Clinical trials: Perianal Fistula, open to volunteers
Perianal Abscess, Anal Fistulas
Multicenter Study for Diagnosis and Treatment of Perianal Abscesses
Drainage of perianal abscesses is a well established treatment. Traditionally its been done in general anesthesia after the swelling has been localised its been drained with a knife.
- Conditions
- Perianal Abscess, Anal Fistulas, Incontinence
- Trial name
- NCT02306382
- Testing
- Perianal abscess drainage, 3D ultrasonography
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- University Hospital, Umeå
Perianal Fistula
Role of MRI in Perianal Fistula
The aim of this study is to assess the diagnostic accuracy of MRI in detecting and assessment the primary fistulous tract, internal openings, secondary extensions, and associated abscesses.
- Trial name
- MRI PA fistula (NCT07510204)
- Testing
- Diagnostic imaging (MRI)
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Sohag University
Perianal Crohn Disease, Perianal Fistula
The Impact of Perianal Disease on Patient's Sex Life
Perianal diseases, such as perianal abcesses, anal fistulae and perianal Crohn's disease, are often associated with significant physical symptoms, including pain and chronic drainage.
- Conditions
- Perianal Crohn Disease, Perianal Fistula, Fistula in Ano, Perianal Abscess
- Trial name
- SEXTON (NCT07519850)
- Testing
- Patient Reported Outcome Assessment (Questionnaires)
- Where
- Greece
- Volunteers
- 60 people
- Sponsor
- AHEPA University Hospital
Perianal Fistula
FiLaC and PRGF-Endoret for Multi-recurrent Cryptoglandular Perianal Fistula (PLASMA Pilot Study)
Multi-recurrent cryptoglandular perianal fistula represents a challenging clinical problem with no established surgical solution after repeated failures.
- Trial name
- PLASMA (NCT07810075)
- Testing
- Laser ablation of fistula tract using 1000-µm radial fibre (Biolitec, 1470 nm, 12 W, continuous, 1 mm/s withdrawal). Internal opening closed with Vicryl 2/0 suture in all patients
- Volunteers
- 25 people
- Sponsor
- Complejo Hospitalario Universitario de Santiago
Rectal Fistulas
FISTULA-RFA Trial: Radiofrequency Ablation for Perianal Fistula
The goal of this pilot clinical study is to learn whether radiofrequency ablation (RFA) can safely and effectively treat perianal fistulas in adults.
- Trial name
- FISTULA-RFA (NCT07452666)
- Testing
- Radiofrequency Ablation (RFA) for Perianal Fistula
- Volunteers
- 80 people
- Sponsor
- Korea University Ansan Hospital
Perianal Fistula, Fistula-in-Ano
Open Fistulectomy vs. Laser Closure for Low Perianal Fistula
Perianal fistula is an abnormal tunnel connecting the anal canal to the perianal skin, frequently causing chronic pain, discharge, and impaired quality of life.
- Conditions
- Perianal Fistula, Fistula-in-Ano, Low Perianal Fistula
- Trial name
- NCT07797842
- Testing
- Fistula-tract Laser Closure (FiLaC), Open Fistulectomy
- Volunteers
- 40 people
- Sponsor
- Assiut University
Perianal Fistula Due to Crohn's Disease
DB-3Q bmMSC-EVs in Patients With Perianal Fistulizing Crohn's Disease
This is a double-blind, randomized, placebo-controlled, sequential cohort, ascending dose clinical trial to evaluate the safety and determine the efficacy of ascending doses of DB-3Q for the treatment of Perianal Fistulizing…
- Trial name
- NCT06918808
- Testing
- DB-3Q
- Where
- 5 sites in United States
- Volunteers
- 36 people
- Sponsor
- Direct Biologics, LLC
Fistula Perianal
Efficacy Of Minimally Invasive Approach In The Surgical Treatment Of Complex Perianal Fistula
The goal of this clinical trial is to study whether the minimally invasive approach in the mucosal advancement flap technique for the treatment of complex perianal fistula improves the healing rate compared to non-minimally…
- Trial name
- NCT06484660
- Testing
- Minimally Invasive Approach In The Mucosal Advancement Flap Technique
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Hospital Son Llatzer
Perianal Fistula
Comparing Three Surgical Techniques for the Treatment of Transsphincteric Perianal Fistula: (1) Traditional Fistulotomy (Lay Open), (2) Ligation of the Intersphincteric Tract (LIFT) With Adjunctive Endo Fistula Laser Ablation, and (3) Open LIFT Procedure Followed by LASER
>This randomized clinical trial compares three different surgical techniques for the treatment of transsphincteric perianal fistula: (1) traditional fistulotomy (lay open), (2) ligation of the intersphincteric tract (LIFT) with…
- Trial name
- NCT07236047
- Testing
- fistula lay open, LIFT plus LASER, open LIFT plus LASER
- Volunteers
- 90 people
- Sponsor
- Alexandria University
Crohn Disease
Evaluation of Local Co-administration of Autologous ADIpose Derived Stromal Vascular Fraction With Microfat for Refractory Perianal CROHN's Fistulas.
Autologous ADSVF constitutes an innovative therapeutic strategy that concentrates various types of regenerative stem cells and paracrine factors able to promote angiogenesis and tissue repair.
- Trial name
- ADICROHN2 (NCT04010526)
- Testing
- local co-administration of autologous ADIpose
- Where
- France
- Volunteers
- 84 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Cryptoglandular Perianal Fistula
Loose Seton Prior to Surgery for Single-tract Cryptoglandular Fistula vs no Seton
Cryptoglandular anal fistulas can cause pain, discharge, recurrent infection, and a prolonged treatment course. In current practice, patients with a single-tract mid-high or high cryptoglandular anal fistula often first undergo…
- Trial name
- SETON (NCT07807319)
- Testing
- No seton placement prior to surgery
- Where
- 2 sites in Netherlands
- Volunteers
- 277 people, healthy volunteers welcome
- Sponsor
- Proctos Kliniek
Crohn Disease, Perianal Fistula
Risankizumab for Refractory Perianal Fistulizing Crohn's Disease
Crohn's disease is an inflammatory bowel disease characterized by relapses and remissions, causing lesions throughout the digestive tract and accompanied by diarrhea, abdominal pain, and nutritional disorders.
- Conditions
- Crohn Disease, Perianal Fistula, Perianal Fistula Due to Crohn's Disease, Perianal Crohn's Disease
- Trial name
- RIS-PERIANAL (NCT07872449)
- Testing
- Risankizumab
- Where
- 4 sites in Japan
- Volunteers
- 25 people
- Sponsor
- Yuki Horio
Perianal Abscess, Anal Fistula
Antibiotics After Incision and Drainage to Prevent Fistula Formation After First Episode of Perianal Abscess
The goal of this clinical trial is to learn if antibiotics can prevent the formation of fistula-in-ano after incision and drainage of a first time of perianal abscess in adults.
- Trial name
- RAPID (NCT07704359)
- Testing
- Amoxicillin + Clavulanate, Ciprofloxacin + Metronidazole
- Where
- United States
- Volunteers
- 236 people
- Sponsor
- University of Illinois Chicago
Wrist-Ankle Acupuncture
Application Effects of Wrist-Ankle Acupuncture in Patients With Different Types of Pain Following Perianal Surgery
This study is a prospective clinical observation designed to evaluate the analgesic effect of wrist-ankle acupuncture in patients with different types of pain after perianal surgery, as well as its applicability.
- Trial name
- NCT07340307
- Testing
- wrist-ankle acupuncture
- Where
- China
- Volunteers
- 58 people
- Sponsor
- The Affiliated Hospital of Putian University
Crohn Disease
Dose Escalation of Allogeneic Adipose Derived Stroma/Stem Cells for the Treatment of Crohn's Fistula
Perianal fistulas are in the forefront (42 to 72, 4%) of morbid complication of Crohn's disease, affecting nearly one- third of patients and complicating abscesses in 35-48% of cases.
- Trial name
- ALLOFIST (NCT06636032)
- Testing
- AdMSC (CellReady®)
- Where
- France
- Volunteers
- 9 people
- Sponsor
- University Hospital, Toulouse
Perianal Abscess, Anal Fistula
Machine Learning-Based Risk Stratification for Fistula Formation After Perianal Abscess Drainage
This prospective cohort study investigates the influence of provider experience and drainage location on fistula formation within 6 months following perianal abscess drainage.
- Trial name
- PRISM (NCT07019532)
- Volunteers
- 450 people
- Sponsor
- Gumushane State Hospital
Crohn Disease (CD), Cryptoglandular Perianal Fistula
A Study Comparing Transperineal Ultrasound, Magnetic Resonance Imaging, Endoscopic Ultrasound, and Examination Under Anesthesia to Detect and Classify Perianal Fistulas in Patients With Crohn's Disease or Fistulas of Unknown Cause
The goal of this study is to learn how well different imaging tests detect and describe perianal fistulas in adults with Crohn's disease or fistulas with no known cause (cryptogenic).
- Trial name
- TRANSIT CD (NCT07794410)
- Testing
- Transperineal Ultrasound (TPUS), Magnetic Resonance Imaging (MRI), Endoscopic Ultrasound (EUS)
- Where
- India
- Volunteers
- 50 people
- Sponsor
- Asian Institute of Gastroenterology, India
Anal Fistula Surgery, Anal Fistula
Recurrence and Anal Fistula Patient Reported Outcomes Trial
Perianal fistulas are a chronic anorectal condition associated with significant morbidity, including pain, persistent discharge, infection, and impaired continence, all of which can substantially affect patients' quality of life.
- Conditions
- Anal Fistula Surgery, Anal Fistula, Perianal Fistula
- Trial name
- RAPPORT (NCT07477496)
- Testing
- Perianal fistula surgical repair
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- National and Kapodistrian University of Athens
Crohn's Disease
A Survey of Darvadstrocel in People With Crohn's Disease
This study is a survey in Japan of Darvadstrocel injection used to treat Crohn's disease people with complicated anal fistula. The study sponsor will not be involved in how the participants are treated but will provide…
- Trial name
- J-INSPIRE (NCT05113095)
- Testing
- Darvadstrocel
- Where
- Japan
- Volunteers
- 275 people
- Sponsor
- Takeda
Crohn Disease, Infliximab
TDM-based Infliximab Treatment for Active Perianal Fistulizing Crohn's Disease
This study will compare the efficacy and safety of TDM (therapeutic drug monitoring)-based infliximab (CT-P13, RemsimaTM) intravenous therapy compared with the standard infliximab (RemsimaTM) intravenous therapy for patients with…
- Conditions
- Crohn Disease, Infliximab, Perianal Fistula Due to Crohn's Disease, Therapeutic Drug Monitoring
- Trial name
- NCT06051253
- Testing
- TDM-based infliximab intravenous therapy, Standard infliximab intravenous therapy
- Where
- South Korea
- Volunteers
- 86 people
- Sponsor
- Asan Medical Center