Clinical trials: Perimenopausal Depression
Perimenopause, Perimenopause-Related Depression
Impact of a Novel Functional Snack on Perimenopausal Symptoms and Well-being
This is a clinical trial aimed to investigate if a novel phytochemical and fibre-rich snack can improve perimenopausal symptoms and well-being in perimenopausal women aged 40-55 and not on hormone replacement therapy.
- Conditions
- Perimenopause, Perimenopause-Related Depression, Mood, Sleep
- Trial name
- SWAP (NCT07599930)
- Testing
- Functional Snacks
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- King's College London
Perimenopause-Related Depression
Estrogen Receptor Beta and Mood
Background: Our previous studies have found that women who had depression during the perimenopause may have mood symptoms again if they stop estrogen therapy.
- Trial name
- NCT03689543
- Testing
- Estradiol, ER Beta Agonist, Provera
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- National Institute of Mental Health (NIMH)
Menopausal Depression, Menopause Hot Flashes
Transcranial Electrical Stimulation for Noninvasive Study of Menopausal/Perimenopausal Symptoms
Participants are being invited to a research study. This research aims to assess the tolerability of transcranial electrical stimulation of the brain, and explore the response of TES on menopausal/perimenopausal symptoms…
- Conditions
- Menopausal Depression, Menopause Hot Flashes, Menopause, Menopause Related Conditions
- Trial name
- NCT07375732
- Testing
- Transcranial Electrical Stimulation
- Volunteers
- 50 people
- Sponsor
- Carnegie Mellon University
Depressive Symptoms, Urinary Incontinence
BTL-699-2 and HPM-6000UF Devices for the Improvement of Depressive Symptoms and Sexual Function Among Perimenopausal and Postmenopausal Women
The goal of this clinical trial is to evaluate if the combined treatment with EXOMIND (BTL-699-2) and EMSELLA (HPM-6000UF) devices is able to improve depressive symptoms and sexual function in women who are perimenopausal or…
- Conditions
- Depressive Symptoms, Urinary Incontinence, Sexual Dysfunction
- Trial name
- NCT07413705
- Testing
- EXOMIND (BTL-699-2) Active Treatment, EMSELLA (HPM-6000UF) ActiveTreatment
- Where
- 3 sites in United States, Canada
- Volunteers
- 41 people
- Sponsor
- BTL Industries Ltd.
Depression
Probiotics Therapy of Mood Disorders
The evaluation of the influence of a probiotics therapy on mood improvement and the reduction of depressive symptoms in women in the perimenopausal age group.
- Trial name
- NCT04753944
- Testing
- Active Comparator: Probiotic
- Where
- Poland
- Volunteers
- 60 people
- Sponsor
- Pomeranian Medical University Szczecin
Perimenopausal Disorder
Efficacy and Safety for Cimicifuga/Hypericum Product
Climacteric Complains bring to women many problems for living a normal life - hot flashes, irritation are 2 of many problems and the mixture of those 2 plant extract must bring a new horizon for this part of time.
- Trial name
- CH (NCT01481025)
- Testing
- Cimicifuga + Hiperico, Cimicifuga Herbarium, Aplause®
- Where
- Brazil
- Volunteers
- 210 people
- Sponsor
- Phytopharm Consulting Brazil
Perimenopausal Depression, Post Menopausal
The Effects of Estrogen Withdrawal on Mood Symptoms in Women
This study evaluates the effects on mood when stopping estrogen replacement therapy. The purpose of this study is to investigate the effects of estrogen levels on perimenopausal depression.
- Conditions
- Perimenopausal Depression, Post Menopausal, Healthy, Depression
- Trial name
- NCT00060736
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- National Institute of Mental Health (NIMH)
Perimenopausal Depression, Depressive Symptoms
Testing the Efficacy of Mindfulness-based Stress Reduction in the Prevention of Perimenopausal Depression
Depression is the leading cause of disability worldwide and a risk factor for other diseases. While women are at elevated risk for depression in general, the menopause transition is a particularly vulnerable time for many women…
- Trial name
- NCT03526523
- Testing
- Mindfulness-based stress reduction
- Where
- Canada
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- University of Regina
Major Depressive Disorder, Menopause
A Neurosteroid Intervention for Menopausal and Perimenopausal Depression
HYPOTHESIS: Pregnenolone administration will be associated with greater reduction in depressive symptom severity than placebo in women with current mMDD.
- Conditions
- Major Depressive Disorder, Menopause, Perimenopause
- Trial name
- NCT03505905
- Testing
- Pregnenolone
- Where
- United States
- Volunteers
- 73 people
- Sponsor
- University of Texas Southwestern Medical Center
Emotional Processing and Cognitive Function in Perimenopausal Women Experiencing Cognitive Perturbations, Perimenopause
Probiotic Intake and Perimenopausal Psychological Assessments
Recent evidence suggests multi-strain probiotics containing Lactobacillus rhamnosus and Bifidobacterium longum have been found to enhance emotional processing and reduce salience to negative cues in studies involving people with…
- Conditions
- Emotional Processing and Cognitive Function in Perimenopausal Women Experiencing Cognitive Perturbations, Perimenopause, Perimenopause-Related Depression, Perimenopausal Women
- Trial name
- PIPPA (NCT07590999)
- Testing
- Multi-strain probiotic
- Where
- United Kingdom
- Volunteers
- 106 people
- Sponsor
- University of Oxford
Perimenopause, Menopause
The Effects of Resistance Training and a Plant-Based Supplement on Perimenopausal Symptoms and Muscle Health.
The aim of this clinical trial is to determine if resistance training and a newly developed plant-based nutritional supplement can improve the symptoms and musculoskeletal health of perimenopausal women.
- Trial name
- NCT07135232
- Testing
- Sarmentosin - L- theanine, Resistance Training
- Where
- United Kingdom
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Leeds Beckett University
Depression, Anxiety
Whole Body Hyperthermia Registry Study
This protocol will allow for the implementation of a research registry pertaining to Whole Body Hyperthermia (WBH) use in various subject populations.
- Conditions
- Depression, Anxiety, PTSD, Fibromyalgia
- Trial name
- NCT02174003
- Testing
- High intensity whole-body infrared heating
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Hot Flashes, Climactericum
The Effect of Cold Packs on Hot Flushes and Depression in Women Going Through the Climacteric Period
This study is planned as a pre-post test, randomised controlled, experimental trial designed to determine the effect of applying a cold gel pack to the Sanyinjiao (SP6) and Hegu (Large Intestinal 4 (LI4)) acupoints on hot flushes…
- Conditions
- Hot Flashes, Climactericum, Perimenopausal Depression, Cold Application
- Trial name
- NCT07533097
- Testing
- Cold gel packs application
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Rabia Atilla
Perimenopausal Depression
Investigation of Tibolone and Escitalopram in Perimenopausal Depression
Many perimenopausal women experience severe mood symptoms for the first time in their life, with no past psychiatric history. The importance of clearly identifying and treating a disorder that is increasingly referred to as…
- Trial name
- NCT01368068
- Testing
- Tibolone, Escitalopram, Natvia
- Where
- Australia
- Volunteers
- 2 people
- Sponsor
- The Alfred