Clinical trials: Periampullary Cancer
Pancreatic and Periampullary Tumors
Pancreatoduodenectomy in Pancreatic and Periampullary Tumors
Background: Recently it has been observed in pancreatic cancer that after apparently complete surgical resection, histological examination of the surgical specimen according to a standard protocol reveals tumor infiltration of…
- Trial name
- DUOPAN-EPAM (NCT02803814)
- Testing
- Superior mesenteric artery approach for pancreatoduodenectomy, Classic approach for pancreatoduodenectomy
- Where
- Spain
- Volunteers
- 154 people
- Sponsor
- Fundación para la Investigación del Hospital Clínico de Valencia
Pancreatic Neoplasms
Respiratory-gated Stereotactic Body Radiation Therapy for Adenocarcinoma of the Pancreas or Periampullary Region
This is a single center, single arm unblinded prospective study of the safety of pancreatic stereotactic body radiation therapy (SBRT) in patients with unresectable, borderline resectable, or recurrent pancreatic/periampullary…
- Trial name
- NCT02780648
- Testing
- Stereotactic Body Radiation
- Where
- 2 sites in United States
- Volunteers
- 36 people
- Sponsor
- Indiana University
Pancreatic Cancer, Pancreatic Adenocarcinoma
EUS BD vs ERCP TP for Pancreatic Cancer
This Endoscopic Ultrasound guided Biliary Drainage (EUS-BD) vs. Endoscopic Retrograde Cholangiopancreatography (ERCP-TP) trial (BILPAL) is a randomized controlled multicenter trial that will provide evidence whether or not…
- Conditions
- Pancreatic Cancer, Pancreatic Adenocarcinoma, Biliary Tract Neoplasms, Biliary Duct Obstruction
- Trial name
- BILPAL (NCT03063554)
- Testing
- Endoscopic Ultrasound Guided Biliary Drainage, ERCP
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Weill Medical College of Cornell University
Pancreatic Cancer, Biliopancreatic Diseases
Endoscopic Management of Biliopancreatic Disease in the Lombardy Pancreas Units
The GENTLENESS study is a prospective, multicenter, observational registry designed to evaluate the endoscopic management of patients with suspected biliopancreatic and periampullary neoplastic diseases within the Pancreas Units…
- Conditions
- Pancreatic Cancer, Biliopancreatic Diseases, Periampullary Neoplasms
- Trial name
- GENTLENESS (NCT07418164)
- Where
- 13 sites in Italy
- Volunteers
- 2,500 people
- Sponsor
- IRCCS San Raffaele
Pancreas Cancer, Periampullary Carcinoma
Role of Pre-operative CPET in Pancreatoduodenectomy
A clinical database has been prospectively maintained by the investigators, with details of pancreatic resections since January 2016.
- Trial name
- WHIPPLES (NCT06068452)
- Where
- United Kingdom
- Volunteers
- 113 people
- Sponsor
- East Lancashire Hospitals NHS Trust
Adult Primary Cholangiocellular Carcinoma, Advanced Adult Primary Liver Cancer
Cediranib Maleate and Combination Chemotherapy in Treating Patients With Advanced Biliary Cancers
This phase II trial is studying how well giving cediranib maleate together with combination chemotherapy works in treating patients with advanced biliary cancers.
- Conditions
- Adult Primary Cholangiocellular Carcinoma, Advanced Adult Primary Liver Cancer, Cholangiocarcinoma of the Extrahepatic Bile Duct, Cholangiocarcinoma of the Gallbladder
- Trial name
- NCT01229111
- Testing
- cediranib maleate, oxaliplatin, leucovorin calcium
- Where
- 7 sites in United States
- Volunteers
- 14 people
- Sponsor
- National Cancer Institute (NCI)
Pancreatic Neoplasm, Pancreatic Periampullary Cancer
The Effect of Application of TachoSil® in Pancreatoduodenectomy
Fibrinogen/thrombin-coated collagen patch (TachoSil®) is known to have the effect of strengthening tissue anastomosis and promoting suturing to prevent leakage.
- Conditions
- Pancreatic Neoplasm, Pancreatic Periampullary Cancer, Pancreatic Bordeline Tumor
- Trial name
- NCT03269955
- Testing
- Fibrinogen/thrombin-coated collagen patch
- Where
- South Korea
- Volunteers
- 126 people
- Sponsor
- Asan Medical Center
Sarcopenia, Pancreatic Cancer
Preoperative Prehabilitation for Sarcopenic Patients Prior to Pancreatic Surgery for Cancer
Major digestive surgery is associated with a significant rate of postoperative complications. To improve postoperative outcome, efforts are focused on postoperative course leading to the concept of rehabilitation.
- Trial name
- PSOAS (NCT04469504)
- Testing
- Prehabilitation program, Oral Impact
- Where
- France
- Volunteers
- 6 people
- Sponsor
- University Hospital, Lille
Periampullary Adenocarcinoma, Periampullary Cancer
Chemotherapy, Host Response and Molecular Dynamics in Periampullary Cancer
The CHAMP (Chemotherapy, Host response And Molecular dynamics in Periampullary cancer) study is a prospective, single-arm observational study that started Sept 1 2018.
- Conditions
- Periampullary Adenocarcinoma, Periampullary Cancer, Pancreatic Cancer
- Trial name
- CHAMP (NCT03724994)
- Testing
- Gemcitabine
- Where
- Sweden
- Volunteers
- 201 people
- Sponsor
- Lund University
Pancreatic Fistula After Pancreaticoduodenectomy
Isolated Roux Loop Pancreaticojejunostomy Versus Pancreaticogastrostomy After Pancreaticoduodenectomy
Pancreaticoduodenectomy (PD)is the treatment of choice for patients with periampullary tumour (benign or malignant). In the recent years, the mortality rate of PD has decreased to 5% in many centers.
- Trial name
- PD (NCT01859806)
- Testing
- Pancreaticogastrostomy group, Isolated Roux PJ group
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Mansoura University
Pancreas Cancer, Pancreas Neoplasm
The Role of the Human Microbiome in Patients After Pancreatic Resection.
The goal of this observational study is to classify patients that undergo pancreatic resection for presumed pancreatic or periampullary malignancy into high and low risk groups for postoperative complications based on…
- Conditions
- Pancreas Cancer, Pancreas Neoplasm, Pancreas Adenocarcinoma, Periampullary Cancer
- Trial name
- MiPac (NCT06381882)
- Testing
- Pancreatic resection
- Where
- Netherlands
- Volunteers
- 200 people
- Sponsor
- St. Antonius Hospital
Hepatocellular Carcinoma, Cholangiocellular Carcinoma
Gemcitabine, Oxaliplatin, Tarceva &/or Cisplatin in HCC & Biliary Tree Cancers
This is a single arm phase II trial of Gemcitabine and Oxaliplatin (Gem-Ox) with Erlotinib (Tarceva) for the treatment of hepatocellular carcinoma (HCC) and biliary tree cancer (BTC) patients with platelet counts 100,000/µL.
- Conditions
- Hepatocellular Carcinoma, Cholangiocellular Carcinoma, Cholangiocarcinoma of the Extrahepatic Bile Duct, Bile Duct Cancer
- Trial name
- Gem-ox (NCT00832637)
- Testing
- Cisplatin, Erlotinib, Gemcitabine
- Where
- 2 sites in United States
- Volunteers
- 33 people
- Sponsor
- New Mexico Cancer Research Alliance
Pancreatic Cancer, Cholangiocarcinoma
Margin Status After Pancreaticoduodenectomy for Cancer
This multicentric prospective randomized controlled trial (RCT) compares the Leeds Pathology Protocol (LEEPP) with other "conventional" pathological protocol of PD specimen for periampullary cancer.
- Conditions
- Pancreatic Cancer, Cholangiocarcinoma, Ampullary Cancer
- Trial name
- NCT03267966
- Testing
- Leeds Pathology Protocol (LEEPP)
- Volunteers
- 168 people
- Sponsor
- Campus Bio-Medico University
Biliary Stricture, Biliary Obstruction Due to Common Bile Duct Stone
SpyGlass AMEA Registry
The purpose of this study is to document indications for cholangioscopy and clinical utility of the SpyGlass Direct Visualization System (DVS) throughout the AMEA (Asia, Middle-East, Africa) region when used per standard of…
- Conditions
- Biliary Stricture, Biliary Obstruction Due to Common Bile Duct Stone, Periampullary Tumor, Hemobilia
- Trial name
- NCT02281019
- Testing
- ERCP (Endoscopic Retrograde Cholangiopancreatography), SpyGlass DVS and SpyGlass Digital Simple (DS)
- Where
- 20 sites in Australia, Hong Kong and 8 more
- Volunteers
- 526 people
- Sponsor
- Boston Scientific Corporation
Pancreaticoduodenectomy, Postoperative Pancreatic Fistula
Pancreatic Parenchymal Injection of N-butyl-2-cyanoacrylate
This randomized controlled trial investigates the safety and efficacy of injecting N-butyl-2- cyanoacrylate (Histoacryl®) into the pancreatic parenchyma during pancreaticoduodenectomy (PD) to enhance the security of the…
- Conditions
- Pancreaticoduodenectomy, Postoperative Pancreatic Fistula, Pancreas Cancer, Periampullary Cancer
- Trial name
- NBCA (NCT07230509)
- Testing
- Pancreatic parenchymal injection of N-butyl-2- cyanoacrylate(Histoacryl®)Injection Group., Standard Pancreaticojejunostomy
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Minia University
Pancreatic Fistula, Pancreas Cancer
Reinforced Pancreaticojejunostomy With or Without glubran2
Pancreatic fistula is one of the most serious complication after pancreatoduodenectomy. To reduce pancreatic fistula, many authors recommend different techniques in pancreatojejunostomy.
- Conditions
- Pancreatic Fistula, Pancreas Cancer, Periampullary Carcinoma, Pancreatic Ductal Adenocarcinoma
- Trial name
- NCT06756074
- Testing
- Reinforced pancreaticojejunostomy with tissue adhesive glue modified cyanoacrylate (glubran 2), Pancreaticojejunostomy without tissue adhesive glue modified cyanoacrylate (glubran 2)
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Minia University
Pancreaticoduodenectomy
Minimally Invasive Pancreatico-duodenectomy
Open pancreaticoduodenectomy (PD) is the standard treatment for a wide array of periampullary and pancreatic diseases including malignant and benign conditions.
- Trial name
- LPD (NCT02807701)
- Testing
- Laparoscopic pancreaticoduodenectomy, Open pancreaticoduodenectomy
- Volunteers
- 40 people
- Sponsor
- Mansoura University
Periampullary Cancer, Borderline Malignancy Tumor
The Effect of ERAS on Pancreaticoduodenectomy (v2.0)
Enhanced Recovery After Surgery (ERAS) is not a program that aims to reduce postoperative hospital stay, but the multimodal strategies that aim to attenuate the loss of, and improve the restoration of, functional capacity after…
- Trial name
- NCT06009224
- Testing
- ERAS perioperative management
- Where
- South Korea
- Volunteers
- 334 people
- Sponsor
- Asan Medical Center
Pancreatic Cancer, Periampullary Carcinoma
Evaluation of Preoperative Biliary Drainage Before Pancreatoduodenectomy
The purpose of this study is to evaluate the efficacy of preoperative biliary drainage (PBD) which is performed prior to pancreatoduodenectomy candidates with obstructive jaundice by observing the prevalence of drainage and…
- Trial name
- NCT01941342
- Testing
- Pancreatoduodenectomy, ENBD and Pancreatoduodenectomy, EBD and Pancreatoduodenectomy
- Where
- China
- Volunteers
- 274 people
- Sponsor
- Southwest Hospital, China
Pancreatic Neoplasms; Periampullary Neoplasms
Enhanced Recovery After Minimally Invasive Pancreaticoduodenectomy
This prospective observational cohort study aims to improve the postoperative course after minimally invasive pancreaticoduodenectomy (MIP) with stented pancreaticogastrostomy (sPG) for pancreatic head or peri-ampullary…
- Trial name
- ERAMIP (NCT02671357)
- Testing
- ERAMIP
- Where
- Belgium
- Volunteers
- 210 people
- Sponsor
- University Hospital, Gasthuisberg