Clinical trials: Periampullary Neoplasms
Pancreatic Neoplasm, Pancreatic Periampullary Cancer
The Effect of Application of TachoSil® in Pancreatoduodenectomy
Fibrinogen/thrombin-coated collagen patch (TachoSil®) is known to have the effect of strengthening tissue anastomosis and promoting suturing to prevent leakage.
- Conditions
- Pancreatic Neoplasm, Pancreatic Periampullary Cancer, Pancreatic Bordeline Tumor
- Trial name
- NCT03269955
- Testing
- Fibrinogen/thrombin-coated collagen patch
- Where
- South Korea
- Volunteers
- 126 people
- Sponsor
- Asan Medical Center
Pancreatic Neoplasms, Periampullary Carcinoma
Multidimensional Prehabilitation in Pancreatic Surgery for Pancreatic and Periampullary Neoplasms
Randomized Clinical Trial Investigating Multidimensional Prehabilitation in Pancreatic Surgery for participants with Pancreatic and Periampullary Neoplasms
- Trial name
- NCT05225038
- Testing
- Exercise, Nutritional, Behavioral Medicine
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Case Comprehensive Cancer Center
Periampullary Carcinoma Nos
Effect of Probiotics in Patients Undergoing Surgery for Periampullary Neoplasms
The purpose of this study is to evaluate the effect of the probiotic use in patients with periampullary cancers undergone curative or palliative treatment considering nutritional status, postoperative complications, infection…
- Trial name
- NCT01468779
- Testing
- Probiotics, Sugar pill
- Where
- Brazil
- Volunteers
- 58 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Periampullary Tumor, Common Bile Duct Neoplasms
Pancreaticoduodenectomy With or Without Preoperative Hyperbaric Oxygen Therapy
The primary objective of this study is to assess the safety, tolerability and toxicity of preoperative HBOT in patients undergoing a pancreaticoduodenal resection for premalignant and malignant tumors of the common bile duct…
- Conditions
- Periampullary Tumor, Common Bile Duct Neoplasms, Duodenal Neoplasms
- Trial name
- HBOT (NCT02575014)
- Testing
- Preoperative hyperbaric oxygen
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Florida Hospital Tampa Bay Division
Pancreatic Cancer, Periampullary Carcinoma
Evaluation of A New Digestive Reconstruction Procedure Following Pancreatoduodenectomy
The purpose of this study is to evaluate the validity and safety of a modified operative procedure of digestive tract reconstruction following pancreatoduodenectomy which enables the pancreatic juice and bile to bypass at the…
- Trial name
- NCT01931449
- Testing
- Modified method of digestive tract reconstruction, Routine digestive tract reconstruction
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Southwest Hospital, China
Biliary Tract Cancer, Periampullary Adenocarcinoma
SOX Sequential S-1 in Advanced Biliary Tract Carcinoma（BTC）and Pancreatic Cancer
This is an exploratory, single-armed, open label study on the efficacy and safety of sequential S-1 therapy after SOX in unresectable metastatic or locally advanced biliary system or periampullary cancer or pancreatic cancer…
- Conditions
- Biliary Tract Cancer, Periampullary Adenocarcinoma, Pancreatic Cancer
- Trial name
- NCT01811277
- Testing
- SOX sequential S-1
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Peking University
Periampullary Tumor, Complication
RCT Study on Safety of LPD and OPD in the Treatment of Periampullary Tumors
Pancreaticoduodenectomy (PD) is considered one of the most complex and dangerous procedures in general surgery. This procedure is the preferred surgical procedure for treating tumors around the ampulla.
- Conditions
- Periampullary Tumor, Complication, Death, Survival
- Trial name
- NCT04037982
- Testing
- laparoscopic pancreaticoduodenectomy, Open pancreaticoduodenectomy
- Where
- China
- Volunteers
- 102 people
- Sponsor
- Beijing Friendship Hospital
Pancreatic Cancer, Cancer of the Duodenum
Early Oral Versus Enteral Nutrition After Pancreatoduodenectomy
Pancreatoduodenectomy carries high morbidity rates even in high-volume centers. Postoperative complications often preclude or delay adequate oral nutrition and nutritional support may be required.
- Conditions
- Pancreatic Cancer, Cancer of the Duodenum, Cholangiocarcinoma, Chronic Pancreatitis
- Trial name
- NCT01642875
- Testing
- Enteral nutrition, Oral nutrition
- Where
- Poland
- Volunteers
- 96 people
- Sponsor
- Medical University of Warsaw
Pancreas Cancer, Periampullary Cancer
Neoadjuvant vs Upfront Surgery for Resectable Pancreatic Cancer and Periampullary Cancer
Adjuvant chemotherapy after surgery significantly improved the survival of pancreatic cancer (PC) patients, but there is a problem that only about 50% of patients start adjuvant chemotherapy after pancreatectomy.
- Conditions
- Pancreas Cancer, Periampullary Cancer, Periampullary Carcinoma Resectable, Pancreatic Cancer Resectable
- Trial name
- NCT07081360
- Testing
- Neoadjuvant chemotherapy, Upfront Surgery Group
- Where
- Egypt
- Volunteers
- 262 people
- Sponsor
- Minia University
Stage, Pancreatic Cancer, Neoplasm, Residual
Multicolour Versus Monocolour Specimens Inking After Pancreaticoduodenectomy for Periampullary Cancer
A single-centre, randomised clinical trial of patients affected by periampullary cancer who underwent pancreaticoduodenectomies which included two different types of specimen margination: arm A (multicolour inking) and arm B…
- Conditions
- Stage, Pancreatic Cancer, Neoplasm, Residual, Pancreatic Neoplasm, Periampullary Cancer
- Trial name
- MPM (NCT02900950)
- Testing
- Multicolour inking specimens, Monocolour inking specimens
- Where
- Italy
- Volunteers
- 68 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Periampullary Cancers With Obstructive Jaundice, Pancreas Head Cancer
Comparison Between Internal and External Preoperative Biliary Drainage in Periampullary Cancers
Preoperative biliary drainage methods include percutaneous transhepatic biliary drainage (PTBD), endoscopic nasobiliary drainage (ENBD), and endoscopic retrograde biliary drainage (ERBD).
- Conditions
- Periampullary Cancers With Obstructive Jaundice, Pancreas Head Cancer, Bile Duct Cancer, Ampulla of Vater Cancer
- Trial name
- NCT01134276
- Testing
- biliary drainage
- Where
- South Korea
- Volunteers
- 211 people
- Sponsor
- Seoul National University Hospital
Cancer Gi
Prophylactic EUS-guided Gastroenterostomy in Advanced Periampullary Cancers
The goal of this randomized controlled trial is to investigate the effectiveness and safety of Prophylactic EUS-gastroenterostomy (ProEUS-GE) as a preventative approach for malignant gastric outlet obstruction (MGOO) in men and…
- Trial name
- INTERCEPT (NCT05994521)
- Testing
- ERCP alone, ERCP +ProEUS-GE
- Where
- 5 sites in Canada, France and 1 more
- Volunteers
- 110 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Periampullary Cancer, Biliary Obstruction
Preoperative Biliary Drainage in Patients With Operable Malignant Periampulary Tumors
The impact of preoperative biliary drainage (PBD) on morbidity and mortality associated with Pancreaticoduodenectomy (PD) in patients with peri-ampulary tumors is still controversial.
- Conditions
- Periampullary Cancer, Biliary Obstruction, Preoperative Biliary Drainage
- Trial name
- NCT04289831
- Testing
- Preoperative Biliary Drainage (PBD), Surgery
- Volunteers
- 150 people
- Sponsor
- University of Alexandria
Pancreas Cancer, Pancreas Neoplasm
Predictive Risk Factors for Pancreatic Fistula After Pancreaticoduodenectomy
Pancreaticoduodenectomy (PD) is a complex procedure performed in patients with malignant or benign tumors of the pancreatic head and periampullary region, associated with high morbidity and mortality.
- Conditions
- Pancreas Cancer, Pancreas Neoplasm, Pancreatic Fistula, Pancreas Adenocarcinoma
- Trial name
- POPF (NCT07022015)
- Testing
- pancreaticoduodenectomy procedure
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Minia University
Pancreatic Fistula, Pancreas Cancer
Reinforced Pancreaticojejunostomy With or Without glubran2
Pancreatic fistula is one of the most serious complication after pancreatoduodenectomy. To reduce pancreatic fistula, many authors recommend different techniques in pancreatojejunostomy.
- Conditions
- Pancreatic Fistula, Pancreas Cancer, Periampullary Carcinoma, Pancreatic Ductal Adenocarcinoma
- Trial name
- NCT06756074
- Testing
- Reinforced pancreaticojejunostomy with tissue adhesive glue modified cyanoacrylate (glubran 2), Pancreaticojejunostomy without tissue adhesive glue modified cyanoacrylate (glubran 2)
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Minia University
Pancreatic and Periampullary Tumors
Pancreatoduodenectomy in Pancreatic and Periampullary Tumors
Background: Recently it has been observed in pancreatic cancer that after apparently complete surgical resection, histological examination of the surgical specimen according to a standard protocol reveals tumor infiltration of…
- Trial name
- DUOPAN-EPAM (NCT02803814)
- Testing
- Superior mesenteric artery approach for pancreatoduodenectomy, Classic approach for pancreatoduodenectomy
- Where
- Spain
- Volunteers
- 154 people
- Sponsor
- Fundación para la Investigación del Hospital Clínico de Valencia
Sarcopenia, Pancreatic Cancer
Preoperative Prehabilitation for Sarcopenic Patients Prior to Pancreatic Surgery for Cancer
Major digestive surgery is associated with a significant rate of postoperative complications. To improve postoperative outcome, efforts are focused on postoperative course leading to the concept of rehabilitation.
- Trial name
- PSOAS (NCT04469504)
- Testing
- Prehabilitation program, Oral Impact
- Where
- France
- Volunteers
- 6 people
- Sponsor
- University Hospital, Lille
Periampullary Cancer, Borderline Malignancy Tumor
The Effect of ERAS on Pancreaticoduodenectomy (v2.0)
Enhanced Recovery After Surgery (ERAS) is not a program that aims to reduce postoperative hospital stay, but the multimodal strategies that aim to attenuate the loss of, and improve the restoration of, functional capacity after…
- Trial name
- NCT06009224
- Testing
- ERAS perioperative management
- Where
- South Korea
- Volunteers
- 334 people
- Sponsor
- Asan Medical Center
Pancreaticoduodenectomy
Minimally Invasive Pancreatico-duodenectomy
Open pancreaticoduodenectomy (PD) is the standard treatment for a wide array of periampullary and pancreatic diseases including malignant and benign conditions.
- Trial name
- LPD (NCT02807701)
- Testing
- Laparoscopic pancreaticoduodenectomy, Open pancreaticoduodenectomy
- Volunteers
- 40 people
- Sponsor
- Mansoura University
Pancreatic Cancer, Common Bile Duct Diseases
A Multicenter Prospective Randomized Controlled Study of RPD Versus LPD
laparoscopic pancreaticoduodenectomy(LPD) and Robot Pancreaticoduodenectomy (RPD), as two minimally invasive methods of pancreaticoduodenectomy(PD), have obvious advantages over traditional open pancreaticoduodenectomy(OPD) in…
- Conditions
- Pancreatic Cancer, Common Bile Duct Diseases, Periampullary Carcinoma
- Trial name
- NCT05755607
- Testing
- laparoscopic pancreaticoduodenectomy, Robot Pancreaticoduodenectomy
- Volunteers
- 200 people
- Sponsor
- The First Affiliated Hospital of University of South China