Clinical trials: Periapical Periodontitis
Periapical Periodontitis
Effect of Corticosteroid Injection in Symptomatic Pulpitis Cases
This randomized clinical trial compared standard single-visit root canal treatment with adjunctive submucosal betamethasone and gentamicin in 100 patients with symptomatic irreversible pulpitis, assessing postoperative pain and…
- Trial name
- (SCIP) (NCT07704398)
- Testing
- Corticosteroid, Standard endodontic treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Liver Cirrhosis, Periapical Lesions
Oral Health Status in Patients With Cirrhosis and Effect of Dental Treatment on MELD Score of Cirrhosis Patients
It has been found that there is an association between prevalence of odontogenic infection and systemic diseases.Cirrhosis has also been associated with poor oral health status.Treating those patients accordingly can help in…
- Trial name
- NCT04399512
- Testing
- Nonsurgical root canal treatment
- Where
- India
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Apical Periodontitis
"Effect of Apical Patency on Post-endodontic Pain"
This study is designed to find out the effect of maintaining apical patency versus non maintaining apical patency on post-operative pain after single visit endodontic treatment in necrotic teeth with asymptomatic apical…
- Trial name
- NCT04551209
- Testing
- Maintaining apical patency
- Where
- Pakistan
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- National University of Medical Sciences, Pakistan
Apical Periodontitis, Coronary Artery Disease
hsCRP & CH Indices in Patients With Coronary Artery Disease With and Without Apical Periodontitis
Endodontic treatment is done in Patients with chronic pulp exposure in patients with Coronary Artery Disease and systemic inflammatory markers recorded before and and after treatment and compared with patients with Coronary…
- Trial name
- NCT06270693
- Testing
- Endodontic treatment
- Where
- India
- Volunteers
- 70 people
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Cryotherapy
Effect of Two Different Cryotherapy Irrigation Protocols on Postoperative Endodontic Pain
The aim of this study is to evaluate the effect of intracanal cryotreated (2-3°C) 2.5% sodium hypochlorite and Saline used throughout the procedure, compared with a room-temperature irrigation protocol with a final cryotreated…
- Trial name
- NAOCL/EDTA (NCT07676409)
- Testing
- Full Cryotherapy Irrigation (FC), Final Flush Cryotherapy Irrigation (FFC), Conventional Irrigation (CI)
- Volunteers
- 45 people
- Sponsor
- Cairo University
Endodontic Disease, Pulp Disease, Dental
The Antimicrobial Potential of Diclofenac Sodium as an Intracanal Medicament
The goal of this randomized clinical trial is to evaluate the capability of the material to exert bacterial reduction of diclofenac sodium versus of that calcium hydroxide paste when these materials are used as intracanal…
- Conditions
- Endodontic Disease, Pulp Disease, Dental, Intracanal Medication
- Trial name
- NCT06207253
- Testing
- Diclofenac Sodium, Calcium hydroxide
- Where
- Egypt
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- British University In Egypt
Apical Periodontitis
Association Between Apical Periodontitis and Psoriasis Vulgaris
The aim of the present cross-sectional study is to assess the presence of AP and caries in psoriasis vulgaris individuals and to examine whether these medications influence these oral conditions.
- Trial name
- NCT06436339
- Where
- Italy
- Volunteers
- 152 people
- Sponsor
- University of Siena
Apical Periodontitis, Dental Pulp Necrosis
Chitosan Irrigation in Premolar Root Canal Therapy (Randomized Trial)
The goal of this clinical trial is to learn which of three common root-canal rinsing (irrigation) methods removes bacteria most effectively in adult patients who need root-canal treatment.
- Conditions
- Apical Periodontitis, Dental Pulp Necrosis, Root Canal Infection
- Trial name
- CHITO-PRE RCT (NCT07048028)
- Testing
- Chitosan Low Molecular Weight (20-200 Mpa.S), Sodium Hypochlorite, EDTA chelating agents
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- ESRA DAĞCI
Necrotic Pulp
Healing Potentiality Of Blood Clot S-PRF and A-PRF in the Treatment Of Necrotic Mature Single-Rooted Teeth With Chronic Peri-Apical Periodontitis
Earlier, it was believed that successful regeneration cannot be achieved once tooth has become infected. However, recent studies suggest that regenerative endodontics may in fact be possible in teeth with pulpal necrosis and…
- Trial name
- NCT04606719
- Testing
- Advanced Platelet Rich fibrin
- Where
- Egypt
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Cairo University
Irreversible Pulpitis With Apical Periodontitis
The Effect of Eddy Sonic Versus AF Max Activation of Bio-ceramic Sealer on Post-operative Pain in Teeth With Symptomatic Irreversible Pulpitis With Apical Periodontitis
The aim of endodontic therapy for an inflamed tooth is to eliminate the source of inflammation. Relieving pain depends on the effectiveness of root canal therapy.3 Postoperative pain in endodontic treatments, affecting 3-58% of…
- Trial name
- NCT06640218
- Testing
- sealer activation with Eddy sonic and AF max, without AF max or Eddy sonic sealer activation
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Future University in Egypt
Apical Periodontitis
Bone Regenerative Techniques in Endodontic Microsurgery
The purpose of this randomized controlled clinical trial was to evaluate two dimensionally and 3-dimensionally the effect of resorbable collagen-based bone filling material on periapical healing following endodontic microsurgery…
- Trial name
- NCT04514991
- Testing
- Foundation
- Where
- United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Diabete Type 2
Effect of Diode Laser, Gudmar and Vinegar in Diabetic Patients During Root Canal Treatment
Methodology Patient with diabetes 2 with informed consent -convenience sampling over a one year period.The tooth isolated with a rubber dam and the correct disinfection procedures will be used.
- Trial name
- NCT07549373
- Testing
- 940 nm diode laser, apple cider vinegar, Gymnema Sylvestre
- Where
- India
- Volunteers
- 90 people
- Sponsor
- Sharda University
Apical Periodontitis
Effect of Different Instrumentation Technique on Endodontic Outcome
Aim: To evaluate and compare the outcome of primary endodontic treatment following use of different instrumentation techniques. Materials and methods: Study subjects were recruited from the pool of patients referred for the…
- Trial name
- NCT03278054
- Testing
- Root Canal Treatment with hand instruments, Root canal treatment with Protaper instruments, Root canal treatment with hybrid instrumentation
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Chronic Apical Periodontitis, Necrosis of Pulp
Using Platelet-rich Fibrin in Regenerative Endodontic Treatment in Mature Permanent Teeth
This study aims to evaluate the antibacterial effects of injectable platelet-rich fibrin (i-PRF) in vitro, and to assess the clinical and radiographic outcomes of using advanced platelet-rich fibrin (A-PRF+) and i-PRF in…
- Conditions
- Chronic Apical Periodontitis, Necrosis of Pulp, Acute Apical Periodontitis of Pulpal Origin, Periapical Abscess
- Trial name
- NCT07192289
- Testing
- Using advanced platelet-rich fibrin (A-PRF+) or injectable platelet-rich fibrin (i-PRF) in regenerative endodontic treatment in mature permanent teeth.
- Where
- Vietnam
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City
Post Operative Pain, Post-Op Complication
Effect of Occlusal Reduction on Relief of Pain and Sensitivity to Percussion in Patients With Irreversible Pulpitis
One of the most important aspects of endodontic practice is to abate pain during and post root canal treatment. An endodontist by all means should provide a painless endodontic treatment to their patients.
- Trial name
- NCT05306535
- Testing
- Occlusal reduction
- Where
- Pakistan
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Altamash Institute of Dental Medicine
Asymptomatic Apical Periodontitis
Comparison of the Effects of Bio Ceramic and Epoxy Resin-based Sealers on Postoperative Pain After Root Canal Treatment
This study aims to compare the effect of bio ceramic sealer and resin-based sealer on the intensity and occurrence of post operative pain in single rooted teeth with asymptomatic apical periodontitis.
- Trial name
- NCT06543004
- Testing
- AH plus sealer, Bioceramic sealer
- Where
- Qatar
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Primary Health Care Corporation, Qatar
Pain, Postoperative, Irreversible Pulpitis
Can Instrumentation Kinematics Affect Post Operative Pain and Substance P Levels? A Randomized Controlled Trial
The aim of this study was to evaluate the effect of continuous rotation and reciprocation kinematics on post operative pain and difference in substance P levels in patients with irreversible pulpitis with symptomatic apical…
- Conditions
- Pain, Postoperative, Irreversible Pulpitis, Apical Periodontitis
- Trial name
- NCT06081335
- Testing
- EdgeEndo x7 continuous rotation files, EdgeOne Fire reciprocating files
- Where
- 2 sites in Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Apical Periodontitis
Expression of IL-8 Before and After Root Canal Treatment in Patients With Symptomatic Apical Periodontitis
This clinical study aimed to Compare the levels of Interleukin 8 before and after root canal treatment in patients with apical periodontitis Diagnosis Local anesthesia Isolation and disinfection of the tooth Two-staged access…
- Trial name
- NCT05653947
- Testing
- Root canal instrumentation, 2.5% NaOCl irrigation
- Where
- Egypt
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Cairo University
Apical Periodontitis, Irreversible Pulpitis with Apical Periodontitis
To Measure Post Operative Pain Severity by Using Two Different Intra Canal Medicaments Calcium Hydroxide and Triple Antibiotic Paste in Teeth with Single Roots and Periapical Disease Called Apical Periodontitis
The aim of this study is to compare post operative pain effectiveness between two most commonly available intra canal medicaments that are Triple Antibiotic Paste and Calcium Hydroxide during root canal treatment of single rooted…
- Trial name
- NCT06821763
- Testing
- Calcium Hydroxide Intracanal medication, triple antibiotic paste (TAP)
- Where
- Pakistan
- Volunteers
- 180 people
- Sponsor
- Komal Ashraf Khan
Pulp Necrosis, Immature Permanent Teeth
PRF and CGF Scaffolds With EDTA in Regeneration
This study evaluated the regenerative outcomes of immature permanent teeth with necrotic pulps treated using three scaffold types-blood clot, platelet-rich fibrin (PRF), and concentrated growth factor (CGF)-combined with either…
- Conditions
- Pulp Necrosis, Immature Permanent Teeth, Open Apex, Periapical Periodontitis
- Trial name
- RET-EDTA-CGF (NCT07265804)
- Testing
- Blood Clot + 5% EDTA, Blood Clot + 17% EDTA, PRF + 5% EDTA
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Kahramanmaras Sutcu Imam University