Clinical trials: Periapical Diseases
Periapical Diseases, Periapical Cyst
The Impact of Root End Filling Material Type and the Application of Bone Graft on Healing of Periapical Tissues After Endodontic Microsurgery (A Clinical Randomized Controlled Trial)
The goal of this triple blinded randomized clinical trial is to evaluate the effect of combining different bioactive root end filling materials with composite bone graft (xenogeneic mixed with autogenous bone fragments) on the…
- Trial name
- NCT05943769
- Testing
- Apical microsurgery
- Where
- Egypt
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Apical Periodontitis, Coronary Artery Disease
hsCRP & CH Indices in Patients With Coronary Artery Disease With and Without Apical Periodontitis
Endodontic treatment is done in Patients with chronic pulp exposure in patients with Coronary Artery Disease and systemic inflammatory markers recorded before and and after treatment and compared with patients with Coronary…
- Trial name
- NCT06270693
- Testing
- Endodontic treatment
- Where
- India
- Volunteers
- 70 people
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Apical Periodontitis
Accuracy of ERCLMDs in Teeth With Apical Periodontitis
The aim of this in vivo study is to evaluate the influence of apical periodontitis (AP) on the accuracy of Dentaport ZX, Raypex 5, and i-Root electronic root canal length measurement devices.
- Trial name
- ERCLMDs (NCT01904552)
- Testing
- Electronic Root Canal Length Measurement Device
- Where
- Iran
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Isfahan University of Medical Sciences
Irreversible Pulpitis, Apical Periodontitis
Bite Force Measurements
ABSTRACT: Acute dental pain from untreated decay often drives patients to emergency rooms (ERs), where the lack of definitive dental treatment results in nearly 75% of these patients receiving analgesics, predominantly opioids.
- Conditions
- Irreversible Pulpitis, Apical Periodontitis, Pulpal Necrosis
- Trial name
- NCT06843525
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- Rutgers, The State University of New Jersey
Periapical Diseases
Detection of Periapical Lesions on Dental Panoramic Radiographs Based on Artificial Intelligence
Dental periapical damages can have various reasons and is reflected by a radiolucent lesion on complementary imaging: angulated retro-alveolar (RA) radiographs, dental panoramic radiographs, and three-dimensional imaging such as…
- Trial name
- OPTITOMO (NCT05888935)
- Where
- France
- Volunteers
- 2,000 people
- Sponsor
- Centre Hospitalier Régional Metz-Thionville
Caries,Dental, Apical Periodontitis
Kovanaze Vs. Articaine in Achieving Pulpal Anesthesia of Maxillary Teeth - Endodontics
The primary goal of the study is to compare the success rates of pulpal anesthesia (defined as ability to complete the intended dental procedure without the need for rescue anesthesia) between Kovanaze nasal mist and Articaine…
- Trial name
- NCT04105985
- Testing
- Kovanaze Nasal Spray, Articaine Injection
- Sponsor
- Virginia Commonwealth University
Endodontic Treatment, Pulp Necrosis
Dexamethasone Treatment for Patients Undergoing Endodontics
This Phase IV randomized clinical trial (RCT) evaluated the efficacy of preoperative administration of a single 4 mg oral dose of dexamethasone in reducing postoperative pain and inflammation following endodontic treatment.
- Conditions
- Endodontic Treatment, Pulp Necrosis, Periapical Lesions, Postoperative Pain
- Trial name
- (DTPE-RCT) (NCT06906315)
- Testing
- Dexamethasone 4 mg, Ibuprofen group
- Where
- Spain
- Volunteers
- 82 people
- Sponsor
- University of Salamanca
Apical Periodontitis
Outcome of Endodontic Treatment in Patient Treated With a Hydraulic Sealer
The objective of the study is to evaluate and compare, clinically and radiographically, the outcome of non surgical primary/secondary root canal treatment using a hydraulic sealer or a zinc oxide-eugenol sealer.
- Trial name
- NCT04249206
- Testing
- Root Canal Treatment
- Volunteers
- 54 people
- Sponsor
- Cittadella Universitaria
Apical Periodontitis
Accuracy of PoCT to ELISA by Detecting Human IL-6 in Teeth with Apical Periodontitis
To compare the diagnostic agreement of human IL-6 chairside PoCT to ELISA in apical periodontitis undergoing endodontic therapy which could be clinically helpful to monitor the healing of periapical tissues enabling the clinician…
- Trial name
- PoCT ELISA (NCT06701266)
- Testing
- Point of Care Test
- Where
- Malaysia
- Volunteers
- 30 people
- Sponsor
- Manipal University College Malaysia
Root Canal Obturation, Apical Periodontitis
Evaluation of Postoperative Pain and Lesion Healing in Periapical Lesion-Affected Teeth Obturated With Different Root Canal Sealers
The root canal treatment of volunteers with asymptomatic apical periodontitis will be completed using TotalFill BC and AH Plus root canal sealers, and postoperative pain as well as healing will be comparatively evaluated through…
- Trial name
- NCT07307807
- Testing
- AH Plus and PAI 2-3, AH Plus and PAI 4, TotalFill BC Sealer and PAI 2-3
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Ankara Yildirim Beyazıt University
Dental Pulp Necrosis, Apical Periodontitis
Antimicrobial Efficacy of NaOCl and PDT in Primary Root Canal Treatment
This clinical study will compare different root canal disinfection methods used during primary root canal treatment. Root canal infection is mainly caused by bacteria inside the root canal system.
- Trial name
- PDT-NaOCl (NCT07666932)
- Testing
- Sodium Hypochlorite Irrigation, Sodium Hypochlorite Irrigation Plus Photodynamic Therapy, Photodynamic Therapy Adjunct Evaluation
- Where
- Jordan
- Volunteers
- 64 people
- Sponsor
- Bayan Alqrenawi
Apical Periodontitis
Prospective Endodontics Database
Endodontic treatment is necessary after certain dental trauma or in the presence of a large carious lesion, associated with signs of irreversible pulpal inflammation.
- Trial name
- REone (NCT04716478)
- Testing
- Clinical and radiological data collection
- Where
- 21 sites in France
- Volunteers
- 400 people
- Sponsor
- Hospices Civils de Lyon
Apical Cyst
Examining the Effect of Different Filling Techniques on Healing in Lesional Teeth
Microorganisms are an important factor in the development of periradicular diseases. The goal of non-surgical endodontic treatment is to eliminate microorganisms and their byproducts from the root canal system and to create an…
- Trial name
- NCT06384014
- Testing
- retrograde and orthograde root canal filling
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Apical Periodontitis, Anxiety
Apical Periodontitis and Mental Health
This study is investigating the relationship between anxiety, depression and apical periodontitis (AP), a common oral inflammatory condition.
- Conditions
- Apical Periodontitis, Anxiety, Depression
- Trial name
- NCT06589076
- Testing
- Clinical and Radiographic assessment + Questionnaires
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- University of Siena
Apical Periodontitis, Postoperative Pain
The Effect of Using Octenidine Hydrochloride as a Final Irrigation Solution on Teeth With Asymptomatic Apical Periodontitis on Postoperative Pain and Treatment Success: A Prospective Randomized Clinical Study
This single-centre, randomized, parallel-group clinical trial compared two commonly used final irrigants in single-visit root canal treatment: octenidine dihydrochloride (OCT) and chlorhexidine (CHX).
- Trial name
- NCT07173725
- Testing
- Octenidine dihydrochloride 0.1%, Chlorhexidine 2%
- Where
- Turkey (Türkiye)
- Volunteers
- 142 people
- Sponsor
- Bezmialem Vakif University
Endodontic-Periodontal Lesions, Apical Periodontitis
The Effect of Different Intra-canal Medications on Healing of Endo-perio Cases.
Assessment of different intra-canal medications in endo-perio lesion regarding their healing potentiality and their effect on local cytokine levels.
- Trial name
- NCT07858396
- Testing
- Bio-ceramic, Calcium Hydroxide (CH), Chlorhexidine
- Where
- Egypt
- Volunteers
- 42 people
- Sponsor
- Ain Shams University
Apical Periodontitis
Sclerostin Regulation in Apical Periodontitis Lesions in Apical Periodontitis Lesions
Our aim was to examine the relationship between inflammatory bone resorption associated with the severity of AP and gingival crevicular fluid (GCF) and blood sclerostin and PGE2 levels in cases of AP.
- Trial name
- NCT06512103
- Testing
- Apical periodontitis group
- Where
- Turkey (Türkiye)
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Necrotic Teeth With Apical Periodontitis
Evaluation of the Aloe Vera Anti-inflammatory Effect on Apical Periodontitis.
The goal of this clinical trial is to evaluation aloe vera as intracanal medication anti-inflammatory also inter-appointment pain incidence compared with calcium hydroxide.
- Trial name
- NCT07826091
- Testing
- Aloe vera gel, Calcium Hydroxide (Ca(OH)2) Intracanal Medication
- Where
- Egypt
- Volunteers
- 33 people
- Sponsor
- Ain Shams University
Chronic Apical Periodontitis of Pulpal Origin
Longitudinal Endodontic Study of Apical Preparation Size
This protocol is for a clinical trial evaluating the clinical success of root canal therapy performed on teeth with chronic apical periodontitis of pulpal origin with either large or small apical root canal preparation techniques.
- Trial name
- NCT00223379
- Testing
- Endodontic procedure with varied apical preparation size
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Periapical Diseases, Periapical Periodontitis
Postoperative Pain After Conservative Root Canal Preparation
The goal of this clinical trial is to compare the pain experienced by healthy participants after root canal treatment with small versus large root canal sizes. The main questions it aims to answer are: 1.
- Conditions
- Periapical Diseases, Periapical Periodontitis, Postoperative Pain, Pulp Necroses
- Trial name
- NCT06545773
- Testing
- Root Canal Treatment with ProTaper Next Nickel-Titanium File (PTN), Root Canal Treatment withTruNatomy Nickel-Titanium File (TN)
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Istanbul University