Clinical trials: Periapical Lesion
Periapical Abscess
Comparison of Triple Antibiotic Paste With Combination of Chitosan and Calcium Hydroxide as a Root Canal Disinfectant
Investigators observed the clinical and radiographic healing of periapical lesion using Chitosan mixed with calcium hydroxide and compared it with triple antibiotic paste when used as intracanal medicament in 3months, 6 months…
- Trial name
- NCT04319575
- Testing
- root canal treatment and intracanal medicament
- Where
- India
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Dr. D. Y. Patil Dental College & Hospital
Periapical Lesions
Clinical and Radiographic Healing After Microscope-Assisted Endodontic Surgery
This study aimed to evaluate clinical and periapical radiographic healing following endodontic surgery using a surgical microscope.
- Trial name
- NCT07877168
- Testing
- Microscope-Assisted Endodontic Surgery
- Where
- 2 sites in Vietnam
- Volunteers
- 12 people
- Sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City
Periapical Lesion Healing, Apical Periodontitis
The Effect of Different Intracanal Medicaments on Periapical Lesion Healing
This study is planned to evaluate the effects of two different intracanal medicaments-calcium hydroxide and diclofenac sodium-on periapical healing following endodontic retreatment.
- Trial name
- NCT07237620
- Testing
- Diclofenac sodium
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mustafa Kemal University
Pulp Disease, Dental, Pulp Necrosis
Chloramphenicol, Tetracycline, Zinc Oxide and Eugenol Paste (CTZ Paste) for Emergency Dental Treatment in Public Health Settings: A Randomized Trial
The treatment of pulpal diseases in primary teeth represents a significant challenge in public health, particularly in emergency dental care settings, where factors such as limited clinical time, low child cooperation, and…
- Conditions
- Pulp Disease, Dental, Pulp Necrosis, Pulp Therapy in Primary Molars, Primary Teeth
- Trial name
- CTZ- emergency (NCT07542639)
- Testing
- CTZ Paste, ZOE Pulpectomy
- Volunteers
- 110 people
- Sponsor
- University of Sao Paulo
Endodontically Retard Teeth, Periapical Radiolucency
Antimicrobial and Anti-inflammatory Effects of Simvastatin as an Intracanal Medication
Successful endodontic treatment and a predictable outcome can only be achieved by effective root canal debridement, irrigation, and elimination of microorganisms .
- Trial name
- NCT07256561
- Testing
- Simvastatin as an intracanal medication
- Where
- Egypt
- Volunteers
- 54 people
- Sponsor
- Hadeer Maher Mostafa Mohamed
Endodontic Treatment, Pulp Necrosis
Dexamethasone Treatment for Patients Undergoing Endodontics
This Phase IV randomized clinical trial (RCT) evaluated the efficacy of preoperative administration of a single 4 mg oral dose of dexamethasone in reducing postoperative pain and inflammation following endodontic treatment.
- Conditions
- Endodontic Treatment, Pulp Necrosis, Periapical Lesions, Postoperative Pain
- Trial name
- (DTPE-RCT) (NCT06906315)
- Testing
- Dexamethasone 4 mg, Ibuprofen group
- Where
- Spain
- Volunteers
- 82 people
- Sponsor
- University of Salamanca
Immediate Dental Implant, Tooth Exratction
Immediate Dental Implant Placed in the Presence of Chronic Inflammatory Periapical Lesions
Compromised teeth with periapical pathologies are removed before dental implant placement and sockets are left to heal. Some clinicians began to immediately place dental implants in fresh extraction sockets associated with…
- Conditions
- Immediate Dental Implant, Tooth Exratction, Periapical; Infection
- Trial name
- NCT05101941
- Testing
- Immediate dental implants
- Where
- Egypt
- Volunteers
- 12 people
- Sponsor
- Hams Hamed Abdelrahman
Periapical Lesions
The Accuracy of Computer Aided Detection of Periapical Radiolucencies on Cone -Beam Computed Tomography Images Using Artificial Intelligence
A diagnostic accuracy study to assess the accuracy of a newly developed deep learning model in the automatic detection of periapical radiolucent lesions of upper and lower jaws by comparing it with experienced radiologists'…
- Trial name
- NCT05538104
- Volunteers
- 50 people
- Sponsor
- Cairo University
Apical Lesion
The Effect of Injectable Platelet Rich Fibrin on Apical Lesion Healing
In recent years, the use of autologously obtained blood products that stimulate cell proliferation, such as platelet-rich plasma (PRP) and platelet-rich fibrin (PRF), has become increasingly widespread.
- Trial name
- NCT07876427
- Testing
- i-PRF, root canal treatment and intracanal medicament
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Hande Has Elçi
Effects of the Elements
Healing Assessment of Osseous Defects After Surgical Removal of Periapical Lesions
recruited patients with periapical lesions will be divided into three groups and surgically treated with three types of bone graft (hydroxyappatite, nanohydroxyappatite and PRF WITH NANOHYDROXTAPPATITE) and then evaluated for…
- Trial name
- NCT05100615
- Testing
- surgery
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Minia University
Periapical; Infection
Effect of Calcium Silicate Based Root Canal Medicament on Inflammatory Mediators
Calcium hydroxide is generally preferred in endodontics as an intracanal medicament because of its antimicrobial and biological effects. However, the antimicrobial effect of calcium hydroxide is limited.
- Trial name
- NCT06307678
- Testing
- Calcium Hydroxide, Calcium Silicate
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Ataturk University
Pulp Necroses, Periapical Lesion
Magnetic Resonance Imaging (MRI) of Pulp Regeneration
The present study was conducted to test whether pulp-like tissue can be regenerated in mature teeth with closed apex? And whether the size of the apical diameter affects the success of REPs? And whether Magnetic resonance imaging…
- Conditions
- Pulp Necroses, Periapical Lesion, Regeneration
- Trial name
- NCT03804450
- Testing
- Regenerative endodontic procedures (REPs)
- Where
- Egypt
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Root Canal Obturation
Root Canal Obturation With a Ready-to-use Root Canal Sealer (PA1704) Versus BioRoot™ RCS: a Randomized Controlled Trial
The study design is a multicentric randomized controlled non-inferiority trial. 160 subjects (teeth) requiring a primary or a secondary root canal treatment will be enrolled in 2 groups (80 in each group).
- Trial name
- OPTIFILL (NCT04757753)
- Testing
- ready-to-use root canal sealer: PA1704, root canal sealer: BioRoot™ RCS
- Where
- 5 sites in Belgium, France
- Volunteers
- 160 people
- Sponsor
- Septodont
Irreversible Pulpitis With Apical Periodontitis
Full Pulpotomy in Permanent Teeth With Irreversible Pulpitis and Apical Periodontitis
This study will evaluate whether full pulpotomy can successfully treat mature permanent teeth with irreversible pulp inflammation and a periapical lesion.
- Trial name
- NCT07768852
- Testing
- Full pulpotomy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- King Abdullah University Hospital
PERIAPICAL LESIONS
Effect of NSRCT on HbA1c and Inflammatory Markers in Healthy and Type 2 Diabetes Patients With Apical Periodontitis
To the best of knowledge, only 2 prospective studies, and 1 cross-sectional study have been reported which have seen the periapical healing after non surgical endodontic treatment in diabetic patients and their effect on HbA1c.
- Trial name
- NCT05609747
- Testing
- Nonsurgical root canal therapy
- Where
- 2 sites in India
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Apical Periodontitis, Periapical Lesion
Evaluation of the Effect of Leukocyte and Platelet-rich Fibrin on Healing After Periradicular Surgery
The aim of this study is to evaluate the effect of two different periapical surgery methods ("curettage+apical resection" and "curettage") on the bone regeneration and clinical healing without applying any material or with…
- Trial name
- NCT05847647
- Testing
- Retrograde Filling Group, Retrograde Filling+L-PRF Group, (Orthograde Filling Group / OG Group).
- Where
- Turkey (Türkiye)
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Seyda Ersahan, DDS, PhD
Early Apical Peri-implantitis
Etiology of Early Apical Peri-implantitis
A case-control study was performed was performed following the STROBE statement from 1996 to 2016 including patients who were diagnosed with early apical peri-implantitis.
- Trial name
- EAP (NCT03523845)
- Testing
- Observational intervention to diagnose an early apical peri-implantitis
- Volunteers
- 46 people
- Sponsor
- University of Valencia
Periapical Diseases
Detection of Periapical Lesions on Dental Panoramic Radiographs Based on Artificial Intelligence
Dental periapical damages can have various reasons and is reflected by a radiolucent lesion on complementary imaging: angulated retro-alveolar (RA) radiographs, dental panoramic radiographs, and three-dimensional imaging such as…
- Trial name
- OPTITOMO (NCT05888935)
- Where
- France
- Volunteers
- 2,000 people
- Sponsor
- Centre Hospitalier Régional Metz-Thionville
Periapical Periodontitis
Encapsulated Mesenchymal Stem Cells for Dental Pulp Regeneration.
To compare the dental survival in a period of one year of mature permanent teeth with apical lesion following the administration of encapsulated Mesenchymal Stem Cells under a regenerative endodontic procedure and a conventional…
- Trial name
- RanoKure (NCT03102879)
- Testing
- Regenerative Endodontic Procedure, Conventional Root Canal Treatment
- Where
- Chile
- Volunteers
- 36 people
- Sponsor
- Universidad de los Andes, Chile
Periapical Diseases, Root Canal Infection
Comparing Efficacy of a Stainless-steel Rotary File with Two Nickel-titanium Systems on Periapical Lesion Healing
Background: This study used cone-beam computed tomography (CBCT) to compare a stainless-steel Tornado file system with OneShape and WaveOne rotary systems for biomechanical canal preparation as indicated by the healing of…
- Trial name
- NCT06752837
- Testing
- Tornado rotary system, WaveOne rotary system, OneShape rotary system
- Where
- 2 sites in Lebanon
- Volunteers
- 60 people
- Sponsor
- Beirut Arab University