Clinical trials: Periodontal Bone Defects
Periodontal Diseases, Intrabony Periodontal Defect
Papilla Preservation Technique in Combination With Tooth Enamel Proteins and Animal Derived Bone Graft in Treating Isolated Bone Defects Between Teeth
The present three-arm study compared the clinical and tomographic efficacy of the Entire Papilla Preservation Surgical Technique (EPPT) alone and combined with enamel matrix derivative (EMD) plus bone mineral derivedxenograph…
- Trial name
- NCT07119307
- Testing
- Entire Papilla Preservation Technique, Entire Papilla Preservation Surgical Technique (EPPT) alone, Entire Papilla Preservation Surgical Technique (EPPT) alone and combined with enamel matrix derivative (EMD)
- Where
- India
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Rungta College of Dental Sciences and Research
Periodontitis, Aggressive
Clinical and Radiographic Evaluation of Guided Tissue Regeneration With Radiation-sterilized Allogenic Bone Grafts or Xenogenic Grafts for the Treatment of Intrabony Defects in Aggressive Periodontitis
The treatment of intrabony defects in patients with aggressive periodontitis remains a challenging procedure and novel therapeutic strategies are sought.
- Trial name
- NCT03340012
- Testing
- GTR + radiation-sterilize allogenic bone graft, GTR + xenogenic graft
- Where
- Poland
- Volunteers
- 20 people
- Sponsor
- Medical University of Warsaw
Isolated Intrabony Periodontal Defects in Patients With Periodontitis
Clinical and Radiographic Evaluation of Using the Entire Papilla Preservation Technique With and Without Autogenous Bone Graft and Injectable Platelet Rich Fibrin in Treatment of Periodontal Intraosseous Defects
The goal of this Clinical trial is to evaluate the clinical and radiographic outcomes of using entire papilla preservation technique with and without autogenous bone and injectable platelet rich fibrin in treatment of isolated…
- Trial name
- NCT06347263
- Testing
- Entire papilla preservation technique
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Cairo University
Periodontitis (Stage 3), Minimally Invasive Surgical Procedures
Bone Substitutes and NIPSA in Intrabony Periodontal Defects: A Randomized Controlled Trial
This multicenter randomized controlled clinical trial aims to compare the clinical, radiographic, microbiological and molecular outcomes of two collagenated xenogeneic bone substitutes (GTO® and GenOs®) used in combination with…
- Conditions
- Periodontitis (Stage 3), Minimally Invasive Surgical Procedures, Bone Substitutes
- Trial name
- NCT07671963
- Testing
- GTO® with NIPSA surgical approach, GenOs® + NIPSA
- Where
- 2 sites in Italy, Serbia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Belgrade
Periodontitis
RhBMP-2 in Intrabony Defects - A Randomized Controlled Trial
This study evaluated the regenerative potential of rhBMP-2 gel in intrabony defects when compared to sticky bone (control).
- Trial name
- NCT04368650
- Testing
- BMP-2, PRF
- Where
- India
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- SVS Institute of Dental Sciences
Furcation Defects
Comparison of Bone Graft and Photodynamic Therapy in Class II Furcation
This is a surgical comparative clinical trial which aims to assess class II buccal furcation defects treated with Xenograft alone or preceded by antimicrobial photodynamic therapy.
- Trial name
- NCT06519409
- Testing
- Open flap debridement and photodynamic therapy
- Where
- India
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Krishnadevaraya College of Dental Sciences & Hospital
Periodontitis, Periodontitis Stage III
Alb-PRF as an Adjunct to Regenerative Periodontal Surgery
Periodontitis is characterized by the progressive destruction of tooth-supporting tissues and may lead to the formation of intrabony periodontal defects.
- Conditions
- Periodontitis, Periodontitis Stage III, Periodontal Intrabony Defects
- Trial name
- NCT07805317
- Testing
- Regenerative Periodontal Surgery With EDTA and Allogeneic Bone Graft, Albumin Platelet-Rich Fibrin
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 24 people
- Sponsor
- Halil Ata BIÇAKÇIOĞLU
Periodontal Attachment Loss, Periodontal Bone Loss
Added Benefit of L-PRF to Autogenous Bone Graft in the Treatment of Mandibular Degree II Furcation Defects
Different therapeutic approaches have been proposed for the treatment of furcation defects and the regeneration of periodontium within the furcation area is considered one of the most challenging aspect of surgical periodontal…
- Trial name
- NCT03756493
- Testing
- Periodontal Surgery with OFD+ABG+L-PRF, Periodontal Surgery with OFD+ABG, Periodontal Surgery OFD
- Where
- Italy
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- G. d'Annunzio University
Periodontal Bone Loss, Periodontal Disease
Healing of Intrabony Defects Following Treatment With PRF or EMD
Objective: To evaluate clinically the long-term results following treatment of deep intrabony defects with either platelet-rich fibrin gel (PRF) or an enamel matrix derivative (EMD).
- Conditions
- Periodontal Bone Loss, Periodontal Disease, Platelet Rich Fibrin
- Trial name
- NCT07183631
- Testing
- Platelet rich fibrin, Enamel matrix derivate
- Where
- Hungary
- Volunteers
- 28 people
- Sponsor
- Semmelweis University
Intrabony Periodontal Defect
Efficacy of Insulin Like Growth Factor-1(IGF-1) on Bone Regeneration in Intrabony Defects : A Clinico-radiograph Study
The aim of this study is to clinically evaluate the efficacy of Insulin like Growth Factor (IGF-1) on bone regeneration in intrabony defects.
- Trial name
- NCT06426524
- Testing
- IGF-1 Gel, Hydroxyapatite
- Where
- India
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Dr R Viswa Chandra
Intrabony Periodontal Defect
Effect of Alendronate With β - TCP Bone Substitute in Surgical Therapy of Periodontal Intra-osseous Defects.
The aim of the present study was to evaluate the bone formation potential of 400µg alendronate delivered in β-TCP in the treatment of periodontal intra-osseous defects.
- Trial name
- NCT02795546
- Testing
- Alendronate sodium, beta-tricalcium phosphate bone substitute
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre
Intrabony Periodontal Defect
Clinical Effect of APRF With DFDBA Compare to Collagen Membrane With DFDBA in Intraosseous Defect
to assess the effectiveness of advanced PRF in combination of Demineralized freeze-dried bone allograft (DFDBA) as compared to collagen membrane in combination with Demineralized freeze-dried bone allograft (DFDBA) treatment of…
- Trial name
- NCT03922503
- Testing
- Advanced- platelets rich fibrin (A-PRF) with Demineralized freeze-dried bone allograft (DFDBA), Collagen membrane with Demineralized freeze-dried bone allograft (DFDBA)
- Where
- Egypt
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Cairo University
Periodontitis
Polynucleotide + Hyaluronic Acid Gel With Xenogeneic Graft for Intrabony Periodontal Defects
Over the last 30 years, the prevalence of periodontitis (PE) has increased substantially, including among younger populations, highlighting the need to improve the management of this condition as a chronic disease and to develop…
- Trial name
- NCT07522684
- Testing
- Polynucleotide and hyaluronic acid-based gel, Control, Xenogeneic bone graft
- Where
- Brazil
- Volunteers
- 66 people
- Sponsor
- University of Sao Paulo
Maxillofacial Bone Defect, Alveolar Bone Loss
Bone Marrow Mononuclear Cells for the Repair of Severe Maxillofacial Bone Defects
This is a single-center, single-arm, open-label clinical study conducted at the Department of Stomatology, Nanjing Drum Tower Hospital.
- Trial name
- NCT07852806
- Testing
- Autologous bone marrow-derived mononuclear cells (BMMNCs), Bio-Oss bone graft material with collagen membrane
- Where
- China
- Volunteers
- 20 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Periodontal Bone Loss
Evaluation of the Effect of Incorporation of Vitamin C Into Platelet Rich Fibrin Scaffold in Treatment of Intra-osseous Periodontal Defects
This study is meant to assess clinically the possible predictable clinical attachment gain regarding the use of vitamin C with platelet rich fibrin versus platelet rich fibrin alone in the treatment of periodontal intrabony…
- Trial name
- NCT03707483
- Testing
- combination of vitamin C and platelet rich fibrin
- Volunteers
- 20 people
- Sponsor
- Cairo University
Periodontal Diseases, Periodontal Bone Loss
Entire Papilla Preservation Technique in the Treatment of Periodontal IntraBony Defects: a 1-year Follow-up Study
The aim of this study was to investigate the radiographic and clinical outcomes associated with the whole papilla preservation technique in the treatment of isolated intraosseous defects in patients with stage III periodontitis.
- Trial name
- EPP (NCT06744348)
- Testing
- ENTİRE PAPİLLA PRESERVATİON
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Necmettin Erbakan University
Periodontitis
Emdogain and Straumann Bone Ceramic in Infrabony Defects
Randomised, controlled, clinical study to compare the effect of the combination of bone ceramic and enamel matrix proteins (test) versus autogenous bone graft alone (control) in the treatment of deep-wide intrabony defects
- Trial name
- NCT00906776
- Testing
- Emdogain PLUS, Autogenous bone
- Where
- France
- Volunteers
- 19 people
- Sponsor
- Institut Straumann AG
Peri-implantitis
Reconstruction of Peri-implant Osseous Defects: A Randomized Trial
The purpose of this randomized trial was to compare reconstructive surgery of advanced peri-implant intra-osseous defects with porous titanium granules (PTG/Test) to open flap debridement (OFD/Control) in a non-submerged…
- Trial name
- NCT02406001
- Testing
- Tigran PTG, Surgical intervention
- Where
- Sweden
- Volunteers
- 70 people
- Sponsor
- Tigran Technologies AB
Furcation Defects, Periodontal Diseases
Osteoplasty in Conjunction With Surgical Treatment of Mandibular Grade II Furcation Defects
Teeth with furcation grade II defects will be treated with open flap debridement, with or without osteoplasty. The study is designed to examine the effect of osteoplasty in the treatment of teeth with furcation grade II defects…
- Trial name
- FURC-II-OST (NCT03917030)
- Testing
- Open flap debridement with osteoplasty, Open flap debridement without osteoplasty
- Where
- Norway
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Oslo
Periodontal Bone Loss, Periodontal Attachment Loss
Platelet-rich Fibrin and Autogenous Bone vs Enamel Matrix Derivative and Autogenous Bone in Intrabony Defects
Currently, the most positive documented outcomes of periodontal regenerative therapy (PRT) in intrabony defects (IBDs) have been achieved with a combination of bone grafts ( BGs) and a regeneration material like membranes in…
- Trial name
- NCT03510780
- Testing
- Periodontal surgery with Enamel Matrix Derivative, Periodontal surgery with Platlet Rich fibrin
- Where
- Italy
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- G. d'Annunzio University