Clinical trials: Periodontal Bone Defects
Periodontal Diseases, Bone Diseases
Regenerative Potential of a Collagen Membrane Associated or Not to Bovine Bone in Class II Furcation Defects.
Periodontal disease is an infectious-inflammatory disease that accommodates the supporting and supporting tissues of the teeth, with the formation of periodontal pockets, and this destruction can generate anatomical defects in…
- Trial name
- RPPCMABBICFD (NCT04450849)
- Testing
- guided tissue regeneration with using an absorbable collagen membrane associated with inorganic bovine bone associated., guided tissue regeneration with using an absorbable collagen membrane associated or not with inorganic bovine bone associated with collagen matrix.
- Where
- Brazil
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Periodontitis, Periodontal Bone Loss
Non-incised Papillae Surgical Approach (NIPSA) and Connective Tissue Graft Plus Emdogain for Periodontal Defects
The present study pretends to show the results of combining a modification of the Non-incised papillae surgical approach (NIPSA) attempting to improve the outcome in the treatment of teeth with advanced periodontal support loss.
- Conditions
- Periodontitis, Periodontal Bone Loss, Periodontal; Lesion
- Trial name
- NCT03997578
- Testing
- NIPSA (Non-incised papilla surgical approach), NIPSA plus connective tissue graft
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Universidad de Murcia
Alveolar Bone Loss
Treatment of Alveolar Bone Defects Using Aastrom Biosciences Autologous Tissue Repair Cell Therapy
The purpose of this research is to determine if a subject's own bone marrow tissue can help regenerate bone in the area of his/her jaw where a tooth has been removed using Tissue Repair Cell (TRC) Therapy.
- Trial name
- NCT00755911
- Testing
- Tissue Repair Cells (TRC), Control
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Michigan
Periodontal Diseases, Bone Resorption
Bioactive Glass and Platelet Rich Fibrin in Intrabony Defects
Background: Platelet-rich fibrin (PRF) and bioactive glass putty has been shown to be effective in promoting reduction in probing depth, gain in clinical attachment, and defect fill in intrabony periodontal defects.
- Trial name
- NCT02982681
- Testing
- Platelet rich fibrin, Bioactive Glass
- Volunteers
- 10 people
- Sponsor
- Dr. D. Y. Patil Dental College & Hospital
Periodontal Bone Loss
Platelet-rich Fibrin and Autogenous Bone vs Membrane and Autogenous Bone in Intrabony Defects
Currently, the most positive documented outcomes of periodontal regenerative therapy (PRT) in intrabony defects (IBDs) have been achieved with a combination of bone grafts ( BGs) and a regeneration material like membranes in…
- Trial name
- NCT04043754
- Testing
- Procedure/Surgery: Periodontal surgery with Membrane, Periodontal surgery with Platlet Rich fibrin
- Where
- Italy
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- G. d'Annunzio University
Periodontal Bone Loss
Regenerative Therapy of Periodontal Bone Defects
To compare clinically and radiographically the efficacy of demineralized freeze-dried bone allograft with and without decortication in the treatment of periodontal intrabony defects assessed by gain in clinical attachment…
- Trial name
- NCT03435653
- Testing
- OFD with DFDBA, OFD with decortication and DFDBA
- Where
- India
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Furcation Defects, Periodontal Disease
Conventional or Minimally Invasive Surgical Technique for the Treatment of Furcation Defects Using Enamel Matrix Derivative and Anorganic Bovine Bone - a Randomized Controlled Clinical Trial.
This clinical study compared a conventional surgical technique (CST) and a minimally invasive surgical technique (MIST) in the regenerative treatment of mandibular furcation defects.
- Trial name
- NCT02102360
- Testing
- Anorganic Bovine Bone, Enamel Matrix Derivative
- Where
- Brazil
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Intrabony Periodontal Defect
Evaluation of Autogenous Demineralized Dentin Graft Vs Autogenous Bone Graft in Management of Intrabony Defects
The main goal is to evaluate and compare the clinical and radiographic efficacy of autogenous demineralized dentin as bone graft substitute versus autogenous bone graft when performed with modified minimally invasive surgical…
- Trial name
- NCT06048042
- Testing
- Autogenous Demineralized Dentin Graft, Autogenous Bone Graft
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Cairo University
Periodontal Pocket
Gingival Crevicular Fluid Bone Morphogenetic Protein - 2 Release Profile Following the Use of Perforated Membrane
One of the most important elements suggested to be provided through membrane perforations to augment regeneration are cell released growth factors from the overlying periosteal and gingival cells.
- Trial name
- MPM (NCT01860495)
- Testing
- perforated membrane, G2
- Where
- Egypt
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Peri-Implantitis
Guided Bone Regeneration of Peri-implant Defects Comparing Submerged Versus Non-submerged Healing
Objective: the objective of the present randomized clinical trial is to compare changes in radiographic peri-implant bone defect fill after regeneration of peri-implant intrabony defects with a submerged versus a non-submerged…
- Trial name
- NCT03900741
- Testing
- Submerged healing, Non-submerged healing
- Where
- Spain
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Ana Molina Villar
Periodontal Diseases
Treatment of Periodontal Intra-bony Defects With a Volume Stable Collagen Matrix or Deproteinized Bovine Bone Mineral With 10% Collagen
To compare the healing of intrabony periodontal defects treated with either open flap debridement and a volume-stable collagen matrix (VCMX) or a deproteinized bovine bone mineral with 10% collagen.
- Trial name
- NCT06676826
- Testing
- Infrabony defects will be filled with a volume-stable collagen matrix (VCMX), Infrabony defects will be filled treated with a deproteinized bovine bone mineral with 10% collagen
- Where
- Switzerland
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Bern
Periodontitis, Periodontal Diseases
Clinical And Radiographic Evaluation Of Zinc Substituted Nanohyrdoxyappatite Bone Graft And Advanced Platelet Rich Fibrin Block In The Treatment Of Periodontal Intrabony Defects
Periodontal intrabony defects pose a significant challenge in clinical dentistry due to their complex anatomy and limited regenerative potential.
- Trial name
- R C S (NCT07313254)
- Testing
- OFD with zinc substituted nano HA combined with PRF block, OFD with zinc substituted nano HA, OFD with nano HA
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Suez Canal University
Periodontal Bone Loss, Periodontal Defect
Polynucleotides and Hyaluronic Acid vs Enamel Matrix Proteins in the Treatment of Intrabony Defects
The goal of this clinical trial is to compare two periodontal regenerative treatments in adults with Stage III or IV periodontitis and infrabony periodontal defects ≥3 mm.
- Conditions
- Periodontal Bone Loss, Periodontal Defect, Periodontitis Stage III, Periodontitis Stage IV
- Trial name
- PN-HAVSEMPIND (NCT07589959)
- Testing
- Regenerative periodontal surgery using Regenfast® (hyaluronic acid + polynucleotides) with Bio-Oss® graft, Regenerative periodontal surgery using Emdogain® (enamel matrix derivative) with Bio-Oss® graft
- Volunteers
- 40 people
- Sponsor
- Shashi Dadlani
Intrabony Periodontal Defects
Using MIST With or Without EMD in Treatment of Intrabony Periodontal Defects.
After performing the power calculation, healthy adult participants for the study will be randomly allocated into two groups. The intervention group will receive minimally invasive surgical techniques (MIST) with enamel matrix…
- Trial name
- NCT02810054
- Testing
- Minimally Invasive Surgical Techniques (MIST), Enamel Matrix Derivative (EMD)
- Volunteers
- 30 people
- Sponsor
- University of Manchester
Peri-implantitis
Reconstructive Treatment of Peri-implantitis With Combined Defects
The aim of this randomized clinical study is to assess the additional clinical benefit of incorporating a resorbable collagen membrane (CM) alongside a xenogeneic bone graft-specifically, deproteinized bovine bone mineral with…
- Trial name
- NCT06957652
- Testing
- DBMM-C plus Resorbable collagen membrane, DBMM-C
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Gazi University
Periodontal Bone Loss, Chronic Periodontitis
Treatment of Intrabony Periodontal Defects With Enamel Matrix Derivatives and Autogenous Bone Graft
The present study aimed to evaluate the effects of enamel matrix derivatives either alone or combined with autogenous bone graft applied to intrabony defects in chronic periodontitis patients on clinical/radiographic parameters…
- Trial name
- NCT02218515
- Testing
- Open Flap Debridement, EmdogainⓇ(Enamel Matrix Derivative), EmdogainⓇEnamel Matrix Derivative+Autogenous Bone
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Haner Direskeneli, Prof
Intrabony Periodontal Defect, Periodontal Disease
Evaluation of NIPSA Using Alloplastic Bone Graft and Cross-Linked Hyaluronic Acid in theTreatment of Intrabony Defects
Sixty patients will be selected from the outpatient clinic in the Oral Medicine and Periodontology Department, Faculty of Dentistry, Mansoura University, Egypt, according to preoperative clinical and radiographic data that will…
- Trial name
- RCT (NCT07737678)
- Testing
- allopastic bone graft, cross-linked hyaluronic acid, Non-Incised Papillae Surgical Approach
- Volunteers
- 60 people
- Sponsor
- Mansoura University
Periodontal Diseases, Periodontal Bone Loss
Clinical and Radiographic Assessment of Efficacy of Modified Minimally Invasive SurgicalTechnique (M-MIST) Alone and Combined With Enamel Matrix Proteins and Ox-derived Bone Graft in the Treatment of Single Bone Defects Between Teeth.
This study was performed to investigate the adjunctive clinical benefit of the application of enamel matric derivatives and xenograft with the modified minimally invasive surgical technique in the treatment of isolated intrabony…
- Trial name
- NCT07310732
- Testing
- modified minimally invasive surgical technique, modified minimally invasive surgical technique plus emdogain, modified minimally invasive surgical technique plus emdogain and xenograft
- Where
- India
- Volunteers
- 45 people
- Sponsor
- Rungta College of Dental Sciences and Research
Peri-implantitis
Implant Survival After Surgical Treatment of Peri-implantitis of Infra-bony Defects
To report the 10 years outcomes of a reconstructive surgical protocol for peri-implantitis defects with different morphologies, by means of deproteinized bovine bone mineral with 10% collagen (DBBMC).
- Trial name
- Bony defects (NCT07809334)
- Testing
- Reconstructive therapy
- Where
- Italy
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Turin, Italy
Chronic Periodontitis
Benefits of Platelet Rich Fibrin In Mandibular Molar Furcation Defects
Background: Furcation is the bifurcation or trifurcation of a multirooted tooth. It is an area of complex anatomic morphology difficult to debride by routine periodontal instrumentation.
- Trial name
- PRFMMFD (NCT02430519)
- Testing
- Furcation treatment with PRF, Furcation Treatment with Allograft and GTR, allograft and guided tissue regeneration (GTR) membrane (DFDBM and Healiguide)
- Volunteers
- 22 people
- Sponsor
- Dr.Syed Asimuddin