Clinical trials: Perianal Crohn Disease
Crohn's Disease
MRI-Based Screening in a Retrospective Cohort Reveals Adverse Prognosis of Asymptomatic Perianal Fistulas in Crohn's Disease: A Long-term Follow-Up Study
The goal of this observational study is to learn about the necessity of imaging screening for perianal fistula in Crohn's disease (CD) patients without perianal symptoms by comparing the natural history and long-term outcomes…
- Trial name
- NCT07555808
- Volunteers
- 669 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Fistula Perianal
Human Placenta Mesenchymal Stem Cells Derived Exosomes Injection for Treatment of Complex Anal Fistula
The goal of this clinical trial is to learn if human placenta mesenchymal stem cells (MSC)-derived exosomes work to treat complex perianal fistula in adults without Crohn's disease.
- Trial name
- NCT06568653
- Testing
- exosome, routine conventional fistulotomy
- Volunteers
- 40 people
- Sponsor
- Tehran University of Medical Sciences
Crohn Disease, Fistula
An Open Label, Prospective, One Arm, Feasibility, Study for The Use of Halevy Kit for the Treatment of Perianal Fistulas in Patients With Crohn's Disease
Today, there is no available equipment specifically designed for the procedure of instillation of fibrin glue for the repair of perianal fistulae.
- Trial name
- NCT00653094
- Testing
- Halevy kit
- Where
- Israel
- Volunteers
- 10 people
- Sponsor
- ResQ Medical Ltd
Perianal Fistula
MR Assessment of Perianal Crohn's Disease
Perianal Crohn's disease (pCD) is the commonest form of fistulising Crohn's disease, with up to 38% of patients affected and with 30% of them experiencing recurring disease symptoms.
- Trial name
- MAP (NCT03325582)
- Where
- 3 sites in United Kingdom
- Volunteers
- 25 people
- Sponsor
- University of Nottingham
Inflammatory Bowel Disease (IBD), Crohn Disease
Hyperbaric Oxygen Therapy for Perianal Fistulizing Crohn's Disease Not Responsive or Intolerant to Conventional Care: HYPNOTIC Pilot Study
This study aims to test a new treatment called hyperbaric oxygen therapy (HBOT) for a severe type of inflammatory bowel disease called perianal Crohn's disease (PCD).
- Trial name
- HYPNOTIC (NCT06109961)
- Testing
- Oxygen Gas for Inhalation, Standard of care
- Volunteers
- 54 people
- Sponsor
- University of British Columbia
Perianal Crohns Disease
VirtuAl Technology to Improve the Management of Perianal Crohn's (VAMP) - PROSPECTIVE
Crohn's is an inflammatory condition that can affect any part of the gut. Over half a million people in the UK live with Crohn's disease and about a quarter will develop a fistula near their back passage.
- Trial name
- VAMP-PROSPECT (NCT06587646)
- Testing
- Virtual Examination under Anaeastehtic - 3D reconstruction imaging, Standard Care - Written MRI report
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Nottingham University Hospitals NHS Trust
Crohn
Study of Photographs of Interest in Training to Obtain Good Reproducibility of the Diagnosis of Perianal Lesions of Crohn's Disease Inspection in Internal Gastroenterology
The diagnosis of LAP (lesions Ano-perineal) requires the inspection, palpation, anoscopy and possibly additional examinations including endoscopy and imaging; any of these steps of the diagnosis can only be replaced by another.
- Trial name
- PhotoCrohn (NCT02842450)
- Testing
- Photos + definitions, definitions only
- Where
- France
- Volunteers
- 249 people, healthy volunteers welcome
- Sponsor
- Fondation Hôpital Saint-Joseph
Crohn Disease, Fistula
Treatment of Perianal Fistulas in Crohn's Disease With Autologous Microfragmented Adipose Tissue With the Lipogems System
The aim of the study is to verify the efficacy of microfragmented autologous adipose tissue with the Lipogems® system, in the treatment of perianal fistulas of m. Crohn's.
- Conditions
- Crohn Disease, Fistula, Adipose Tissue
- Trial name
- NCT05766566
- Testing
- Perianal fistula surgery
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis
Crohns Disease
EUS Evaluation of Perianal and Peri-rectal Fistulizing Crohn's Disease With CERTOLIZUMAB Treatment
The primary objective of this study is to assess perianal and perirectal fistula healing (complete closure) based on endoscopic ultrasound (EUS) evaluation at 3 months and by PDAI (Pouchitis Disease Activity Index) and Fistula…
- Trial name
- EUS (NCT01582568)
- Testing
- Certolizumab
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Baylor College of Medicine
Crohn's Disease, Fistula
Dose-escalating Therapeutic Study of Allogeneic Bone Marrow Derived Mesenchymal Stem Cells for the Treatment of Fistulas in Patients With Refractory Perianal Crohn's Disease
In a dose escalation study we will determine the safety and preliminary efficacy of allogeneic bone marrow mesenchymal stem cells (bmMSCs) in the induction of response for active fistulizing Crohn's Disease (CD).
- Trial name
- NCT01144962
- Testing
- Localization, curettage of the fistulous tract and closure of the internal opening without MSC injection., Localization, curettage of the fistulous tract and closure of the internal opening with local MSC injection.
- Where
- Netherlands
- Volunteers
- 21 people
- Sponsor
- Leiden University Medical Center
Perianal Fistula, Crohn Disease
Treatment of Perianal Disease Using Adipose-derived Stem Cells
This study will compare healing and surgical outcomes in patients with chronic perianal disease treated with Adipose-derived Stem Cells (ASCs) to outcomes in patients treated in traditional surgical techniques without ASCs.
- Trial name
- NCT03913572
- Testing
- Injection of adipose-derived stem cells into perianal fistula
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of California, San Diego
Crohn's Disease
A Survey of Darvadstrocel in People With Crohn's Disease
This study is a survey in Japan of Darvadstrocel injection used to treat Crohn's disease people with complicated anal fistula. The study sponsor will not be involved in how the participants are treated but will provide…
- Trial name
- J-INSPIRE (NCT05113095)
- Testing
- Darvadstrocel
- Where
- Japan
- Volunteers
- 275 people
- Sponsor
- Takeda
Crohn Disease, Perianal Fistulas
Adipose Tissue Injection in Perianal Fistulas in Crohn´s Disease
This randomized and placebo controlled study investigates the efficacy of injections with freshly harvested autologous adipose tissue in CD patients with complex perianal fistulas refractory to standard surgical and/or medical…
- Conditions
- Crohn Disease, Perianal Fistulas, Cell- and Tissue-Based Therapy, Treatment
- Trial name
- NCT03904212
- Testing
- Adipose tissue injection, saline
- Where
- Denmark
- Volunteers
- 140 people
- Sponsor
- University of Aarhus
Crohn Disease, Perianal Fistula
Comparative Accuracy of Transperineal Ultrasound (TPUS) Versus Magnetic Resonance Imaging (MRI) for the Assessment of Perianal Fistulae in Patients With Crohn's Disease (CD): a Prospective Observational Longitudinal Cohort Study
Crohn's disease (CD) is a life-long chronic inflammatory bowel disease (IBD) that may affect any site of the gastrointestinal tract, most frequently the ileum and colon.
- Trial name
- TPUS-MRI (NCT05721794)
- Testing
- A multicentric prospective observational longitudinal cohort study.
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- IRCCS San Raffaele
Crohn's Disease
A Phase II Efficacy Study in Fistulizing Crohn's Disease Patients
This study will assess the safety and efficacy of QAX576 if patients with fistulizing Crohn's disease.
- Trial name
- NCT01355614
- Testing
- QAX576, Infliximab
- Where
- 6 sites in Germany, Switzerland
- Volunteers
- 10 people
- Sponsor
- Novartis Pharmaceuticals
Crohn's Disease, Complex Perianal Fistula
Long-term Follow-up Study With Darvadstrocel in the Treatment of Complex Perianal Fistula
The main aim is to follow-up on long term side effect and symptom improvement of Darvadstrocel in the treatment of complex perianal fistula in adults. Participants will not receive any drug in this study.
- Trial name
- NCT04075825
- Testing
- Darvadstrocel
- Where
- 58 sites in United States, Belgium and 7 more
- Volunteers
- 150 people
- Sponsor
- Takeda
Perianal Fistula, Crohn's Disease
Seeded Cells on Matrix Plug Treating Crohn's Perianal Fistulas (STOMP-II)
A Phase II study to assess the safety and efficacy of AVB-114 in treatment of complex Crohn's perianal fistulas in subjects with quiescent rectal disease and whose fistula has failed to respond to biologic or conventional…
- Trial name
- NCT04847739
- Testing
- Seton Placement, AVB-114
- Where
- 15 sites in United States
- Volunteers
- 60 people
- Sponsor
- Avobis Bio, LLC
Perianal Fistula Due to Crohn's Disease
Expanded Access Protocol for STOMP-II Patients Who Were Unable to Receive Treatment Subsequent to Adipose Tissue Collection
The goal of this Expanded Access Protocol is to provide expanded access of AVB-114 to patients who had their fat tissue collected as part of a clinical trial (STOMP-II), but who were subsequently not treated with AVB-114 because…
- Trial name
- EAP-STOMP2 (NCT06509828)
- Testing
- AVB-114
- Sponsor
- Avobis Bio, LLC
Perianal Fistula, Crohn Disease
Autologous Adipose-derived Stem Cells (ASCs) for the Treatment of Perianal Fistula in Crohn Disease: A Pilot Study
Crohn's disease is an immunologically mediated inflammatory bowel disease with a reported incidence of 4.0-7.0, 7.1, and 1.34 per 100,000 persons in Europe, the U.S., and Korea, respectively.
- Trial name
- ASPEFIC1 (NCT02403232)
- Testing
- ASCs injection, Closure of fistula tract.
- Where
- Italy
- Volunteers
- 10 people
- Sponsor
- Papa Giovanni XXIII Hospital
Crohn Disease
Anorectal Function in Perianal Crohn's Disease
Perianal Crohn's disease is a disabling disease associated with increased morbidity and impaired quality of life. It is associated with pain, discharge, fecal incontinence and sexual and psychological impairment.
- Trial name
- NCT03819257
- Testing
- Endoanal ultrasound, High-resolution anorectal manometry, Balloon expulsion test
- Where
- United Kingdom
- Volunteers
- 16 people
- Sponsor
- The Leeds Teaching Hospitals NHS Trust