Clinical trials: Periampullary Cancer, active
Cancer Gi
Prophylactic EUS-guided Gastroenterostomy in Advanced Periampullary Cancers
The goal of this randomized controlled trial is to investigate the effectiveness and safety of Prophylactic EUS-gastroenterostomy (ProEUS-GE) as a preventative approach for malignant gastric outlet obstruction (MGOO) in men and…
- Trial name
- INTERCEPT (NCT05994521)
- Testing
- ERCP alone, ERCP +ProEUS-GE
- Where
- 5 sites in Canada, France and 1 more
- Volunteers
- 110 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Whipple Operation
Dachengqi Decoction for Enhancing Early Gastrointestinal Recovery After Whipple Surgery
To investigate the clinical efficacy of the traditional Chinese medicine formula Dachengqi Decoction in promoting early gastrointestinal function recovery after Whipple surgery, and to evaluate its impact on postoperative…
- Trial name
- NCT06948474
- Testing
- Dachengqi decoction, modified gastrointestinal dual-lumen feeding tube, Normal Saline (0.9% NaCl)
- Where
- China
- Volunteers
- 45 people
- Sponsor
- China-Japan Friendship Hospital
Pancreatic Cancer, Pancreatic Neoplasms
Wearable-Supported Prehabilitation and Rehabilitation for Patients Undergoing Surgery for Pancreatic Cancer
The goal of this clinical trial is to evaluate whether a wearable-enabled prehabilitation and rehabilitation pathway can improve recovery and post-operative outcomes in adults undergoing surgery for pancreatic cancer or related…
- Conditions
- Pancreatic Cancer, Pancreatic Neoplasms, Periampullary Carcinoma, Pancreatic Surgery
- Trial name
- POWR-PaC (NCT07772258)
- Testing
- Corsano CardioWatch, Prehab4Cancer Programme
- Volunteers
- 120 people
- Sponsor
- Manchester University NHS Foundation Trust
Periampullary Neoplasms, Pancreatic Cancer
Total Pancreatectomy With Islet Autotransplantation (TPIAT) for High-Risk Patients With Pancreatic Tumors
This is a single-center, prospective, single-arm feasibility study evaluating whether adult patients with periampullary neoplasms who are at high risk for postoperative pancreatic fistula after pancreaticoduodenectomy can be…
- Conditions
- Periampullary Neoplasms, Pancreatic Cancer, Pancreatic Neoplasms
- Trial name
- NCT07360119
- Testing
- Total Pancreatectomy with Islet Autotransplantation (TPIAT)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Pancreatic Cancer, Periampullary Cancer
Tissue Adhesive Glue Modified Cyanoacrylate (Glubran® 2) in Soft Pancreas
This is a single-center, randomized controlled trial comparing the efficacy of pancreaticojejunostomy with modified N-butyl-2-cyanoacrylate(Glubran® 2) versus standard pancreaticojejunostomy without cyanoacrylate in preventing…
- Conditions
- Pancreatic Cancer, Periampullary Cancer, Duodenal Cancer, Cholangiocarcinoma
- Trial name
- NBCA-MS (NCT07155525)
- Testing
- Pancreaticojejunostomy with Modified N-Butyl-2-Cyanoacrylate (Glubran® 2), Standard(duct-to-mucosa) Pancreaticojejunostomy
- Where
- Egypt
- Volunteers
- 194 people
- Sponsor
- Minia University
Pancreatic Cancer, Pancreatic Fistula
Laparoscopic Pancreaticoduodenectomy
Laparoscopic pancreaticoduodenectomy was first performed by Garner and Pomp in 1994. This is a technically difficult, time consuming and high rate of complication procedure.
- Conditions
- Pancreatic Cancer, Pancreatic Fistula, Periampullary Cancer
- Trial name
- LPD (NCT07009119)
- Testing
- laparoscopic Pancreaticoduodenectomy
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Minia University
Pancreatic Cancer, Periampullary Cancer
Prehabilitation in Pancreatic Surgery
In patients with pancreatic cancer, older age, multiple comorbidities, frailty, malnutrition and poor functional status are common, especially in individuals receiving neoadjuvant chemotherapy.
- Conditions
- Pancreatic Cancer, Periampullary Cancer, Frailty Syndrome, Malnutrition
- Trial name
- PIPS (NCT06069297)
- Testing
- Multimodal Prehabilitation
- Where
- Italy
- Volunteers
- 238 people
- Sponsor
- IRCCS San Raffaele
Pancreas Cancer, Pancreas Neoplasm
Prognostic Factors in Periampullary Tumors and Cysts
The project aims at analysing prognostic and predictive factors involved in diagnostics and surgical treatment of cysts and tumors in the pancreas and periampullary region using both clinical data and blood and tissue samples for…
- Conditions
- Pancreas Cancer, Pancreas Neoplasm, Pancreas Cyst, Pancreatic Fistula
- Trial name
- NCT05155878
- Where
- Sweden
- Volunteers
- 500 people
- Sponsor
- Umeå University
Pancreaticoduodenectomy, Postoperative Pancreatic Fistula
Pancreatic Parenchymal Injection of N-butyl-2-cyanoacrylate
This randomized controlled trial investigates the safety and efficacy of injecting N-butyl-2- cyanoacrylate (Histoacryl®) into the pancreatic parenchyma during pancreaticoduodenectomy (PD) to enhance the security of the…
- Conditions
- Pancreaticoduodenectomy, Postoperative Pancreatic Fistula, Pancreas Cancer, Periampullary Cancer
- Trial name
- NBCA (NCT07230509)
- Testing
- Pancreatic parenchymal injection of N-butyl-2- cyanoacrylate(Histoacryl®)Injection Group., Standard Pancreaticojejunostomy
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Minia University
Periampullary Adenocarcinoma
Comparing Laparoscopic and Open Pancreaticoduodenectomy for Nonpancreatic Periampullary Adenocarcinomas
The aim of this study was to evaluate the outcomes of LPD versus OPD in non-pancreatic periampullary adenocarcinoma
- Trial name
- NPPC (NCT05788029)
- Testing
- laparoscopic pancreaticoduodenectomy, open pancreaticoduodenectomy
- Where
- China
- Volunteers
- 212 people
- Sponsor
- Tongji Hospital
Pancreatic Fistula, Pancreas Cancer
Reinforced Pancreaticojejunostomy With or Without glubran2
Pancreatic fistula is one of the most serious complication after pancreatoduodenectomy. To reduce pancreatic fistula, many authors recommend different techniques in pancreatojejunostomy.
- Conditions
- Pancreatic Fistula, Pancreas Cancer, Periampullary Carcinoma, Pancreatic Ductal Adenocarcinoma
- Trial name
- NCT06756074
- Testing
- Reinforced pancreaticojejunostomy with tissue adhesive glue modified cyanoacrylate (glubran 2), Pancreaticojejunostomy without tissue adhesive glue modified cyanoacrylate (glubran 2)
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Minia University
Ampullary Cancer, Bile Duct Cancer
Modified vs Conventional Blumgart Anastomosis of LPD for the Effects of Pancreatic Fistula of Periampullary Carcinoma
The incidence rate and mortality rate of periampullary cancer at home and abroad both show an increasing trend, seriously affecting the health level of the people.
- Conditions
- Ampullary Cancer, Bile Duct Cancer, Pancreas Cancer, Duodenum Cancer
- Trial name
- NCT06076252
- Testing
- Modified Blumgart Anastomosis in LPD, conventional Blumgart anastomosis in LPD
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Affiliated Hospital of Guangdong Medical University
Pancreas Cancer, Periampullary Cancer
Neoadjuvant vs Upfront Surgery for Resectable Pancreatic Cancer and Periampullary Cancer
Adjuvant chemotherapy after surgery significantly improved the survival of pancreatic cancer (PC) patients, but there is a problem that only about 50% of patients start adjuvant chemotherapy after pancreatectomy.
- Conditions
- Pancreas Cancer, Periampullary Cancer, Periampullary Carcinoma Resectable, Pancreatic Cancer Resectable
- Trial name
- NCT07081360
- Testing
- Neoadjuvant chemotherapy, Upfront Surgery Group
- Where
- Egypt
- Volunteers
- 262 people
- Sponsor
- Minia University
Gastric Outlet Obstruction
Enteral Anastomosis for the Treatment of Gastric Outlet Obstruction: A Randomized Controlled Study Comparing Endoscopic Versus Surgical Gastrojejunostomy
Gastric outlet obstruction (GOO) occurs commonly in malignancies involving the periampullary region (cancers originating in the head of the pancreas, duodenum, bile duct, or ampulla) or the distal stomach.
- Trial name
- EAT-GO (NCT05561907)
- Testing
- Surgical gastrojejunostomy (SGJ), Endoscopic gastrojejunostomy (EGJ)
- Where
- 4 sites in United States
- Volunteers
- 32 people
- Sponsor
- Northwell Health
Pancreatic Cancer, Biliopancreatic Diseases
Endoscopic Management of Biliopancreatic Disease in the Lombardy Pancreas Units
The GENTLENESS study is a prospective, multicenter, observational registry designed to evaluate the endoscopic management of patients with suspected biliopancreatic and periampullary neoplastic diseases within the Pancreas Units…
- Conditions
- Pancreatic Cancer, Biliopancreatic Diseases, Periampullary Neoplasms
- Trial name
- GENTLENESS (NCT07418164)
- Where
- 13 sites in Italy
- Volunteers
- 2,500 people
- Sponsor
- IRCCS San Raffaele
Acinar Cell Carcinoma, Ampulla of Vater Adenocarcinoma
WASH Trial: Intraoperative Lavage as a Treatment for Pancreatic Cancer
The goal of this clinical trial is to learn if a special washing treatment used during surgery can help people with pancreatic cancer live longer.
- Conditions
- Acinar Cell Carcinoma, Ampulla of Vater Adenocarcinoma, Cholangiocarcinoma, Duodenal Adenocarcinoma
- Trial name
- NCT02757859
- Testing
- Pancreatectomy, Lavage
- Where
- United States
- Volunteers
- 845 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
Pancreas Cancer, Pancreas Neoplasm
Predictive Risk Factors for Pancreatic Fistula After Pancreaticoduodenectomy
Pancreaticoduodenectomy (PD) is a complex procedure performed in patients with malignant or benign tumors of the pancreatic head and periampullary region, associated with high morbidity and mortality.
- Conditions
- Pancreas Cancer, Pancreas Neoplasm, Pancreatic Fistula, Pancreas Adenocarcinoma
- Trial name
- POPF (NCT07022015)
- Testing
- pancreaticoduodenectomy procedure
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Minia University
Pancreatic Cancer, Common Bile Duct Diseases
A Multicenter Prospective Randomized Controlled Study of RPD Versus LPD
laparoscopic pancreaticoduodenectomy(LPD) and Robot Pancreaticoduodenectomy (RPD), as two minimally invasive methods of pancreaticoduodenectomy(PD), have obvious advantages over traditional open pancreaticoduodenectomy(OPD) in…
- Conditions
- Pancreatic Cancer, Common Bile Duct Diseases, Periampullary Carcinoma
- Trial name
- NCT05755607
- Testing
- laparoscopic pancreaticoduodenectomy, Robot Pancreaticoduodenectomy
- Volunteers
- 200 people
- Sponsor
- The First Affiliated Hospital of University of South China
Pancreatic Cancer, Common Bile Duct Diseases
A Prospective Study on the Safety and Efficacy of Robot-assisted Pancreaticoduodenectomy
Further studies are needed to investigate the prognosis and perioperative safety of patients undergoing robotic-assisted pancreaticoduodenectomy.
- Conditions
- Pancreatic Cancer, Common Bile Duct Diseases, Periampullary Carcinoma
- Trial name
- NCT05755594
- Testing
- Robot-assisted Pancreaticoduodenectomy
- Volunteers
- 100 people
- Sponsor
- The First Affiliated Hospital of University of South China
Pancreas Cancer, Pancreas Neoplasm
The Role of the Human Microbiome in Patients After Pancreatic Resection.
The goal of this observational study is to classify patients that undergo pancreatic resection for presumed pancreatic or periampullary malignancy into high and low risk groups for postoperative complications based on…
- Conditions
- Pancreas Cancer, Pancreas Neoplasm, Pancreas Adenocarcinoma, Periampullary Cancer
- Trial name
- MiPac (NCT06381882)
- Testing
- Pancreatic resection
- Where
- Netherlands
- Volunteers
- 200 people
- Sponsor
- St. Antonius Hospital