Clinical trials: Perinatal Disorder
Neonatal Encephalopathy
Transcutaneous Carbon Dioxide Monitoring in Neonates Receiving Therapeutic Hypothermia for Neonatal Encephalopathy
The aim of our study is to evaluate the feasibility of applying transcutaneous CO2 monitoring (tcPCO2) in neonates receiving therapeutic hypothermia and to quantify the agreement between tcPCO2 and PCO2 in this population with or…
- Trial name
- NCT04603547
- Testing
- Transcutaneous Carbon Dioxide Monitoring
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- Brigham and Women's Hospital
Grief, Post Traumatic Stress Disorder
Walk With Me (WWM) for Perinatal Grief
The goal of this clinical trial is to learn if the Along With Me web-based intervention works to decrease posttraumatic stress symptoms and suicidal ideation among bereaved parents following pregnancy and early infant loss.
- Conditions
- Grief, Post Traumatic Stress Disorder, Suicidal Ideation, Miscarriage
- Trial name
- PeriGrief-II (NCT07011940)
- Testing
- Along With Me, Peer Guide
- Where
- 2 sites in United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Oregon Research Behavioral Intervention Strategies, Inc.
Pregnancy, Helicobacter Pylori Infection
Effects of Dietary Heme/Non-heme Iron and Helicobacter Pylori (Hp) Infection on Maternal Iron-deficiency Anemia and Fetal Growth Outcomes
Iron deficiency is considered one of the main nutritional deficiency disorders despite the apparent availability of a high-quality diet even in developed countries, and Iron deficiency anemia (IDA) is the most common form of…
- Conditions
- Pregnancy, Helicobacter Pylori Infection, Iron-Deficiency Anemia
- Trial name
- NCT01071759
- Where
- Taiwan
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- E-DA Hospital
Anxiety Disorder (Panic Disorder or GAD), Anxiety Symptoms
Anxiety is One of the Most Frequent Disorders During the Perinatal Stage Which is Associated with Adverse Health Effects for Women and Their Babies. This Study Will Be to Evaluate the Effectiveness of a Telematic Cognitive-behavioral Preventive Intervention to Manage Anxiety During Pregnancy.
Anxiety is one of the most frequent disorders during the perinatal stage which is associated with adverse health effects for women and their babies. In spite of this, preventive interventions during this stage are scarce.
- Trial name
- NCT06609291
- Testing
- Telematic Prenatal Psychological Intervention for Preventing Anxious Symptomatology
- Where
- Spain
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- University of Santiago de Compostela
Hypoxic Ischaemic Encephalopathy (HIE), Hypoxic Ischemic Encephalopathy of Newborn
Feasibility and Safety of Intranasally Administered Breast Milk in HIE
This is a prospective intervention single center study to evaluate the feasibility and safety of intranasal breast milk in hypoxic-ischaemic encephalopathic neonates receiving therapeutic hypothermia.
- Conditions
- Hypoxic Ischaemic Encephalopathy (HIE), Hypoxic Ischemic Encephalopathy of Newborn, Neonatal Encephalopathy, Neonatal Hypoxic Ischemic Encephalopathy
- Trial name
- F-NEO-BRIGHT (NCT06747260)
- Testing
- Intranasal breast milk
- Where
- Hungary
- Volunteers
- 10 people
- Sponsor
- Semmelweis University
Attachment Disorder
Investigation of the Effect of Attachment-Based Support Given in the Perinatal Period
It is important that effective intervention programs are developed and implemented in our country by identifying risk factors in the early period. In this aspect, the work is unique.
- Trial name
- NCT05676996
- Testing
- attachment-based support
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Sakarya University
Brain Injury, Fetus and Neonate
Diffusion-Tensor Magnetic Resonance Imaging (MRI) and the Evaluation of Perinatal Brain Injury
The researchers' objective is to use diffusion-tensor imaging (DTI) to evaluate infants diagnosed with cerebral white matter injury during the neonatal period and identify antenatal risk factors, electronic fetal heart rate…
- Trial name
- NCT00131859
- Testing
- Diffusion-tensor imaging
- Where
- 2 sites in United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Perinatal Depression, Affective Disorder
Validation of the French Version of the Perinatal Assessment of Paternal Affectivity (PAPA)
The transition to parenthood is a critical period for both the woman and her partner, and this can affect the mental health of the parents.
- Conditions
- Perinatal Depression, Affective Disorder, Fathers
- Trial name
- French-Papa (NCT06594263)
- Where
- France
- Volunteers
- 343 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Substance Use Treatment, Perinatal Substance Use
Improving Outcomes for Early Postpartum Mothers in Outpatient MOUD Treatment
Drug overdose is a leading cause of death among postpartum women and opioid-related mortality is 4 times higher in the postpartum period when compared to the third trimester of pregnancy.
- Conditions
- Substance Use Treatment, Perinatal Substance Use, Parenting
- Trial name
- NCT07071766
- Testing
- Proud of Baby and Me
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Arkansas
Diabetic Foot Ulcer
Evaluating the Efficacy of Perinatal Membrane Allografts in Addition to the Standard of Care for the Treatment of Non-healing Diabetic Foot Ulcers.
The goal of this clinical trial is to learn if using perinatal tissue allografts improves healing of chronic, non-healing foot ulcers in diabetic patients.
- Trial name
- NCT06437028
- Testing
- Dual-layer perinatal tissue allograft, Three-layer fenestrated perinatal tissue allograft, Standard of care
- Where
- United States
- Volunteers
- 170 people
- Sponsor
- Samaritan Biologics
Prostate Cancer
Evaluating Return to Continence and Potency Following Radical Prostatectomy
The purpose of this research is to determine if using human placental membrane (also called an allograft) helps to improve recovery time for erectile function and bladder control after having robot-assisted radical prostatectomy…
- Trial name
- NCT05742334
- Testing
- Robot-Assisted Radical Prostatectomy with MLG-COMPLETE Allograft Implantation, MLG-COMPLETE Allograft Implantation
- Sponsor
- Wake Forest University Health Sciences
Depression, Anxiety, Antenatal Depression
Integration of Stepped Care for Perinatal Mood and Anxiety Disorders Among Women Attending MCH Clinics
Perinatal mood and anxiety disorders (PMAD), defined as depression and anxiety during pregnancy or up to 1 year postpartum, account for substantial morbidity and mortality among birthing people globally especially in low- and…
- Conditions
- Depression, Anxiety, Antenatal Depression, Postnatal Depression
- Trial name
- IPMH (NCT06456307)
- Testing
- Integrated Perinatal Mental health program (systematic screening for PMAD, PM+ and tele-psychiatry)
- Where
- 2 sites in Kenya
- Volunteers
- 2,970 people, healthy volunteers welcome
- Sponsor
- Kenyatta National Hospital
Preeclampsia
Physical Therapy in Pregnant Women With Preeclampsia
The aim of this study is to evaluate the influence that has a physical therapy protocol in maternal and fetal hemodynamics in relation to blood pressure, maternal and fetal responses and perinatal outcomes.
- Trial name
- FPE (NCT01630772)
- Testing
- Physical therapy, No physical therapy
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- University of Sao Paulo
Thromboembolism, Venous Thromboembolism
Retrospective Study of Patients Who Were Treated With Fondaparinux Pre-, Peri- and/or Postpartum for Prophylaxis or Treatment of Venous Thromboembolism
The objective of this retrospective study is to gather information about how fondaparinux is used pre-, peri- and/or postpartum for both the prophylaxis and treatment of venous thromboembolism (VTE) in order to fill an…
- Trial name
- FondaPPP (NCT01004939)
- Testing
- fondaparinux
- Where
- 7 sites in Germany
- Volunteers
- 120 people
- Sponsor
- GlaxoSmithKline
Postpartum Depression, Anxiety
Mothers and Babies Qatar (MB-Q): A Postpartum Depression Intervention
Qatar Mothers and Babies is a 4-year collaboration between Northwestern University Feinberg School of Medicine and Sidra Medicine in Doha, Qatar that will generate and evaluate a cultural and contextual adaptation of the Mothers…
- Conditions
- Postpartum Depression, Anxiety, Diabetes
- Trial name
- MB (NCT04442529)
- Testing
- Mothers and Babies (MB)
- Where
- Qatar
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Sidra Medicine
Fetus Fetus, Pregnancy Complications
the Fetal Epicardial Thickness in Obese Pregnant Women (EFT)
the effects of fetal EFT on fetal cardiac function and fetal and maternal outcomes were investigated in obese pregnant women compared with normal-weight pregnant women.
- Trial name
- EFT (NCT05948319)
- Testing
- Doppler ultrasonography
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Necmettin Erbakan University
Asphyxia Neonatorum, Hypoxia
TOBY (TOtal Body hYpothermia): a Study of Treatment for Perinatal Asphyxia
Hypothesis: Prolonged whole body cooling in term infants with perinatal asphyxial encephalopathy reduces death and severe neurodevelopmental disability.
- Conditions
- Asphyxia Neonatorum, Hypoxia, Encephalopathy, Seizures
- Trial name
- NCT00147030
- Testing
- Whole body mild induced hypothermia
- Where
- United Kingdom
- Volunteers
- 325 people
- Sponsor
- Imperial College London
Infection
Determination of Gentamicin Dosing in Neonatal Patients
The purpose of this study is to determine what dosage of gentamicin for use in one-time administration device (Uniject) is appropriate.
- Trial name
- NCT00198601
- Testing
- Gentamicin in Uniject Pre-filled syringe
- Where
- 3 sites in Bangladesh, India and 1 more
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Anoxic-Ischemic Encephalopathy
Becoming Children With Perinatal Anoxo-Ischemic Encephalopathy Without Indication of Therapeutic Hypothermia
There are 3 levels of severity of anoxo-ischemic encephalopathy (EAI): mild, moderate and severe. Therapeutic hypothermia is beneficial in children with moderate EAI.
- Trial name
- SARNATUN (NCT03744481)
- Testing
- Questionaire
- Where
- France
- Volunteers
- 68 people
- Sponsor
- Hospices Civils de Lyon
Maternal Death, Neonatal Death
Incentives for Postnatal Care Demand
The purpose of this study is to identify the causal impact of performance-based monetary incentives in increasing postnatal care (PNC) referrals by traditional birth attendants (TBAs), via a randomized controlled trial (RCT).
- Trial name
- NCT02936869
- Testing
- Performance-based monetary incentives
- Volunteers
- 207 people, healthy volunteers welcome
- Sponsor
- Harvard School of Public Health (HSPH)