusion Tracer, 99mTc-4BOH vs. 13N-NH3 to Evaluate Diagnostic Efficacy of Ischemic Heart Disease
The objective of the study is to assess the diagnostic efficacy (specificity and sensitivity) of 99mTc-4BOH SPECT myocardial perfusion imaging (MPI) compared to 13N-ammonia PET MPI in the detection of significant coronary artery…
- Trial name
- NCT06980194
- Testing
- 99mTc-4BOH SPECT myocardial perfusion imaging, 13N-ammonia PET myocardial perfusion imaging
- Volunteers
- 300 people
- Sponsor
- China National Center for Cardiovascular Diseases
Soft Tissue Filler Complication, Surgical Flap Ischemia
Randomized Evaluation of Indocyanine Green Fluorescence Angiography-Guided Versus Standard Clinical Perfusion Assessment During Gluteal Permanent Synthetic Filler Removal
This randomized clinical trial will compare indocyanine green fluorescence angiography-guided assessment with standard clinical assessment of gluteal flap perfusion during removal of permanent synthetic fillers.
- Conditions
- Soft Tissue Filler Complication, Surgical Flap Ischemia, Tissue Necrosis
- Trial name
- NCT07808957
- Testing
- Indocyanine Green, Standard Clinical Perfusion Assessment
- Where
- Colombia
- Volunteers
- 300 people
- Sponsor
- Research Inc
Cardiac Disease
Replacing Spatial Filtering With Deep-learning Noise Reduction
Spatial filtering is routinely required to reduce the statistical noise of gated SPECT myocardial perfusion imaging, but at the expense of image blurring.
- Trial name
- DEEPLAIM (NCT07888218)
- Where
- France
- Volunteers
- 49 people
- Sponsor
- Central Hospital, Nancy, France
Coronary Artery Disease, Chronic Coronary Syndrome
Quantitative Myocardial Perfusion Imaging Assessment by SPECT/CT
Myocardial perfusion single-photon emission computed tomography (SPECT) is a well-established functional imaging technique for the assessment of coronary artery disease.
- Trial name
- SUV-RESERVE (NCT07708805)
- Testing
- stress SPECT/CT, rest SPECT/CT
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Régional d'Orléans
Status Epilepticus, Ictal-interictal Continuum
The Role of Imaging in the Diagnosis, Management and Prognosis of Possible Non-convulsive Status Epilepticus
The investigators propose a prospective study of 20 control subjects and 180 consecutive patients with possible non-convulsive status epilepticus (NCSE). The investigators will obtain three functional images of the brain: 1.
- Conditions
- Status Epilepticus, Ictal-interictal Continuum, Positron-emission Tomography, Perfusion Weighted MRI
- Trial name
- NCT06017973
- Testing
- MRI scan including arterial spin labelling of the brain, CT perfusion scan of the brain, FDG-PET scan of the brain
- Where
- Belgium
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Liver Neoplasms, Gastric Cancer (GC)
A Subharmonic-Aided Pressure Estimate Technology for Prediction of Response to Systemic Therapy in Gastric Cancer Liver Metastases
Gastric cancer is a common type of cancer that often spreads to the liver. When cancer spreads to the liver, treatment becomes very difficult. Many patients will undergo chemotherapy to shrink the tumor.
- Conditions
- Liver Neoplasms, Gastric Cancer (GC), Gastric Cancer Metastatic to Liver
- Trial name
- NCT07581730
- Testing
- SHAPE
- Volunteers
- 107 people
- Sponsor
- The First Hospital of Jilin University
Colorectal Liver Metastasis, Liver Neoplasms
A Prospective Study of a Subharmonic-Aided Pressure Estimate Technology for Early Prediction of Response to Systemic Therapy in Colorectal Cancer Liver Metastases
Colorectal cancer is a common type of cancer that often spreads to the liver. When cancer spreads to the liver, treatment becomes very difficult. Many patients will undergo chemotherapy to shrink the tumor.
- Conditions
- Colorectal Liver Metastasis, Liver Neoplasms, Colorectal Neoplasms
- Trial name
- NCT07583381
- Testing
- SHAPE
- Volunteers
- 107 people
- Sponsor
- The First Hospital of Jilin University
Healthy Volunteer, Coronary Arterial Disease
Ultralow Dose PET Imaging of 18F-flurpiridaz
The goal of this clinical trial is to evaluate an investigational ultralow dose positron emission tomography (PET) imaging technique for known or suspected coronary artery disease (for detecting myocardial ischemia or infarction)…
- Conditions
- Healthy Volunteer, Coronary Arterial Disease, Myocardial Ischemia, Myocardial Infarction
- Trial name
- NCT07284576
- Testing
- 18F-flurpiridaz
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Akiva Mintz
Perfusion, Fluorescence Imaging
Micro-dosing Indocyanine Green (ICG) in Children
The goal of this cohort study is to identify the lowest dose of Indocyanine Green (ICG) that achieves satisfactory intra-operative fluorescence for the assessment of gastrointestinal or genitourinary tract perfusion in children.
- Conditions
- Perfusion, Fluorescence Imaging, Gastrointestinal Tract Disorders, Genitourinary Disease
- Trial name
- NCT06421103
- Testing
- Indocyanine Green (ICG)
- Where
- United Kingdom
- Volunteers
- 90 people
- Sponsor
- Great Ormond Street Hospital for Children NHS Foundation Trust