Clinical trials: Perianal Crohn's Disease
Crohns Disease
EUS Evaluation of Perianal and Peri-rectal Fistulizing Crohn's Disease With CERTOLIZUMAB Treatment
The primary objective of this study is to assess perianal and perirectal fistula healing (complete closure) based on endoscopic ultrasound (EUS) evaluation at 3 months and by PDAI (Pouchitis Disease Activity Index) and Fistula…
- Trial name
- EUS (NCT01582568)
- Testing
- Certolizumab
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Baylor College of Medicine
Fistulizing Crohn's Disease
Randomized, Double-blind, Placebo-controlled Study in Patients With Fistulizing Crohn's Disease
The primary objective of this study is to investigate the safety and tolerability of locally administered DLX105 in treating enterocutaneous fistulas in Crohn's Disease patients.
- Trial name
- NCT01624376
- Testing
- DLX105
- Where
- Switzerland
- Volunteers
- 18 people
- Sponsor
- Delenex Therapeutics AG
Crohn's Disease, Peri-anal Fistulas
Investigation of Sexual Function in Crohn's Disease Patients With Perianal Fistulas
Objective: The aim of this study is to investigate whether Crohn's Disease patients with peri-anal fistulas will suffer from sexual dysfunction in an attempt to help us identify Crohn's Disease patients that would benefit from…
- Conditions
- Crohn's Disease, Peri-anal Fistulas, Sexual Dysfunction
- Trial name
- NCT01635543
- Where
- Canada
- Sponsor
- University of British Columbia
Crohn Disease, Complex Perianal Fistula
A Study to Check How Often People Treated With Darvadstrocel for Crohn's Disease Are Diagnosed With Cancer
The main aim is to learn about the risk of cancer after treatment with darvadstrocel compared to other standards of care in people with Crohn's Disease (CD).
- Trial name
- NCT04971525
- Where
- 4 sites in France, Germany and 2 more
- Sponsor
- Takeda
Inflammatory Bowel Diseases, Perianal Fistula
Tight Control Management in Perianal Crohn's Disease
Perianal Crohn's disease (pCD) affects around one-third of patients with Crohn's disease (CD) during their disease course. It represents a distinct disease phenotype and causes significant morbidity, often requiring multiple…
- Trial name
- PLACE-PCD (NCT03861689)
- Testing
- MRI pelvis
- Where
- Hong Kong
- Volunteers
- 40 people
- Sponsor
- Chinese University of Hong Kong
Perianal Crohn's Disease
Stem Cell Fistula Plug in Perianal Crohn's Disease
The investigators propose to study the safety of autologous mesenchymal stromal cell transfer using a biomatrix (the Gore® Bio-A®; Fistula Plug) in a Phase I study using a single dose of 20 million cells.
- Trial name
- MSC-AFP (NCT01915927)
- Testing
- MSC-AFP
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- William A. Faubion, M.D.
Crohn's Disease
Visilizumab for Treatment of Perianal Fistulas in Crohn's Disease
The purpose of the study is to evaluate an intravenous (by injection) investigational medication to treat Crohn's disease in patients with at least one perianal fistula.
- Trial name
- NCT00267709
- Testing
- Visilizumab
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Facet Biotech
Anal Fistula
Treatment of Perianal Fistulas by Endorectal Advancement Flap Associated With Adipose Tissue Injection
The study aims to evaluate effectiveness of the association of endorectal advancement flap technique with local injection of autologous and micro-fragmented adipose tissue, obtained with the Lipogems® system, in patients with…
- Trial name
- Fistula_CM1 (NCT04750499)
- Testing
- Adipose tissue injection associated with endorectal advancement flap.
- Where
- Spain
- Volunteers
- 12 people
- Sponsor
- Hospital Clinic of Barcelona
Crohn's Disease, Fistula
The Role of MSC in the Treatment of Fistulas in Patients With Perianal Crohn's Disease
Here investigators will carry out this phase II clinical trial to explore a effective therapeutic regimen of MSC in the Crohn's perianal fistula.
- Trial name
- NCT03056664
- Testing
- Routine drainage surgery, MSC injection 01, MSC injection 02
- Volunteers
- 3 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Crohn's Disease
Study to Assess Efficacy and Safety of Cx601, Adult Allogeneic Expanded Adipose-derived Stem Cells (eASC) for the Treatment of Complex Perianal Fistula(s) in Participants With Crohn's Disease (CD)
The purpose of this study is to evaluate the combined remission of complex perianal fistulas, defined as the clinical assessment at Week 24 of closure of all treated external openings that were draining at baseline despite gentle…
- Trial name
- ADMIRE-CD-II (NCT03279081)
- Testing
- Cx601
- Where
- 159 sites in United States, Belgium and 13 more
- Volunteers
- 568 people
- Sponsor
- Tigenix S.A.U.
Crohn's Disease With Perianal Fistulas
Adalimumab in Combination With Ciprofloxacin/Placebo Treatment of Perianal Fistulas in Crohn's
To assess whether a combination of ciprofloxacin and adalimumab is more effective than adalimumab alone for the treatment of perianal fistulas in Crohn's disease
- Trial name
- Adafi (NCT00736983)
- Testing
- adalimumab, ciprofloxacin
- Where
- 13 sites in Netherlands
- Volunteers
- 76 people
- Sponsor
- Foundation for Liver Research
Crohn's Disease
Treatment of Perianal Crohn's Disease, Combining Medical and Surgical Treatment.
This study is aimed to assess the hypothesis that instillation of fibrin glue with the induction of local conditions using Infliximab, may be useful in the treatment of perianal Crohn's disease.
- Trial name
- NCT00252369
- Testing
- Infliximab, Instillation of fibrin glue
- Where
- 4 sites in Israel
- Sponsor
- Sheba Medical Center
Crohns Disease, Fistula
Study to Look at Benefit of Surgical Drainage Before Beginning Medical Therapy for Crohns Perianal Fistulas
This study is looking at the advantage of establishing surgical drainage for Crohn's fistulas and abscesses prior to starting medical therapy.
- Conditions
- Crohns Disease, Fistula, Abscess
- Trial name
- NCT01145365
- Testing
- Exam under anesthesia (EUA)
- Where
- 3 sites in United States
- Volunteers
- 21 people
- Sponsor
- Vanderbilt University Medical Center
Crohn's Disease, Perianal Fistulas
The Influence of Hyperbaric Oxygen in Patients With Perianal Crohn's Disease Already Treated With TNF Alpha Blockers Treated With TNF Alpha Blockers
The aim of this study is to evaluate the effect of hyperbaric oxygen therapy (HBOT) on patient suffering from residual Crohn's disease related perianal fistulas already treated with TNF alpha blockers
- Trial name
- NCT01828190
- Testing
- Hyperbaric oxygen
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Assaf-Harofeh Medical Center
Crohn
Study of Photographs of Interest in Training to Obtain Good Reproducibility of the Diagnosis of Perianal Lesions of Crohn's Disease Inspection in Internal Gastroenterology
The diagnosis of LAP (lesions Ano-perineal) requires the inspection, palpation, anoscopy and possibly additional examinations including endoscopy and imaging; any of these steps of the diagnosis can only be replaced by another.
- Trial name
- PhotoCrohn (NCT02842450)
- Testing
- Photos + definitions, definitions only
- Where
- France
- Volunteers
- 249 people, healthy volunteers welcome
- Sponsor
- Fondation Hôpital Saint-Joseph
Perianal Fistula Due to Crohn's Disease
DB-3Q bmMSC-EVs in Patients With Perianal Fistulizing Crohn's Disease
This is a double-blind, randomized, placebo-controlled, sequential cohort, ascending dose clinical trial to evaluate the safety and determine the efficacy of ascending doses of DB-3Q for the treatment of Perianal Fistulizing…
- Trial name
- NCT06918808
- Testing
- DB-3Q
- Where
- 5 sites in United States
- Volunteers
- 36 people
- Sponsor
- Direct Biologics, LLC
Perianal Fistula, Primary; Complex
Follow-up Study of Autologous Adipose-derived Stem Cells (ANTG-ASC) for the Complex Fistula (ANTG-ASC-211)
This is an open follow-up clinical trial to evaluate a sustained efficacy and safety of ANTG-ASC injection for 4 months (6 months after final dose injection) after Phase II clinical trial.
- Trial name
- ANTG (NCT01623453)
- Testing
- Autologous adipose derived stem cells(low dose group), Autologous adipose derived stem cells(high dose group)
- Where
- 2 sites in South Korea
- Volunteers
- 6 people
- Sponsor
- Anterogen Co., Ltd.
Crohn Disease
Individual Treatment of Ustekinumab in Perianal Fistulizing Crohn's Disease
This study intends to further explore the actual efficacy of ustekinumab in the individualized treatment of anal fistula Crohn's disease.
- Trial name
- NCT06739278
- Where
- China
- Volunteers
- 119 people
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Crohn's Disease
Evaluation of Topical 10% Metronidazole Ointment for the Treatment of Active Perianal Crohn's Disease
The purpose of this study is to compare changes in Perianal Crohn's Disease following use of locally applied 10% metronidazole ointment and a placebo.
- Trial name
- NCT00509639
- Testing
- 10% Metronidazole Ointment
- Where
- 11 sites in United States, United Kingdom
- Volunteers
- 74 people
- Sponsor
- S.L.A. Pharma AG
Perianal Crohn's Disease
A Safety and Efficacy Study of BLI-1300 Ointment in Symptomatic Perianal Crohn's Disease
This randomized, placebo-controlled, parallel, multi-center, double-blind pilot study is designed to determine the effects of BLI-1300 ointment on perianal pain associated with active Perianal Crohn's Disease (PCD).
- Trial name
- NCT01442363
- Testing
- BLI-1300 low dose, BLI-1300 high dose
- Where
- 17 sites in United States
- Volunteers
- 4 people
- Sponsor
- Braintree Laboratories