Clinical trials: Periapical; Infection
Periapical; Infection
PRF and Bone Graft in Endodontic Surgeries
AIM: The aim of this study was to compare and evaluate the radiographic healing in patients undergoing apical surgery, using Freeze dried mineralized bone allograft and Platelet-rich Fibrin.
- Trial name
- NCT04377698
- Testing
- Platelet Rich Fibrin, FDBA
- Where
- India
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Saraswati Dental College
Apical Periodontitis
Intraoral Cryotherapy on Cytokine Levels and Postoperative Endodontic Pain
The aim of this study is to evaluate the effects of intraoral cryotherapy on the inflammatory cytokine levels during root canal treatment and postoperative pain intensity and incidence.
- Trial name
- NCT05017064
- Testing
- Cryotherapy group, Control group
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Periapical Abscess
Comparison of Triple Antibiotic Paste With Combination of Chitosan and Calcium Hydroxide as a Root Canal Disinfectant
Investigators observed the clinical and radiographic healing of periapical lesion using Chitosan mixed with calcium hydroxide and compared it with triple antibiotic paste when used as intracanal medicament in 3months, 6 months…
- Trial name
- NCT04319575
- Testing
- root canal treatment and intracanal medicament
- Where
- India
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Dr. D. Y. Patil Dental College & Hospital
Root Canal Therapy
Clinical Applicability of PBSCIMMO as a Single Material in Endodontic Obturations
A randomized, interventional, prospective, unicentric clinical study, 86 patients will be submitted to endodontic treatment of necrotic teeth.
- Trial name
- PBSCIMMO (NCT03514264)
- Testing
- Gutta Percha and AHPLUS cement (group A), PBS CIMMO cement (group B)
- Where
- Brazil
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Universidade do Vale do Sapucai
Pulp Disease, Dental, Pulp Necrosis
Chloramphenicol, Tetracycline, Zinc Oxide and Eugenol Paste (CTZ Paste) for Emergency Dental Treatment in Public Health Settings: A Randomized Trial
The treatment of pulpal diseases in primary teeth represents a significant challenge in public health, particularly in emergency dental care settings, where factors such as limited clinical time, low child cooperation, and…
- Conditions
- Pulp Disease, Dental, Pulp Necrosis, Pulp Therapy in Primary Molars, Primary Teeth
- Trial name
- CTZ- emergency (NCT07542639)
- Testing
- CTZ Paste, ZOE Pulpectomy
- Volunteers
- 110 people
- Sponsor
- University of Sao Paulo
Periapical Periodontitis, Polymerase Chain Reaction
The Effect of Ca(OH)2 in Apical Periodontitis
Aim of the present study was to determine the intraradicular microbiota of previously root canal-treated teeth with apical periodontitis using droplet digital polymerase chain reaction (ddPCR) and to investigate the antibacterial…
- Conditions
- Periapical Periodontitis, Polymerase Chain Reaction, Intracanal Medicament, Enterococcus Faecalis Infection
- Trial name
- NCT04978545
- Testing
- calciumhydroxide, intracanal medicament, chlorhexidine, intracanal medicament
- Where
- Turkey (Türkiye)
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Seyda Ersahan, DDS, PhD
Apical Periodontitis, Pulp Disease, Dental
A New Clinical Use of Ferumoxytol Nanoparticles: An Antibiofilm Treatment
The goal of this observational is study is to develop a protocol for root canal biofilms disinfection using a clinically approved and commercially available iron oxide nanoparticle formulation Ferumoxytol/H2O2 treatments.
- Trial name
- NCT06110494
- Testing
- Iron oxide nanoparticles treatment Ferumoxytol/H2O2, NaOCl, NaCl
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Endodontic Infection, Periapical Diseases
The Effect of Different Hemostatic Agents on Hemorrhage Control, Pain and Quality of Life After Endodontic Microsurgery.
Background This randomized clinical trial evaluated the effect of two different hemostatic materials for endodontic microsurgery on bleeding control, postoperative pain and patients' quality of life.
- Trial name
- NCT07311291
- Testing
- Hemostatic Agent 1: Surgical glue (IfaBond, Dipromed, Italy), Hemostatic Agent 2: Ferric sulfate
- Where
- Italy
- Volunteers
- 34 people
- Sponsor
- University of Turin, Italy
Irreversible Pulpitis, Apical Periodontitis
Ethanolic Extract of Sapindus Mukorrossi as Final Endodontic Irrigant.
The chief aim of root canal treatment is to reduce the microbial content and prevent further recontamination in the canal. Properly cleaned, shaped and obturated teeth will be having fewer chances of treatment failure.
- Conditions
- Irreversible Pulpitis, Apical Periodontitis, Root Canal Infection
- Trial name
- NCT05038059
- Testing
- ethanolic extract of sapindus mukorossi, ethylene diamine tetra acetic acid
- Where
- Pakistan
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Dow University of Health Sciences
Apical Periodontitis, Root Canal Infection
Clinical Investigation of Chemomechanical Parameters for an Efficient Disinfection of the Root Canal
The aim of the study is first, to evaluate the clinical antibacterial efficacy of two different NaOCl concentrations (2,5% and 5%) under a predefined irrigant flow rate in teeth with pulp necrosis and apical periodontitis by…
- Trial name
- ENDOA (NCT06949176)
- Testing
- Root canal tratment using mecchanical and chemical preparation., Sodium Hypochlorite., Hydrogen peroxide.
- Where
- Greece
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- National and Kapodistrian University of Athens
Endodontic Disease, Endodontically Treated Teeth
Outcome of Endodontic Retreatment in One or Two Visits
This study is a prospective randomized controlled study of patients who come to the University and non-surgical root canal retreatment is considered as the election of choice in presence of periapical disease.
- Conditions
- Endodontic Disease, Endodontically Treated Teeth, Root Canal Infection
- Trial name
- NCT04527705
- Testing
- Non-surgical root canal retreatment
- Where
- Spain
- Volunteers
- 110 people
- Sponsor
- Universitat Internacional de Catalunya
Immediate Dental Implant, Tooth Exratction
Immediate Dental Implant Placed in the Presence of Chronic Inflammatory Periapical Lesions
Compromised teeth with periapical pathologies are removed before dental implant placement and sockets are left to heal. Some clinicians began to immediately place dental implants in fresh extraction sockets associated with…
- Conditions
- Immediate Dental Implant, Tooth Exratction, Periapical; Infection
- Trial name
- NCT05101941
- Testing
- Immediate dental implants
- Where
- Egypt
- Volunteers
- 12 people
- Sponsor
- Hams Hamed Abdelrahman
Periapical Abscess
Prospective Clinical Trial of Three Apical Sealing Materials
This prospective comparative randomized clinical trial compares healing and bony regeneration in patients who received 1 of 3 different retrograde filling materials following microsurgical apicoectomies for the treatment of…
- Trial name
- NCT04198298
- Testing
- EndoSequence, ProRoot MTA, Biodentine
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- University of the Pacific
Periapical Periodontitis, Root Canal Infection
Antibacterial Efficacy of Bioceramic and Calcium Hydroxide Intracanal Medicaments
This study evaluates the antibacterial effectiveness of two different intracanal medicaments, Bio-C Temp and UltraCal XS , in mandibular molar teeth with chronic apical periodontitis.
- Conditions
- Periapical Periodontitis, Root Canal Infection, Intracanal Medicaments
- Trial name
- NCT07671326
- Testing
- Root canal treatment with Bio-C Temp, a calcium silicate-based bioceramic intracanal medicament, Root canal treatment with UltraCal XS, a calcium hydroxide-based intracanal medicament
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Medipol University
Apical Periodontitis, Postoperative Pain
Cryotherapy on Inflammatory Profile and Postoperative Pain Levels in Endodontic Infections
The aim of this study is to evaluate the effects of cryotherapy applications on the inflammatory cytokine and collagenase matrix metalloproteinase levels during root canal treatment and postoperative pain intensity and incidence.
- Conditions
- Apical Periodontitis, Postoperative Pain, Cytokine Levels
- Trial name
- NCT04798144
- Testing
- Distilled water irrigation kept at 2.5°C degree, Distilled water irrigation kept at room temperature
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Periapical Periodontitis
Safety and Efficacy of the Apexum Ablator
The study is designed to test the hypothesis that there is a difference in healing kinetics and healing rate between teeth treated by conventional endodontic procedure alone and those in which such procedure was supplemented with…
- Trial name
- NCT00762840
- Testing
- the Apexum Protocol, Conventional endodontic procedure
- Where
- 2 sites in Romania
- Volunteers
- 100 people
- Sponsor
- Apexum Ltd.
Periapical Lesion, Periapical Periodontitis
Comparing Two Medicines for Healing Jaw Bone Infections After Root Canal Treatment
This study compares two commonly used intracanal medicaments-Triple Antibiotic Paste and Calcium Hydroxide-in patients with infected single-rooted teeth.
- Trial name
- NCT07239739
- Testing
- Triple Antibiotic Paste, Calcium Hydroxide (Ca(OH)2)
- Volunteers
- 62 people
- Sponsor
- Faiz ur rahman
Persistent Infection, Periapical Lesion
The Effectiveness of Hyperpure Chlorine Dioxide and Sodium Hypochlorite Irrigants in Endodontic Retreament in RCT
Endodontic treatment aims to eliminate pathogenic microbes from the root canal. Hyperpure chlorine dioxide is an endodontic irrigant.
- Trial name
- NCT04954638
- Testing
- endodontic desinfection
- Where
- Hungary
- Volunteers
- 40 people
- Sponsor
- Eniko Vaszine Szabo
Asymptomatic Apical Periodontitis, Root Canal Infection
Effect of EDDY Sonic Irrigation on Root Canal Microbiota and Pain in Asymptomatic Apical Periodontitis
This randomized controlled clinical trial aimed to evaluate the effect of sonic activation using the EDDY device on root canal microbiota and postoperative pain in teeth with asymptomatic apical periodontitis.
- Conditions
- Asymptomatic Apical Periodontitis, Root Canal Infection, Periapical Diseases, Dental Pain
- Trial name
- NCT07120126
- Testing
- EDDY Sonic Activation, Conventional Syringe Irrigation
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Abdulkadir Tiftik,DDS
Dental Pulp Necrosis, Periapical Abscess
Efficiency of Triple Antibiotic Paste, Ciprofloxacin/Propolis, Ciprofloxacin/Metronidazole, Propolis/Metronidazole Combinations on Revascularization Process of Immature Necrotic Maxillary Incisors of Patients 8-18 Years Old.
This Study Was Made to Evaluate the Antibacterial Effect of Different Antibacterial Combinations on Revascularization Process in Permanent Anterior Immature Teeth.
- Conditions
- Dental Pulp Necrosis, Periapical Abscess, Root Canal Infection
- Trial name
- NCT03533231
- Testing
- Canal Disinfection Triple Antibiotic Paste (TAP), Ciprofloxacin + Propolis Paste, Ciprofloxacin + Metronidazole Paste
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Tariq Yehia