Clinical trials: Periapical Lesions
Endodontic Treatment, Pulp Necrosis
Dexamethasone Treatment for Patients Undergoing Endodontics
This Phase IV randomized clinical trial (RCT) evaluated the efficacy of preoperative administration of a single 4 mg oral dose of dexamethasone in reducing postoperative pain and inflammation following endodontic treatment.
- Conditions
- Endodontic Treatment, Pulp Necrosis, Periapical Lesions, Postoperative Pain
- Trial name
- (DTPE-RCT) (NCT06906315)
- Testing
- Dexamethasone 4 mg, Ibuprofen group
- Where
- Spain
- Volunteers
- 82 people
- Sponsor
- University of Salamanca
Periapical Lesion
Accuracy of Artificial Intelligence Technology in Detecting Periapical Lesions in Human Teeth.
Aims to evaluate the accuracy of using Artificial intelligence software in detecting the presence of periapical lesion compared to CBCT imaging.
- Trial name
- AI (NCT07319182)
- Testing
- Cone beam computed tomography, artificial intelligence software
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Future University in Egypt
Obesity, Periodontitis
Evaluation of the Dental Health Condition in Obesity Patients Before and After Bariatric Surgery
The aim of this study is to investigate whether there was an association between obesity and periodontitis, tendency to caries and periapical lesions.
- Conditions
- Obesity, Periodontitis, Caries, Periapical Lesion
- Trial name
- NCT00531154
- Where
- Israel
- Volunteers
- healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Periapical Periodontitis, Periapical Abscess
A Retrospective Cohort Study on the Non-Surgical Treatment of Periapical Inflammatory Lesions With Vitapex Paste
Background: Periapical inflammation is a common clinical condition, classified into periapical periodontitis, periapical granuloma, and periapical cyst.
- Conditions
- Periapical Periodontitis, Periapical Abscess, Periapical Radiolucency
- Trial name
- NCT07907367
- Testing
- Vitapex Paste
- Where
- China
- Volunteers
- 80 people
- Sponsor
- The Affiliated Hospital of Jinggangshan University
Root Canal Infection, Periapical Diseases
Microbial Load After Apical Enlargement in Asymptomatic Teeth With Periapical Lesion
The goal of this observational study is to define the role of apical shaping and irrigation activation on root canal cleanliness.
- Conditions
- Root Canal Infection, Periapical Diseases, Periapical; Infection, Endodontic Disease
- Trial name
- NCT06035185
- Testing
- apical shaping size
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Endodontic Treatment, Periapical Diseases
Effectiveness of Photodynamic Therapy in the Disinfection of Root Canals in Patients With Apical Lesion
The object of the present study is to compare the effectiveness of conventional endodontic treatment with that of endodontic treatment combined with Photodynamic Therapy (PDT) in patients with apical lesion.
- Trial name
- PDT (NCT05916859)
- Testing
- Group 2 PDT (10 s), Group 3 PDT 20 s
- Where
- Chile
- Volunteers
- 159 people
- Sponsor
- Universidad de La Frontera
Effect of Irrigation Activation on Periapical Healing
Effect of Irrigation-Activation Techniques on Healing in Large Periapical Lesions
The aim of this study was to highlight the healing rates of large periapical lesions after different irrigation activation treatments as manual dynamic activation (MDA), passive ultrasonic irrigation (PUI), shock wave-enhanced…
- Trial name
- NCT06204887
- Testing
- Manual dynamic activation, Passive ultrasonic activation, Laser activation
- Where
- Turkey (Türkiye)
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Recep Tayyip Erdogan University
Periapical Disease
Comparing the Effect of Different Intracanal Dressing on Failed Root Canal Treated Cases on Periapical Healing
The goal of this clinical trial is to compare the effects of different intracanal medication between endodontic retreatment visits in previously failed root canal treatment patients (single root canal anteriors or premolars…
- Trial name
- NCT06342830
- Testing
- nanocurcumin gel, Curcumin Gel, Ciprofloxacin 500 mg +ibuprofen 400mg
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Persistent Infection, Periapical Lesion
The Effectiveness of Hyperpure Chlorine Dioxide and Sodium Hypochlorite Irrigants in Endodontic Retreament in RCT
Endodontic treatment aims to eliminate pathogenic microbes from the root canal. Hyperpure chlorine dioxide is an endodontic irrigant.
- Trial name
- NCT04954638
- Testing
- endodontic desinfection
- Where
- Hungary
- Volunteers
- 40 people
- Sponsor
- Eniko Vaszine Szabo
Apical Periodontitis, Periapical Lesion
Evaluation of Different Root Canal Obturation Techniques
The aim of this clinical study is to evaluate the effect of root canal filling, which is the last stage of root canal treatment (RCT), on the post-operative pain level on single rooted permanent teeth with wide lesions with…
- Trial name
- NCT07106307
- Testing
- Bioceramic Sealer, Warm Vertical Compaction, Epoxy Resin-Based Sealer
- Where
- Turkey (Türkiye)
- Volunteers
- 168 people
- Sponsor
- Medipol University
Periapical Lesion
A Comparative Analysis of Biomaterials for Retrograde Filling in Apical Surgery.
The aim of this study is to compare two biomaterials used for retrograde obturation during apical surgery. This surgery is indicated in healthy patients when root canal treatment (endodontics) has failed to eliminate a periapical…
- Trial name
- NCT07246512
- Testing
- Mineral Trioxide Aggregate, BioCeramic Root Repair Material Fast Set Putty.
- Where
- Spain
- Volunteers
- 110 people
- Sponsor
- University of Valencia
Periapical Diseases, Periapical Cyst
The Impact of Root End Filling Material Type and the Application of Bone Graft on Healing of Periapical Tissues After Endodontic Microsurgery (A Clinical Randomized Controlled Trial)
The goal of this triple blinded randomized clinical trial is to evaluate the effect of combining different bioactive root end filling materials with composite bone graft (xenogeneic mixed with autogenous bone fragments) on the…
- Trial name
- NCT05943769
- Testing
- Apical microsurgery
- Where
- Egypt
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Apical Periodontitis
The Effect of Human Umbilical Cord Mesenchymal Stem Cells and Exosomes on the Healing of Postoperative Pain and Periapical Lesions in the Treatment of Apical Periodontitis: Randomized Controlled Clinical Study
The main purpose of this study is to evaluate the effect of Mesenchymal Stem Cells (MSCs) isolated from the umbilical cord and exosomes derived from these cells on the success of the treatment in the regenerative endodontic…
- Trial name
- NCT06764004
- Testing
- Stem Cell Product, Bleeding and clots
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Periapical Periodontitis
Safety and Efficacy of the Apexum Ablator
The study is designed to test the hypothesis that there is a difference in healing kinetics and healing rate between teeth treated by conventional endodontic procedure alone and those in which such procedure was supplemented with…
- Trial name
- NCT00762840
- Testing
- the Apexum Protocol, Conventional endodontic procedure
- Where
- 2 sites in Romania
- Volunteers
- 100 people
- Sponsor
- Apexum Ltd.
Periapical Lesions
A Comparison Between Two Types of Sealers in the Healing of Periapical Lesions
This clinical study will evaluate the effect of BioCeramic sealer with single cone compared with the control group treated with AH Plus with lateral condensation in root canal obturation on the healing of periapical lesions.
- Trial name
- NCT06400030
- Testing
- Root canal treatment with AH Plus sealer, Root canal treatment with BioCeramic sealer
- Where
- Syria
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Damascus University
Necrotic Pulp With Symptomatic Apical Periodontitis
Evaluation of the Impact of Different Final Irrigation Activation Modes on Healing of Periapical Lesions Related to Permanent Mandibular First Molars Using CBCT.
The goal of this clinical trial is to learn how different ways of activating the cleaning liquid (irrigation) during endodontic treatment affect healing of infections at the root tip (periapical lesions) in adults aged 20 to 40…
- Trial name
- NCT07589556
- Testing
- root canal treatment
- Where
- Egypt
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Future University in Egypt
Root Canal Infection
One and Two-visit Root Canal Retreatment
A hundred previously root canal treated asymptomatic single-rooted teeth with periapical lesions were treated in single versus multiple visit root canal retreatment.
- Trial name
- NCT05137613
- Testing
- One visit root canal retreatment, Two visit root canal retreatment
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ege University
Early Apical Peri-implantitis
Etiology of Early Apical Peri-implantitis
A case-control study was performed was performed following the STROBE statement from 1996 to 2016 including patients who were diagnosed with early apical peri-implantitis.
- Trial name
- EAP (NCT03523845)
- Testing
- Observational intervention to diagnose an early apical peri-implantitis
- Volunteers
- 46 people
- Sponsor
- University of Valencia
Dental Implant Failure Nos, Periapical Granuloma
Periapical Lesions and Immediate Implants
The aim of this case-control study is to evaluate the success and survival rates of dental implants immediately placed into extraction sites in the presence of periapical pathology.
- Conditions
- Dental Implant Failure Nos, Periapical Granuloma, Osseointegration Failure of Dental Implant
- Trial name
- NCT06521203
- Where
- Turkey (Türkiye)
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Periapical Diseases
Detection of Periapical Lesions on Dental Panoramic Radiographs Based on Artificial Intelligence
Dental periapical damages can have various reasons and is reflected by a radiolucent lesion on complementary imaging: angulated retro-alveolar (RA) radiographs, dental panoramic radiographs, and three-dimensional imaging such as…
- Trial name
- OPTITOMO (NCT05888935)
- Where
- France
- Volunteers
- 2,000 people
- Sponsor
- Centre Hospitalier Régional Metz-Thionville